Pyrrolidinones as herbicides

ABSTRACT

Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof:wherein R1, R2, R3, R4, R5, R6, Q1, Q2, Y1, and Y2 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation application of U.S. application Ser.No. 16/415,241, filed on May 17, 2019; which is a continuationapplication of U.S. application Ser. No. 15/101,615, filed on Jun. 3,2016, now U.S. Pat. No. 10,294,202; which is a national stage ofinternational application no. PCT/US14/68073, filed on Dec. 2, 2014;which claims priority to U.S. provisional application No. 61/911,324,filed on Dec. 3, 2013.

FIELD OF THE INVENTION

This invention relates to certain pyrrolidinones, their N-oxides andsalts, and compositions and methods of their use for controllingundesirable vegetation.

BACKGROUND OF THE INVENTION

The control of undesired vegetation is extremely important in achievinghigh crop efficiency. Achievement of selective control of the growth ofweeds especially in such useful crops as rice, soybean, sugar beet,maize, potato, wheat, barley, tomato and plantation crops, among others,is very desirable. Unchecked weed growth in such useful crops can causesignificant reduction in productivity and thereby result in increasedcosts to the consumer. The control of undesired vegetation in noncropareas is also important. Many products are commercially available forthese purposes, but the need continues for new compounds that are moreeffective, less costly, less toxic, environmentally safer or havedifferent sites of action.

SUMMARY OF THE INVENTION

This invention is directed to compounds of Formula 1 (including allstereoisomers), including N-oxides and salts thereof, agriculturalcompositions containing them and their use as herbicides:

wherein

-   -   Q¹ is a phenyl ring or a naphthalenyl ring system, each ring or        ring system optionally substituted with up to 5 substituents        independently selected from R⁷; or a 5- to 6-membered fully        unsaturated heterocyclic ring or an 8- to 10-membered        heteroaromatic bicyclic ring system, each ring or ring system        containing ring members selected from carbon atoms and 1 to 4        heteroatoms independently selected from up to 2 O, up to 2 S and        up to 4 N atoms, wherein up to 3 carbon ring members are        independently selected from C(═O) and C(═S), and the sulfur atom        ring members are independently selected from        S(═O)_(u)(═NR⁸)_(v), each ring or ring system optionally        substituted with up to 5 substituents independently selected        from R⁷ on carbon atom ring members and selected from R⁹ on        nitrogen atom ring members;    -   Q² is a phenyl ring or a naphthalenyl ring system, each ring or        ring system optionally substituted with up to 5 substituents        independently selected from R¹⁰; or a 5- to 6-membered fully        unsaturated heterocyclic ring or an 8- to 10-membered        heteroaromatic bicyclic ring system, each ring or ring system        containing ring members selected from carbon atoms and 1 to 4        heteroatoms independently selected from up to 2 O, up to 2 S and        up to 4 N atoms, wherein up to 3 carbon ring members are        independently selected from C(═0) and C(═S), and the sulfur atom        ring members are independently selected from        S(═O)_(u)(═NR⁸)_(v), each ring or ring system optionally        substituted with up to 5 substituents independently selected        from R¹⁰ on carbon atom ring members and selected from R¹¹ on        nitrogen atom ring members;    -   Y¹ and Y² are each independently O, S or NR¹²;    -   R¹ is H, hydroxy, amino, C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₂-C₆        alkenyl, C₃-C₆ alkynyl, C₄-C₈ cycloalkylalkyl, C₂-C₈        alkoxyalkyl, C₂-C₈ haloalkoxyalkyl, C₂-C₈ alkylthioalkyl, C₂-C₈        alkylsulfinylalkyl, C₂-C₈ alkylsulfonylalkyl, C₂-C₈        alkylcarbonyl, C₂-C₈ haloalkylcarbonyl, C₄-C₁₀        cycloalkylcarbonyl, C₂-C₈ alkoxycarbonyl, C₂-C₈        haloalkoxycarbonyl, C₄-C₁₀ cycloalkoxycarbonyl, C₂-C₈        alkylaminocarbonyl, C₃-C₁₀ dialkylaminocarbonyl, C₄-C₁₀        cycloalkylaminocarbonyl, C₁-C₆ alkoxy, C₁-C₆ alkylthio, C₁-C₆        haloalkylthio, C₃-C₈ cycloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆        haloalkylsulfinyl, C₃-C₈ cycloalkylsulfinyl, C₁-C₆        alkylsulfonyl, C₁-C₆ haloalkylsulfonyl, C₃-C₈        cycloalkylsulfonyl, C₁-C₆ alkylaminosulfonyl, C₂-C₈        dialkylaminosulfonyl, C₃-C₁₀ trialkylsilyl or G¹;    -   R² and R³ are each independently H, halogen or C₁-C₄ alkyl; or    -   R² and R³ are taken together with the carbon atom to which they        are bonded to form a C₃-C₇ cycloalkyl ring;    -   R⁴ and R⁵ are each independently H, halogen or C₁-C₄ alkyl;    -   R⁶ is H, hydroxy, amino, C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₂-C₆        alkenyl, C₃-C₆ alkynyl, C₂-C₈ alkoxyalkyl, C₂-C₈        haloalkoxyalkyl, C₂-C₈ alkylthioalkyl, C₂-C₈ alkylsulfinylalkyl,        C₂-C₈ alkylsulfonylalkyl, C₂-C₈ alkylcarbonyl, C₂-C₈        haloalkylcarbonyl, C₄-C₁₀ cycloalkylcarbonyl, C₂-C₈        alkoxycarbonyl, C₂-C₈ haloalkoxycarbonyl, C₄-C₁₀        cycloalkoxycarbonyl, C₂-C₈ alkylaminocarbonyl, C₃-C₁₀        dialkylaminocarbonyl, C₄-C₁₀ cycloalkylaminocarbonyl, C₁-C₆        alkoxy, C₁-C₆ alkylthio, C₁-C₆ haloalkylthio, C₃-C₈        cycloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆ haloalkylsulfinyl,        C₃-C₈ cycloalkylsulfinyl, C₁-C₆ alkylsulfonyl, C₁-C₆        haloalkylsulfonyl, C₃-C₈ cycloalkylsulfonyl, C₁-C₆        alkylaminosulfonyl, C₂-C₈ dialkylaminosulfonyl, C₃-C₁₀        trialkylsilyl or G¹;    -   each R⁷ and R¹⁰ is independently halogen, cyano, nitro, C₁-C₈        alkyl, C₁-C₈ haloalkyl, C₁-C₈ nitroalkyl, C₂-C₈ alkenyl, C₂-C₈        haloalkenyl, C₂-C₈ nitroalkenyl, C₂-C₈ alkynyl, C₂-C₈        haloalkynyl, C₄-C₁₀ cycloalkylalkyl, C₄-C₁₀ halocycloalkylalkyl,        C₅-C₁₂ alkylcycloalkylalkyl, C₅-C₁₂ cycloalkylalkenyl, C₅-C₁₂        cycloalkylalkynyl, C₃-C₈ cycloalkyl, C₃-C₈ halocycloalkyl,        C₄-C₁₀ alkylcycloalkyl, C₆-C₁₂ cycloalkylcycloalkyl, C₃-C₈        cycloalkenyl, C₃-C₈ halocycloalkenyl, C₂-C₈ alkoxyalkyl, C₂-C₈        haloalkoxyalkyl, C₃-C₈ haloalkoxyalkoxy, C₃-C₈ alkoxyalkoxy,        C₄-C₁₀ cycloalkoxyalkyl, C₃-C₁₀ alkoxyalkoxyalkyl, C₂-C₈        alkylthioalkyl, C₂-C₈ alkylsulfinylalkyl, C₂-C₈        alkylsulfonylalkyl, C₂-C₈ alkylaminoalkyl, C₂-C₈        haloalkylaminoalkyl, C₄-C₁₀ cycloalkylaminoalkyl, C₃-C₁₀        dialkylaminoalkyl, —CHO, C₂-C₈ alkylcarbonyl, C₂-C₈        haloalkylcarbonyl, C₄-C₁₀ cycloalkylcarbonyl, —C(═O)OH, C₂-C₈        alkoxycarbonyl, C₂-C₈ haloalkoxycarbonyl, C₄-C₁₀        cycloalkoxycarbonyl, C₅-C₁₂ cycloalkylalkoxycarbonyl, —C(═O)NH₂,        C₂-C₈ alkylaminocarbonyl, C₄-C₁₀ cycloalkylaminocarbonyl, C₃-C₁₀        dialkylaminocarbonyl, C₁-C₈ alkoxy, C₁-C₈ haloalkoxy, C₂-C₈        alkoxyalkoxy, C₂-C₈ alkenyloxy, C₂-C₈ haloalkenyloxy, C₃-C₈        alkynyloxy, C₃-C₈ haloalkynyloxy, C₃-C₈ cycloalkoxy, C₃-C₈        halocycloalkoxy, C₄-C₁₀ cycloalkylalkoxy, C₃-C₁₀        alkylcarbonylalkoxy, C₂-C₈ alkylcarbonyloxy, C₂-C₈        haloalkylcarbonyloxy, C₄-C₁₀ cycloalkylcarbonyloxy, C₁-C₈        alkylsulfonyloxy, C₁-C₈ haloalkylsulfonyloxy, C₁-C₈ alkylthio,        C₁-C₈ haloalkylthio, C₃-C₈ cycloalkylthio, C₁-C₈ alkylsulfinyl,        C₁-C₈ haloalkylsulfinyl, C₁-C₈ alkylsulfonyl, C₁-C₈        haloalkylsulfonyl, C₃-C₈ cycloalkylsulfonyl, formylamino, C₂-C₈        alkylcarbonylamino, C₂-C₈ haloalkylcarbonylamino, C₂-C₈        alkoxycarbonylamino, C₁-C₆ alkylsulfonylamino, C₁-C₆        haloalkylsulfonylamino, —SF₅, —SCN, SO₂NH₂, C₃-C₁₂        trialkylsilyl, C₄-C₁₂ trialkylsilylalkyl, C₄-C₁₂        trialkylsilylalkoxy or G²;    -   each R⁸ is independently H, cyano, C₂-C₃ alkylcarbonyl or C₂-C₃        haloalkylcarbonyl;    -   each R⁹ and R¹¹ is independently cyano, C₁-C₃ alkyl, C₂-C₃        alkenyl, C₂-C₃ alkynyl, C₃-C₆ cycloalkyl, C₂-C₃ alkoxyalkyl,        C₁-C₃ alkoxy, C₂-C₃ alkylcarbonyl, C₂-C₃ alkoxycarbonyl, C₂-C₃        alkylaminoalkyl or C₃-C₄ dialkylaminoalkyl;    -   each R¹² is independently H, cyano, C₁-C₄ alkyl, C₁-C₄        haloalkyl, —(C═O)CH₃ or —(C═O)CF₃;    -   each G¹ is independently phenyl, phenylmethyl (i.e. benzyl),        pyridinylmethyl, phenylcarbonyl (i.e. benzoyl), phenoxy,        phenylethynyl, phenylsulfonyl or a 5- or 6-membered        heteroaromatic ring, each optionally substituted on ring members        with up to 5 substituents independently selected from R¹³;    -   each G² is independently phenyl, phenylmethyl (i.e. benzyl),        pyridinylmethyl, phenylcarbonyl (i.e. benzoyl), phenoxy,        phenylethynyl, phenylsulfonyl or a 5- or 6-membered        heteroaromatic ring, each optionally substituted on ring members        with up to 5 substituents independently selected from R¹⁴;    -   each R¹³ and R¹⁴ is independently halogen, cyano, hydroxy,        amino, nitro, —CHO, —C(═O)OH, —C(═O)NH₂, —SO₂NH₂, C₁-C₆ alkyl,        C₁-C₆ haloalkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, C₂-C₈        alkylcarbonyl, C₂-C₈ haloalkylcarbonyl, C₂-C₈ alkoxycarbonyl,        C₄-C₁₀ cycloalkoxycarbonyl, C₅-C₁₂ cycloalkylalkoxycarbonyl,        C₂-C₈ alkylaminocarbonyl, C₃-C₁₀ dialkylaminocarbonyl, C₁-C₆        alkoxy, C₁-C₆ haloalkoxy, C₂-C₈ alkylcarbonyloxy, C₁-C₆        alkylthio, C₁-C₆ haloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆        haloalkylsulfinyl, C₁-C₆ alkylsulfonyl, C₁-C₆ haloalkylsulfonyl,        C₁-C₆ alkylaminosulfonyl, C₂-C₈ dialkylaminosulfonyl, C₃-C₁₀        trialkylsilyl, C₁-C₆ alkylamino, C₂-C₈ dialkylamino, C₂-C₈        alkylcarbonylamino, C₁-C₆ alkylsulfonylamino, phenyl, pyridinyl        or thienyl; and    -   each u and v are independently 0, 1 or 2 in each instance of        S(═O)_(u)(═NR⁸)_(v), provided that the sum of u and v is 0, 1 or        2;    -   provided that    -   (a) the compound of Formula 1 is other than        N-1H-benzotriazol-1-yl-2-oxo-4-phenyl-3-pyrrolidinecarboxamide;

(b) when Q¹ comprises a 3-furanyl or 3-pyridinyl ring directly bonded tothe remainder of Formula 1, then said ring is substituted with at leastone substituent selected from R⁷;

-   -   (c) when Q¹ is an unsubstituted phenyl ring, and Q² comprises a        phenyl ring directly bonded to the remainder of Formula 1, then        said Q² ring is substituted with R¹⁰ other than optionally        substituted phenoxy or F at a 2-position, cyano or —CF₃ at the        4-position and R⁵ is H or halogen;    -   (d) when Q¹ is unsubstituted phenyl, and Q² comprises a        pyridinyl ring directly bonded to the remainder of Formula 1,        then said pyridinyl ring is substituted with at least one        substituent selected from R¹⁰;    -   (e) when Q¹ is a phenyl ring substituted with 4-phenyl or        4-phenoxy, said Q¹ ring is further substituted with and R⁷        substituent;    -   (f) when Q¹ comprises a phenyl ring directly bonded to the        remainder of Formula 1 and said ring is substituted with R⁷ at        both ortho positions (relative to the bond to the remainder of        Formula 1), then said ring is also independently substituted        with R⁷ on at least one additional position;    -   (g) when Q¹ is other than unsubstituted 1-naphthalenyl, then Q²        is other than 2,3-difluorophenyl or 2-CF₃-phenyl;

(h) Q² is other than optionally substituted 1H-pyrazol-5-yl; and

-   -   (i) when Q² comprises a 1H-pyrazol-3-yl ring directly bonded to        the remainder of Formula 1, said ring is substituted at the        1-position with R⁹.

More particularly, this invention pertains to a compound of Formula 1(including all stereoisomers), an N-oxide or a salt thereof. Thisinvention also relates to a herbicidal composition comprising a compoundof the invention (i.e. in a herbicidally effective amount) and at leastone component selected from the group consisting of surfactants, soliddiluents and liquid diluents, the composition optionally furthercomprising at least one additional active ingredient selected from thegroup consisting of other herbicides and herbicide safeners. Thisinvention further relates to a method for controlling the growth ofundesired vegetation comprising contacting the vegetation or itsenvironment with a herbicidally effective amount of a compound of theinvention (e.g., as a composition described herein).

DETAILS OF THE INVENTION

As used herein, the terms “comprises,” “comprising,” “includes,”“including,” “has,” “having,” “contains”, “containing,” “characterizedby” or any other variation thereof, are intended to cover anon-exclusive inclusion, subject to any limitation explicitly indicated.For example, a composition, mixture, process or method that comprises alist of elements is not necessarily limited to only those elements butmay include other elements not expressly listed or inherent to suchcomposition, mixture, process, or method.

The transitional phrase “consisting of” excludes any element, step, oringredient not specified. If in the claim, such would close the claim tothe inclusion of materials other than those recited except forimpurities ordinarily associated therewith. When the phrase “consistingof” appears in a clause of the body of a claim, rather than immediatelyfollowing the preamble, it limits only the element set forth in thatclause; other elements are not excluded from the claim as a whole.

The transitional phrase “consisting essentially of” is used to define acomposition, method that includes materials, steps, features,components, or elements, in addition to those literally disclosed,provided that these additional materials, steps, features, components,or elements do not materially affect the basic and novelcharacteristic(s) of the claimed invention. The term “consistingessentially of” occupies a middle ground between “comprising” and“consisting of”.

Where applicants have defined an invention or a portion thereof with anopen-ended term such as “comprising,” it should be readily understoodthat (unless otherwise stated) the description should be interpreted toalso describe such an invention using the terms “consisting essentiallyof” or “consisting of.”

Further, unless expressly stated to the contrary, “or” refers to aninclusive or and not to an exclusive or. For example, a condition A or Bis satisfied by any one of the following: A is true (or present) and Bis false (or not present), A is false (or not present) and B is true (orpresent), and both A and B are true (or present).

Also, the indefinite articles “a” and “an” preceding an element orcomponent of the invention are intended to be nonrestrictive regardingthe number of instances (i.e. occurrences) of the element or component.Therefore “a” or “an” should be read to include one or at least one, andthe singular word form of the element or component also includes theplural unless the number is obviously meant to be singular.

As referred to herein, the term “seedling”, used either alone or in acombination of words means a young plant developing from the embryo of aseed.

As referred to herein, the term “broadleaf” used either alone or inwords such as “broadleaf weed” means dicot or dicotyledon, a term usedto describe a group of angiosperms characterized by embryos having twocotyledons.

As used herein, the term “alkylating agent” refers to a chemicalcompound in which a carbon-containing radical is bound through a carbonatom to a leaving group such as halide or sulfonate, which isdisplaceable by bonding of a nucleophile to said carbon atom. Unlessotherwise indicated, the term “alkylating” does not limit thecarbon-containing radical to alkyl; the carbon-containing radicals inalkylating agents include the variety of carbon-bound substituentradicals specified for R¹.

In the above recitations, the term “alkyl”, used either alone or incompound words such as “alkylthio” or “haloalkyl” includesstraight-chain or branched alkyl, such as, methyl, ethyl, n-propyl,i-propyl, or the different butyl, pentyl or hexyl isomers. “Alkenyl”includes straight-chain or branched alkenes such as ethenyl, 1-propenyl,2-propenyl, and the different butenyl, pentenyl and hexenyl isomers.“Alkenyl” also includes polyenes such as 1,2-propadienyl and2,4-hexadienyl. “Alkynyl” includes straight-chain or branched alkynessuch as ethynyl, 1-propynyl, 2-propynyl and the different butynyl,pentynyl and hexynyl isomers. “Alkynyl” can also include moietiescomprised of multiple triple bonds such as 2,5-hexadiynyl.

“Alkoxy” includes, for example, methoxy, ethoxy, n-propyloxy,isopropyloxy and the different butoxy, pentoxy and hexyloxy isomers.“Alkoxyalkyl” denotes alkoxy substitution on alkyl. Examples of“alkoxyalkyl” include CH₃OCH₂, CH₃OCH₂CH₂, CH₃CH₂OCH₂, CH₃CH₂CH₂CH₂OCH₂and CH₃CH₂OCH₂CH₂. “Alkoxyalkoxyalkyl” denotes at least alkoxysubstitution on the alkoxy moiety of alkoxyalkyl moiety. Examples of“alkoxyalkoxyalkyl” include CH₃OCH₂OCH₂—, CH₃CH₂O(CH₃)CHOCH₂— and(CH₃O)₂CHOCH₂—. “Alkoxyalkoxy” denotes alkoxy substitution on alkoxy.“Alkenyloxy” includes straight-chain or branched alkenyloxy moieties.Examples of “alkenyloxy” include H₂C═CHCH₂O, (CH₃)₂C═CHCH₂O,(CH₃)CH═CHCH₂O, (CH₃)CH═C(CH₃)CH₂O and CH₂═CHCH₂CH₂O. “Alkynyloxy”includes straight-chain or branched alkynyloxy moieties. Examples of“alkynyloxy” include HC≡CCH₂O, CH₃C≡CCH₂O and CH₃C≡CCH₂CH₂O. “Alkylthio”includes branched or straight-chain alkylthio moieties such asmethylthio, ethylthio, and the different propylthio, butylthio,pentylthio and hexylthio isomers. “Alkylsulfinyl” includes bothenantiomers of an alkylsulfinyl group. Examples of “alkylsulfinyl”include CH₃S(O)—, CH₃CH₂S(O)—, CH₃CH₂CH₂S(O)—, (CH₃)₂CHS(O)— and thedifferent butylsulfinyl, pentylsulfinyl and hexylsulfinyl isomers.Examples of “alkylsulfonyl” include CH₃S(O)₂—, CH₃CH₂S(O)₂—,CH₃CH₂CH₂S(O)₂—, (CH₃)₂CHS(O)₂—, and the different butylsulfonyl,pentylsulfonyl and hexylsulfonyl isomers. “Alkylthioalkyl” denotesalkylthio substitution on alkyl. Examples of “alkylthioalkyl” includeCH₃SCH₂, CH₃SCH₂CH₂, CH₃CH₂SCH₂, CH₃CH₂CH₂CH₂SCH₂ and CH₃CH₂SCH₂CH₂.“Alkylsulfinylalkyl” denotes alkylsulfinyl substitution on alkyl.Examples of “alkylsulfinylalkyl” include CH₃S(═O)CH₂, CH₃S(═O)CH₂CH₂,CH₃CH₂S(═O)CH₂ and CH₃CH₂S(═O)CH₂CH₂. “Alkylsulfonylalkyl” denotesalkylsulfinyl substitution on alkyl. Examples of “alkylsulfinylalkyl”include CH₃S(═O)₂CH₂, CH₃S(═O)₂CH₂CH₂, CH₃CH₂S(═O)₂CH₂ andCH₃CH₂S(═O)₂CH₂CH₂. “Alkylamino”, “dialkylamino”, and the like, aredefined analogously to the above examples. Examples of “alkylaminoalkyl”include CH₃NHCH₂—, (CH₃)₂CHNHCH₂— and CH₃NHCH(CH₃)—. Examples of“dialkylaminoalkyl” include (CH₃)₂NCH₂—, (CH₃)₂NC(CH₃)H— and(CH₃)(CH₃)NCH₂—. Examples of “dialkylaminocarbonyl” include(CH₃)₂NC(O)—. Examples of “dialkylaminosulfonyl” include (CH₃)₂NS(O)₂—.The term “alkoxycarbonylamino” denotes a straight-chain or branchedalkoxy moieties bonded to a C(═O) moiety of carbonylamino group.Examples of “alkoxycarbonylamino” include CH₃OC(═O)NH— andCH₃CH₂OC(═O)NH—.

“Cycloalkyl” includes, for example, cyclopropyl, cyclobutyl, cyclopentyland cyclohexyl. The term “alkylcycloalkyl” denotes alkyl substitution ona cycloalkyl moiety and includes, for example, ethylcyclopropyl,i-propylcyclobutyl, 3-methylcyclopentyl and 4-methylcyclohexyl. The term“cycloalkylalkyl” denotes cycloalkyl substitution on an alkyl moiety.Examples of “cycloalkylalkyl” include cyclopropylmethyl,cyclopentylethyl, and other cycloalkyl moieties bonded to straight-chainor branched alkyl groups. The term “cycloalkoxy” denotes cycloalkyllinked through an oxygen atom such as cyclopentyloxy and cyclohexyloxy.“Cycloalkylalkoxy” denotes cycloalkylalkyl linked through an oxygen atomattached to the alkyl chain. Examples of “cycloalkylalkoxy” includecyclopropylmethoxy, cyclopentylethoxy, and other cycloalkyl moietiesbonded to straight-chain or branched alkoxy groups. “Cycloalkenyl”includes groups such as cyclopentenyl and cyclohexenyl as well as groupswith more than one double bond such as 1,3- and 1,4-cyclohexadienyl.

The term “halogen”, either alone or in compound words such as“haloalkyl”, or when used in descriptions such as “alkyl substitutedwith halogen” includes fluorine, chlorine, bromine or iodine. Further,when used in compound words such as “haloalkyl”, or when used indescriptions such as “alkyl substituted with halogen” said alkyl may bepartially or fully substituted with halogen atoms which may be the sameor different. Examples of “haloalkyl” or “alkyl substituted withhalogen” include F₃C, ClCH₂, CF₃CH₂ and CF₃CCl₂. The terms“halocycloalkyl”, “haloalkoxy”, “haloalkylthio”, “haloalkenyl”,“haloalkynyl”, “haloalkenyloxy”, “haloalkylcarbonylamino”,“haloalkylsulfonylamino”, “haloalkylsulfonyloxy”, “haloalkoxyalkyl”,“haloalkylcarbonyloxy”, “haloalkylaminoalkyl” and the like, are definedanalogously to the term “haloalkyl”. Examples of “haloalkoxy” includeCF₃O—, CCl₃CH₂O—, HCF₂CH₂CH₂O— and CF₃CH₂O—. Examples of “haloalkylthio”include CCl₃S—, CF₃S—, CCl₃CH₂S— and ClCH₂CH₂CH₂S—. Examples of“haloalkylsulfinyl” include CF₃S(O)—, CCl₃S(O)—, CF₃CH₂S(O)— andCF₃CF₂S(O)—. Examples of “haloalkylsulfonyl” include CF₃S(O)₂—,CCl₃S(O)₂—, CF₃CH₂S(O)₂— and CF₃CF₂S(O)₂—. Examples of “haloalkenyl”include (Cl)₂C═CHCH₂— and CF₃CH₂CH═CHCH₂—. Examples of “haloalkenyloxy”include (Cl)₂C═CHCH₂O— and CF₃CH₂CH═CHCH₂O—. Examples of “haloalkynyl”include HC≡CCHCl—, CF₃C≡C—, CCl₃C≡C— and FCH₂C≡CCH₂—. Examples of“haloalkoxyalkyl” include CF₃OCH₂—, ClCH₂CH₂OCH₂CH₂—, Cl₃CCH₂OCH₂— aswell as branched alkyl derivatives. Examples of “haloalkoxycarbonyl”include CF₃OC(O)—, ClCH₂CH₂OCH₂CH₂—, Cl₃CCH₂OCH₂OC(O)— as well asbranched alkyl derivatives.

“Alkylcarbonyl” denotes a straight-chain or branched alkyl moietiesbonded to a C(═O) moiety. Examples of “alkylcarbonyl” include CH₃C(═O)—,CH₃CH₂CH₂C(═O)— and (CH₃)₂CHC(═O)—. Examples of “alkoxycarbonyl” includeCH₃OC(═O)—, CH₃CH₂OC(═O)—, CH₃CH₂CH₂OC(═O)—, (CH₃)₂CHOC(═O)— and thedifferent butoxy- or pentoxycarbonyl isomers. “Cycloalkylalkoxycarbonyl”denotes a cycloalkylalkyl moieties bonded to an oxygen atom ofalkoxycarbonyl moiety. Examples of “cycloalkylalkoxycarbonyl” includecyclopropyl-CH₂OC(═O)—, cyclopropyl-CH(CH₃)OC(═O)— andcyclopentyl-CH₂OC(═O)—.

The total number of carbon atoms in a substituent group is indicated bythe “C_(i)-C_(j)” prefix where i and j are numbers from 1 to 12. Forexample, C₁-C₄ alkylsulfonyl designates methylsulfonyl throughbutylsulfonyl; C₂ alkoxyalkyl designates CH₃OCH₂—; C₃ alkoxyalkyldesignates, for example, CH₃CH(OCH₃)—, CH₃OCH₂CH₂— or CH₃CH₂OCH₂—; andC₄ alkoxyalkyl designates the various isomers of an alkyl groupsubstituted with an alkoxy group containing a total of four carbonatoms, examples including CH₃CH₂CH₂OCH₂— and CH₃CH₂OCH₂CH₂—.

When a compound is substituted with a substituent bearing a subscriptthat indicates the number of said substituents can exceed 1, saidsubstituents (when they exceed 1) are independently selected from thegroup of defined substituents, e.g., [R⁷)_(n)], n is 1, 2, 3, 4 or 5).Further, when the subscript indicates a range, e.g. (R)_(i-j), then thenumber of substituents may be selected from the integers between i and jinclusive. When a group contains a substituent which can be hydrogen,for example R¹ or R², then when this substituent is taken as hydrogen,it is recognized that this is equivalent to said group beingunsubstituted. When a variable group is shown to be optionally attachedto a position, for example [R⁽⁷⁾ _(n)] wherein n may be 0, then hydrogenmay be at the position even if not recited in the variable groupdefinition. When one or more positions on a group are said to be “notsubstituted” or “unsubstituted”, then hydrogen atoms are attached totake up any free valency.

The expression “fully saturated” in relation to a ring of atoms meansthat the bonds between the atoms of the ring are all single. Theexpression “fully unsaturated” in relation to a ring means that thebonds between the atoms in the ring are single or double bonds accordingto valence bond theory and furthermore the bonds between the atoms inthe ring include as many double bonds as possible without double bondsbeing cumulative (i.e. no C═C═C, N═C═C, etc.). The term “partiallyunsaturated” in relation to a ring denotes a ring comprising at leastone ring member bonded to an adjacent ring member though a double bondand which conceptually potentially accommodates a number ofnon-cumulated double bonds through adjacent ring members (i.e. in itsfully unsaturated counterpart form) greater than the number of doublebonds present (i.e. in its partially unsaturated form). When a fullyunsaturated ring satisfies Hückel's rule then it can also be describedas aromatic.

Unless otherwise indicated, a “ring” or “ring system” as a component ofFormula 1 (e.g., substituent Q¹) is carbocyclic or heterocyclic. Theterm “ring system” denotes two or more fused rings. The terms “bicyclicring system” and “fused bicyclic ring system” denote a ring systemconsisting of two fused rings, in which either ring can be saturated,partially unsaturated, or fully unsaturated unless otherwise indicated.The term “fused heterobicyclic ring system” denotes a fused bicyclicring system in which at least one ring atom is not carbon. A “bridgedbicyclic ring system” is formed by bonding a segment of one or moreatoms to nonadjacent ring members of a ring. The term “ring member”refers to an atom or other moiety (e.g., C(═O), C(═S), S(O) or S(O)₂)forming the backbone of a ring or ring system.

The terms “carbocyclic ring”, “carbocycle” or “carbocyclic ring system”denote a ring or ring system wherein the atoms forming the ring backboneare selected only from carbon. Unless otherwise indicated, a carbocyclicring can be a saturated, partially unsaturated, or fully unsaturatedring. When a fully unsaturated carbocyclic ring satisfies Hückel's rule,then said ring is also called an “aromatic ring”. “Saturatedcarbocyclic” refers to a ring having a backbone consisting of carbonatoms linked to one another by single bonds; unless otherwise specified,the remaining carbon valences are occupied by hydrogen atoms.

The terms “heterocyclic ring”, “heterocycle” or “heterocyclic ringsystem” denote a ring or ring system in which at least one atom formingthe ring backbone is not carbon, e.g., nitrogen, oxygen or sulfur.Typically a heterocyclic ring contains no more than 4 nitrogens, no morethan 2 oxygens and no more than 2 sulfurs. Unless otherwise indicated, aheterocyclic ring can be a saturated, partially unsaturated, or fullyunsaturated ring. When a fully unsaturated heterocyclic ring satisfiesHückel's rule, then said ring is also called a “heteroaromatic ring” or“aromatic heterocyclic ring”. Unless otherwise indicated, heterocyclicrings and ring systems can be attached through any available carbon ornitrogen by replacement of a hydrogen on said carbon or nitrogen.

“Aromatic” indicates that each of the ring atoms is essentially in thesame plane and has a p-orbital perpendicular to the ring plane, and that(4n+2)π electrons, where n is a positive integer, are associated withthe ring to comply with Hückel's rule. The term “aromatic ring system”denotes a carbocyclic or heterocyclic ring system in which at least onering of the ring system is aromatic. The term “aromatic carbocyclic ringsystem” denotes a carbocyclic ring system in which at least one ring ofthe ring system is aromatic. The term “aromatic heterocyclic ringsystem” denotes a heterocyclic ring system in which at least one ring ofthe ring system is aromatic. The term “nonaromatic ring system” denotesa carbocyclic or heterocyclic ring system that may be fully saturated,as well as partially or fully unsaturated, provided that none of therings in the ring system are aromatic. The term “nonaromatic carbocyclicring system” in which no ring in the ring system is aromatic. The term“nonaromatic heterocyclic ring system” denotes a heterocyclic ringsystem in which no ring in the ring system is aromatic.

The term “optionally substituted” in connection with the heterocyclicrings refers to groups which are unsubstituted or have at least onenon-hydrogen substituent that does not extinguish the biologicalactivity possessed by the unsubstituted analog. As used herein, thefollowing definitions shall apply unless otherwise indicated. The term“optionally substituted” is used interchangeably with the phrase“substituted or unsubstituted” or with the term “(un)substituted.”Unless otherwise indicated, an optionally substituted group may have asubstituent at each substitutable position of the group, and eachsubstitution is independent of the other.

When Q¹ or Q² is 5- or 6-membered nitrogen-containing heterocyclic ring,it may be attached to the remainder of Formula 1 though any availablecarbon or nitrogen ring atom, unless otherwise described. As notedabove, Q¹ and Q² can be (among others) phenyl optionally substitutedwith one or more substituents selected from a group of substituents asdefined in the Summary of the Invention. An example of phenyl optionallysubstituted with one to five substituents is the ring illustrated as U-1in Exhibit 1, wherein, for example, R^(v) is R⁷ as defined in theSummary of the Invention for Q¹, or R^(v) is R¹⁰ as defined in theSummary of the Invention for Q², and r is an integer (from 0 to 5).

As noted above, Q¹ and Q² can be (among others) a 5- or 6-membered fullyunsaturated heterocyclic ring, optionally substituted with one or moresubstituents selected from a group of substituents as defined in theSummary of the Invention. Examples of a 5- or 6-membered unsaturatedaromatic heterocyclic ring optionally substituted with from one or moresubstituents include the rings U-2 through U-61 illustrated in Exhibit 1wherein R^(v) is any substituent as defined in the Summary of theInvention for Q¹ and Q², and r is an integer from 0 to 4, limited by thenumber of available positions on each U group. As U-29, U-30, U-36,U-37, U-38, U-39, U-40, U-41, U-42 and U-43 have only one availableposition, for these U groups r is limited to the integers 0 or 1, and rbeing 0 means that the U group is unsubstituted and a hydrogen ispresent at the position indicated by (R^(v))_(r).

As noted above, Q¹ and Q² can be (among others) an 8-, 9- or 10-memberedheteroaromatic bicyclic ring system optionally substituted with one ormore substituents selected from a group of substituents as defined inthe Summary of the Invention for Q¹ and Q². Examples of 8-, 9- or10-membered heteroaromatic bicyclic ring system optionally substitutedwith from one or more substituents include the rings U-62 through U-100illustrated in Exhibit 2 wherein R^(v) is any substituent as defined inthe Summary of the Invention for Q¹ or Q², and r is typically an integerfrom 0 to 4.

Although R^(v) groups are shown in the structures U-1 through U-100, itis noted that they do not need to be present since they are optionalsubstituents. Note that when R^(v) is H when attached to an atom, thisis the same as if said atom is unsubstituted. The nitrogen atoms thatrequire substitution to fill their valence are substituted with H orR^(v). Note that when the attachment point between (R^(v))_(r) and the Ugroup is illustrated as floating, (R^(v))_(r) can be attached to anyavailable carbon atom or nitrogen atom of the U group. Note that whenthe attachment point on the U group is illustrated as floating, the Ugroup can be attached to the remainder of Formula 1 through anyavailable carbon or nitrogen of the U group by replacement of a hydrogenatom. Preferably for greatest herbicidal activity, the U group isattached to the remainder of Formula 1 through an available carbon ornitrogen on a fully unsaturated ring of the U group. Note that some Ugroups can only be substituted with less than 4 R^(v) groups (e.g., U-2through U-5, U-7 through U-48, and U-52 through U-61).

In the present disclosure and claims, the term “pyrrolidinone” andrelated terms such as “pyrrolidinone ring” refer to 2-oxo-pyrrolidinederivatives according to the Chemical Abstracts system of nomenclature,including derivatives in which the oxygen atom of the 2-oxo moiety isreplaced by S or NR¹² as Y¹, unless limited to oxygen by particularcontext.

A wide variety of synthetic methods are known in the art to enablepreparation of aromatic and nonaromatic heterocyclic rings and ringsystems; for extensive reviews see the eight volume set of ComprehensiveHeterocyclic Chemistry, A. R. Katritzky and C. W. Rees editors-in-chief,Pergamon Press, Oxford, 1984 and the twelve volume set of ComprehensiveHeterocyclic Chemistry II, A. R. Katritzky, C. W. Rees and E. F. V.Scriven editors-in-chief, Pergamon Press, Oxford, 1996.

Compounds of this invention can exist as one or more stereoisomers. Thevarious stereoisomers include enantiomers, diastereomers, atropisomersand geometric isomers. Stereoisomers are isomers of identicalconstitution but differing in the arrangement of their atoms in spaceand include enantiomers, diastereomers, cis-trans isomers (also known asgeometric isomers) and atropisomers. Atropisomers result from restrictedrotation about single bonds where the rotational barrier is high enoughto permit isolation of the isomeric species. One skilled in the art willappreciate that one stereoisomer may be more active and/or may exhibitbeneficial effects when enriched relative to the other stereoisomer(s)or when separated from the other stereoisomer(s). Additionally, theskilled artisan knows how to separate, enrich, and/or to selectivelyprepare said stereoisomers. The compounds of the invention may bepresent as a mixture of stereoisomers, individual stereoisomers or as anoptically active form. Particularly when R⁴ and R⁵ are each H, theC(O)N(Q²)(R⁶) and Q¹ substituents are typically mostly in thethermodynamically preferred trans configuration on the pyrrolidinonering.

For example the C(O)N(Q²)(R⁶) moiety (bonded to the carbon at the3-position of the pyrrolidinone ring) and Q¹ (bonded to the carbon atthe 4-position of the pyrrolidinone ring) are generally found in thetrans configuration. These two carbon atoms (i.e. at the 3- and4-positions each possess the pyrrolidinone ring of Formula 1) bothpossess a chiral center. The two most prevalent pairs of enantiomers aredepicted as Formula 1′ and Formula 1″ where the chiral centers areidentified (i.e. as 3R,4S or as 3S,4R) wherein R¹ is hydrogen. Whilethis invention pertains to all stereoisomers, the preferred enantiomericpair for biological operability is identified as Formula 1′ (i.e. the3R,4S configuration) wherein R¹ is hydrogen. For a comprehensivediscussion of all aspects of stereoisomerism, see Ernest L. Eliel andSamuel H. Wilen, Stereochemistry of Organic Compounds, John Wiley &Sons, 1994.

The skilled artisan will also recognize that the carbon atom at the5-position of the pyrrolidinone ring (i.e. the carbon atom to which bothR² and R³ are bonded) also contains a stereocenter indicated by a (*) asshown in Formula 1′″. This invention pertains to all stereoisomers, andtherefore, when either R² or R³ are other than the same substituent,then a mixture of diastereomers is possible.

Molecular depictions drawn herein follow standard conventions fordepicting stereochemistry. To indicate stereoconfiguration, bonds risingfrom the plane of the drawing and towards the viewer are denoted bysolid wedges wherein the broad end of the wedge is attached to the atomrising from the plane of the drawing towards the viewer. Bonds goingbelow the plane of the drawing and away from the viewer are denoted bydashed wedges wherein the narrow end of the wedge is attached to theatom further away from the viewer. Constant width lines indicate bondswith a direction opposite or neutral relative to bonds shown with solidor dashed wedges; constant width lines also depict bonds in molecules orparts of molecules in which no particular stereoconfiguration isintended to be specified.

This invention also comprises racemic mixtures, for example, equalamounts of the enantiomers of Formulae 1′ and 1″ (and optionally 1′″).In addition, this invention includes compounds that are enrichedcompared to the racemic mixture in an enantiomer of Formula 1. Alsoincluded are the essentially pure enantiomers of compounds of Formula 1,for example, Formula 1′ and Formula 1″.

When enantiomerically enriched, one enantiomer is present in greateramounts than the other, and the extent of enrichment can be defined byan expression of enantiomeric ratio (ER) expressed as the relative area% of the two entantiomers determined by chiral high-performance liquidchromatography.

Preferably the compositions of this invention have at least a 50% ER;more preferably at least a 75% ER; still more preferably at least a 90%ER; and the most preferably at least a 94% ER of the more active isomer.Of particular note are enantiomerically pure embodiments of the moreactive isomer.

Compounds of Formula 1 can comprise additional chiral centers. Forexample, substituents and other molecular constituents such as R², R³and R⁶ may themselves contain chiral centers. This invention comprisesracemic mixtures as well as enriched and essentially purestereoconfigurations at these additional chiral centers.

Compounds of this invention can exist as one or more conformationalisomers due to restricted rotation about the amide bond C(O)N(Q²)(R⁶) inFormula 1. This invention comprises mixtures of conformational isomers.In addition, this invention includes compounds that are enriched in oneconformer relative to others. Compounds of Formula 1 typically exist inmore than one form, and Formula 1 thus include all crystalline andnon-crystalline forms of the compounds they represent. Non-crystallineforms include embodiments which are solids such as waxes and gums aswell as embodiments which are liquids such as solutions and melts.Crystalline forms include embodiments which represent essentially asingle crystal type and embodiments which represent a mixture ofpolymorphs (i.e. different crystalline types). The term “polymorph”refers to a particular crystalline form of a chemical compound that cancrystallize in different crystalline forms, these forms having differentarrangements and/or conformations of the molecules in the crystallattice. Although polymorphs can have the same chemical composition,they can also differ in composition due the presence or absence ofco-crystallized water or other molecules, which can be weakly orstrongly bound in the lattice. Polymorphs can differ in such chemical,physical and biological properties as crystal shape, density, hardness,color, chemical stability, melting point, hygroscopicity,suspensibility, dissolution rate and biological availability. Oneskilled in the art will appreciate that a polymorph of a compound ofFormula 1 can exhibit beneficial effects (e.g., suitability forpreparation of useful formulations, improved biological performance)relative to another polymorph or a mixture of polymorphs of the samecompound of Formula 1. Preparation and isolation of a particularpolymorph of a compound of Formula 1 can be achieved by methods known tothose skilled in the art including, for example, crystallization usingselected solvents and temperatures. For a comprehensive discussion ofpolymorphism see R. Hilfiker, Ed., Polymorphism in the PharmaceuticalIndustry, Wiley-VCH, Weinheim, 2006.

One skilled in the art will appreciate that not all nitrogen-containingheterocycles can form N-oxides since the nitrogen requires an availablelone pair for oxidation to the oxide; one skilled in the art willrecognize those nitrogen-containing heterocycles which can formN-oxides. One skilled in the art will also recognize that tertiaryamines can form N-oxides. Synthetic methods for the preparation ofN-oxides of heterocycles and tertiary amines are very well known by oneskilled in the art including the oxidation of heterocycles and tertiaryamines with peroxy acids such as peracetic and m-chloroperbenzoic acid(MCPBA), hydrogen peroxide, alkyl hydroperoxides such as t-butylhydroperoxide, sodium perborate, and dioxiranes such asdimethyldioxirane. These methods for the preparation of N-oxides havebeen extensively described and reviewed in the literature, see forexample: T. L. Gilchrist in Comprehensive Organic Synthesis, vol. 7, pp748-750, S. V. Ley, Ed., Pergamon Press; M. Tisler and B. Stanovnik inComprehensive Heterocyclic Chemistry, vol. 3, pp 18-20, A. J. Boultonand A. McKillop, Eds., Pergamon Press; M. R. Grimmett and B. R. T. Keenein Advances in Heterocyclic Chemistry, vol. 43, pp 149-161, A. R.Katritzky, Ed., Academic Press; M. Tisler and B. Stanovnik in Advancesin Heterocyclic Chemistry, vol. 9, pp 285-291, A. R. Katritzky and A. J.Boulton, Eds., Academic Press; and G. W. H. Cheeseman and E. S. G.Werstiuk in Advances in Heterocyclic Chemistry, vol. 22, pp 390-392, A.R. Katritzky and A. J. Boulton, Eds., Academic Press.

One skilled in the art recognizes that because in the environment andunder physiological conditions salts of chemical compounds are inequilibrium with their corresponding nonsalt forms, salts share thebiological utility of the nonsalt forms. Thus a wide variety of salts ofa compound of Formula 1 are useful for control of undesired vegetation(i.e. are agriculturally suitable). The salts of a compound of Formula 1include acid-addition salts with inorganic or organic acids such ashydrobromic, hydrochloric, nitric, phosphoric, sulfuric, acetic,butyric, fumaric, lactic, maleic, malonic, oxalic, propionic, salicylic,tartaric, 4-toluenesulfonic or valeric acids. When a compound of Formula1 contains an acidic moiety such as a carboxylic acid or phenol, saltsalso include those formed with organic or inorganic bases such aspyridine, triethylamine or ammonia, or amides, hydrides, hydroxides orcarbonates of sodium, potassium, lithium, calcium, magnesium or barium.Accordingly, the present invention comprises compounds selected fromFormula 1, N-oxides and agriculturally suitable salts thereof.

Embodiments of the present invention as described in the Summary of theInvention include (where Formula 1 as used in the following Embodimentsincludes N-oxides and salts thereof):

-   -   Embodiment 1. A compound of Formula 1 wherein when Q¹ is an 8-        to 10-membered heteroaromatic bicyclic ring system optionally        substituted with R⁷ and R⁹, the remainder of Formula 1 is bonded        to a fully unsaturated ring of said bicyclic ring system.    -   Embodiment 2. A compound of Formula 1 or Embodiment 1 wherein Q¹        is a phenyl ring optionally substituted with up to 5        substituents independently selected from R⁷.    -   Embodiment 3. A compound of Embodiment 2 wherein Q¹ is a phenyl        ring substituted with 1 to 3 substituents independently selected        from R⁷.    -   Embodiment 4. A compound of Embodiment 3 wherein Q¹ is a phenyl        ring substituted with 1 to 2 substituents independently selected        from R⁷.    -   Embodiment 5. A compound of Formula 1 or any one of Embodiments        1 through 4 wherein Q¹ is a phenyl ring having a substituent        selected from R⁷ at the para (4-) position (and optionally other        substituents).    -   Embodiment 6. A compound of Formula 1 or any one of Embodiments        1 through 5 wherein when Q¹ is a phenyl ring substituted with at        least two substituents selected from R⁷, then one substituent is        at the para (4-) position and at least one other substituent is        at a meta position (of the phenyl ring).    -   Embodiment 7. A compound of Formula 1 or any one of Embodiments        1 through 6 wherein when Q² is an 8- to 10-membered        heteroaromatic bicyclic ring system optionally substituted with        R¹⁰ and R¹¹, the remainder of Formula 1 is bonded to a fully        unsaturated ring of said bicyclic ring system.    -   Embodiment 8. A compound of Formula 1 or any one of Embodiments        1 through 7 wherein Q² is a phenyl ring substituted with up to 5        substituents independently selected from R¹⁰.    -   Embodiment 9. A compound of Embodiment 8 wherein Q² is a phenyl        ring substituted with 1 to 3 substituents independently selected        from R¹⁰.    -   Embodiment 10. A compound of Embodiment 9 wherein Q² is a phenyl        ring substituted with 1 to 2 substituents independently selected        from R¹⁰.    -   Embodiment 11. A compound of Formula 1 or any one of Embodiments        1 through 10 wherein Q² is a phenyl ring having at least one        substituent selected from R¹⁰ at an ortho (e.g., 2-) position        (and optionally other substituents).    -   Embodiment 12. A compound of Formula 1 or any one of Embodiments        1 through 11 wherein when Q² is a phenyl ring substituted with        at least two substituents selected from R¹⁰, then at least one        substituent is at an ortho (e.g., 2-) position and at least one        substituent is at an adjacent meta (e.g., 3-) position (of the        phenyl ring).    -   Embodiment 13. A compound of Formula 1 or any one of Embodiments        1 through 12 wherein, independently, each R⁷ and R¹⁰ is        independently halogen, cyano, nitro, C₁-C₄ alkyl, C₁-C₄        haloalkyl, C₂-C₄ alkenyl, C₂-C₄ haloalkenyl C₂-C₄ alkynyl, C₂-C₄        haloalkynyl, C₁-C₄ nitroalkyl, C₂-C₄ nitroalkenyl, C₂-C₄        alkoxyalkyl, C₂-C₄ haloalkoxyalkyl, C₃-C₄ cycloalkyl, C₃-C₄        halocycloalkyl, cyclopropylmethyl, methylcyclopropyl, C₁-C₄        alkoxy, C₁-C₄ haloalkoxy, C₂-C₄ alkenyloxy, C₂-C₄        haloalkenyloxy, C₃-C₄ alkynyloxy, C₃-C₄ haloalkynyloxy, C₃-C₄        cycloalkoxy, C₁-C₄ alkylthio, C₁-C₄ haloalkylthio, C₁-C₄        alkylsulfinyl, C₁-C₄ haloalkylsulfinyl, C₁-C₄ alkylsulfonyl,        C₁-C₄ haloalkylsulfonyl, hydroxy, formyl, C₂-C₄ alkylcarbonyl,        C₂-C₄ alkylcarbonyloxy, C₁-C₄ alkylsulfonyloxy, C₁-C₄        haloalkylsulfonyloxy, amino, C₁-C₄ alkylamino, C₂-C₄        dialkylamino, formylamino, C₂-C₄ alkylcarbonylamino, —SF₅, —SCN,        C₃-C₄ trialkylsilyl, trimethylsilylmethyl or        trimethylsilylmethoxy.    -   Embodiment 14. A compound of Embodiment 13 wherein each R⁷ is        independently halogen, cyano, C₁-C₂ alkyl, C₁-C₃ haloalkyl or        C₁-C₃ alkylsulfonyl.    -   Embodiment 15. A compound of Embodiment 14 wherein each R⁷ is        independently halogen or C₁-C₂ haloalkyl.    -   Embodiment 16. A compound of Embodiment 15 wherein each R⁷ is        independently halogen or C₁ haloalkyl.    -   Embodiment 17. A compound of Embodiment 16 wherein each R⁷ is        independently halogen or C₁ fluoroalkyl.    -   Embodiment 18. A compound of Embodiment 17 wherein each R⁷ is        independently halogen or CF₃.    -   Embodiment 19. A compound of Embodiment 18 wherein each R⁷ is        independently F, Cl, Br or CF₃.    -   Embodiment 20. A compound of Embodiment 19 wherein each R⁷ is        independently F or CF₃.    -   Embodiment 21. A compound of Embodiment 19 or 20 wherein at most        only one CF₃ substituent is present and is at the para position        of the Q¹ phenyl ring.    -   Embodiment 22. A compound of any one of Embodiments 13 through        21 wherein each R¹⁰ is independently halogen, cyano, nitro,        C₁-C₂ alkyl, C₁-C₃ haloalkyl or C₁-C₃ alkylsulfonyl.    -   Embodiment 23. A compound of Embodiment 22 wherein each R¹⁰ is        independently halogen or C₁-C₂ haloalkyl.    -   Embodiment 24. A compound of Embodiment 23 wherein each R¹⁰ is        independently halogen or C₁ haloalkyl.    -   Embodiment 25. A compound of Embodiment 24 wherein each R¹⁰ is        independently halogen or C₁ fluoroalkyl.    -   Embodiment 26. A compound of Embodiment 25 wherein each R¹⁰ is        independently halogen or CF₃.    -   Embodiment 27. A compound of Embodiment 26 wherein each R¹⁰ is        independently F, Cl, Br or CF₃.    -   Embodiment 28. A compound of Embodiment 27 wherein each R¹⁰ is        independently F or CF₃.    -   Embodiment 29. A compound of Embodiment 28 wherein each R¹⁰ is        F.    -   Embodiment 30. A compound of Formula 1 or any one of Embodiments        1 through 29 wherein, independently, each R⁹ and R¹¹ is        independently H or C₁-C₂ alkyl.    -   Embodiment 31. A compound of Embodiment 28 wherein,        independently, each R⁹ and R¹¹ is CH₃.    -   Embodiment 32. A compound of Formula 1 or any one of Embodiments        1 through 31 wherein Y¹ is O.    -   Embodiment 33. A compound of Formula 1 or any one of Embodiments        1 through 32 wherein Y² is O.    -   Embodiment 33a. A compound of Formula 1 or any one of        Embodiments 1 through 33 wherein R¹ is H, C₁-C₆ alkyl, C₁-C₆        haloalkyl or C₄-C₈ cycloalkylalkyl.    -   Embodiment 33b. A compound of Formula 1 or any one of        Embodiments 1 through 33a wherein R¹ is H, C₁-C₆ alkyl or C₁-C₆        haloalkyl.    -   Embodiment 33c. A compound of Formula 1 or any one of        Embodiments 1 through 33b wherein R¹ is H, Me, Et or CHF₂.    -   Embodiment 33d. A compound of Formula 1 or any one of        Embodiments 1 through 33c wherein R¹ is H, Me or Et.    -   Embodiment 34. A compound of Formula 1 or any one of Embodiments        1 through 33 wherein R¹ is H or CH₃.    -   Embodiment 34a. A compound of Formula 1 or any one of        Embodiments 1 through 34 wherein R¹ is CH₃.    -   Embodiment 35. A compound of Embodiment 34 wherein R¹ is H.    -   Embodiment 36. A compound of Formula 1 or any one of Embodiments        1 through 35 wherein R² is H or CH₃.    -   Embodiment 37. A compound of Embodiment 36 wherein R² is H.    -   Embodiment 38. A compound of Formula 1 or any one of Embodiments        1 through 37 wherein R³ is H or CH₃.    -   Embodiment 39. A compound of Embodiment 38 wherein R³ is H.    -   Embodiment 40. A compound of Formula 1 or any one of Embodiments        1 through 39 wherein R⁴ is H or CH₃.    -   Embodiment 41. A compound of Embodiment 40 wherein R⁴ is H.    -   Embodiment 42. A compound of Formula 1 or any one of Embodiments        1 through 41 wherein R⁵ is H or CH₃.    -   Embodiment 43. A compound of Embodiment 42 wherein R⁵ is H.    -   Embodiment 44. A compound of Formula 1 or any one of Embodiments        1 through 43 wherein R⁶ is H or CH₃.    -   Embodiment 45. A compound of Embodiment 44 wherein R⁶ is H.    -   Embodiment 46. A compound of Formula 1 or any one of Embodiments        1 through 45 wherein Q² is other than 1H-indazol-5-yl optionally        substituted at the 3-position.    -   Embodiment 47. A compound of Embodiment 46 wherein Q² is other        than 1H-indazol-5-yl optionally substituted at the 1- and        3-positions.    -   Embodiment 48. A compound of Embodiment 47 wherein Q² is other        than optionally substituted 1H-indazol-5-yl.    -   Embodiment 49. A compound of any one of Embodiments 1 through 48        wherein Q¹ is other than unsubstituted phenyl.    -   Embodiment 50. A compound of any one of Embodiments 1 through 49        wherein Q² is other than unsubstituted pyridinyl.    -   Embodiment 51. A compound of any one of Embodiments 1 through 50        wherein Q¹ is other than optionally substituted naphthalenyl.    -   Embodiment 52. A compound of any one of Embodiments 1 through 51        wherein G² is other than optionally substituted phenyl.    -   Embodiment 53. A compound of any one of Embodiments 1 through 51        wherein G2 is other then optionally substituted phenyl at the 4        position (of Q¹).    -   Embodiment 54. A compound of any one of Embodiments 1 through 52        wherein G² is other than optionally substituted phenoxy    -   Embodiment 55. A compound of any one of Embodiments 1 through 54        wherein G² is other than optionally substituted phenoxy at the        4-position (of Q¹).    -   Embodiment 56. A compound of Formula 1 or any one of Embodiments        1 through 55 wherein the stereochemistry is (3R,4S) or (3S,4R).    -   Embodiment 57. A compound of Embodiment 54 wherein the        stereochemistry is (3R,4S)    -   Embodiment 58. A compound of Embodiment 54 wherein the        stereochemistry is (3S,4R).

Embodiments of this invention, including Embodiments 1-58 above as wellas any other embodiments described herein, can be combined in anymanner, and the descriptions of variables in the embodiments pertain notonly to the compounds of Formula 1 but also to the starting compoundsand intermediate compounds useful for preparing the compounds ofFormula 1. In addition, embodiments of this invention, includingEmbodiments 1-58 above as well as any other embodiments describedherein, and any combination thereof, pertain to the compositions andmethods of the present invention.

Combinations of Embodiments 1-58 are illustrated by:

-   -   Embodiment A. A compound of Formula 1 wherein        -   each R⁷ and R¹⁰ is independently halogen, cyano, nitro,            C₁-C₄ alkyl, C₁-C₄ haloalkyl, C₂-C₄ alkenyl, C₂-C₄            haloalkenyl C₂-C₄ alkynyl, C₂-C₄ haloalkynyl, C₁-C₄            nitroalkyl, C₂-C₄ nitroalkenyl, C₂-C₄ alkoxyalkyl, C₂-C₄            haloalkoxyalkyl, C₃-C₄ cycloalkyl, C₃-C₄ halocycloalkyl,            cyclopropylmethyl, methylcyclopropyl, C₁-C₄ alkoxy, C₁-C₄            haloalkoxy, C₂-C₄ alkenyloxy, C₂-C₄ haloalkenyloxy, C₃-C₄            alkynyloxy, C₃-C₄ haloalkynyloxy, C₃-C₄ cycloalkoxy, C₁-C₄            alkylthio, C₁-C₄ haloalkylthio, C₁-C₄ alkylsulfinyl,            C₁-C₄haloalkylsulfinyl, C₁-C₄ alkylsulfonyl, C₁-C₄            haloalkylsulfonyl, hydroxy, formyl, C₂-C₄ alkylcarbonyl,            C₂-C₄ alkylcarbonyloxy, C₁-C₄ alkylsulfonyloxy, C₁-C₄            haloalkylsulfonyloxy, amino, C₁-C₄ alkylamino, C₂-C₄            dialkylamino, formylamino, C₂-C₄ alkylcarbonylamino, —SF₅,            —SCN, C₃-C₄ trialkylsilyl, trimethylsilylmethyl or            trimethylsilylmethoxy; and        -   each R⁹ and RH is independently H or C₁-C₂ alkyl.    -   Embodiment B. A compound of Embodiment A wherein        -   Y¹ and Y² are each O; and        -   R¹, R², R³, R⁴, R⁵ and R⁶ are each H.    -   Embodiment C. A compound of Embodiment B wherein        -   Q¹ is a phenyl ring substituted with 1 to 3 substituents            independently selected from R⁷; and        -   Q² is a phenyl ring substituted with 1 to 3 substituents            independently selected from R¹⁰.    -   Embodiment D. A compound of Embodiment C wherein        -   each R⁷ is independently halogen, cyano, C₁-C₂ alkyl, C₁-C₃            haloalkyl or C₁-C₃ alkylsulfonyl; and        -   each R¹⁰ is independently halogen, cyano, nitro, C₁-C₂            alkyl, C₁-C₃ haloalkyl or C₁-C₃ alkylsulfonyl.    -   Embodiment E. A compound of Embodiment D wherein        -   Q¹ is a phenyl ring substituted with 1 substituent selected            from R⁷ at the para position or substituted with 2            substituents independently selected from R⁷ wherein one            substituent is at the para position and the other            substituent is at a meta position; and        -   Q² is a phenyl ring substituted with 1 substituent selected            from R¹⁰ at an ortho position or substituted with 2            substituents independently selected from R¹⁰ wherein one            substituent is at an ortho position and the other            substituent is at the adjacent meta position.    -   Embodiment F. A compound of Embodiment E wherein        -   each R⁷ is independently F or CF₃; and        -   each R¹⁰ is F.

Specific embodiments include compounds of Formula 1 selected from thegroup consisting of:

-   N-(2,3-difluorophenyl)-4-(3,4-difluorophenyl)-2-oxo-3-pyrrolidinecarboxamide    (Compound 17);-   N-(2-fluorophenyl)-2-oxo-4-[4-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide    (Compound 79);-   N-(2,3-difluorophenyl)-2-oxo-4-[4-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide    (Compound 80);-   N-(3,4-difluorophenyl)-N-(2-fluorophenyl)-2-oxo-3-pyrrolidinecarboxamide    (Compound 5); and-   (3R,4S)—N-(2-fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide    (Compound 204).

Specific Embodiments include a compound of Formula 1 selected from thegroup consisting of Compound Numbers (where the Compound Number refersto the compound in Index Tables A, B or C): 80, 202, 204, 206, 232, 263,304, 306, 315 and 319; or 202, 206, 232, 304 and 306; or 202, 232 and306.

Specific Embodiments include a compound of Formula 1 selected from thegroup consisting of Compound Numbers (where the Compound Number refersto the compound in Index Tables A, B or C): 3, 5, 17, 101, 103, 156,204, 271, 323 and 351; or 3, 17, 103, 156, and 204; or 103, 204 and 351.

This invention also relates to a method for controlling undesiredvegetation comprising applying to the locus of the vegetationherbicidally effective amounts of the compounds of the invention (e.g.,as a composition described herein). Of note as embodiments relating tomethods of use are those involving the compounds of embodimentsdescribed above. Compounds of the invention are particularly useful forselective control of weeds in crops such as wheat, barley, maize,soybean, sunflower, cotton, oilseed rape and rice, and specialty cropssuch as sugarcane, citrus, fruit and nut crops.

Also noteworthy as embodiments are herbicidal compositions of thepresent invention comprising the compounds of embodiments describedabove.

This invention also includes a herbicidal mixture comprising (a) acompound selected from Formula 1, N-oxides, and salts thereof, and (b)at least one additional active ingredient selected from (b1) photosystemII inhibitors, (b2) acetohydroxy acid synthase (AHAS) inhibitors, (b3)acetyl-CoA carboxylase (ACCase) inhibitors, (b4) auxin mimics, (b5)5-enol-pyruvylshikimate-3-phosphate (EPSP) synthase inhibitors, (b6)photosystem I electron diverters, (b7) protoporphyrinogen oxidase (PPO)inhibitors, (b8) glutamine synthetase (GS) inhibitors, (b9) very longchain fatty acid (VLCFA) elongase inhibitors, (b10) auxin transportinhibitors, (b11) phytoene desaturase (PDS) inhibitors, (b12)4-hydroxyphenyl-pyruvate dioxygenase (HPPD) inhibitors, (b13)homogentisate solanesyltransferase (HST) inhibitors, (b14) cellulosebiosynthesis inhibitors, (b15) other herbicides including mitoticdisruptors, organic arsenicals, asulam, bromobutide, cinmethylin,cumyluron, dazomet, difenzoquat, dymron, etobenzanid, flurenol,fosamine, fosamine-ammonium, metam, methyldymron, oleic acid,oxaziclomefone, pelargonic acid and pyributicarb, and (b16) herbicidesafeners; and salts of compounds of (b1) through (b16).

“Photosystem II inhibitors” (b1) are chemical compounds that bind to theD-1 protein at the Q_(B)-binding niche and thus block electron transportfrom Q_(A) to Q_(B) in the chloroplast thylakoid membranes. Theelectrons blocked from passing through photosystem II are transferredthrough a series of reactions to form toxic compounds that disrupt cellmembranes and cause chloroplast swelling, membrane leakage, andultimately cellular destruction. The Q_(B)-binding niche has threedifferent binding sites: binding site A binds the triazines such asatrazine, triazinones such as hexazinone, and uracils such as bromacil,binding site B binds the phenylureas such as diuron, and binding site Cbinds benzothiadiazoles such as bentazone, nitriles such as bromoxyniland phenyl-pyridazines such as pyridate. Examples of photosystem IIinhibitors include ametryn, amicarbazone, atrazine, bentazon, bromacil,bromofenoxim, bromoxynil, chlorbromuron, chloridazon, chlorotoluron,chloroxuron, cumyluron, cyanazine, daimuron, desmedipham, desmetryn,dimefuron, dimethametryn, diuron, ethidimuron, fenuron, fluometuron,hexazinone, ioxynil, isoproturon, isouron, lenacil, linuron, metamitron,methabenzthiazuron, metobromuron, metoxuron, metribuzin, monolinuron,neburon, pentanochlor, phenmedipham, prometon, prometryn, propanil,propazine, pyridafol, pyridate, siduron, simazine, simetryn,tebuthiuron, terbacil, terbumeton, terbuthylazine, terbutryn andtrietazine.

“AHAS inhibitors” (b2) are chemical compounds that inhibit acetohydroxyacid synthase (AHAS), also known as acetolactate synthase (ALS), andthus kill plants by inhibiting the production of the branched-chainaliphatic amino acids such as valine, leucine and isoleucine, which arerequired for protein synthesis and cell growth. Examples of AHASinhibitors include amidosulfuron, azimsulfuron, bensulfuron-methyl,bispyribac-sodium, cloransulam-methyl, chlorimuron-ethyl, chlorsulfuron,cinosulfuron, cyclosulfamuron, diclosulam, ethametsulfuron-methyl,ethoxysulfuron, flazasulfuron, florasulam, flucarbazone-sodium,flumetsulam, flupyrsulfuron-methyl, flupyrsulfuron-sodium,foramsulfuron, halosulfuron-methyl, imazamethabenz-methyl, imazamox,imazapic, imazapyr, imazaquin, imazethapyr, imazosulfuron,iodosulfuron-methyl (including sodium salt), iofensulfuron(2-iodo-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]-benzenesulfonamide),mesosulfuron-methyl, metazosulfuron(3-chloro-4-(5,6-dihydro-5-methyl-1,4,2-dioxazin-3-yl)-N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-1-methyl-1H-pyrazole-5-sulfonamide),metosulam, metsulfuron-methyl, nicosulfuron, oxasulfuron, penoxsulam,primisulfuron-methyl, propoxycarbazone-sodium, propyrisulfuron(2-chloro-N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-6-propylimidazo[1,2-b]pyridazine-3-sulfonamide),prosulfuron, pyrazosulfuron-ethyl, pyribenzoxim, pyriftalid,pyriminobac-methyl, pyrithiobac-sodium, rimsulfuron,sulfometuron-methyl, sulfosulfuron, thiencarbazone,thifensulfuron-methyl, triafamone(N-[2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)carbonyl]-6-fluorophenyl]-1,1-difluoro-N-methylmethanesulfonamide),triasulfuron, tribenuron-methyl, trifloxysulfuron (including sodiumsalt), triflusulfuron-methyl and tritosulfuron.

“ACCase inhibitors” (b3) are chemical compounds that inhibit theacetyl-CoA carboxylase enzyme, which is responsible for catalyzing anearly step in lipid and fatty acid synthesis in plants. Lipids areessential components of cell membranes, and without them, new cellscannot be produced. The inhibition of acetyl CoA carboxylase and thesubsequent lack of lipid production leads to losses in cell membraneintegrity, especially in regions of active growth such as meristems.Eventually shoot and rhizome growth ceases, and shoot meristems andrhizome buds begin to die back. Examples of ACCase inhibitors includealloxydim, butroxydim, clethodim, clodinafop, cycloxydim, cyhalofop,diclofop, fenoxaprop, fluazifop, haloxyfop, pinoxaden, profoxydim,propaquizafop, quizalofop, sethoxydim, tepraloxydim and tralkoxydim,including resolved forms such as fenoxaprop-P, fluazifop-P, haloxyfop-Pand quizalofop-P and ester forms such as clodinafop-propargyl,cyhalofop-butyl, diclofop-methyl and fenoxaprop-P-ethyl.

Auxin is a plant hormone that regulates growth in many plant tissues.“Auxin mimics” (b4) are chemical compounds mimicking the plant growthhormone auxin, thus causing uncontrolled and disorganized growth leadingto plant death in susceptible species. Examples of auxin mimics includeaminocyclopyrachlor(6-amino-5-chloro-2-cyclopropyl-4-pyrimidinecarboxylic acid) and itsmethyl and ethyl esters and its sodium and potassium salts,aminopyralid, benazolin-ethyl, chloramben, clacyfos, clomeprop,clopyralid, dicamba, 2,4-D, 2,4-DB, dichlorprop, fluroxypyr, halauxifen(4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-2-pyridinecarboxylicacid), halauxifen-methyl (methyl4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-2-pyridinecarboxylate),MCPA, MCPB, mecoprop, picloram, quinclorac, quinmerac, 2,3,6-TBA,triclopyr, and methyl4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-2-pyridinecarboxylate.

“EPSP (5-enol-pyruvylshikimate-3-phosphate) synthase inhibitors” (b5)are chemical compounds that inhibit the enzyme,5-enol-pyruvylshikimate-3-phosphate synthase, which is involved in thesynthesis of aromatic amino acids such as tyrosine, tryptophan andphenylalanine. EPSP inhibitor herbicides are readily absorbed throughplant foliage and translocated in the phloem to the growing points.Glyphosate is a relatively nonselective postemergence herbicide thatbelongs to this group. Glyphosate includes esters and salts such asammonium, isopropylammonium, potassium, sodium (including sesquisodium)and trimesium (alternatively named sulfosate).

“Photosystem I electron diverters” (b6) are chemical compounds thataccept electrons from Photosystem I, and after several cycles, generatehydroxyl radicals. These radicals are extremely reactive and readilydestroy unsaturated lipids, including membrane fatty acids andchlorophyll. This destroys cell membrane integrity, so that cells andorganelles “leak”, leading to rapid leaf wilting and desiccation, andeventually to plant death. Examples of this second type ofphotosynthesis inhibitor include diquat and paraquat.

“PPO inhibitors” (b7) are chemical compounds that inhibit the enzymeprotoporphyrinogen oxidase, quickly resulting in formation of highlyreactive compounds in plants that rupture cell membranes, causing cellfluids to leak out. Examples of PPO inhibitors includeacifluorfen-sodium, azafenidin, benzfendizone, bifenox, butafenacil,carfentrazone, carfentrazone-ethyl, chlomethoxyfen, cinidon-ethyl,fluazolate, flufenpyr-ethyl, flumiclorac-pentyl, flumioxazin,fluoroglycofen-ethyl, fluthiacet-methyl, fomesafen, halosafen, lactofen,oxadiargyl, oxadiazon, oxyfluorfen, pentoxazone, profluazol, pyraclonil,pyraflufen-ethyl, saflufenacil, sulfentrazone, thidiazimin, tiafenacil(methylN-[2-[[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenyl]thio]-1-oxopropyl]-β-alaninate)and3-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl]dihydro-1,5-dimethyl-6-thioxo-1,3,5-triazine-2,4(1H,3H)-dione.

“GS (glutamine synthase) inhibitors” (b8) are chemical compounds thatinhibit the activity of the glutamine synthetase enzyme, which plantsuse to convert ammonia into glutamine. Consequently, ammonia accumulatesand glutamine levels decrease. Plant damage probably occurs due to thecombined effects of ammonia toxicity and deficiency of amino acidsrequired for other metabolic processes. The GS inhibitors includeglufosinate and its esters and salts, such as glufosinate-ammonium andother phosphinothricin derivatives, glufosinate-P((2S)-2-amino-4-(hydroxymethylphosphinyl)butanoic acid) and bilanaphos.

“VLCFA (very long chain fatty acid) elongase inhibitors” (b9) areherbicides having a wide variety of chemical structures, which inhibitthe elongase. Elongase is one of the enzymes located in or nearchloroplasts which are involved in biosynthesis of VLCFAs. In plants,very-long-chain fatty acids are the main constituents of hydrophobicpolymers that prevent desiccation at the leaf surface and providestability to pollen grains. Such herbicides include acetochlor,alachlor, anilofos, butachlor, cafenstrole, dimethachlor, dimethenamid,diphenamid, fenoxasulfone(3-[[(2,5-dichloro-4-ethoxyphenyl)methyl]sulfonyl]-4,5-dihydro-5,5-dimethylisoxazole),fentrazamide, flufenacet, indanofan, mefenacet, metazachlor,metolachlor, naproanilide, napropamide, napropamide-M((2R)—N,N-diethyl-2-(1-naphthalenyloxy)propanamide), pethoxamid,piperophos, pretilachlor, propachlor, propisochlor, pyroxasulfone, andthenylchlor, including resolved forms such as S-metolachlor andchloroacetamides and oxyacetamides.

“Auxin transport inhibitors” (b10) are chemical substances that inhibitauxin transport in plants, such as by binding with an auxin-carrierprotein. Examples of auxin transport inhibitors include diflufenzopyr,naptalam (also known as N-(1-naphthyl)phthalamic acid and2-[(1-naphthalenylamino)carbonyl]benzoic acid).

“PDS (phytoene desaturase inhibitors) (b11) are chemical compounds thatinhibit carotenoid biosynthesis pathway at the phytoene desaturase step.Examples of PDS inhibitors include beflubutamid, diflufenican,fluridone, flurochloridone, flurtamone norflurazon and picolinafen.

“HPPD (4-hydroxyphenyl-pyruvate dioxygenase) inhibitors” (b12) arechemical substances that inhibit the biosynthesis of synthesis of4-hydroxyphenyl-pyruvate dioxygenase. Examples of HPPD inhibitorsinclude benzobicyclon, benzofenap, bicyclopyrone(4-hydroxy-3-[[2-[(2-methoxyethoxy)methyl]-6-(trifluoromethyl)-3-pyridinyl]carbonyl]bicyclo[3.2.1]oct-3-en-2-one),fenquinotrione(2-[[8-chloro-3,4-dihydro-4-(4-methoxyphenyl)-3-oxo-2-quinoxalinyl]carbonyl]-1,3-cyclohexanedione),isoxachlortole, isoxaflutole, mesotrione, pyrasulfotole, pyrazolynate,pyrazoxyfen, sulcotrione, tefuryltrione, tembotrione, topramezone,5-chloro-3-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-1-(4-methoxyphenyl)-2(1H)-quinoxalinone,4-(2,6-diethyl-4-methylphenyl)-5-hydroxy-2,6-dimethyl-3(2H)-pyridazinone,4-(4-fluorophenyl)-6-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-2-methyl-1,2,4-triazine-3,5(2H,4H)-dione,5-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-2-(3-methoxyphenyl)-3-(3-methoxy-propyl)-4(3H)-pyrimidinone,2-methyl-N-(4-methyl-1,2,5-oxadiazol-3-yl)-3-(methyl-sulfinyl)-4-(trifluoromethyl)benzamideand2-methyl-3-(methylsulfonyl)-N-(1-methyl-1H-tetrazol-5-yl)-4-(trifluoromethyl)benzamide.

HST (homogentisate solanesyltransferase) inhibitors (b13) disrupt aplant's ability to convert homogentisate to2-methyl-6-solanyl-1,4-benzoquinone, thereby disrupting carotenoidbiosynthesis. Examples of HST inhibitors include haloxydine, pyriclor,3-(2-chloro-3,6-difluorophenyl)-4-hydroxy-1-methyl-1,5-naphthyridin-2(1H)-one,dichloro-4-pyridinyl)-5-(2,2-difluoroethyl)-8-hydroxypyrido[2,3-b]pyrazin-6(5H)-oneand4-(2,6-diethyl-4-methylphenyl)-5-hydroxy-2,6-dimethyl-3(2H)-pyridazinone.

HST inhibitors also include compounds of Formulae A and B.

-   wherein R^(d1) is H, Cl or CF₃; R^(d2) is H, Cl or Br; R^(d3) is H    or Cl; R^(d4) is H, Cl or CF₃; R^(d5) is CH₃, CH₂CH₃ or CH₂CHF₂; and    R^(d6) is OH, or —OC(═O)-i-Pr; and R^(e1) is H, F, Cl, CH₃ or    CH₂CH₃; R^(e2) is H or CF₃; R^(e3) is H, CH₃ or CH₂CH₃; R^(e4) is H,    F or Br; R^(e5) is Cl, CH₃, CF₃, OCF₃ or CH₂CH₃; R^(e6) is H, CH₃,    CH₂CHF₂ or C≡CH; R^(e7) is OH, —OC(═O)Et, —OC(═O)-i-Pr or    —OC(═O)-t-Bu; and A^(e8) is N or CH.

Cellulose biosynthesis inhibitors (b14) inhibit the biosynthesis ofcellulose in certain plants. They are most effective when using apre-application or early post-application on young or rapidly growingplants. Examples of cellulose biosynthesis inhibitors includechlorthiamid, dichlobenil, flupoxam, indaziflam(N²-[(1R,2S)-2,3-dihydro-2,6-dimethyl-1H-inden-1-yl]-6-(1-fluoroethyl)-1,3,5-triazine-2,4-diamine),isoxaben and triaziflam.

Other herbicides (b15) include herbicides that act through a variety ofdifferent modes of action such as mitotic disruptors (e.g.,flamprop-M-methyl and flamprop-M-isopropyl) organic arsenicals (e.g.,DSMA, and MSMA), 7,8-dihydropteroate synthase inhibitors, chloroplastisoprenoid synthesis inhibitors and cell-wall biosynthesis inhibitors.Other herbicides include those herbicides having unknown modes of actionor do not fall into a specific category listed in (b1) through (b14) oract through a combination of modes of action listed above. Examples ofother herbicides include aclonifen, asulam, amitrole, bromobutide,cinmethylin, clomazone, cumyluron, cyclopyrimorate(6-chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinyl4-morpholinecarboxylate), daimuron, difenzoquat, etobenzanid,fluometuron, flurenol, fosamine, fosamine-ammonium, dazomet, dymron,ipfencarbazone(1-(2,4-dichlorophenyl)-N-(2,4-difluorophenyl)-1,5-dihydro-N-(1-methylethyl)-5-oxo-4H-1,2,4-triazole-4-carboxamide),metam, methyldymron, oleic acid, oxaziclomefone, pelargonic acid,pyributicarb and5-[[(2,6-difluorophenyl)methoxy]methyl]-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)isoxazole.

“Herbicide safeners” (b16) are substances added to a herbicideformulation to eliminate or reduce phytotoxic effects of the herbicideto certain crops. These compounds protect crops from injury byherbicides but typically do not prevent the herbicide from controllingundesired vegetation. Examples of herbicide safeners include but are notlimited to benoxacor, cloquintocet-mexyl, cumyluron, cyometrinil,cyprosulfamide, daimuron, dichlormid, dicyclonon, dimepiperate,fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole,isoxadifen-ethyl, mefenpyr-diethyl, mephenate, methoxyphenone,naphthalic anhydride, oxabetrinil,N-(aminocarbonyl)-2-methylbenzenesulfonamide andN-(aminocarbonyl)-2-fluorobenzenesulfonamide,1-bromo-4-[(chloromethyl)sulfonyl]benzene,2-(dichloromethyl)-2-methyl-1,3-dioxolane (MG 191),4-(dichloroacetyl)-1-oxa-4-azospiro-[4.5]decane (MON 4660).

The compounds of Formula 1 can be prepared by general methods known inthe art of synthetic organic chemistry. Of note are the followingmethods described in Schemes 1-15 and variations thereof. Thedefinitions of R¹, R², R³, R⁴, R⁵, R⁶, Q¹, Q², Y¹, and Y² in thecompounds of Formulae 1 through 19 below are as defined above in theSummary of the Invention unless otherwise noted. Formulae 1a-1h and 5aand 10a are various subsets of a compound of Formulae 1, 5 and 10respectively. Substituents for each subset formula are as defined forits parent formula unless otherwise noted.

As shown in Scheme 1 compounds of Formula 1a (i.e. Formula 1 wherein R¹,R⁴ and R⁵ are H, and Y¹ and Y² are O) can be prepared by reaction ofacids of Formula 2 with amines of Formula 3 in the presence of adehydrative coupling reagent such as propylphosphonic anhydride,dicyclohexylcarbodiimide, N-(3-dimethylaminopropyl)-N-ethylcarbodiimide,N,N-carbonyldiimidazole, 2-chloro-1,3-dimethylimidazolium chloride or2-chloro-1-methylpyridinium iodide. Polymer-supported reagents, such aspolymer-supported cyclohexylcarbodiimide, are also suitable. Thesereactions are typically run at temperatures ranging from 0-60° C. in asolvent such as dichloromethane, acetonitrile, N,N-dimethylformamide orethyl acetate in the presence of a base such as triethylamine,N,N-diisopropylamine, or 1,8-diazabicyclo[5.4.0]undec-7-ene. See OrganicProcess Research & Development 2009, 13, 900-906 for coupling conditionsemploying propylphosphonic anhydride. The method of Scheme 1 utilizingpropylphosphonic anhydride is illustrated by Step E of SynthesisExample 1. Substituents in the 3- and 4-positions of the pyrrolidinonering of compounds of Formula 1a, i.e. C(O)N(Q²)(R⁶) and Q¹,respectively, are predominantly in the trans configuration. In someinstances, the presence of minor amounts of the cis isomer can bedetected by NMR.

As shown in Scheme 2 compounds of Formula 2 can be prepared byhydrolysis of esters of Formula 4 by methods well known to those skilledin the art. Hydrolysis is carried out with aqueous base or aqueous acid,typically in the presence of a co-solvent. Suitable bases for thereaction include, but are not limited to, hydroxides such as sodium andpotassium hydroxide and carbonates such as sodium and potassiumcarbonate. Suitable acids for the reaction include, but are not limitedto, inorganic acids such as hydrochloric acid, hydrobromic acid andsulfuric acid, and organic acids such as acetic acid and trifluoroaceticacid. A wide variety of co-solvents are suitable for the reactionincluding, but not limited to, methanol, ethanol and tetrahydrofuran.The reaction is conducted at temperatures ranging from −20° C. to theboiling point of the solvent, and typically from 0 to 100° C. The methodof Scheme 2 is illustrated by Step D of Synthesis Example 1.

As shown in Scheme 3, compounds of Formula 4 can be obtained byreduction of compounds of Formula 5 and subsequent in situ cyclizationof the resulting intermediate amine. A wide variety of methods forreduction of the aliphatic nitro group in compounds of Formula 5 areknown in the literature. Methods well known to those skilled in the artinclude catalytic hydrogenation in the presence of palladium on carbonor Raney nickel, iron or zinc metal in acidic medium (see, for example,Berichte der Deutschen Chemischen Gesellschaft 1904, 37, 3520-3525), andlithium aluminum hydride. Reduction can also be achieved withsamarium(II) iodide in the presence of a proton source such as methanol(see for example, Tetrahedron Letters 1991, 32 (14), 1699-1702).Alternatively sodium borohydride in the presence of a nickel catalystsuch as nickel(II) acetate or nickel(II) chloride can be used (see forexample, Tetrahedron Letters 1985, 26 (52), 6413-6416). The method ofScheme 3 utilizing sodium borohydride in the presence of nickel(II)acetate is illustrated by Step C of Synthesis Example 1. Specificexamples of a compound of Formula 4 that is useful in the preparation ofa compound of Formula 1 can be found in Tables I through IV.

As shown in Scheme 4, compounds of Formula 5 can be prepared by reactingdiesters of Formula 6 with nitroalkanes of Formula 7, typically in thepresence of a base. Suitable bases for the reaction include alkali metallower alkoxides such as sodium methoxide in methanol or sodium ethoxidein ethanol. The method of Scheme 4 is illustrated by Step B of SynthesisExample 1. Compounds of Formula 6 can readily be prepared by methodsknown to those skilled in the art, e.g., by Knoevenagel condensation ofaldehydes and malonates (see for example G. Jones, Organic ReactionsVolume 15, John Wiley and Sons, 1967).

Compounds of Formula 5a (i.e. Formula 5 wherein R² and R³ are H) can beprepared by reacting nitroalkenes of Formula 8 with malonates of Formula9 in the presence of a base as shown in Scheme 5. Suitable bases forthis reaction include, but are not limited to, alkali metal loweralkoxides such as sodium methoxide in methanol or sodium ethoxide inethanol, or bases such as lithium bis(trimethylsilyl)amide, sodiumbis(trimethylsilyl)amide and lithium diisopropylamide in solvents suchas tetrahydrofuran. Typically, the reaction is carried out in the rangeof from −78° C. to 23° C. See Synthesis 2005, 2239-2245 for conditionsfor effecting this transformation. Conditions for effecting thistransformation in refluxing water in the absence of a catalyst have beenreported in Synthetic Communications 2013, 43, 744-748. Nitroalkenes ofFormula 8 can readily be prepared from aldehydes and nitromethane bymethods known to those skilled in the art.

Compounds of Formula 5a′ and 5a″ can be prepared stereoselectively byreacting nitroalkenes of Formula 8 with malonates of Formula 9 in thepresence of a chiral catalyst and optionally in the presence of asuitable base as shown in Scheme 5A. Suitable catalysts include, but arenot limited to Ni(II) with vicinal diamine ligands such as Ni(II)Bis[(R,R)—N,N′-dibenzylcyclohexane-1,2-di amine]dibromide, Ni(II)Bis[(S,S)—N,N-dibenzylcyclohexane-1,2-diamine]dibromide or nickel(II)bromide with chiral 1,1′-bi(tetrahydroisoquinoline) type diamines.Suitable organic bases for this reaction include, but are not limitedto, piperidine, morpholine, triethylamine, 4-methylmorpholine orN,N-diisopropylethylamine. This transformation can be accomplished neator in solvents such as tetrahydrofuran, toluene or dichloromethane.Typically, the reaction is carried out in the range of from −78° C. to80° C. using 0 to 1 equivalent of catalyst and optionally 0 to 1equivalent of a base. Conditions for effecting this transformation havebeen reported in J. Am. Chem. Soc. 2005, 9958-9959 or Eur. J. Org. Chem.2011, 5441-5446 for conditions. Nitroalkenes of Formula 8 can readily beprepared from aldehydes and nitromethane by methods known to thoseskilled in the art.

As shown in Scheme 6, compounds of Formula 1a can also be prepared byreductive cyclization of compounds of Formula 10 analogous to the methodof Scheme 3. As also shown in Scheme 6, compounds of Formula 1b (i.e.Formula 1 wherein R¹ is OH, R⁴ and R⁵ are H, and Y¹ and Y² are O) can beprepared from compounds of Formula 10 by catalytic transferhydrogenation with ammonium formate in the presence of palladium oncarbon, and subsequent in situ cyclization of the intermediatehydroxylamine. See J. Med. Chem. 1993, 36, 1041-1047 for catalytictransfer hydrogenation/cyclization conditions to produceN-hydroxypyrrolidinones. The method of Scheme 6 for preparingN-hydroxypyrrolidinones is illustrated by Step D of Synthesis Example 3.

As shown in Scheme 7, compounds of Formula 10 can be prepared byreacting compounds of Formula 11 with nitroalkanes of Formula 7 in asolvent, in the presence of a base analogous to the method described inScheme 4. The method of Scheme 7 is illustrated by Step C of SynthesisExample 3.

As shown in Scheme 8, compounds of Formula 10a (i.e. Formula 10 whereinR² and R³ are H) can be prepared, analogous to the method of Scheme 5,by reacting nitroalkenes of Formula 8 with malonates of Formula 12.

As shown in Scheme 9, compounds of Formula 11 can be prepared byreaction of malonic amide Formula 12 with aldehydes of Formula 14 bymethods known to those skilled in the art. As also shown in Scheme 9,malonates of Formula 12 can readily be prepared from lower alkyl malonylchlorides of Formula 13 such as methyl malonyl chloride and amines ofFormula 3 by methods known to those skilled in the art. The method ofScheme 9 is illustrated by Steps A and B of Synthesis Example 3.

As shown in Scheme 10, mixtures of compounds of Formula 1c (i.e. Formula1 wherein R¹ and R⁵ are H, R⁴ is halogen and Y¹ and Y² are O) andFormula 1d (i.e. Formula 1 wherein R¹ and R⁴ are H, R⁵ is halogen and Y¹and Y² are O) can be prepared by reacting compounds of Formula 1a with ahalogen source in a solvent, in the presence or absence of an initiator.Separation of the regioisomers produced in this reaction can be achievedby standard methods such as chromatography or fractionalcrystallization. Suitable halogen sources for this reaction includebromine, chlorine, N-chlorosuccinimide, N-bromosuccinimide andN-iodosuccinimide. Suitable initiators for this reaction include2,2′-azobisisobutyronitrile (AIBN) and benzoyl peroxide. Typically, thereaction is carried out in solvents such as dichloromethane in the rangeof from 0° C. to the boiling point of the solvent. The method of Scheme10 is illustrated by Synthesis Example 2.

As shown in Scheme 11, compounds of Formula 1e (i.e. Formula 1 whereinR¹ is NH₂, R⁴ and R⁵ are H and Y¹ and Y² are O) can be prepared byreacting compounds of Formula 1a with an aminating reagent such asO-(diphenylphosphinyl)hydroxylamine and hydroxylamino-O-sulphonic acid.For procedures, conditions and reagents see Bioorganic & MedicinalChemistry Letters 2009, 19, 5924-5926 and Journal of Organic Chemistry2002, 67, 6236-6239.

As shown in Scheme 12, compounds of Formula if (i.e. Formula 1 whereinR⁴, R⁵ and R⁶ are H and Y¹ is O) can be produced by reaction ofcompounds of Formula 15 with isocyanates (i.e. Formula 16 wherein Y² isO) or isothiocyanates (i.e. Formula 16 wherein Y² is S) in the presenceof base. Examples of the base which can be used for the present processinclude those listed for the method of Scheme 4. The reactiontemperature can be selected from the range of from −78° C. to theboiling point of an inert solvent used. Typically, the reaction iscarried out at temperatures ranging from −78° C. to 100° C. in solventssuch as toluene.

As shown in Scheme 13, compounds of Formula 15 can be prepared byreaction of compounds of Formula 17 with corresponding electrophiles ofFormula 18 in the presence of base. In Formula 18, G denotes a leavinggroup, i.e. a nucleofuge. Depending upon selection of R¹, suitableelectrophiles for the reaction can include alkyl halides such aschlorides, bromides and iodides, alkylsulfonates, acid anhydrides suchas tert-butoxycarbonyl anhydride and acetic anhydride, andhaloalkylsilanes such as chlorotrimethylsilane. Suitable bases for thereaction include inorganic bases such as alkali or alkaline earth metal(e.g., lithium, sodium, potassium and cesium) hydroxides, alkoxides,carbonates, and phosphates, and organic bases such as triethylamine,N,N-diisopropylethylamine and 1,8-diazabicyclo[5.4.0]undec-7-ene. A widevariety of solvents are suitable for the reaction including, for examplebut not limited to, tetrahydrofuran, dichloromethane,N,N-dimethylformamide, N,N-dimethylacetamide, N-methylpyrrolidinone,acetonitrile, C₂-C₆ alcohols and acetone as well as mixtures of thesesolvents. This reaction is conducted at temperatures ranging from −20 to200° C., and typically between 0 and 50° C.

As shown in Scheme 14, compounds of Formula 17 can be prepared bydecarboxylation of acids of Formula 2 by methods well known to thoseskilled in the art. Decarboxylation is carried by heating compounds ofFormula 2 in a solvent, typically in the presence of an acid. Suitableacids for the reaction include, but are not limited to,p-toluenesulfonic acid. A wide variety of co-solvents are suitable forthe reaction including, but not limited to, toluene, isopropanol acetateand isobutyl methylketone. The reaction is conducted at temperaturesranging from −20° C. and to the boiling point of the solvent, andtypically from 0 to 150° C. The method of Scheme 14 is illustrated byStep A of Synthesis Example 6.

As shown in Scheme 15, compounds of Formula 1g (i.e. Formula 1 whereinR¹ is H, R⁴ and R⁵ are H, and Y¹ and Y² are S) can be prepared byreacting compounds of Formula 1a with at least two equivalents of athionation reagent such as Lawesson's reagent, tetraphosphorusdecasulfide or diphosphorus pentasulfide in a solvent such astetrahydrofuran or toluene. Typically, the reaction is carried out attemperatures ranging from 0 to 115° C. One skilled in the art recognizesthat using less than two equivalents of the thionating reagent canprovide mixtures comprising Formula 1 products wherein Y¹ is O and Y² isS, or Y¹ is S and Y² is O, which can be separated by conventionalmethods such as chromatography and crystallization.

As shown in Scheme 16, compounds of Formula 1h (i.e. Formula 1 whereinR¹, R⁴, R⁵ are H, Y² is O and Y¹ is NH) can be prepared by alkylation ofcompounds of Formula 1a triethyloxonium tetrafluoroborate (Meerwein'sreagent) followed by treatment of the resulting imino ether of Formula19 with aqueous ammonia. The method of Scheme 16 is illustrated by StepsA and B of Synthesis Example 4.

It is recognized by one skilled in the art that various functionalgroups can be converted into others to provide different compounds ofFormula 1. For a valuable resource that illustrates the interconversionof functional groups in a simple and straightforward fashion, seeLarock, R. C., Comprehensive Organic Transformations: A Guide toFunctional Group Preparations, 2nd Ed., Wiley-VCH, New York, 1999. Forexample, intermediates for the preparation of compounds of Formula 1 maycontain aromatic nitro groups, which can be reduced to amino groups, andthen be converted via reactions well known in the art such as theSandmeyer reaction, to various halides, providing compounds ofFormula 1. The above reactions can also in many cases be performed inalternate order

It is recognized that some reagents and reaction conditions describedabove for preparing compounds of Formula 1 may not be compatible withcertain functionalities present in the intermediates. In theseinstances, the incorporation of protection/deprotection sequences orfunctional group interconversions into the synthesis will aid inobtaining the desired products. The use and choice of the protectinggroups will be apparent to one skilled in chemical synthesis (see, forexample, Greene, T. W.; Wuts, P. G. M. Protective Groups in OrganicSynthesis, 2nd ed.; Wiley: New York, 1991). One skilled in the art willrecognize that, in some cases, after the introduction of a given reagentas it is depicted in any individual scheme, it may be necessary toperform additional routine synthetic steps not described in detail tocomplete the synthesis of compounds of Formula 1. One skilled in the artwill also recognize that it may be necessary to perform a combination ofthe steps illustrated in the above schemes in an order other than thatimplied by the particular presented to prepare the compounds of Formula1.

One skilled in the art will also recognize that compounds of Formula 1and the intermediates described herein can be subjected to variouselectrophilic, nucleophilic, radical, organometallic, oxidation, andreduction reactions to add substituents or modify existing substituents.

Without further elaboration, it is believed that one skilled in the artusing the preceding description can utilize the present invention to itsfullest extent. The following Examples are, therefore, to be construedas merely illustrative, and not limiting of the disclosure in any waywhatsoever. Steps in the following Examples illustrate a procedure foreach step in an overall synthetic transformation, and the startingmaterial for each step may not have necessarily been prepared by aparticular preparative run whose procedure is described in otherExamples or Steps. Percentages are by weight except for chromatographicsolvent mixtures or where otherwise indicated. Parts and percentages forchromatographic solvent mixtures are by volume unless otherwiseindicated. ¹H NMR spectra are reported in ppm downfield fromtetramethylsilane in CDCl₃ solution unless indicated otherwise; “s”means singlet, “d” means doublet, “t” means triplet, “q” means quartet,“m” means multiplet and “br s” means broad singlet. ¹⁹F NMR spectra arereported in ppm downfield from CFCl₃ in CDCl₃ unless indicatedotherwise. The enantiomeric ratio (ER) was determined by chiral highperformance liquid chromatography analysis using a Chiralpak AD-RHcolumn and eluting with a 50:50 isopropanol/water mixture at 40° C. at0.3 mL/min.

Synthesis Example 1 Preparation of4-(3-chloro-4-fluorophenyl)-2-oxo-N-[2-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide(Compound 74) Step A: Preparation of 1,3-diethyl2-(3-chloro-4-fluorophenyl)methylenepropanedioate

A mixture of 3-chloro-4-fluorobenzaldehyde (3 g, 18.9 mmol), diethylmalonate (3.16 mL, 20.8 mmol), piperidine (0.37 mL, 3.8 mmol) andtoluene (40 mL) was refluxed for 18 h with continuous removal of water(Dean-Stark trap). The cooled reaction mixture was concentrated underreduced pressure, and the residue was chromatographed on silica gel,eluted with 0% to 10% ethyl acetate in hexanes, to afford the titlecompound as a yellow oil (5 g).

¹H NMR δ 7.61 (m, 1H), 7.61 (m, 1H), 7.53 (m, 1H), 7.35 (m, 1H), 7.15(m, 1H), 4.33 (m, 4H), 1.33 (m, 6H).

Step B: Preparation 1,3-diethyl2-[1-(3-chloro-4-fluorophenyl)-2-nitroethyl]-propanedioate

A mixture of 1,3-diethyl2-(3-chloro-4-fluorophenyl)methylenepropanedioate (i.e. the product ofStep A, 5 g, 16.7 mmol), nitromethane (8.9 mL, 166 mmol) and a methanolsolution of sodium methoxide (25 wt %, 0.36 g, 1.67 mmol) in ethanol (60mL) was stirred at 23° C. for 18 h. The reaction mixture was thenconcentrated under reduced pressure to afford a thick oil, which wasdiluted with 25% ethyl acetate in hexanes and filtered through a pad ofCelite® diatomaceous filter aid to remove insoluble particulates. Thefiltrate was concentrated under reduced pressure to afford the titlecompound as a yellow oil (5.3 g).

¹H NMR δ 7.32 (m, 1H), 7.15 (m, 1H), 7.10 (m, 1H), 4.87 (m, 2H), 4.22(m, 3H), 4.07 (m, 2H), 3.76 (d, 1H), 1.27 (m, 3H), 1.12 (m, 3H).

Step C: Preparation of ethyl4-(3-chloro-4-fluorophenyl)-2-oxo-3-pyrrolidinecarboxylate

A stirred mixture of 1,3-diethyl2-[1-(3-chloro-4-fluorophenyl)-2-nitroethyl]-propanedioate (i.e. theproduct of Step B, 5.3 g, 14.7 mmol), nickel(II) acetate tetrahydrate(18.3 g, 73.4 mmol) and ethanol (120 mL) was cooled in an ice bath andtreated with sodium borohydride (2.8 g, 73.4 mmol) in 0.5 g portionsadded over 5 minutes. The resulting mixture was stirred at 26° C. for 18h. Saturated ammonium chloride solution (120 mL) and ethyl acetate (120mL) were then added, the mixture was stirred for 1 h and then filteredthrough a pad of Celite® diatomaceous filter aid to remove insolubleparticulates. The layers of the filtrate were separated, and the aqueouslayer was extracted with ethyl acetate (2×100 mL). The combined organicextracts were washed with saturated ammonium chloride solution (100 mL),brine (100 mL), dried (MgSO₄) and concentrated under reduced pressure toafford the title compound as a yellow-orange solid (4.73 g) which wasused without purification.

¹H NMR δ 7.31 (m, 1H), 7.12 (m, 2H), 6.93 (br s, 1H), 4.24 (m, 2H), 4.06(m, 1H), 3.82 (m, 1H), 3.49 (d, 1H), 3.39 (m, 1H), 1.29 (m, 3H).

Step D: Preparation of4-(3-chloro-4-fluorophenyl)-2-oxo-3-pyrrolidinecarboxylic acid

A mixture of ethyl4-(3-chloro-4-fluorophenyl)-2-oxo-3-pyrrolidinecarboxylate (i.e. theproduct of Step C, 4.73 g, 16.5 mmol) and aqueous sodium hydroxide (50wt %, 1.98 g, 49.5 mmol) in ethanol (50 mL) was stirred at 26° C. for 18h. The reaction mixture was then diluted with water (50 mL) andextracted with diethyl ether (2×50 mL). The aqueous phase was acidifiedwith concentrated hydrochloric acid to pH 2 and extracted withdichloromethane (3×50 mL). The combined dichloromethane extracts werewashed with brine, dried (MgSO₄), and concentrated under reducedpressure to afford the title compound as a white solid (2.37 g).

¹H NMR (acetone-d₆) δ 7.63 (m, 1H), 7.46 (m, 1H), 7.31 (m, 1H), 4.05 (m,1H), 3.82 (m, 1H), 3.70 (d, 1H), 3.45 (m, 1H).

Step E: Preparation of4-(3-chloro-4-fluorophenyl)-2-oxo-N-[2-(trifluoromethyl)-phenyl]-3-pyrrolidinecarboxamide

A mixture of 4-(3-chloro-4-fluorophenyl)-2-oxo-3-pyrrolidinecarboxylicacid (i.e. the product of Step D, 0.3 g, 1.17 mmol), triethylamine (0.49mL, 3.5 mmol) and 2-(trifluoromethyl)aniline (0.16 mL, 1.28 mmol) indichloromethane (8 mL) was stirred at ambient temperature for 30minutes, and then treated with propylphosphonic anhydride in ethylacetate (50%, 1.26 g, 1.98 mmol). The resulting mixture was stirred atambient temperature for 18 h. The reaction mixture was then concentratedunder reduced pressure, and the residue was chromatographed on silicagel, eluted with 0-30% ethyl acetate in hexanes, to afford a solidresidue which on trituration with 1-chlorobutane afforded the titleproduct, a compound of the present invention, as a light pink solid (0.2g).

¹H NMR δ 9.85 (s, 1H), 8.15 (m, 1H), 7.62 (m, 1H), 7.52 (m, 1H), 7.43(m, 1H), 7.27 (m, 1H), 7.22 (m, 1H), 7.14 (m, 1H), 6.93 (s, 1H), 4.15(m, 1H), 3.82 (m, 1H), 3.55 (d, 1H), 3.44 (m, 1H).

Synthesis Example 2 Preparation of4-bromo-N-(2-fluorophenyl)-2-oxo-4-phenyl-3-pyrrolidinecarboxamide and3-bromo-N-(2-fluorophenyl)-2-oxo-4-phenyl-3-pyrrolidinecarboxamide(Compounds 92 and 93)

A mixture of 4-phenyl-2-oxo-N-(2-fluorophenyl)-3-pyrrolidinecarboxamide(prepared by the method of Example 1, 0.75 g, 2.5 mmol) indichloromethane (25 mL) at room temperature was treated with bromine(0.16 mL, 3.0 mmol), and the resulting mixture was stirred for 18 h. Thereaction mixture was then concentrated under reduced pressure, and theresidue was chromatographed on silica gel, eluted with 0-2% methanol indichloromethane, to give as the faster eluting product,4-bromo-N-(2-fluorophenyl)-2-oxo-4-phenyl-3-pyrrolidinecarboxamide, acompound of the present invention, as a white solid (90 mg):

¹H NMR δ 10.2 (br s, 1H), 8.00 (m, 1H), 7.28 (m, 5H), 7.02 (m, 3H), 6.45(br s, 1H), 4.15 (d, 1H), 4.05 (m, 1H), 3.55 (d, 1H);

and the slower eluting product,3-bromo-N-(2-fluorophenyl)-2-oxo-4-phenyl-3-pyrrolidinecarboxamide, acompound of the present invention, as a clear yellow oil (0.31 g):

¹H NMR δ 9.55 (br s, 1H), 8.25 (t, 1H), 7.48 (d, 2H), 7.38 (m, 3H), 7.11(m, 3H), 6.85 (br s, 1H), 4.45 (m, 1H), 3.77 (m, 1H), 3.65 (m, 1H).

Synthesis Example 3 Preparation of4-(3,4-difluorophenyl)-N-(2-fluorophenyl)-1-hydroxy-2-oxo-3-pyrrolidinecarboxamide(Compound 44) Step A: Preparation of ethyl3-[(2-fluorophenyl)amino]-3-oxopropanote

To a stirred solution of 2-fluoroaniline (10 g, 90.0 mmol) andtriethylamine (9.1 g, 90.0 mmol) in dichloromethane (50 mL) at 0° C. wasadded dropwise over 10 minutes a solution of ethyl malonyl chloride(15.5 g, 90.0 mmol) in dichloromethane (30 mL). The resulting mixturewas stirred at room temperature for 24 h. The reaction mixture was thenpoured into water (100 mL), and the organic layer was separated, washedwith water (50 mL) and brine (50 mL), dried (MgSO₄) and concentratedunder reduced pressure to provide the title compound as an amber oil(19.0 g).

¹H NMR δ 9.46 (br s, 1H), 8.28 (m, 1H), 7.1 (m, 2H), 4.26 (m, 2H), 3.51(s, 2H), 1.32 (t, 3H).

Step B: Preparation of ethyl3-(3,4-difluorophenyl)-2-[[(2-fluorophenyl)amino]-carbonyl]-2-propenoate

A solution of ethyl 3-[(2-fluorophenyl)amino]-3-oxopropanote (i.e. theproduct of Step A, 20.27 g, 90.0 mmol), 3,4-difluorobenzaldehyde (16.62g, 117 mmol), acetic acid (2.6 mL, 45 mmol) and piperidine (0.89 mL, 9.0mmol) in toluene (150 mL) was refluxed for 10 h with continuous removalof water (Dean-Stark trap). The reaction mixture was then cooled to roomtemperature and poured into water (100 mL). The organic layer wasseparated, and the water layer was extracted with ethyl acetate (3×50mL). The combined organic extracts were washed with aqueous hydrochloricacid (1 N, 100 mL), dried (MgSO₄) and concentrated under reducedpressure to give a solid residue. Recrystallization of the solid fromdiethyl ether (100 mL) afforded the title compound as a white solid(10.5 g).

¹H NMR δ 8.26-8.48 (m, 1H), 8.15 (m, 1H), 7.74 (s, 1H), 7.51 (m, 1H),7.35 (m, 1H), 7.11 (m, 4H), 4.35 (m, 2H), 1.36 (t, 3H).

Step C: Preparation of ethyl3,4-difluoro-α-[[(2-fluorophenyl)amino]carbonyl]-β-(nitromethyl)benzenepropanoate

To a stirred suspension of ethyl3-(3,4-difluorophenyl)-2-[[(2-fluorophenyl)amino]-carbonyl]-2-propenoate(i.e. the product of Step B, 4.42 g, 12.7 mmol) and nitromethane (17 mL,317.5 mmol) at −20° C. was added 1,1,3,3-tetramethylguanidine (0.288 mL,2.3 mmol). The mixture was stirred at −20° C. for 30 minutes, and thenallowed to come to room temperature and stirred for an additional 2 h.The reaction mixture was diluted with dichloromethane (50 mL) andextracted with water (3×25 mL). The organic layer was dried (MgSO₄) andconcentrated under reduced pressure to provide a solid residue. Thesolid was chromatographed on silica gel, eluted with 0-100% ethylacetate in hexane, to provide the title compound as a white solid (4.42g).

¹H NMR δ 8.6 (br s, 1H), 8.00-8.30 (m, 3H), 7.23 (m, 4H), 5.41 (m, 1H),4.6 (m, 1H), 4.35 (m, 2H), 3.77-4.00 (m, 2H), 1.45 (m, 3H).

Step D: Preparation of4-(3,4-difluorophenyl)-N-(2-fluorophenyl)-1-hydroxy-2-oxo-3-pyrrolidinecarboxamide

A mixture of ethyl3,4-difluoro-α-[[(2-fluorophenyl)amino]carbonyl]-β-(nitromethyl)-benzenepropanoate(i.e. the product of Step C, 0.50 g, 1.22 mmol), 5% palladium on carbon(0.25 g) and methanol-ethyl acetate (1:1 by volume, 10 mL) was stirredat room temperature for 30 minutes, then cooled to at 0° C. and treatedwith ammonium formate (0.5 g). The resulting mixture was stirred for 1 hat room temperature. Additional 5% palladium on carbon (0.25 g) andammonium formate (0.5 g) were added, and stirring at room temperaturewas continued for an additional 4 h. The reaction mixture was thenfiltered, and the filtrate was concentrated under reduced pressure toprovide a residue, which was suspended in water (10 mL) and extractedwith ethyl acetate (3×20 mL). The combined organic extracts were dried(MgSO₄) and concentrated under reduced pressure to provide an oil, whichon recrystallization from dichloromethane afforded the title product, acompound of the present invention, as a white solid (0.1 g).

¹H NMR (DMSO-d₆) δ 10.11 (br s, 2H), 8.00 (m, 1H), 7.71 (m, 1H), 7.42(m, 1H), 7.33 (m, 3H), 7.1 (m, 1H), 4.25-3.61 (m, 4H).

Synthesis Example 4 Preparation of2-amino-4-(3,4-difluorophenyl)-N-(2-fluorophenyl)dihydro-3H-pyrrole-3-carboxamide(Compound 95) Step A: Preparation of4-(3,4-difluorophenyl)-N-(2-fluorophenyl)-2-oxo-3-pyrrolidinecarboxamide

To a stirred mixture of ethyl3,4-difluoro-α-[[(2-fluorophenyl)amino]carbonyl]-β-(nitromethyl)benzenepropanoate(i.e. the product of Example 3 Step C, 3.346 g, 8.16 mmol) andnickel(II) acetate tetrahydrate (10.15 g, 40.8 mmol) in ethanol (50 mL)at 0° C., was added portionwise sodium borohydride (1.54 g, 40.8 mmol),and the resulting mixture was stirred at room temperature for 24 h. Thereaction mixture was concentrated under reduced pressure, dissolved inethyl acetate (100 mL) and washed successively with saturated ammoniumchloride solution (50 mL), water (2×25 mL) and saturated sodium chloride(20 mL). The organic layer was dried (MgSO₄) and concentrated underreduced pressure to provide a solid residue. The residue waschromatographed on silica gel, eluted with 0-100% ethyl acetate inhexane, to provide the title compound as a white solid (0.746 g).

¹H NMR δ 9.67 (br s, 1H), 8.21 (m, 1H), 7.09 (m, 6H), 4.75 (br s, 1H),4.21 (m, 1H), 3.82 (m, 1H), 3.52 (m, 1H), 3.43 (m, 1H).

Step B: Preparation of4-(3,4-difluorophenyl)-N-(2-fluorophenyl)dihydro-2-methoxy-3H-pyrrole-3-carboxamide

A mixture of4-(3,4-difluorophenyl)-N-(2-fluorophenyl)-2-oxo-3-pyrrolidinecarboxamide(i.e. the product of Step A, 0.187 g, 0.56 mmol) and trimethyloxoniumtetrafluoroborate (0.083 g, 0.56 mmol) in dichloromethane (5 mL) wasstirred under an atmosphere of nitrogen for 2 days. The reaction mixturewas then treated with 1 N aqueous sodium hydroxide until basic (pH 10)and extracted with dichloromethane (3×5 mL). The organic layer was dried(MgSO₄) and concentrated under reduced pressure to provide titlecompound as light yellow oil (0.138 g).

¹H NMR δ 9.7 (br s, 1H), 8.62 (m, 1H), 8.25 (s, 1H), 7.26 (m, 4H), 7.00(m, 1H), 4.26 (m, 2H), 4.00 (s, 3H), 3.42 (m, 2H).

Step C: Preparation of2-amino-4-(3,4-difluorophenyl)-N-(2-fluorophenyl)dihydro-3H-pyrrole-3-carboxamide

A mixture of4-(3,4-difluorophenyl)-N-(2-fluorophenyl)dihydro-2-methoxy-3H-pyrrole-3-carboxamide(i.e. the product Step B, 0.10 g, 0.287 mmol) and aqueous ammoniumhydroxide (50%, 0.5 mL) in ethanol (2 mL) was heated in microwaveapparatus for 10 minutes. The reaction mixture was concentrated underreduced pressure and the residue chromatographed on silica gel, elutedwith 0-100% ethyl acetate/hexane, to afford the title product, acompound of the present invention, as a solid (0.016 g).

¹H NMR δ 9.67 (br s, 1H), 8.21 (m, 1H), 7.27-7.01 (m, 6H), 6.50 (br s,1H), 5.00 (br s, 1H), 4.26 (m, 1H), 3.82 (m, 1H), 3.55 (m, 1H), 3.43 (m,1H).

Synthesis Example 5 Preparation of(3R,4S)—N-(2-fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide(Compound 204) Step A: Preparation of1-[(E)-2-nitroethenyl]-3-(trifluoromethyl)benzene

To a stirred solution of 3-(trifluoromethyl)benzaldehyde (12.2 g, 70.1mmol) in methanol (50 mL) was added nitromethane (4.34 g, 71.1 mmol).The mixture was cooled to 2° C. and sodium hydroxide (5.65 g, 70.6 mmol)was added as a 50% solution in 24.3 mL of water dropwise over 15 min. Anexotherm was noted and additional ice was added to maintain thetemperature below 10° C. while stirring for an additional 1 h. Thereaction mixture was poured into 75 mL (75 mmol) of 1 N hydrochloricacid, rinsing the flask with 10 mL of methanol/water. The quenchedreaction mixture was transferred to a separatory funnel and extractedwith 150 mL of toluene. The aqueous layer was separated and concentratedunder vacuum to yield 15.84 g of a yellow oil.

The intermediate thus obtained (15.84 g, 67.3 mmol) was taken up in 160mL dichloromethane. The solution was cooled to 3° C. and methanesulfonylchloride (8.03 g, 71.1 mmol) was added via pipette as a solution in 50mL of dichloromethane. A solution of triethylamine (14.2 g, 140 mmol) in50 mL of dichloromethane was then added dropwise over 50 min, and theresulting solution was stirred for 2 h. The reaction mixture was pouredinto 150 mL (150 mmol) of 1 N hydrochloric acid and transferred to aseparatory funnel. The layers were separated and the organic layer waswashed with 150 mL water and then filtered. The organic layer wasconcentrated under reduced pressure and the crude solid was tritratedwith hexanes to yield 12.09 g of product as a yellow solid.

¹H NMR (500 MHz) δ 7.54-7.66 (m, 2H) 7.69-7.84 (m, 3H) 7.96-8.08 (m,1H).

Step B: Preparation of 1,3-diethyl2-[(1S)-2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl]propanedioate

To a stirred mixture of1-[(E)-2-nitroethenyl]-3-(trifluoromethyl)benzene (i.e. the product ofStep A, 3 g, 13.8 mmol) and diethyl malonate (3.319 g, 20.7 mmol) intoluene (1.5 mL) was added Ni(II)bis[(R,R)—N,N′-dibenzylcyclohexane-1,2-diamine]bromide (prepared asdescribed in J. Am. Chem. Soc. 2005, 127, 9958-9959; 0.111 g, 0.1 mmol).The resulting solution was stirred at 55° C. for 16 h. The solution wasdiluted with dichloromethane (20 mL) and concentrated under reducedpressure onto silica gel and purified by chromatography eluting with agradient of ethyl acetate in hexanes (0 to 50%) to give 3.6 g of a lightyellow oil. ER 94:6 (major eluting at 26.5 min, minor eluting at 20.3min).

¹H NMR (500 MHz) δ 7.54-7.60 (m, 1H), 7.43-7.48 (m, 2H), 7.51 (s, 1H),4.83-5.00 (m, 2H), 4.17-4.35 (m, 3H), 3.98-4.06 (m, 2H), 3.77-3.85 (m,1H), 1.20-1.29 (m, 3H), 0.99-1.10 (m, 3H). ¹⁹F NMR (471 MHz) δ −62.78(s, 3F). ESI [M−1] 376.3.

Step C: Preparation of ethyl(3R,4S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylate

A stirred mixture of 1,3-diethyl2-[(1S)-2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl]propanedioate (i.e.the product of Step B, 3.24 g, 8.48 mmol), nickel(II) chloridehexahydrate (2.01 g, 8.48 mmol) and ethanol (60 mL) was cooled in an icebath and treated with sodium borohydride (0.97 g, 25.8 mmol) in 0.5 gportions added over 5 min. The resulting mixture was stirred at 26° C.for 18 h. Saturated ammonium chloride solution (120 mL) and ethylacetate (120 mL) were then added, the mixture was stirred for 1 h andthen filtered through a pad of Celite® diatomaceous filter aid to removeinsoluble particulates. The layers of the filtrate were separated, andthe aqueous layer was extracted with ethyl acetate (2×100 mL). Thecombined organic extracts were washed with saturated ammonium chloridesolution (100 mL), brine (100 mL), dried (MgSO₄) and concentrated underreduced pressure to afford the title compound as a thick yellow oil(2.66 g) which was used without purification.

¹H NMR (500 MHz) δ 7.38-7.62 (m, 4H), 6.50 (br s, 1H), 4.21-4.31 (m,2H), 4.15-4.21 (m, 1H), 3.82-3.92 (m, 1H), 3.51-3.58 (m, 1H), 3.37-3.50(m, 1H), 1.27-1.34 (m, 3H). ¹⁹F NMR (471 MHz) δ −62.70 (s, 3F). ESI;[M+1]=302.0.

Step D: Preparation of(3R,4S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylic acid

A mixture of ethyl(3R,4S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylate(i.e. the product of Step C, 2.66 g, 8.8 mmol) and aqueous sodiumhydroxide (50 wt %, 2.12 g, 26.5 mmol) in ethanol (30 mL) was stirred at26° C. for 18 h. The reaction mixture was then diluted with water (50mL) and extracted with diethyl ether (2×50 mL). The aqueous phase wasacidified with concentrated hydrochloric acid to pH 2 and extracted withdichloromethane (3×50 mL). The combined dichloromethane extracts werewashed with brine, dried (MgSO₄), and concentrated under reducedpressure to afford the title compound as a white solid (2.05 g).

¹H NMR (500 MHz, acetone-d₆) δ 11.50 (br s, 1H), 7.70-7.89 (m, 2H),7.56-7.68 (m, 2H), 7.45 (br s, 1H), 4.09-4.21 (m, 1H), 3.83-3.92 (m,1H), 3.73-3.81 (m, 1H), 3.42-3.55 (m, 1H). ¹⁹F NMR (471 MHz, acetone-d₆)δ −63.03 (s, 3F). ESI [M+1] 274.0.

Step E: Preparation of(3R,4S)—N-(2-fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide

A mixture of(3R,4S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylic acid(i.e. the product of Step D, 2.0 g, 7.32 mmol), triethylamine (3.06 mL,21.96 mmol) and 2-fluoroaniline (0.85 mL, 8.78 mmol) in dichloromethane(50 mL) was stirred at ambient temperature for 30 min, and then treatedwith propylphosphonic anhydride in ethyl acetate (50%, 7.92 g, 12.44mmol). The resulting mixture was stirred at ambient temperature for 18h. The reaction mixture was then concentrated under reduced pressure,and the residue was chromatographed on silica gel, eluted with 0-100%ethyl acetate in hexanes, to afford a solid residue which on triturationwith 1-chlorobutane afforded the title product, a compound of thepresent invention, as a white solid (1.9 g). ER 88:12 (major eluting at25.86 min, minor eluting at 17.66 min). Specific Rotation +74.71 at23.4° C. at 589 nm, as a 1% solution (1 g/100 mL) in CHCl₃.

¹H NMR (500 MHz, acetone-d₆) δ 10.05 (br s, 1H), 8.21-8.35 (m, 1H),7.77-7.91 (m, 2H), 7.58-7.66 (m, 2H), 7.51 (br s, 1H), 7.02-7.22 (m,3H), 4.18-4.30 (m, 1H), 3.94-4.04 (m, 1H), 3.84-3.93 (m, 1H), 3.42-3.53(m, 1H). ¹⁹F NMR (471 MHz, acetone-d₆) δ −62.93 (s, 3F), −131.13-−131.02(m, 1F).

Synthesis Example 6 Preparation of(3S,4S)—N-(2-fluorophenyl)-1-methyl-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide(Compound 351) Step A Preparation of(4S)-4-[3-(trifluoromethyl)phenyl]-2-pyrrolidinone

A mixture of(3R,4S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylic acid(i.e. the product of Example 5, Step D, 1.5 g, 5.5 mmol) andtoluene-4-sulfonic acid (0.010 g, 0.055 mmol) in toluene (12 mL) wasstirred at 90° C. overnight. The reaction mixture was then concentratedunder reduced pressure to afford a clear oil (1.29 g). The crude productwas used without further purification.

¹H NMR (500 MHz) δ 7.36-7.59 (m, 4H), 6.84 (br s, 1H), 3.70-3.88 (m,2H), 3.35-3.50 (m, 1H), 2.72-2.87 (m, 1H), 2.44-2.58 (m, 1H). ¹⁹F NMR(471 MHz) δ −62.66 (s, 3F).

Step B: Preparation of(4S)-1-methyl-4-[3-(trifluoromethyl)phenyl]-2-pyrrolidinone

To a solution of (4S)-4-[3-(trifluoromethyl)phenyl]-2-pyrrolidinone(i.e. the product of Step A, 1.29 g, 5.6 mmol) in N,N-dimethylformamide(7 mL) was added sodium hydride (60% dispersion in mineral oil, 0.25 g,6.2 mmol) in portions. The mixture was stirred for 10 min and theniodomethane (0.88 mL, 14.1 mmol) was added. The solution was stirredovernight at ambient temperature. The reaction mixture was diluted withwater and extracted with diethyl ether (2×50 mL). The organic layer waswashed with water, brine and then dried (MgSO₄), filtered andconcentrated under reduced pressure. The crude residue waschromatographed on silica gel, eluted with 0-20% ethyl acetate indichloromethane, to afford a light brown oil (0.775 g).

¹H NMR (500 MHz) δ 7.38-7.57 (m, 4H), 3.75-3.83 (m, 1H), 3.59-3.70 (m,1H), 3.38-3.45 (m, 1H), 2.90-2.94 (m, 3H), 2.80-2.89 (m, 1H), 2.48-2.58(m, 1H). ¹⁹F NMR (471 MHz) δ −62.67 (s, 3F).

Step C Preparation of(3S,4S)—N-(2-fluorophenyl-methyl-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide

A solution of(4S)-1-methyl-4-[3-(trifluoromethyl)phenyl]-2-pyrrolidinone (i.e. theproduct of Step B, 0.350 g, 1.44 mmol) in tetrahydrofuran (5 mL) wascooled to −78° C. To this mixture lithium bis(trimethylsilyl)amide (1.6mL, 1.6 mmol as a 1 M solution in tetrahydrofuran) was added dropwiseand the resulting solution was stirred for 30 min. Then1-fluoro-2-isocyanatobenzene (0.17 mL, 1.44 mmol) was added dropwise andthe solution was stirred for 2 h at −78° C. The reaction mixture wasquenched with saturated aqueous ammonium chloride (10 mL), warmed toambient temperature and the aqueous layer was extracted with ethylacetate (3×25 mL). The organic layers were combined, washed with brineand then dried (MgSO₄), filtered and concentrated under reduced pressureonto silica gel. The crude residue was chromatographed on silica gel,eluting with 0 to 40% ethyl acetate in hexanes, to afford a light pinksolid (0.223 g).

¹H NMR (500 MHz) δ 9.93 (br s, 1H), 8.15-8.27 (m, 1H), 7.38-7.65 (m,4H), 6.93-7.15 (m, 3H), 4.10-4.23 (m, 1H), 3.72-3.88 (m, 1H), 3.56-3.68(m, 1H), 3.39-3.53 (m, 1H), 2.90-3.06 (m, 3H). ¹⁹F NMR (471 MHz) δ−62.55 (s, 3F), 129.83-−129.50 (m, 1F). ESI [M+1] 381.0.

Synthesis Example 7 Preparation of 1,3-diethyl2-[(1S)-1-(3,4-difluorophenyl)-2-nitro-ethyl]propanedioate (Intermediateto Prepare Compound 103) Step A: Preparation of 1,3-diethyl2-[(1S)-1-(3,4-difluorophenyl)-2-nitro-ethyl]propanedioate

To a stirred mixture of 1-[(E)-2-nitroethenyl]-3,4-difluorobenzene(prepared as described generally in WO2008/39882 A1, 1.67 g, 9.0 mmol)and diethyl malonate (1.73 g, 10.8 mmol) in toluene (10 mL) was addedNi(II) bis[(R,R)—N,N-dibenzylcyclohexane-1,2-diamine]bromide (preparedas described in J. Am. Chem. Soc. 2005, 127, 9958-9959; 0.072 g, 0.1mmol). The resulting solution was stirred at ambient temperature for 72h. The solution was diluted with dichloromethane (20 mL) andconcentrated under reduced pressure onto silica gel and purified bysilica gel chromatography eluting with a gradient of ethyl acetate inhexanes (0 to 50%) to provide 2.18 g of a light yellow waxy solid. ER96:4 (major eluting at 37.05 min, minor eluting at 27.09 min).

¹H NMR (500 MHz) δ 7.06-7.16 (m, 2H), 6.95-7.03 (m, 1H), 4.73-4.94 (m,2H), 4.16-4.29 (m, 3H), 4.01-4.10 (m, 2H), 3.71-3.79 (m, 1H), 1.22-1.30(m, 3H), 1.07-1.15 (m, 3H). ¹⁹F NMR (471 MHz) δ −137.66-−137.47 (m, 1F)−136.10-−135.87 (m, 1F). ESI [M+1]; 346.4

By the procedures described herein together with methods known in theart, the following compounds of Tables 1 to 6800 can be prepared. Thefollowing abbreviations are used in the Tables which follow: t meanstertiary, s means secondary, n means normal, i means iso, c means cyclo,Me means methyl, Et means ethyl, Pr means propyl, Bu means butyl, i-Prmeans isopropyl, c-Pr cyclopropyl, t-Bu means tertiary butyl, c-Bu meanscyclobutyl, Ph means phenyl, OMe means methoxy, OEt means ethoxy, SMemeans methylthio, NHMe means methylamino, CN means cyano, NO₂ meansnitro, TMS means trimethylsilyl, SOMe means methylsulfinyl, C₂F₅ meansCF₂CF₃ and SO₂Me means methylsulfonyl.

TABLE 1

Q1 Ph(3-Cl) Ph(3-F) Ph(3-Br) Ph(3-Me) Ph(3-Et) Ph(3-t-Bu) Ph(3-i-Pr)Ph(3-c-Pr) Ph(3-cyclohexyl) Ph(3-CH═CH₂) Ph(3-CF₃) Ph(3-CH₂CF₃)Ph(3-CHF₂) Ph(3-CH₂F) Ph(3-OCF₃) Ph(3-OCH₂F) Ph(3-SCF₃) Ph(3-SMe)Ph(3-SOMe) 3-SO₂Me Ph(3-OSO₂Me) Ph(3-C≡CH) Ph(3-OMe) Ph(3-OEt)Ph(3-NHCO₂-t-Bu) Ph(3-NHCOMe) Ph(3-NHCOCF₃) Ph(3-CN) Ph(3-NO₂) Ph(3-Ph)Ph(3-COMe) Ph(3-OCOMe) Ph(3-CO₂Me) Ph(3-OCO₂Me) Ph(3-TMS) Ph(3-SF₅)Ph[3-(1H-pyrazol-1-yl)] Ph[3-(2H-1,2,3-triazol-2-yl)]Ph[3-(1H-imidazol-1-yl)] Ph[3-(3-pyridinyl)] Ph[3-(4-pyridinyl)]Ph[3-(2-pyridinyl)] 4-Pyridinyl(2-CF₃) 4-Pyridinyl(2-Cl)4-Pyridinyl(2-F) 4-Pyridinyl(2-OCF₃) 4-Pyridinyl(2-Me) 4-Pyridinyl(2-Br)4-Pyridinyl 1H-Pyrazol-4-yl(1-Me) 1H-Pyrazol-4-yl(1-CH₂CF₃)1H-Imidazol-2-yl(1-Me) 1H-Imidazol-2-yl(1-CH₂CF₃)1H-Imidazol-2-yl(1-Me,5-Cl) 1H-Imidazol-2-yl(1-Me,5-F) 2-Thienyl2-Thienyl(4-F) 2-Thienyl(4-Cl) 2-Thienyl(4-CF₃) 2-Thienyl(5-F)2-Thienyl(5-Cl) 2-Thienyl(5-CF₃) Ph(4-Cl) Ph(4-F) Ph(4-Br) Ph(4-Me)Ph(4-Et) Ph(4-t-Bu) Ph(4-i-Pr) Ph(4-c-Pr) Ph(4-cyclohexyl) Ph(4-CH═CH₂)Ph(4-CF₃) Ph(4-CH₂CF₃) Ph(4-CHF₂) Ph(4-CH₂F) Ph(4-OCF₃) Ph(4-OCH₂F)Ph(4-SCF₃) Ph(4-SMe) Ph(4-SOMe) Ph(4-SO₂Me) Ph(4-OSO₂Me) Ph(4-C≡CH)Ph(4-OMe) Ph(4-OEt) Ph(4-NHCO₂-t-Bu) Ph(4-NHCOMe) Ph(4-NHCOCF₃) Ph(4-CN)Ph(4-NO₂) Ph(4-Ph) Ph(4-COMe) Ph(4-OCOMe) Ph(4-CO₂Me) Ph(4-OCO₂Me)Ph(4-TMS) Ph(4-SF₅) Ph(1H-pyrazol-1-yl) Ph(2H-1,2,3-triazol-2-yl)Ph(1H-imidazol-1-yl) Ph[4-(3-pyridinyl)] Ph[4-(4-pyridinyl)]Ph[4-(2-pyridinyl)] 3-Pyridinyl(5-CF₃) 3-Pyridinyl(5-Cl)3-Pyridinyl(5-F) 3-Pyridinyl(5-OCF₃) 3-Pyridinyl(5-Me) 3-Pyridinyl(5-Br)3-Pyridinyl 1H-Pyrazol-3-yl(1-Me) 1H-Pyrazol-3-yl(1-CH₂CF₃)1H-Pyrazol-3-yl(1-Me,4-F) 1H-Pyrazol-3-yl(1-Me,4-Cl)1H-Imidazol-5-yl(1-Me) 1H-Imidazol-5-yl(1-CH₂CF₃) 1H-Imidazol-4-yl(1-Me)1H-Imidazol-4-yl(1-CH₂CF₃) 3-Thienyl 3-Thienyl(5-F) 3-Thienyl(5-Cl)3-Thienyl(5-CF₃) Ph(3,4-di-Cl) Ph(3-Cl,4-F) Ph(3-Cl,4-Br) Ph(3-Cl,4-Me)Ph(3-Cl,4-t-Bu) Ph(3-Cl,4-c-Pr) Ph(3-Cl,4-CF₃) Ph(3-Cl,4-CHF₂)Ph(3-Cl,4-OCF₃) Ph(3-Cl,4-OCHF₂) Ph(3-Cl,4-SO₂Me) Ph(3-Cl,4-TMS)Ph(3-Cl,4-CN) Ph(3-F,4-Cl) Ph(3,4-di-F)* Ph(3-F,4-Br) Ph(3-F,4-Me)Ph(3-F,4-t-Bu) Ph(3-F,4-c-Pr) Ph(3-F,4-CF₃) Ph(3-F,4-CHF₂)Ph(3-F,4-OCF₃) Ph(3-F,4-OCHF₂) Ph(3-F,4-SO₂Me) Ph(3-F,4-TMS)Ph(3-F,4-CN) Ph(3-F,4-SF₅) Ph(3-Br,4-Cl) Ph(3-Br,4-F) Ph(3,4-di-Br)Ph(3-Br,4-Me) Ph(3-Br,4-c-Pr) Ph(3-Br,4-CF₃) Ph(3-Br,4-CHF₂)Ph(3-Br,4-OCF₃) Ph(3-Br,4-OCHF₂) Ph(3-Br,4-SO₂Me) Ph(3-Br,4-TMS)Ph(3-Br,4-CN) Ph(3-Me,4-Cl) Ph(3-Me,4-F) Ph(3-Me,4-Br) Ph(3,4-di-Me)Ph(3-Me,4-t-Bu) Ph(3-Me,4-c-Pr) Ph(3-Me,4-CF₃) Ph(3-Me,4-OCF₃)Ph(3-Me,4-OCHF₂) Ph(3-Me,4-SO₂Me) Ph(3-Me,4-TMS) Ph(3-Me,4-CN)Ph(3-t-Bu,4-Cl) Ph(3-t-Bu,4-F) Ph(3-t-Bu,4-Br) Ph(3-t-Bu,4-Me)Ph(3,4-di-t-Bu) Ph(3-t-Bu,4-c-Pr) Ph(3-t-Bu,4-CF₃) Ph(3-t-Bu,4-CHF₂)Ph(3-t-Bu,4-OCF₃) Ph(3-t-Bu,4-OCHF₂) Ph(3-t-Bu,4-SO₂Me) Ph(3-t-Bu,4-TMS)Ph(3-t-Bu,4-CN) Ph(3-c-Pr,4-Cl) Ph(3-c-Pr,4-F) Ph(3-c-Pr,4-Br)Ph(3-c-Pr,4-Me) Ph(3-c-Pr,4-t-Bu) Ph(3,4-di-c-Pr) Ph(3-c-Pr,4-CF₃)Ph(3-c-Pr,4-CHF₂) Ph(3-c-Pr,4-OCF₃) Ph(3-c-Pr,4-OCHF₂)Ph(3-c-Pr,4-SO₂Me) Ph(3-c-Pr,4-TMS) Ph(3-c-Pr,4-CN) Ph(3-CF3,4-Cl)Ph(3-CF3,4-F) Ph(3-CF3,4-Br) Ph(3-CF3,4-Me) Ph(3-CF3,4-t-Bu)Ph(3-CF3,4-c-Pr) Ph(3,4-di-CF₃) Ph(3-CF₃,4-CHF₂) Ph(3-CF₃,4-OCF₃)Ph(3-CF₃,4-OCHF₂) Ph(3-CF₃,4-SO₂Me) Ph(3-CF₃,4-TMS) Ph(3-CF₃,4-CN)Ph(3-OCF₃,4-Cl) Ph(3-OCF₃,4-F) Ph(3-OCF₃,4-Br) Ph(3-OCF₃,4-Me)Ph(3-OCF₃,4-t-Bu) Ph(3-OCF₃,4-c-Pr) Ph(3-OCF₃-4-CF₃) Ph(3-OCF₃,4-CHF₂)Ph(3,4-di-OCF₃) Ph(3-OCF₃,4-OCHF₂) Ph(3-OCF₃,4-SO₂Me) Ph(3-OCF₃,4-TMS)Ph(3-OCF₃,4-CN) Ph(3-SO₂Me,4-Cl) Ph(3-SO₂Me,4-F) Ph(3-SO₂Me,4-Br)Ph(3-SO₂Me,4-Me) Ph(3-SO₂Me,4-t-Bu) Ph(3-SO₂Me,4-c-Pr) Ph(3-SO₂Me,4-CF₃)Ph(3-SO₂Me,4-CHF₂) Ph(3-SO₂Me,4-OCF₃) Ph(3-SO₂Me,4-OCHF₂)Ph(3,4-di-SO₂Me) Ph(3-SO₂Me,4-TMS) Ph(3-SO₂Me,4-CN) Ph(3-CHF₂,4-Cl)Ph(3-CHF₂,4-F) Ph(3-CHF₂,4-Br) Ph(3-CHF₂,4-Me) Ph(3-CHF₂,4-t-Bu)Ph(3-CHF₂,4-c-Pr) Ph(3-CHF₂,4-CF₃) Ph(3-CHF₂,4-CHF₂) Ph(3-CHF₂,4-OCF₃)Ph(3-CHF₂,4-OCHF₂) Ph(3-CHF₂,4-SO₂Me) Ph(3-CHF₂,4-TMS) Ph(3-CHF₂,4-CN)Ph(3-CN,4-Cl) Ph(3-CN,4-F) Ph(3-CN,4-Br) Ph(3-CN,4-Me) Ph(3-CN,4-t-Bu)Ph(3-CN,4-c-Pr) Ph(3-CN,4-CF₃) Ph(3-CN,4-CHF₂) Ph(3-CN,4-OCF₃)Ph(3-CN,4-OCHF₂) Ph(3-CN,4-SO₂Me) Ph(3-CN,4-TMS) Ph(3,4-di-CN)Ph(3-SF₅,4-F) Ph(2-F,3-Cl,4-Cl) Ph(2-F,3-Cl,4-F) Ph(2-F,3-Cl,4-Br)Ph(2-F,3-Cl,4-Me) Ph(2-F,3-Cl,4-t-Bu) Ph(2-F,3-Cl,4-c-Pr)Ph(2-F,3-Cl,4-CF3) Ph(2-F,3-Cl,4-CHF2) Ph(2-F,3-Cl,4-OCF3)Ph(2-F,3-Cl,4-OCHF2) Ph(2-F,3-Cl,4-SO2Me) Ph(2-F,3-Cl,4-TMS)Ph(2-F,3-Cl,4-CN) Ph(2-F,3-F,4-Cl) Ph(2-F,3-F,4-F) Ph(2-F,3-F,4-Br)Ph(2-F,3-F,4-Me) Ph(2-F,3-F,4-t-Bu) Ph(2-F,3-F,4-c-Pr) Ph(2-F,3-F,4-CF₃)Ph(2-F,3-F,4-CHF₂) Ph(2-F,3-F,4-OCF₃) Ph(2-F,3-F,4-OCHF₂)Ph(2-F,3-F,4-SO₂Me) Ph(2-F,3-F,4-TMS) Ph(2-F,3-F,4-CN) Ph(2-F,3-Br,4-Cl)Ph(2-F,3-Br,4-F) Ph(2-F,3-Br,4-Br) Ph(2-F,3-Br,4-Me) Ph(2-F,3-Br,4-t-Bu)Ph(2-F,3-Br,4-c-Pr) Ph(2-F,3-Br,4-CF₃) Ph(2-F,3-Br,4-CHF₂)Ph(2-F,3-Br,4-OCF₃) Ph(2-F,3-Br,4-OCHF₂) Ph(2-F,3-Br,4-SO₂Me)Ph(2-F,3-Br,4-TMS) Ph(2-F,3-Br,4-CN) Ph(2-F,3-Me,4-Cl) Ph(2-F,3-Me,4-F)Ph(2-F,3-Me,4-Br) Ph(2-F,3-Me,4-Me) Ph(2-F,3-Me,4-t-Bu)Ph(2-F,3-Me,4-CF₃) Ph(2-F,3-Me,4-CHF₂) Ph(2-F,3-Me,4-OCF₃)Ph(2-F,3-Me,4-OCHF₂) Ph(2-F,3-Me,4-SO₂Me) Ph(2-F,3-Me,4-TMS)Ph(2-F,3-Me,4-CN) Ph(2-F,3-t-Bu,4-Cl) Ph(2-F,3-t-Bu,4-F)Ph(2-F,3-t-Bu,4-Br) Ph(2-F,3-t-Bu,4-Me) Ph(2-F,3-t-Bu,4-t-Bu)Ph(2-F,3-t-Bu,4-c-Pr) Ph(2-F,3-t-Bu,4-CF₃) Ph(2-F,3-t-Bu,4-CHF₂)Ph(2-F,3-t-Bu,4-OCF₃) Ph(2-F,3-t-Bu,4-OCHF₂) Ph(2-F,3-t-Bu,4-SO₂Me)Ph(2-F,3-t-Bu,4-TMS) Ph(2-F,3-t-Bu,4-CN) Ph(2-F,3-c-Pr,4-Cl)Ph(2-F,3-c-Pr,4-F) Ph(2-F,3-c-Pr,4-Br) Ph(2-F,3-c-Pr,4-Me)Ph(2-F,3-c-Pr,4-t-Bu) Ph(2-F,3,4-di-c-Pr) Ph(2-F,3-c-Pr,4-CF₃)Ph(2-F,3-c-Pr,4-CHF₂ Ph(2-F,3-c-Pr,4-OCF₃) Ph(2-F,3-c-Pr,4-OCHF₂)Ph(2-F,3-c-Pr,4-SO₂Me) Ph(2-F,3-c-Pr,4-TMS) Ph(2-F,3-c-Pr,4-CN)Ph(2-F,3-CF₃,4-Cl) Ph(2-F,3-CF₃,4-F) Ph(2-F,3-CF₃,4-Br)Ph(2-F,3-CF₃,4-Me) Ph(2-F,3-CF₃,4-t-Bu) Ph(2-F,3-CF₃,4-c-Pr)Ph(2-F,3-CF₃,4-CF₃) Ph(2-F,3-CF₃,4-CHF₂) Ph(2-F,3-CF₃,4-OCF₃)Ph(2-F,3-CF₃,4-OCHF₂) Ph(2-F,3-CF₃,4-SO₂Me) Ph(2-F,3-CF₃,4-TMS)Ph(2-F,3-CF₃,4-CN) Ph(2-F,3-OCF₃,4-Cl) Ph(2-F,3-OCF₃,4-F)Ph(2-F,3-OCF₃,4-Br) Ph(2-F,3-OCF₃,4-Me) Ph(2-F,3-OCF₃,4-t-Bu)Ph(2-F,3-OCF₃,4-c-Pr) Ph(2-F,3-OCF₃,4-CF₃) Ph(2-F,3-OCF₃,4-CHF₂)Ph(2-F,3-OCF₃,4-OCF₃) Ph(2-F,3-OCF₃,4-OCHF₂) Ph(2-F,3-OCF₃,4-SO₂Me)Ph(2-F,3-OCF₃,4-TMS) Ph(2-F,3-OCF₃,4-CN) Ph(2-F,3-SO₂Me,4-Cl)Ph(2-F,3-SO₂Me,4-F) Ph(2-F,3-SO₂Me,4-Br) Ph(2-F,3-SO₂Me,4-Me)Ph(2-F,3-SO₂Me,4-t-Bu) Ph(2-F,3-SO₂Me,4-c-Pr) Ph(2-F,3-SO₂Me,4-CF₃)Ph(2-F,3-SO₂Me,4-CHF₂) Ph(2-F,3-SO₂Me,4-OCF₃) Ph(2-F,3-SO₂Me,4-OCHF₂)Ph(2-F,3,4-di-SO₂Me) Ph(2-F,3-SO₂Me,4-TMS) Ph(2-F,3-SO₂Me,4-CN)Ph(2-F,3-CHF2,4-Cl) Ph(2-F,3-CHF₂,4-F) Ph(2-F,3-CHF₂,4-Br)Ph(2-F,3-CHF₂,4-Me) Ph(2-F,3-CHF₂,4-t-Bu) Ph(2-F,3-CHF₂,4-c-Pr)Ph(2-F,3-CHF₂,4-CF₃) Ph(2-F,3-CHF₂,4-CHF₂) Ph(2-F,3-CHF₂,4-OCF₃)Ph(2-F,3-CHF₂,4-OCHF₂) Ph(2-F,3-CHF₂,4-SO₂Me) Ph(2-F,3-CHF₂,4-TMS)Ph(2-F,3-CHF₂,4-CN) Ph(2-F,3-CN,4-Cl) Ph(2-F,3-CN,4-F) Ph(2-F,3-CN,4-Br)Ph(2-F,3-CN,4-Me) Ph(2-F,3-CN,4-t-Bu) Ph(2-F,3-CN,4-c-Pr)Ph(2-F,3-CN,4-CF₃) Ph(2-F,3-CN,4-CHF₂) Ph(2-F,3-CN,4-OCF₃)Ph(2-F,3-CN,4-OCHF₂) Ph(2-F,3-CN,4-SO₂Me) Ph(2-F,3-CN,4-TMS)Ph(2-F,3-CN,4-CN) Ph(2-F,4-Cl) Ph(2-F,4-F) Ph(2-F,4-Br) Ph(2-F,4-Me)Ph(2-F,4-t-Bu) Ph(2-F,4-c-Pr) Ph(2-F,4-CF₃) Ph(2-F,4-CHF₂)Ph(2-F,4-OCF₃) Ph(2-F,4-OCHF₂) Ph(2-F,4-SO₂Me) Ph(2-F,4-TMS)Ph(2-F,4-CN) Ph(2-F,3-Cl) Ph(2-F,3-F) Ph(2-F,3-Br) Ph(2-F,3-Me)Ph(2-F,3-t-Bu) Ph(2-F,3-c-Pr) Ph(2-F,3-CF₃) Ph(2-F,3-CHF₂)Ph(2-F,3-OCF₃) Ph(2-F,3-OCHF₂) Ph(2-F,3-SO₂Me) Ph(2-F,3-TMS)Ph(2-F,3-CN) Ph(2-Cl) Ph(2-F) Ph(2-Br) Ph(2-I) Ph(2-Me) Ph(2-Et)Ph(2-n-Pr) Ph(2-t-Bu) Ph(2-i-Pr) Ph(2-c-Pr) Ph(2-cyclohexyl)Ph(2-CH═CH₂) Ph(2-CF₃) Ph(2-CH₂CF₃) Ph(2-CF₂H) Ph(2-CH₂F) Ph(2-OCF₃)Ph(2-OCH₂F) Ph(2-OCF₂H) Ph(2-SCF₃) Ph(2-SMe) Ph(2-SOMe) Ph(2-SO₂Me)Ph(2-OSO₂Me) Ph(2-C≡CH) Ph(2-OMe) Ph(2-OEt) Ph(2-NHCO₂-t-Bu)Ph(2-NHCOMe) Ph(2-NHCOCF₃) Ph(2-CN) Ph(2-NO₂) Ph(2-Ph) Ph(2-COMe)Ph(2-OCOMe) Ph(2-CO₂Me) Ph(2-OCO₂Me) Ph(2-TMS) Ph[2-(1H-pyrazol-1-yl)]Ph[2-(2H-1,2,3-triazol-2-yl)] Ph[2-(1H-imidazol-1-yl)]Ph[2-(3-pyridinyl)] Ph[2-(4-pyridinyl)] Ph[2-(2-pyridinyl)] Ph(2-C₂F₅)Ph(2-CF₂CF₂H) Ph(2-OCF₂CF₂H) Ph(2-OC₂F₅) Ph(2-OCH₂CF₃) Ph(2-OCH₂C≡CH)Ph(2-OCH₂C≡CCF₃) Ph(2-OCH₂C≡CCF₂H) Ph(2-OCH₂C≡CCH₃) Ph(2-OCH₂C≡C-c-Pr)Ph(2-C≡CCF₂H) Ph(2-C≡CCH₃) Ph(2-C≡C-c-Pr) Ph(2-OPh) Ph(2-C≡CCF₃)Ph(2-CH═CF₂) Ph(2-CH═CCl₂) Ph(2-CH═CBr₂) Ph(2-OCH═CH₂) Ph(2-OCH═CF₂)Ph(2-OCH═CCl₂) Ph(2-OCH═CBr₂) Ph(2-CH₂CH═CH₂) Ph(2-CH₂CH═CF₂)Ph(2-CH₂CH═CCl₂) Ph(2-CH₂CH═CBr₂) Ph(2-OCH₂CH═CH₂) Ph(2-OCH₂CH═CF₂)Ph(2-OCH₂CH═CCl₂) Ph(2-OCH₂CH═CBr₂) Ph(2-SCF₂H) Ph(2-SCF₂CF₂H) Ph(3-I)Ph(3-n-Pr) Ph(3-CF₂H) Ph(3-OCF₂H) Ph(3-SO₂Me) Ph(3-C₂F₅) Ph(3-CF₂CF₂H)Ph(3-OCF₂CF₂H) Ph(3-OC₂F₅) Ph(3-OCH₂CF₃) Ph(3-OCH₂C≡CH) Ph(3-OCH₂C≡CCF₃)Ph(3-OCH₂C≡CCF₂H) Ph(3-OCH₂C≡CCH₃) Ph(3-OCH₂C≡C-c-Pr) Ph(3-C≡CCF₂H)Ph(3-C≡CCH₃) Ph(3-C≡C-c-Pr) Ph(3-OPh) Ph(3-C≡CCF₃) Ph(3-CH═CF₂)Ph(3-CH═CCl₂) Ph(3-CH═CBr₂) Ph(3-OCH═CH₂) Ph(3-OCH═CF₂) Ph(3-OCH═CCl₂)Ph(3-OCH═CBr₂) Ph(3-CH₂CH═CH₂) Ph(3-CH₂CH═CF₂) Ph(3-CH₂CH═CCl₂)Ph(3-CH₂CH═CBr₂) Ph(3-OCH₂CH═CH₂) Ph(3-OCH₂CH═CF₂) Ph(3-OCH₂CH═CCl₂)Ph(3-OCH₂CH═CBr₂) Ph(3-SCF₂H) Ph(3-SCF₂CF₂H) Ph(2-Cl,3-Cl) Ph(2-Cl,3-F)Ph(2-Cl,3-Br) Ph(2-Cl,3-I) Ph(2-Cl,3-Me) Ph(2-Cl,3-Et) Ph(2-Cl,3-n-Pr)Ph(2-Cl,3-t-Bu) Ph(2-Cl,3-i-Pr) Ph(2-Cl,3-c-Pr) Ph(2-Cl,3-cyclohexyl)Ph(2-Cl,3-CH═CH₂) Ph(2-Cl,3-CF3) Ph(2-Cl,3-CH₂CF₃) Ph(2-Cl,3-CF₂H)Ph(2-Cl,3-CH₂F) Ph(2-Cl,3-OCF₃) Ph(2-Cl,3-OCH₂F) Ph(2-Cl,3-OCF₂H)Ph(2-Cl,3-SCF₃) Ph(2-Cl,3-SMe) Ph(2-Cl,3-SOMe) Ph(2-Cl,3-SO₂Me)Ph(2-Cl,3-OSO₂Me) Ph(2-Cl,3-CCH) Ph(2-Cl,3-OMe) Ph(2-Cl,3-OEt)Ph(2-Cl,3-NHCO₂-t-Bu) Ph(2-Cl,3-NHCOMe) Ph(2-Cl,3-NHCOCF₃) Ph(2-Cl,3-CN)Ph(2-Cl,3-NO₂) Ph(2-Cl,3-Ph) Ph(2-Cl,3-COMe) Ph(2-Cl,3-OCOMe)Ph(2-Cl,3-CO₂Me) Ph(2-Cl,3-OCO₂Me) Ph(2-Cl,3-TMS)Ph[3-(2-Cl,1H-pyrazol-1-yl)] Ph[3-(2-Cl,2H-1,2,3-triazol-2-yl)]Ph[3-(2-Cl,1H-imidazol-1-yl)] Ph[3-(2-Cl,3-pyridinyl)Ph[3-(2-Cl,4-pyridinyl) Ph[3-(2-Cl,2-pyridinyl) Ph(2-Cl,3-C₂F₅)Ph(2-Cl,3-CF₂CF₂H) Ph(2-Cl,3-OCF₂CF₂H) Ph(2-Cl,3-OC₂F₅)Ph(2-Cl,3-OCH₂CF₃) Ph(2-Cl,3-OCH₂C≡CH) Ph(2-Cl,3-OCH₂C≡CCF₃)Ph(2-Cl,3-OCH₂C≡CCF₂H) Ph(2-Cl,3-OCH₂C≡CCH₃) Ph(2-Cl,3-OCH₂C≡C-c-Pr)Ph(2-Cl,3-C≡CCF₂H) Ph(2-Cl,3-CCCH₃) Ph(2-Cl,3-CC-c-Pr) Ph(2-Cl,3-OPh)Ph(2-Cl,3-C≡CCF₃) Ph(2-Cl,3-CH═CF₂) Ph(2-Cl,3-CH═CCl₂)Ph(2-Cl,3-CH═CBr₂) Ph(2-Cl,3-OCH═CH₂) Ph(2-Cl,3-OCH═CF₂)Ph(2-Cl,3-OCH═CCl₂) Ph(2-Cl,3-OCH═CBr₂) Ph(2-Cl,3-CH₂CH═CH₂)Ph(2-Cl,3-CH₂CH═CF₂) Ph(2-Cl,3-CH₂CH═CCl₂) Ph(2-Cl,3-CH₂CH═CBr₂)Ph(2-Cl,3-OCH₂CH═CH₂) Ph(2-Cl,3-OCH₂CH═CF₂) Ph(2-Cl,3-OCH₂CH═CCl₂)Ph(2-Cl,3-OCH₂CH═CBr₂) Ph(2-Cl,3-SCF₂H) Ph(2-Cl,3-SCF₂CF₂H) Ph(2-F,3-F)Ph(2-F,3-Br) Ph(2-F,3-I) Ph(2-F,3-Me) Ph(2-F,3-Et) Ph(2-F,3-n-Pr)Ph(2-F,3-t-Bu) Ph(2-F,3-i-Pr) Ph(2-F,3-cyclohexyl) Ph(2-F,3-CH═CH₂)Ph(2-F,3-CF₃) Ph(2-F,3-CH₂CF₃) Ph(2-F,3-CF₂H) Ph(2-F,3-CH₂F)Ph(2-F,3-OCH₂F) Ph(2-F,3-OCF₂H) Ph(2-F,3-SCF₃) Ph(2-F,3-SMe)Ph(2-F,3-SOMe) Ph(2-F,3-SO₂Me) Ph(2-F,3-OSO₂Me) Ph(2-F,3-CCH)Ph(2-F,3-OMe) Ph(2-F,3-OEt) Ph(2-F,3-NHCO₂-t-Bu) Ph(2-F,3-NHCOMe)Ph(2-F,3-NHCOCF₃) Ph(2-F,3-NO₂) Ph(2-F,3-Ph) Ph(2-F,3-COMe)Ph(2-F,3-OCOMe) Ph(2-F,3-CO₂Me) Ph(2-F,3-OCO₂Me)Ph[3-(2-F,1H-imidazol-1-yl)] Ph[3-(2-F,3-pyridinyl)]Ph[3-(2-F,4-pyridinyl)] Ph[3-(2-F,2-pyridinyl)] Ph(2-F,3-C₂F₅)Ph(2-F,3-CF₂CF₂H) Ph(2-F,3-OCF₂CF₂H) Ph(2-F,3-OC₂F₅) Ph(2-F,3-OCH₂CF₃)Ph(2-F,3-OCH₂C≡CH) Ph(2-F,3-OCH₂C≡CCF₃) Ph(2-F,3-OCH₂C≡CCF₂H)Ph(2-F,3-OCH₂C≡CCH₃) Ph(2-F,3-OCH₂C≡C-c-Pr) Ph(2-F,3-C≡CCF₂H)Ph(2-F,3-C≡CCH₃) Ph(2-F,3-C≡C-c-Pr) Ph(2-F,3-OPh) Ph(2-F,3-C≡CCF₃)Ph(2-F,3-CH═CF₂) Ph(2-F,3-CH═CCl₂) Ph(2-F,3-CH═CBr₂) Ph(2-F,3-OCH═CH₂)Ph(2-F,3-OCH═CF₂) Ph(2-F,3-OCH═CCl₂) Ph(2-F,3-OCH═CBr₂)Ph(2-F,3-CH₂CH═CH₂) Ph(2-F,3-CH₂CH═CF₂) Ph(2-F,3-CH₂CH═CCl₂)Ph(2-F,3-CH₂CH═CBr₂) Ph(2-F,3-OCH₂CH═CH₂) Ph(2-F,3-OCH₂CH═CF₂)Ph(2-F,3-OCH₂CH═CCl2) Ph(2-F,3-OCH₂CH═CBr₂) Ph(2-F,3-SCF₂H)Ph(2-F,3-SCF₂CF₂H) Ph(2-F,3-SF5) 4-Pyridinyl(5-OCF₂H)4-Pyridinyl(5-CF₂H) 4-Pyridinyl(5-OCF₂CF₂H) 2-Thienyl(4-Me)2-Thienyl(4-Et) 2-Thienyl(4-i-Pr) 2-Thienyl(4-c-Pr) 2-Thienyl(4-CF₂H)2-Thienyl(4-OCF₂H) 2-Thienyl(4-OCF₂CF₂H) 2-Thienyl(5-Me) 2-Thienyl(5-Et)2-Thienyl(5-i-Pr) 2-Thienyl(5-c-Pr) 2-Thienyl(5-CF₂H) 2-Thienyl(5-OCF₂H)2-Thienyl(5-OCF₂CF₂H) 2-Thienyl(5-OC₂F₅) 2-Furanyl(4-F) 2-Furanyl(4-Cl)2-Furanyl(4-CF₃) 2-Furanyl(5-F) 2-Furanyl(5-Cl) 2-Furanyl(5-CF₃)2-Furanyl(4-Me) 2-Furanyl(4-Et) 2-Furanyl(4-i-Pr) 2-Furanyl(4-c-Pr)2-Furanyl(4-CF₂H) 2-Furanyl(4-OCF₂H) 2-Furanyl(4-OCF₂CF₂H)2-Furanyl(5-Me) 2-Furanyl(5-Et) 2-Furanyl(5-i-Pr) 2-Furanyl(5-c-Pr)2-Furanyl(5-CF₂H) 2-Furanyl(5-OCF₂H) 2-Furanyl(5-OCF₂CF₂H)2-Furanyl(5-OC₂F₅) Ph(4-I) Ph(4-n-Pr) Ph(4-OCHF₂) Ph(4-C2F₅)Ph(4-CF₂CF₂H) Ph(4-OCF₂CF₂H) Ph(4-OC₂F₅) Ph(4-OCH₂CF₃) Ph(4-OCH₂C≡CH)Ph(4-OCH₂C≡CCF₃) Ph(4-OCH₂C≡CCF₂H) Ph(4-OCH₂C≡CCH₃) Ph(4-OCH₂C≡C-c-Pr)Ph(4-C≡CCF₂H) Ph(4-C≡CCH₃) Ph(4-C≡C-c-Pr) Ph(4-OPh) Ph(4-C≡CCF₃)Ph(4-CH═CF₂) Ph(4-CH═CCl₂) Ph(4-CH═CBr₂) Ph(4-OCH═CH₂) Ph(4-OCH═CF₂)Ph(4-OCH═CCl₂) Ph(4-OCH═CBr₂) Ph(4-CH₂CH═CH₂) Ph(4-CH₂CH═CF₂)Ph(4-CH₂CH═CCl₂) Ph(4-CH₂CH═CBr₂) Ph(4-OCH₂CH═CH₂) Ph(4-OCH₂CH═CF₂)Ph(4-OCH₂CH═CCl₂) Ph(4-OCH₂CH═CBr₂) Ph(4-SCF₂H) Ph(4-SCF₂CF₂H)Ph(2,4-di-Cl) Ph(2-Cl,4-F) Ph(2-Cl,4-Br) Ph(2-Cl,4-I) Ph(2-Cl,4-Me)Ph(2-Cl,4-Et) Ph(2-Cl,4-n-Pr) Ph(2-Cl,4-t-Bu) Ph(2-Cl,4-i-Pr)Ph(2-Cl,4-c-Pr) Ph(2-Cl,4-cyclohexyl) Ph(2-Cl,4-CH═CH₂) Ph(2-Cl,4-CF₃)Ph(2-Cl,4-CH₂CF₃) Ph(2-Cl,4-CHF₂) Ph(2-Cl,4-CH₂F) Ph(2-Cl,4-OCF₃)Ph(2-Cl,4-OCH₂F) Ph(2-Cl,4-OCHF₂) Ph(2-Cl,4-SCF₃) Ph(2-Cl,4-SMe)Ph(2-Cl,4-SOMe) Ph(2-Cl,4-SO₂Me) Ph(2-Cl,4-OSO₂Me) Ph(2-Cl,4-CCH)Ph(2-Cl,4-OMe) Ph(2-Cl,4-OEt) Ph(2-Cl,4-NHCO₂-t-Bu) Ph(2-Cl,4-NHCOMe)Ph(2-Cl,4-NHCOCF₃) Ph(2-Cl,4-CN) Ph(2-Cl,4-NO₂) Ph(2-Cl,4-Ph)Ph(2-Cl,4-COMe) Ph(2-Cl,4-OCOMe) Ph(2-Cl,4-CO₂Me) Ph(2-Cl,4-OCO₂Me)Ph(2-Cl,4-TMS) Ph(2-Cl,4-C₂F₅) Ph(2-Cl,4-CF₂CF₂H) Ph(2-Cl,4-OCF₂CF₂H)Ph(2-Cl,4-OC₂F₅) Ph(2-Cl,4-OCH₂CF₃) Ph(2-Cl,4-OCH₂C≡CH)Ph(2-Cl,4-OCH₂C≡CCF₃) Ph(2-Cl,4-OCH₂C≡CCF₂H) Ph(2-Cl,4-OCH₂C≡CCH₃)Ph(2-Cl,4-OCH₂C≡C-c-Pr) Ph(2-Cl,4-C≡CCF₂H) Ph(2-Cl,4-C≡CCH₃)Ph(2-Cl,4-C≡C-c-Pr) Ph(2-Cl,4-OPh) Ph(2-Cl,4-C≡CCF₃) Ph(2-Cl,4-CH═CF₂)Ph(2-Cl,4-CH═CCl₂) Ph(2-Cl,4-CH═CBr₂) Ph(2-Cl,4-OCH═CH₂)Ph(2-Cl,4-OCH═CF₂) Ph(2-Cl,4-OCH═CCl₂) Ph(2-Cl,4-OCH═CBr₂)Ph(2-Cl,4-CH₂CH═CH₂) Ph(2-Cl,4-CH₂CH═CF₂) Ph(2-Cl,4-CH₂CH═CCl₂)Ph(2-Cl,4-CH₂CH═CBr₂) Ph(2-Cl,4-OCH₂CH═CH₂) Ph(2-Cl,4-OCH₂CH═CF₂)Ph(2-Cl,4-OCH₂CH═CCl₂) Ph(2-Cl,4-OCH₂CH═CBr₂) Ph(2-Cl,4-SCF₂H)Ph(2-Cl,4-SCF₂CF₂H) Ph(2-F,4-Cl) Ph(2,4-di-F) Ph(2-F,4-Br) Ph(2-F,4-I)Ph(2-F,4-Me) Ph(2-F,4-Et) Ph(2-F,4-n-Pr) Ph(2-F,4-t-Bu) Ph(2-F,4-i-Pr)Ph(2-F,4-cyclohexyl) Ph(2-F,4-CH═CH₂) Ph(2-F,4-CF₃) Ph(2-F,4-CH₂CF₃)Ph(2-F,4-CHF₂) Ph(2-F,4-CH₂F) Ph(2-F,4-OCF₃) Ph(2-F,4-OCH₂F)Ph(2-F,4-OCHF₂) Ph(2-F,4-SCF₃) Ph(2-F,4-SMe) Ph(2-F,4-SOMe)Ph(2-F,4-SO₂Me) Ph(2-F,4-OSO₂Me) Ph(2-F,4-C≡CH) Ph(2-F,4-OMe)Ph(2-F,4-OEt) Ph(2-F,4-NHCO₂-t-Bu) Ph(2-F,4-NHCOMe) Ph(2-F,4-NHCOCF₃)Ph(2-F,4-CN) Ph(2-F,4-NO₂) Ph(2-F,4-Ph) Ph(2-F,4-COMe) Ph(2-F,4-OCOMe)Ph(2-F,4-CO₂Me) Ph(2-F,4-OCO₂Me) Ph(2-F,4-C₂F₅) Ph(2-F,4-CF₂CF₂H)Ph(2-F,4-OCF₂CF₂H) Ph(2-F,4-OC₂F₅) Ph(2-F,4-OCH₂CF₃) Ph(2-F,4-OCH₂C≡CH)Ph(2-F,4-OCH₂C≡CCF₃) Ph(2-F,4-OCH₂C≡CCF₂H) Ph(2-F,4-OCH₂C≡CCH₃)Ph(2-F,4-OCH₂C≡C-c-Pr) Ph(2-F,4-C≡CCF₂H) Ph(2-F,4-C≡CCH₃)Ph(2-F,4-C≡C-c-Pr) Ph(2-F,4-OPh) Ph(2-F,4-C≡CCF₃) Ph(2-F,4-CH═CF₂)Ph(2-F,4-CH═CCl₂) Ph(2-F,4-CH═CBr₂) Ph(2-F,4-OCH═CH₂) Ph(2-F,4-OCH═CF₂)Ph(2-F,4-OCH═CCl₂) Ph(2-F,4-OCH═CBr₂) Ph(2-F,4-CH₂CH═CH₂)Ph(2-F,4-CH₂CH═CF₂) Ph(2-F,4-CH₂CH═CCl₂) Ph(2-F,4-CH₂CH═CBr₂)Ph(2-F,4-OCH₂CH═CH₂) Ph(2-F,4-OCH₂CH═CF₂) Ph(2-F,4-OCH₂CH═CCl₂)Ph(2-F,4-OCH₂CH═CBr₂) Ph(2-F,4-SCF₂H) Ph(2-F,4-SCF₂CF₂H) Ph(2-F,4-SF₅)3-Pyridinyl(5-OCF₂H) 3-Pyridinyl(5-CF₂H) 3-Pyridinyl(5-OCF₂CF₂H)3-Thienyl(4-Me) 3-Thienyl(4-Et) 3-Thienyl(4-i-Pr) 3-Thienyl(4-c-Pr)3-Thienyl(4-CFH) 3-Thienyl(4-OCF₂H) 3-Thienyl(4-OCF₂CF₂H)3-Thienyl(4-OC₂F₅) 3-Furanyl(5-F) 3-Furanyl(5-Cl) 3-Furanyl(5-CF₃)3-Furanyl(4-Me) 3-Furanyl(4-Et) 3-Furanyl(4-i-Pr) 3-Furanyl(4-c-Pr)3-Furanyl(4-CFH) 3-Furanyl(4-OCF2H) 3-Furanyl(4-OCF₂CF₂H)3-Furanyl(4-OC₂F₅) Ph(3-Cl,4-I) Ph(3-Cl,4-Et) Ph(3-Cl,4-n-Pr)Ph(3-Cl,4-i-Pr) Ph(3-Cl,4-C₂F₅) Ph(3-Cl,4-CF₂CF₂H) Ph(3-Cl,4-CF₂H)Ph(3-Cl,4-OMe) Ph(3-Cl,4-OCF₂CF₂H) Ph(3-Cl,4-OC₂F₅) Ph(3,4-di-F)Ph(3-F,4-I) Ph(3-F,4-Et) Ph(3-F,4-n-Pr) Ph(3-F,4-i-Pr) Ph(3-F,4-C₂F₅)Ph(3-F,4-CF₂CF₂H) Ph(3-F,4-CF₂H) Ph(3-F,4-OMe) Ph(3-F,4-OCF₂CF₂H)Ph(3-F,4-OC₂F₅) Ph(3-Br,4-I) Ph(3-Br,4-Et) Ph(3-Br,4-n-Pr)Ph(3-Br,4-t-Bu) Ph(3-Br,4-i-Pr) Ph(3-Br,4-C₂F₅) Ph(3-Br,4-CF₂CF₂H)Ph(3-Br,4-CF₂H) Ph(3-Br,4-OMe) Ph(3-Br,4-OCF₂CF₂H) Ph(3-Br,4-OC₂F₅)Ph(3-I,4-Cl) Ph(3-I,4-F) Ph(3-I,4-Br) Ph(3,4-di-I) Ph(3-I,4-Me)Ph(3-I,4-Et) Ph(3-I,4-n-Pr) Ph(3-I,4-t-Bu) Ph(3-I,4-i-Pr) Ph(3-I,4-c-Pr)Ph(3-I,4-CF₃) Ph(3-I,4-C₂F₅) Ph(3-I,4-CF₂CF₂H) Ph(3-I,4-CF₂H)Ph(3-I,4-OMe) Ph(3-I,4-OCF₃) Ph(3-I,4-OCHF₂) Ph(3-I,4-OCF₂CF₂H)Ph(3-I,4-OC₂F₅) Ph(3-I,4-SO₂Me) Ph(3-I,4-TMS) Ph(3-I,4-CN) Ph(3-Me,4-I)Ph(3-Me,4-Et) Ph(3-Me,4-n-Pr) Ph(3-Me,4-i-Pr) Ph(3-Me,4-C₂F₅)Ph(3-Me,4-CF₂CF₂H) Ph(3-Me,4-CF₂H) Ph(3-Me,4-OMe) Ph(3-Me,4-OCF₂CF₂H)Ph(3-Me,4-OC₂F₅) Ph(3-Et,4-Cl) Ph(3-Et,4-F) Ph(3-Et,4-Br) Ph(3-Et,4-I)Ph(3-Et,4-Me) Ph(3,4-di-Et) Ph(3-Et,4-n-Pr) Ph(3-Et,4-t-Bu)Ph(3-Et,4-i-Pr) Ph(3-Et,4-c-Pr) Ph(3-Et,4-CF₃) Ph(3-Et,4-C₂F₅)Ph(3-Et,4-CF₂CF₂H) Ph(3-Et,4-CF₂H) Ph(3-Et,4-OMe) Ph(3-Et,4-OCF₃)Ph(3-Et,4-OCHF₂) Ph(3-Et,4-OCF₂CF₂H) Ph(3-Et,4-OC₂F₅) Ph(3-Et,4-SO₂Me)Ph(3-Et,4-TMS) Ph(3-Et,4-CN) Ph(3-n-Pr,4-Cl) Ph(3-n-Pr,4-F)Ph(3-n-Pr,4-Br) Ph(3-n-Pr,4-I) Ph(3-n-Pr,4-Me) Ph(3-n-Pr,4-Et)Ph(3,4-di-n-Pr) Ph(3-n-Pr,4-t-Bu) Ph(3-n-Pr,4-i-Pr) Ph(3-n-Pr,4-c-Pr)Ph(3-n-Pr,4-CF₃) Ph(3-n-Pr,4-C₂F₅) Ph(3-n-Pr,4-CF₂CF₂H)Ph(3-n-Pr,4-CF₂H) Ph(3-n-Pr,4-OMe) Ph(3-n-Pr,4-OCF₃) Ph(3-n-Pr,4-OCHF₂)Ph(3-n-Pr,4-OCF₂CF₂H) Ph(3-n-Pr,4-OC₂F₅) Ph(3-n-Pr,4-SO₂Me)Ph(3-n-Pr,4-TMS) Ph(3-n-Pr,4-CN) Ph(3-t-Bu,4-I) Ph(3-t-Bu,4-Et)Ph(3-t-Bu,4-n-Pr) Ph(3-t-Bu,4-i-Pr) Ph(3-t-Bu,4-C₂F₅)Ph(3-t-Bu,4-CF₂CF₂H) Ph(3-t-Bu,4-CF₂H) Ph(3-t-Bu,4-OMe)Ph(3-t-Bu,4-OCF₂CF₂H) Ph(3-i-Pr,4-Cl) Ph(3-i-Pr,4-F) Ph(3-i-Pr,4-Br)Ph(3-i-Pr,4-I) Ph(3-i-Pr,4-Me) Ph(3-i-Pr,4-Et) Ph(3-i-Pr,4-n-Pr)Ph(3-i-Pr,4-t-Bu) Ph(3,4-di-i-Pr) Ph(3-i-Pr,4-c-Pr) Ph(3-i-Pr,4-CF₃)Ph(3-i-Pr,4-C₂F₅) Ph(3-i-Pr,4-CF₂CF₂H) Ph(3-i-Pr,4-CF₂H)Ph(3-i-Pr,4-OMe) Ph(3-i-Pr,4-OCF₃) Ph(3-i-Pr,4-OCHF₂)Ph(3-i-Pr,4-OCF₂CF₂H) Ph(3-i-Pr,4-OC₂F₅) Ph(3-i-Pr,4-SO₂Me)Ph(3-i-Pr,4-TMS) Ph(3-i-Pr,4-CN) Ph(3-c-Pr,4-I) Ph(3-c-Pr,4-Et)Ph(3-c-Pr,4-n-Pr) Ph(3-c-Pr,4-i-Pr) Ph(3-c-Pr,4-C₂F₅)Ph(3-c-Pr,4-CF₂CF₂H) Ph(3-c-Pr,4-CF₂H) Ph(3-c-Pr,4-OMe)Ph(3-c-Pr,4-OCF₂CF₂H) Ph(3-c-Pr,4-OC₂F₅) Ph(3-CF₃,4-I) Ph(3-CF₃,4-Et)Ph(3-CF₃,4-n-Pr) Ph(3-CF₃,4-i-Pr) Ph(3-CF₃,4-C₂F₅) Ph(3-CF₃,4-CF₂CF₂H)Ph(3-CF₃,4-CF₂H) Ph(3-CF₃,4-OMe) Ph(3-CF₃,4-OCF₂CF₂H) Ph(3-CF₃,4-OC₂F₅)Ph(3-CF₃,4-TMS) Ph(3-C₂F₅,4-Cl) Ph(3-C₂F₅,4-F) Ph(3-C₂F₅,4-Br)Ph(3-C₂F₅,4-I) Ph(3-C₂F₅,4-Me) Ph(3-C₂F₅,4-Et) Ph(3-C₂F₅,4-n-Pr)Ph(3-C₂F₅,4-t-Bu) Ph(3-C₂F₅,4-i-Pr) Ph(3-C₂F₅,4-c-Pr)Ph(3-C₂F₅CF₃,4-CF₃) Ph(3,4-di-C₂F₅) Ph(3-C₂F₅,4-CF₂CF₂H)Ph(3-C₂F₅,4-CF₂H) Ph(3-C₂F₅,4-OMe) Ph(3-C₂F₅,4-OCF₃) Ph(3-C₂F₅,4-OCHF₂)Ph(3-C₂F₅,4-OCF₂CF₂H) Ph(3-C₂F₅,4-OC₂F₅) Ph(3-C₂F₅,4-SO₂Me)Ph(3-C₂F₅,4-TMS) Ph(3-C₂F₅,4-CN) Ph(3-CF₂CF₂H,4-Cl) Ph(3-CF₂CF₂H,4-F)Ph(3-CF₂CF₂H,4-Br) Ph(3-CF₂CF₂H,4-I) Ph(3-CF₂CF₂H,4-Me)Ph(3-CF₂CF₂H,4-Et) Ph(3-CF₂CF₂H,4-n-Pr) Ph(3-CF₂CF₂H,4-t-Bu)Ph(3-CF₂CF₂H,4-i-Pr) Ph(3-CF₂CF₂H,4-c-Pr) Ph(3-CF₂CF₂H,4-CF₃)Ph(3-CF₂CF₂H,4-C₂F₅) Ph(3,4-di-CF₂CF₂H) Ph(3-CF₂CF₂H,4-CF₂H)Ph(3-CF₂CF₂H,4-OMe) Ph(3-CF₂CF₂H,4-OCF₃) Ph(3-CF₂CF₂H,4-OCHF₂)Ph(3-CF₂CF₂H,4-OCF₂CF₂H) Ph(3-CF₂CF₂H,4-OC₂F₅) Ph(3-CF₂CF₂H,4-SO₂Me)Ph(3-CF₂CF₂H,4-TMS) Ph(3-CF₂CF₂H,4-CN) Ph(3-CF₂H,4-Cl) Ph(3-CF₂H,4-F)Ph(3-CF₂H,4-Br) Ph(3-CF₂H,4-I) Ph(3-CF₂H,4-Me) Ph(3-CF₂H,4-Et)Ph(3-CF₂H,4-n-Pr) Ph(3-CF₂H,4-t-Bu) Ph(3-CF₂H,4-i-Pr) Ph(3-CF₂H,4-c-Pr)Ph(3-CF₂H,4-CF₃) Ph(3-CF₂H,4-C₂F₅) Ph(3-CF₂H,4-CF₂CF₂H) Ph(3,4-di-CF₂H)Ph(3-CF₂H,4-OMe) Ph(3-CF₂H,4-OCF₃) Ph(3-CF₂H,4-OCHF₂)Ph(3-CF₂H,4-OCF₂CF₂H) Ph(3-CF₂H,4-OC₂F₅) Ph(3-CF₂H,4-SO₂Me)Ph(3-CF₂H,4-TMS) Ph(3-CF₂H,4-CN) Ph(3-OMe,4-Cl) Ph(3-OMe,4-F)Ph(3-OMe,4-Br) Ph(3-OMe,4-I) Ph(3-OMe,4-Me) Ph(3-OMe,4-Et)Ph(3-OMe,4-n-Pr) Ph(3-OMe,4-t-Bu) Ph(3-OMe,4-i-Pr) Ph(3-OMe,4-c-Pr)Ph(3-OMe,4-CF₃) Ph(3-OMe,4-C₂F₅) Ph(3-OMe,4-CF₂CF₂H) Ph(3-OMe,4-CF₂H)Ph(3,4-di-OMe) Ph(3-OMe,4-OCF₃) Ph(3-OMe,4-OCHF₂) Ph(3-OMe,4-OCF₂CF₂H)Ph(3-OMe,4-OC₂F₅) Ph(3-OMe,4-SO₂Me) Ph(3-OMe,4-TMS) Ph(3-OMe,4-CN)Ph(3-OCF₃,4-I) Ph(3-OCF₃,4-Et) Ph(3-OCF₃,4-n-Pr) Ph(3-OCF₃,4-i-Pr)Ph(3-OCF₃,4-CF₃) Ph(3-OCF₃,4-C₂F₅) Ph(3-OCF₃,4-CF₂CF₂H)Ph(3-OCF₃,4-CF₂H) Ph(3-OCF₃,4-OMe) Ph(3-OCF₃,4-OCF₂CF₂H)Ph(3-OCF₃,4-OC₂F₅) Ph(3-OCHF₂,4-Cl) Ph(3-OCHF₂,4-F) Ph(3-OCHF₂,4-Br)Ph(3-OCHF₂,4-I) Ph(3-OCHF₂,4-Me) Ph(3-OCHF₂,4-Et) Ph(3-OCHF₂,4-n-Pr)Ph(3-OCHF₂,4-t-Bu) Ph(3-OCHF₂,4-i-Pr) Ph(3-OCHF₂,4-c-Pr)Ph(3-OCHF₂CF₃,4-CF₃) Ph(3-OC₂F₅,4-C₂F₅) Ph(3-OCHF₂,4-CF₂CF₂H)Ph(3-OCHF₂,4-CF₂H) Ph(3-OCHF₂,4-OMe) Ph(3-OCHF₂,4-OCF₃) Ph(3,4-di-OCHF₂)Ph(3-OCHF₂,4-OCF₂CF₂H) Ph(3-OCHF₂,4-OC₂F₅) Ph(3-OCHF₂,4-SO₂Me)Ph(3-OCHF₂,4-TMS) Ph(3-OCHF₂,4-CN) Ph(3-OCF₂CF₂H,4-Cl)Ph(3-OCF₂CF₂H,4-F) Ph(3-OCF₂CF₂H,4-Br) Ph(3-OCF₂CF₂H,4-I)Ph(3-OCF₂CF₂H,4-Me) Ph(3-OCF₂CF₂H,4-Et) Ph(3-OCF₂CF₂H,4-n-Pr)Ph(3-OCF₂CF₂H,4-t-Bu) Ph(3-OCF₂CF₂H,4-i-Pr) Ph(3-OCF₂CF₂H,4-c-Pr)Ph(3-OCF₂CF₂H,4-CF₃) Ph(3-OCF₂CF₂H,4-C₂F₅) Ph(3-OCF₂CF₂H,4-CF₂CF₂H)Ph(3-OCF₂CF₂H,4-CF₂H) Ph(3-OCF₂CF₂H,4-OMe) Ph(3-OCF₂CF₂H,4-OCF₃)Ph(3-OCF₂CF₂H,4-OCHF₂) Ph(3,4-di-OCF₂CF₂H) Ph(3-OCF₂CF₂H,4-OC₂F₅)Ph(3-OCF₂CF₂H,4-SO₂Me) Ph(3-OCF₂CF₂H,4-TMS) Ph(3-OCF₂CF₂H,4-CN)Ph(3-OC₂F₅,4-Cl) Ph(3-OC₂F₅,4-F) Ph(3-OC₂F₅,4-Br) Ph(3-OC₂F₅,4-I)Ph(3-OC₂F₅,4-Me) Ph(3-OC₂F₅,4-Et) Ph(3-OC₂F₅,4-n-Pr) Ph(3-OC₂F₅,4-t-Bu)Ph(3-OC₂F₅,4-i-Pr) Ph(3-OC₂F₅,4-c-Pr) Ph(3-OC₂F₅CF₃,4-CF₃)Ph(3-OC₂F₅,4-CF₂CF₂H) Ph(3-OC₂F₅,4-CF₂H) Ph(3-OC₂F₅,4-OMe)Ph(3-OC₂F₅,4-OCF₃) Ph(3-OC₂F₅,4-OCHF₂) Ph(3-OC₂F₅,4-OCF₂CF₂H)Ph(3,4-di-OC₂F₅) Ph(3-OC₂F₅,4-SO₂Me) Ph(3-OC₂F₅,4-TMS) Ph(3-OC₂F₅,4-CN)Ph(3-SO₂Me,4-I) Ph(3-SO₂Me,4-Et) Ph(3-SO₂Me,4-n-Pr) Ph(3-SO₂Me,4-i-Pr)Ph(3-SO₂MeCF₃,4-CF₃) Ph(3-SO₂Me,4-C₂F₅) Ph(3-SO₂Me,4-CF₂CF₂H)Ph(3-SO₂Me,4-CF₂H) Ph(3-SO₂Me,4-OMe) Ph(3-SO₂Me,4-OCF₂CF₂H)Ph(3-SO₂Me,4-OC₂F₅) Ph(3-TMS,4-Cl) Ph(3-TMS,4-F) Ph(3-TMS,4-Br)Ph(3-TMS,4-I) Ph(3-TMS,4-Me) Ph(3-TMS,4-Et) Ph(3-TMS,4-n-Pr)Ph(3-TMS,4-t-Bu) Ph(3-TMS,4-i-Pr) Ph(3-TMS,4-c-Pr) Ph(3-TMS,4-CF₃)Ph(3-TMS,4-C₂F₅) Ph(3-TMS,4-CF₂CF₂H) Ph(3-TMS,4-CF₂H) Ph(3-TMS,4-OMe)Ph(3-TMS,4-OCF₃) Ph(3-TMS,4-OCHF₂) Ph(3-TMS,4-OCF₂CF₂H)Ph(3-TMS,4-OC₂F₅) Ph(3-TMS,4-SO₂Me) Ph(3,4-di-TMS) Ph(3-TMS,4-CN)Ph(3-CN,4-I) Ph(3-CN,4-Et) Ph(3-CN,4-n-Pr) Ph(3-CN,4-i-Pr)Ph(3-CN,4-C₂F₅) Ph(3-CN,4-CF₂CF₂H) Ph(3-CN,4-CF₂H) Ph(3-CN,4-OMe)Ph(3-CN,4-OCF₂CF₂H) Ph(3-CN,4-OC₂F₅) Ph(3,5-di-Cl) Ph(3-Cl,5-F)Ph(3-Cl,5-Br) Ph(3-Cl,5-I) Ph(3-Cl,5-Me) Ph(3-Cl,5-Et) Ph(3-Cl,5-n-Pr)Ph(3-Cl,5-t-Bu) Ph(3-Cl,5-i-Pr) Ph(3-Cl,5-c-Pr) Ph(3-Cl,5-CF₃)Ph(3-Cl,5-C₂F₅) Ph(3-Cl,5-CF₂CF₂H) Ph(3-Cl,5-CF₂H) Ph(3-Cl,5-OMe)Ph(3-Cl,5-OCF₃) Ph(3-Cl,5-OCHF₂) Ph(3-Cl,5-OCF₂CF₂H) Ph(3-Cl,5-OC₂F₅)Ph(3-Cl,5-SO₂Me) Ph(3-Cl,5-TMS) Ph(3-Cl,5-CN) Ph(3-F,5-Cl) Ph(3,5-di-F)Ph(3-F,5-Br) Ph(3-F,5-I) Ph(3-F,5-Me) Ph(3-F,5-Et) Ph(3-F,5-n-Pr)Ph(3-F,5-t-Bu) Ph(3-F,5-i-Pr) Ph(3-F,5-c-Pr) Ph(3-F,5-CF₃)Ph(3-F,5-C₂F₅) Ph(3-F,5-CF₂CF₂H) Ph(3-F,5-CF₂H) Ph(3-F,5-OMe)Ph(3-F,5-OCF₃) Ph(3-F,5-OCHF₂) Ph(3-F,5-OCF₂CF₂H) Ph(3-F,5-OC₂F₅)Ph(3-F,5-SO₂Me) Ph(3-F,5-TMS) Ph(3-F,5-CN) Ph(3-Br,5-Cl) Ph(3-Br,5-F)Ph(3,5-di-Br) Ph(3-Br,5-I) Ph(3-Br,5-Me) Ph(3-Br,5-Et) Ph(3-Br,5-n-Pr)Ph(3-Br,5-t-Bu) Ph(3-Br,5-i-Pr) Ph(3-Br,5-c-Pr) Ph(3-Br,5-CF₃)Ph(3-Br,5-C₂F₅) Ph(3-Br,5-CF₂CF₂H) Ph(3-Br,5-CF₂H) Ph(3-Br,5-OMe)Ph(3-Br,5-OCF₃) Ph(3-Br,5-OCHF₂) Ph(3-Br,5-OCF₂CF₂H) Ph(3-Br,5-OC₂F₅)Ph(3-Br,5-SO₂Me) Ph(3-Br,5-TMS) Ph(3-Br,5-CN) Ph(3-I,5-Cl) Ph(3-I,5-F)Ph(3-I,5-Br) Ph(3,5-di-I) Ph(3-I,5-Me) Ph(3-I,5-Et) Ph(3-I,5-n-Pr)Ph(3-I,5-t-Bu) Ph(3-I,5-i-Pr) Ph(3-I,5-c-Pr) Ph(3-I,5-CF₃)Ph(3-I,5-C₂F₅) Ph(3-I,5-CF₂CF₂H) Ph(3-I,5-CF₂H) Ph(3-I,5-OMe)Ph(3-I,5-OCF₃) Ph(3-I,5-OCHF₂) Ph(3-I,5-OCF₂CF₂H) Ph(3-I,5-OC₂F₅)Ph(3-I,5-SO₂Me) Ph(3-I,5-TMS) Ph(3-I,5-CN) Ph(3-Me,5-Cl) Ph(3-Me,5-F)Ph(3-Me,5-Br) Ph(3-Me,5-I) Ph(3,5-di-Me) Ph(3-Me,5-Et) Ph(3-Me,5-n-Pr)Ph(3-Me,5-t-Bu) Ph(3-Me,5-i-Pr) Ph(3-Me,5-c-Pr) Ph(3-Me,5-CF₃)Ph(3-Me,5-C₂F₅) Ph(3-Me,5-CF₂CF₂H) Ph(3-Me,5-CF₂H) Ph(3-Me,5-OMe)Ph(3-Me,5-OCF₃) Ph(3-Me,5-OCHF₂) Ph(3-Me,5-OCF₂CF₂H) Ph(3-Me,5-OC₂F₅)Ph(3-Me,5-SO₂Me) Ph(3-Me,5-TMS) Ph(3-Me,5-CN) Ph(3-Et,5-Cl) Ph(3-Et,5-F)Ph(3-Et,5-Br) Ph(3-Et,5-I) Ph(3-Et,5-Me) Ph(3,5-di-Et) Ph(3-Et,5-n-Pr)Ph(3-Et,5-t-Bu) Ph(3-Et,5-i-Pr) Ph(3-Et,5-c-Pr) Ph(3-Et,5-CF₃)Ph(3-Et,5-C₂F₅) Ph(3-Et,5-CF₂CF₂H) Ph(3-Et,5-CF₂H) Ph(3-Et,5-OMe)Ph(3-Et,5-OCF₃) Ph(3-Et,5-OCHF₂) Ph(3-Et,5-OCF₂CF₂H) Ph(3-Et,5-OC₂F₅)Ph(3-Et,5-SO₂Me) Ph(3-Et,5-TMS) Ph(3-Et,5-CN) Ph(3-n-Pr,5-Cl)Ph(3-n-Pr,5-F) Ph(3-n-Pr,5-Br) Ph(3-n-Pr,5-I) Ph(3-n-Pr,5-Me)Ph(3-n-Pr,5-Et) Ph(3,5-di-n-Pr) Ph(3-n-Pr,5-t-Bu) Ph(3-n-Pr,5-i-Pr)Ph(3-n-Pr,5-c-Pr) Ph(3-n-Pr,5-CF₃) Ph(3-n-Pr,5-C₂F₅)Ph(3-n-Pr,5-CF₂CF₂H) Ph(3-n-Pr,5-CF₂H) Ph(3-n-Pr,5-OMe)Ph(3-n-Pr,5-OCF₃) Ph(3-n-Pr,5-OCHF₂) Ph(3-n-Pr,5-OCF₂CF₂H)Ph(3-n-Pr,5-OC₂F₅) Ph(3-n-Pr,5-SO₂Me) Ph(3-n-Pr,5-TMS) Ph(3-n-Pr,5-CN)Ph(3-t-Bu,5-Cl) Ph(3-t-Bu,5-F) Ph(3-t-Bu,5-Br) Ph(3-t-Bu,5-I)Ph(3-t-Bu,5-Me) Ph(3-t-Bu,5-Et) Ph(3-t-Bu,5-n-Pr) Ph(3,5-di-t-Bu)Ph(3-t-Bu,5-i-Pr) Ph(3-t-Bu,5-c-Pr) Ph(3-t-Bu,5-CF₃) Ph(3-t-Bu,5-C₂F₅)Ph(3-t-Bu,5-CF₂CF₂H) Ph(3-t-Bu,5-CF₂H) Ph(3-t-Bu,5-OMe)Ph(3-t-Bu,5-OCF₃) Ph(3-t-Bu,5-OCHF₂) Ph(3-t-Bu,5-OCF₂CF₂H)Ph(3-t-Bu,5-OC₂F₅) Ph(3-t-Bu,5-SO₂Me) Ph(3-t-Bu,5-TMS) Ph(3-t-Bu,5-CN)Ph(3-i-Pr,5-Cl) Ph(3-i-Pr,5-F) Ph(3-i-Pr,5-Br) Ph(3-i-Pr,5-I)Ph(3-i-Pr,5-Me) Ph(3-i-Pr,5-Et) Ph(3-i-Pr,5-n-Pr) Ph(3-i-Pr,5-t-Bu)Ph(3,5-di-i-Pr) Ph(3-i-Pr,5-c-Pr) Ph(3-i-Pr,5-CF₃) Ph(3-i-Pr,5-C₂F₅)Ph(3-i-Pr,5-CF₂CF₂H) Ph(3-i-Pr,5-CF₂H) Ph(3-i-Pr,5-OMe)Ph(3-i-Pr,5-OCF₃) Ph(3-i-Pr,5-OCHF₂) Ph(3-i-Pr,5-OCF₂CF₂H)Ph(3-i-Pr,5-OC₂F₅) Ph(3-i-Pr,5-SO₂Me) Ph(3-i-Pr,5-TMS) Ph(3-i-Pr,5-CN)Ph(3-c-Pr,5-Cl) Ph(3-c-Pr,5-F) Ph(3-c-Pr,5-Br) Ph(3-c-Pr,5-I)Ph(3-c-Pr,5-Me) Ph(3-c-Pr,5-Et) Ph(3-c-Pr,5-n-Pr) Ph(3-c-Pr,5-t-Bu)Ph(3-c-Pr,5-i-Pr) Ph(3,5-di-c-Pr) Ph(3-c-Pr,5-CF₃) Ph(3-c-Pr,5-C₂F₅)Ph(3-c-Pr,5-CF₂CF₂H) Ph(3-c-Pr,5-CF₂H) Ph(3-c-Pr,5-OMe)Ph(3-c-Pr,5-OCF₃) Ph(3-c-Pr,5-OCHF₂) Ph(3-c-Pr,5-OCF₂CF₂H)Ph(3-c-Pr,5-OC₂F₅) Ph(3-c-Pr,5-SO₂Me) Ph(3-c-Pr,5-TMS) Ph(3-c-Pr,5-CN)Ph(3-CF₃,5-Cl) Ph(3-CF₃,5-F) Ph(3-CF₃,5-Br) Ph(3-CF₃,5-I) Ph(3-CF₃,5-Me)Ph(3-CF₃,5-Et) Ph(3-CF₃,5-n-Pr) Ph(3-CF₃,5-t-Bu) Ph(3-CF₃,5-i-Pr)Ph(3-CF₃,5-c-Pr) Ph(3,5-di-CF₃) Ph(3-CF₃,5-C₂F₅) Ph(3-CF₃,5-CF₂CF₂H)Ph(3-CF₃,5-CF₂H) Ph(3-CF₃,5-OMe) Ph(3-CF₃,5-OCF₃) Ph(3-CF₃,5-OCHF₂)Ph(3-CF₃,5-OCF₂CF₂H) Ph(3-CF₃,5-OC₂F₅) Ph(3-CF₃,5-SO₂Me) Ph(3-CF₃,5-TMS)Ph(3-CF₃,5-CN) Ph(3-C₂F₅,5-Cl) Ph(3-C₂F₅,5-F) Ph(3-C₂F₅,5-Br)Ph(3-C₂F₅,5-I) Ph(3-C₂F₅,5-Me) Ph(3-C₂F₅,5-Et) Ph(3-C₂F₅,5-n-Pr)Ph(3-C₂F₅,5-t-Bu) Ph(3-C₂F₅,5-i-Pr) Ph(3-C₂F₅,5-c-Pr)Ph(3-C₂F₅CF₃,5-CF₃) Ph(3,5-di-C₂F₅) Ph(3-C₂F₅,5-CF₂CF₂H)Ph(3-C₂F₅,5-CF₂H) Ph(3-C₂F₅,5-OMe) Ph(3-C₂F₅,5-OCF₃) Ph(3-C₂F₅,5-OCHF₂)Ph(3-C₂F₅,5-OCF₂CF₂H) Ph(3-C₂F₅,5-OC₂F₅) Ph(3-C₂F₅,5-SO₂Me)Ph(3-C₂F₅,5-TMS) Ph(3-C₂F₅,5-CN) Ph(3-CF₂CF₂H,5-Cl) Ph(3-CF₂CF₂H,5-F)Ph(3-CF₂CF₂H,5-Br) Ph(3-CF₂CF₂H,5-I) Ph(3-CF₂CF₂H,5-Me)Ph(3-CF₂CF₂H,5-Et) Ph(3-CF₂CF₂H,5-n-Pr) Ph(3-CF₂CF₂H,5-t-Bu)Ph(3-CF₂CF₂H,5-i-Pr) Ph(3-CF₂CF₂H,5-c-Pr) Ph(3-CF₂CF₂H,5-CF₃)Ph(3-CF₂CF₂H,5-C₂F₅) Ph(3,5-di-CF₂CF₂H) Ph(3-CF₂CF₂H,5-CF₂H)Ph(3-CF₂CF₂H,5-OMe) Ph(3-CF₂CF₂H,5-OCF₃) Ph(3-CF₂CF₂H,5-OCHF₂)Ph(3-CF₂CF₂H,5-OCF₂CF₂H) Ph(3-CF₂CF₂H,5-OC₂F₅) Ph(3-CF₂CF₂H,5-SO₂Me)Ph(3-CF₂CF₂H,5-TMS) Ph(3-CF₂CF₂H,5-CN) Ph(3-CF₂H,5-Cl) Ph(3-CF₂H,5-F)Ph(3-CF₂H,5-Br) Ph(3-CF₂H,5-I) Ph(3-CF₂H,5-Me) Ph(3-CF₂H,5-Et)Ph(3-CF₂H,5-n-Pr) Ph(3-CF₂H,5-t-Bu) Ph(3-CF₂H,5-i-Pr) Ph(3-CF₂H,5-c-Pr)Ph(3-CF₂H,5-CF₃) Ph(3-CF₂H,5-C₂F₅) Ph(3-CF₂H,5-CF₂CF₂H) Ph(3,5-di-CF₂H)Ph(3-CF₂H,5-OMe) Ph(3-CF₂H,5-OCF₃) Ph(3-CF₂H,5-OCHF₂)Ph(3-CF₂H,5-OCF₂CF₂H) Ph(3-CF₂H,5-OC₂F5) Ph(3-CF₂H,5-SO₂Me)Ph(3-CF₂H,5-TMS) Ph(3-CF₂H,5-CN) Ph(3-OMe,5-Cl) Ph(3-OMe,5-F)Ph(3-OMe,5-Br) Ph(3-OMe,5-I) Ph(3-OMe,5-Me) Ph(3-OMe,5-Et)Ph(3-OMe,5-n-Pr) Ph(3-OMe,5-t-Bu) Ph(3-OMe,5-i-Pr) Ph(3-OMe,5-c-Pr)Ph(3-OMeCF₃,5-CF₃) Ph(3-OMe,5-C₂F₅) Ph(3-OMe,5-CF₂CF₂H) Ph(3-OMe,5-CF₂H)Ph(3,5-di-OMe) Ph(3-OMe,5-OCF₃) Ph(3-OMe,5-OCHF₂) Ph(3-OMe,5-OCF₂CF₂H)Ph(3-OMe,5-OC₂F₅) Ph(3-OMe,5-SO₂Me) Ph(3-OMe,5-TMS) Ph(3-OMe,5-CN)Ph(3-OCF₃,5-Cl) Ph(3-OCF₃,5-F) Ph(3-OCF₃,5-Br) Ph(3-OCF₃,5-I)Ph(3-OCF₃,5-Me) Ph(3-OCF₃,5-Et) Ph(3-OCF₃,5-n-Pr) Ph(3-OCF₃,5-t-Bu)Ph(3-OCF₃,5-i-Pr) Ph(3-OCF₃,5-c-Pr) Ph(3-OCF₃,5-CF₃) Ph(3-OCF₃,5-C₂F₅)Ph(3-OCF₃,5-CF₂CF₂H) Ph(3-OCF₃,5-CF₂H) Ph(3-OCF₃,5-OMe) Ph(3,5-di-OCF₃)Ph(3-OCF₃,5-OCHF₂) Ph(3-OCF₃,5-OCF₂CF₂H) Ph(3-OCF₃,5-OC₂F₅)Ph(3-OCF₃,5-SO₂Me) Ph(3-OCF₃,5-TMS) Ph(3-OCF₃,5-CN) Ph(3-OCHF₂,5-Cl)Ph(3-OCHF₂,5-F) Ph(3-OCHF₂,5-Br) Ph(3-OCHF₂,5-I) Ph(3-OCHF₂,5-Me)Ph(3-OCHF₂,5-Et) Ph(3-OCHF₂,5-n-Pr) Ph(3-OCHF₂,5-t-Bu)Ph(3-OCHF₂,5-i-Pr) Ph(3-OCHF₂,5-c-Pr) Ph(3-OCHF₂CF₃,5-CF₃)Ph(3-OC₂F₅,5-C₂F₅) Ph(3-OCHF₂,5-CF₂CF₂H) Ph(3-OCHF₂,5-CF₂H)Ph(3-OCHF₂,5-OMe) Ph(3-OCHF₂,5-OCF₃) Ph(3,5-di-OCHF₂)Ph(3-OCHF₂,5-OCF₂CF₂H) Ph(3-OCHF₂,5-OC₂F₅) Ph(3-OCHF₂,5-SO₂Me)Ph(3-OCHF₂,5-TMS) Ph(3-OCHF₂,5-CN) Ph(3-OCF₂CF₂H,5-Cl)Ph(3-OCF₂CF₂H,5-F) Ph(3-OCF₂CF₂H,5-Br) Ph(3-OCF₂CF₂H,5-I)Ph(3-OCF₂CF₂H,5-Me) Ph(3-OCF₂CF₂H,5-Et) Ph(3-OCF₂CF₂H,5-n-Pr)Ph(3-OCF₂CF₂H,5-t-Bu) Ph(3-OCF₂CF₂H,5-i-Pr) Ph(3-OCF₂CF₂H,5-c-Pr)Ph(3-OCF₂CF₂H,5-CF₃) Ph(3-OCF₂CF₂H,5-C₂F₅) Ph(3-OCF₂CF₂H,5-CF₂CF₂H)Ph(3-OCF₂CF₂H,5-CF₂H) Ph(3-OCF₂CF₂H,5-OMe) Ph(3-OCF₂CF₂H,5-OCF₃)Ph(3-OCF₂CF₂H,5-OCHF₂) Ph(3,5-di-OCF₂CF₂H) Ph(3-OCF₂CF₂H,5-OC₂F₅)Ph(3-OCF₂CF₂H,5-SO₂Me) Ph(3-OCF₂CF₂H,5-TMS) Ph(3-OCF₂CF₂H,5-CN)Ph(3-OC₂F₅,5-Cl) Ph(3-OC₂F₅,5-F) Ph(3-OC₂F₅,5-Br) Ph(3-OC₂F₅,5-I)Ph(3-OC₂F₅,5-Me) Ph(3-OC₂F₅,5-Et) Ph(3-OC₂F₅,5-n-Pr) Ph(3-OC₂F₅,5-t-Bu)Ph(3-OC₂F₅,5-i-Pr) Ph(3-OC₂F₅,5-c-Pr) Ph(3-OC₂F₅CF₃,5-CF₃)Ph(3-OC₂F₅,5-CF₂CF₂H) Ph(3-OC₂F₅,5-CF₂H) Ph(3-OC₂F₅,5-OMe)Ph(3-OC₂F₅,5-OCF₃) Ph(3-OC₂F₅,5-OCHF₂) Ph(3,5-di-OC₂F₅) Ph(3,5-di-OC₂F₅)Ph(3-OC₂F₅,5-SO₂Me) Ph(3-OC₂F₅,5-TMS) Ph(3-OC₂F₅,5-CN) Ph(3-SO₂Me,5-Cl)Ph(3-SO₂Me,5-F) Ph(3-SO₂Me,5-Br) Ph(3-SO₂Me,5-I) Ph(3-SO₂Me,5-Me)Ph(3-SO₂Me,5-Et) Ph(3-SO₂Me,5-n-Pr) Ph(3-SO₂Me,5-t-Bu)Ph(3-SO₂Me,5-i-Pr) Ph(3-SO₂Me,5-c-Pr) Ph(3-SO₂MeCF₃,5-CF₃)Ph(3-SO₂Me,5-C₂F₅) Ph(3-SO₂Me,5-CF₂CF₂H) Ph(3-SO₂Me,5-CF₂H)Ph(3-SO₂Me,5-OMe) Ph(3-SO₂Me,5-OCF₃) Ph(3-SO₂Me,5-OCHF₂)Ph(3-SO₂Me,5-OCF₂CF₂H) Ph(3-SO₂Me,5-OC₂F₅) Ph(3,5-di-SO₂Me)Ph(3-SO₂Me,5-TMS) Ph(3-SO₂Me,5-CN) Ph(3-TMS,5-Cl) Ph(3-TMS,5-F)Ph(3-TMS,5-Br) Ph(3-TMS,5-I) Ph(3-TMS,5-Me) Ph(3-TMS,5-Et)Ph(3-TMS,5-n-Pr) Ph(3-TMS,5-t-Bu) Ph(3-TMS,5-i-Pr) Ph(3-TMS,5-c-Pr)Ph(3-TMS,5-CF₃) Ph(3-TMS,5-C₂F₅) Ph(3-TMS,5-CF₂CF₂H) Ph(3-TMS,5-CF₂H)Ph(3-TMS,5-OMe) Ph(3-TMS,5-OCF₃) Ph(3-TMS,5-OCHF₂) Ph(3-TMS,5-OCF₂CF₂H)Ph(3-TMS,5-OC₂F₅) Ph(3-TMS,5-SO₂Me) Ph(3,5-di-TMS) Ph(3-TMS,5-CN)Ph(3-CN,5-Cl) Ph(3-CN,5-F) Ph(3-CN,5-Br) Ph(3-CN,5-I) Ph(3-CN,5-Me)Ph(3-CN,5-Et) Ph(3-CN,5-n-Pr) Ph(3-CN,5-t-Bu) Ph(3-CN,5-i-Pr)Ph(3-CN,5-c-Pr) Ph(3-CN,5-CF₃) Ph(3-CN,5-C₂F₅) Ph(3-CN,5-CF₂CF₂H)Ph(3-CN,5-CF₂H) Ph(3-CN,5-OMe) Ph(3-CN,5-OCF₃) Ph(3-CN,5-OCHF₂)Ph(3-CN,5-OCF₂CF₂H) Ph(3-CN,5-OC₂F₅) Ph(3-CN,5-SO₂Me) Ph(3-CN,5-TMS)Ph(3,5-di-CN) Ph(2,3,4-tri-Cl) Ph(2-Cl,3-Cl,4-F) Ph(2-Cl,3-Cl,4-Br)Ph(2-Cl,3-Cl,4-I) Ph(2-Cl,3-Cl,4-Me) Ph(2-Cl,3-Cl,4-Et)Ph(2-Cl,3-Cl,4-n-Pr) Ph(2-Cl,3-Cl,4-t-Bu) Ph(2-Cl,3-Cl,4-i-Pr)Ph(2-Cl,3-Cl,4-c-Pr) Ph(2-Cl,3-Cl,4-CF₃) Ph(2-Cl,3-Cl,4-C₂F₅)Ph(2-Cl,3-Cl,4-CF₂CF₂H) Ph(2-Cl,3-Cl,4-CF₂H) Ph(2-Cl,3-Cl,4-OMe)Ph(2-Cl,3-Cl,4-OCF₃) Ph(2-Cl,3-Cl,4-OCHF₂) Ph(2-Cl,3-Cl,4-OCF₂CF₂H)Ph(2-Cl,3-Cl,4-OC₂F₅) Ph(2-Cl,3-Cl,4-SO₂Me) Ph(2-Cl,3-Cl,4-TMS)Ph(2-Cl,3-Cl,4-CN) Ph(2-Cl,3-F,4-Cl) Ph(2-Cl,3,4-di-F) Ph(2-Cl,3-F,4-Br)Ph(2-Cl,3-F,4-I) Ph(2-Cl,3-F,4-Me) Ph(2-Cl,3-F,4-Et) Ph(2-Cl,3-F,4-n-Pr)Ph(2-Cl,3-F,4-t-Bu) Ph(2-Cl,3-F,4-i-Pr) Ph(2-Cl,3-F,4-c-Pr)Ph(2-Cl,3-F,4-CF₃) Ph(2-Cl,3-F,4-C₂F₅) Ph(2-Cl,3-F,4-CF₂CF₂H)Ph(2-Cl,3-F,4-CF₂H) Ph(2-Cl,3-F,4-OMe) Ph(2-Cl,3-F,4-OCF₃)Ph(2-Cl,3-F,4-OCHF₂) Ph(2-Cl,3-F,4-OCF₂CF₂H) Ph(2-Cl,3-F,4-OC₂F₅)Ph(2-Cl,3-F,4-SO₂Me) Ph(2-Cl,3-F,4-TMS) Ph(2-Cl,3-F,4-CN)Ph(2-Cl,3-Br,4-Cl) Ph(2-Cl,3-Br,4-F) Ph(2-Cl,3,4-di-Br)Ph(2-Cl,3-Br,4-I) Ph(2-Cl,3-Br,4-Me) Ph(2-Cl,3-Br,4-Et)Ph(2-Cl,3-Br,4-n-Pr) Ph(2-Cl,3-Br,4-t-Bu) Ph(2-Cl,3-Br,4-i-Pr)Ph(2-Cl,3-Br,4-c-Pr) Ph(2-Cl,3-Br,4-CF₃) Ph(2-Cl,3-Br,4-C₂F₅)Ph(2-Cl,3-Br,4-CF₂CF₂H) Ph(2-Cl,3-Br,4-CF₂H) Ph(2-Cl,3-Br,4-OMe)Ph(2-Cl,3-Br,4-OCF₃) Ph(2-Cl,3-Br,4-OCHF₂) Ph(2-Cl,3-Br,4-OCF₂CF₂H)Ph(2-Cl,3-Br,4-OC₂F₅) Ph(2-Cl,3-Br,4-SO₂Me) Ph(2-Cl,3-Br,4-TMS)Ph(2-Cl,3-Br,4-CN) Ph(2-Cl,3-I,4-Cl) Ph(2-Cl,3-I,4-F) Ph(2-Cl,3-I,4-Br)Ph(2-Cl,3,4-di-I) Ph(2-Cl,3-I,4-Me) Ph(2-Cl,3-I,4-Et)Ph(2-Cl,3-I,4-n-Pr) Ph(2-Cl,3-I,4-t-Bu) Ph(2-Cl,3-I,4-i-Pr)Ph(2-Cl,3-I,4-c-Pr) Ph(2-Cl,3-I,4-CF₃) Ph(2-Cl,3-I,4-C₂F₅)Ph(2-Cl,3-I,4-CF₂CF₂H) Ph(2-Cl,3-I,4-CF₂H) Ph(2-Cl,3-I,4-OMe)Ph(2-Cl,3-I,4-OCF₃) Ph(2-Cl,3-I,4-OCHF₂) Ph(2-Cl,3-I,4-OCF₂CF₂H)Ph(2-Cl,3-I,4-OC₂F₅) Ph(2-Cl,3-I,4-SO₂Me) Ph(2-Cl,3-I,4-TMS)Ph(2-Cl,3-I,4-CN) Ph(2-Cl,3-Me,4-Cl) Ph(2-Cl,3-Me,4-F)Ph(2-Cl,3-Me,4-Br) Ph(2-Cl,3-Me,4-I) Ph(2-Cl,3,4-di-Me)Ph(2-Cl,3-Me,4-Et) Ph(2-Cl,3-Me,4-n-Pr) Ph(2-Cl,3-Me,4-t-Bu)Ph(2-Cl,3-Me,4-i-Pr) Ph(2-Cl,3-Me,4-c-Pr) Ph(2-Cl,3-Me,4-CF₃)Ph(2-Cl,3-Me,4-C₂F₅) Ph(2-Cl,3-Me,4-CF₂CF₂H) Ph(2-Cl,3-Me,4-CF₂H)Ph(2-Cl,3-Me,4-OMe) Ph(2-Cl,3-Me,4-OCF₃) Ph(2-Cl,3-Me,4-OCHF₂)Ph(2-Cl,3-Me,4-OCF₂CF₂H) Ph(2-Cl,3-Me,4-OC₂F₅) Ph(2-Cl,3-Me,4-SO₂Me)Ph(2-Cl,3-Me,4-TMS) Ph(2-Cl,3-Me,4-CN) Ph(2-Cl,3-Et,4-Cl)Ph(2-Cl,3-Et,4-F) Ph(2-Cl,3-Et,4-Br) Ph(2-Cl,3-Et,4-I)Ph(2-Cl,3-Et,4-Me) Ph(2-Cl,3,4-di-Et) Ph(2-Cl,3-Et,4-n-Pr)Ph(2-Cl,3-Et,4-t-Bu) Ph(2-Cl,3-Et,4-i-Pr) Ph(2-Cl,3-Et,4-c-Pr)Ph(2-Cl,3-Et,4-CF₃) Ph(2-Cl,3-Et,4-C₂F₅) Ph(2-Cl,3-Et,4-CF₂CF₂H)Ph(2-Cl,3-Et,4-CF₂H) Ph(2-Cl,3-Et,4-OMe) Ph(2-Cl,3-Et,4-OCF₃)Ph(2-Cl,3-Et,4-OCHF₂) Ph(2-Cl,3-Et,4-OCF₂CF₂H) Ph(2-Cl,3-Et,4-OC₂F₅)Ph(2-Cl,3-Et,4-SO₂Me) Ph(2-Cl,3-Et,4-TMS) Ph(2-Cl,3-Et,4-CN)Ph(2-Cl,3-n-Pr,4-Cl) Ph(2-Cl,3-n-Pr,4-F) Ph(2-Cl,3-n-Pr,4-Br)Ph(2-Cl,3-n-Pr,4-I) Ph(2-Cl,3-n-Pr,4-Me) Ph(2-Cl,3-n-Pr,4-Et)Ph(2-Cl,3,4-di-n-Pr) Ph(2-Cl,3-n-Pr,4-t-Bu) Ph(2-Cl,3-n-Pr,4-i-Pr)Ph(2-Cl,3-n-Pr,4-c-Pr) Ph(2-Cl,3-n-Pr,4-CF₃) Ph(2-Cl,3-n-Pr,4-C₂F₅)Ph(2-Cl,3-n-Pr,4-CF₂CF₂H) Ph(2-Cl,3-n-Pr,4-CF₂H) Ph(2-Cl,3-n-Pr,4-OMe)Ph(2-Cl,3-n-Pr,4-OCF₃) Ph(2-Cl,3-n-Pr,4-OCHF₂)Ph(2-Cl,3-n-Pr,4-OCF₂CF₂H) Ph(2-Cl,3-n-Pr,4-OC₂F₅)Ph(2-Cl,3-n-Pr,4-SO₂Me) Ph(2-Cl,3-n-Pr,4-TMS) Ph(2-Cl,3-n-Pr,4-CN)Ph(2-Cl,3-t-Bu,4-Cl) Ph(2-Cl,3-t-Bu,4-F) Ph(2-Cl,3-t-Bu,4-Br)Ph(2-Cl,3-t-Bu,4-I) Ph(2-Cl,3-t-Bu,4-Me) Ph(2-Cl,3-t-Bu,4-Et)Ph(2-Cl,3-t-Bu,4-n-Pr) Ph(2-Cl,3,4-di-t-Bu) Ph(2-Cl,3-t-Bu,4-i-Pr)Ph(2-Cl,3-t-Bu,4-c-Pr) Ph(2-Cl,3-t-Bu,4-CF₃) Ph(2-Cl,3-t-Bu,4-C₂F₅)Ph(2-Cl,3-t-Bu,4-CF₂CF₂H) Ph(2-Cl,3-t-Bu,4-CF₂H) Ph(2-Cl,3-t-Bu,4-OMe)Ph(2-Cl,3-t-Bu,4-OCF₃) Ph(2-Cl,3-t-Bu,4-OCHF₂)Ph(2-Cl,3-t-Bu,4-OCF₂CF₂H) Ph(2-Cl,3-t-Bu,4-OC₂F₅)Ph(2-Cl,3-t-Bu,4-SO₂Me) Ph(2-Cl,3-t-Bu,4-TMS) Ph(2-Cl,3-t-Bu,4-CN)Ph(2-Cl,3-i-Pr,4-Cl) Ph(2-Cl,3-i-Pr,4-F) Ph(2-Cl,3-i-Pr,4-Br)Ph(2-Cl,3-i-Pr,4-I) Ph(2-Cl,3-i-Pr,4-Me) Ph(2-Cl,3-i-Pr,4-Et)Ph(2-Cl,3-i-Pr,4-n-Pr) Ph(2-Cl,3-i-Pr,4-t-Bu) Ph(2-Cl,3,4-di-i-Pr)Ph(2-Cl,3-i-Pr,4-c-Pr) Ph(2-Cl,3-i-Pr,4-CF₃) Ph(2-Cl,3-i-Pr,4-C₂F₅)Ph(2-Cl,3-i-Pr,4-CF₂CF₂H) Ph(2-Cl,3-i-Pr,4-CF₂H) Ph(2-Cl,3-i-Pr,4-OMe)Ph(2-Cl,3-i-Pr,4-OCF₃) Ph(2-Cl,3-i-Pr,4-OCHF₂)Ph(2-Cl,3-i-Pr,4-OCF₂CF₂H) Ph(2-Cl,3-i-Pr,4-OC₂F5)Ph(2-Cl,3-i-Pr,4-SO₂Me) Ph(2-Cl,3-i-Pr,4-TMS) Ph(2-Cl,3-i-Pr,4-CN)Ph(2-Cl,3-c-Pr,4-Cl) Ph(2-Cl,3-c-Pr,4-F) Ph(2-Cl,3-c-Pr,4-Br)Ph(2-Cl,3-c-Pr,4-I) Ph(2-Cl,3-c-Pr,4-Me) Ph(2-Cl,3-c-Pr,4-Et)Ph(2-Cl,3-c-Pr,4-n-Pr) Ph(2-Cl,3-c-Pr,4-t-Bu) Ph(2-Cl,3-c-Pr,4-i-Pr)Ph(2-Cl,3,4-di-c-Pr) Ph(2-Cl,3-c-Pr,4-CF₃) Ph(2-Cl,3-c-Pr,4-C₂F₅)Ph(2-Cl,3-c-Pr,4-CF₂CF₂H) Ph(2-Cl,3-c-Pr,4-CF₂H) Ph(2-Cl,3-c-Pr,4-OMe)Ph(2-Cl,3-c-Pr,4-OCF₃) Ph(2-Cl,3-c-Pr,4-OCHF₂)Ph(2-Cl,3-c-Pr,4-OCF₂CF₂H) Ph(2-Cl,3-c-Pr,4-OC₂F₅)Ph(2-Cl,3-c-Pr,4-SO₂Me) Ph(2-Cl,3-c-Pr,4-TMS) Ph(2-Cl,3-c-Pr,4-CN)Ph(2-Cl,3-CF₃,4-Cl) Ph(2-Cl,3-CF₃,4-F) Ph(2-Cl,3-CF₃,4-Br)Ph(2-Cl,3-CF₃,4-I) Ph(2-Cl,3-CF₃,4-Me) Ph(2-Cl,3-CF₃,4-Et)Ph(2-Cl,3-CF₃,4-n-Pr) Ph(2-Cl,3-CF₃,4-t-Bu) Ph(2-Cl,3-CF₃,4-i-Pr)Ph(2-Cl,3-CF3,4-c-Pr) Ph(2-Cl,3,4-di-CF₃) Ph(2-Cl,3-CF₃,4-C₂F₅)Ph(2-Cl,3-CF₃,4-CF₂CF₂H) Ph(2-Cl,3-CF₃,4-CF₂H) Ph(2-Cl,3-CF₃,4-OMe)Ph(2-Cl,3-CF₃,4-OCF₃) Ph(2-Cl,3-CF₃,4-OCHF₂) Ph(2-Cl,3-CF₃,4-OCF₂CF₂H)Ph(2-Cl,3-CF₃,4-OC₂F₅) Ph(2-Cl,3-CF₃,4-SO₂Me) Ph(2-Cl,3-CF₃,4-TMS)Ph(2-Cl,3-CF₃,4-CN) Ph(2-Cl,3-C₂F₅,4-Cl) Ph(2-Cl,3-C₂F₅,4-F)Ph(2-Cl,3-C₂F₅,4-Br) Ph(2-Cl,3-C₂F₅,4-I) Ph(2-Cl,3-C₂F₅,4-Me)Ph(2-Cl,3-C₂F₅,4-Et) Ph(2-Cl,3-C₂F₅,4-n-Pr) Ph(2-Cl,3-C₂F₅,4-t-Bu)Ph(2-Cl,3-C₂F₅,4-i-Pr) Ph(2-Cl,3-C₂F₅,4-c-Pr) Ph(2-Cl,3-C₂F₅CF₃,4-CF₃)Ph(2-Cl,3,4-di-C₂F₅) Ph(2-Cl,3-C₂F₅,4-CF₂CF₂H) Ph(2-Cl,3-C₂F₅,4-CF₂H)Ph(2-Cl,3-C₂F₅,4-OMe) Ph(2-Cl,3-C₂F₅,4-OCF₃) Ph(2-Cl,3-C₂F₅,4-OCHF₂)Ph(2-Cl,3-C₂F₅,4-OCF₂CF₂H) Ph(2-Cl,3-C₂F₅,4-OC₂F₅)Ph(2-Cl,3-C₂F₅,4-SO₂Me) Ph(2-Cl,3-C₂F₅,4-TMS) Ph(2-Cl,3-C₂F₅,4-CN)Ph(2-Cl,3-CF₂CF₂H,4-Cl) Ph(2-Cl,3-CF₂CF₂H,4-F) Ph(2-Cl,3-CF₂CF₂H,4-Br)Ph(2-Cl,3-CF₂CF₂H,4-I) Ph(2-Cl,3-CF₂CF₂H,4-Me) Ph(2-Cl,3-CF₂CF₂H,4-Et)Ph(2-Cl,3-CF₂CF₂H,4-n-Pr) Ph(2-Cl,3-CF₂CF₂H,4-t-Bu)Ph(2-Cl,3-CF₂CF₂H,4-i-Pr) Ph(2-Cl,3-CF₂CF₂H,4-c-Pr)Ph(2-Cl,3-CF₂CF₂H,4-CF₃) Ph(2-Cl,3-CF₂CF₂H,4-C₂F₅)Ph(2-Cl,3,4-di-CF₂CF₂H) Ph(2-Cl,3-CF₂CF₂H,4-CF₂H)Ph(2-Cl,3-CF₂CF₂H,4-OMe) Ph(2-Cl,3-CF₂CF₂H,4-OCF₃)Ph(2-Cl,3-CF₂CF₂H,4-OCHF₂) Ph(2-Cl,3-CF₂CF₂H,4- OCF₂CF₂H)Ph(2-Cl,3-CF₂CF₂H,4-OC₂F₅) Ph(2-Cl,3-CF₂CF₂H,4-SO₂Me)Ph(2-Cl,3-CF₂CF₂H,4-TMS) Ph(2-Cl,3-CF₂CF₂H,4-CN) Ph(2-Cl,3-CF₂H,4-Cl)Ph(2-Cl,3-CF₂H,4-F) Ph(2-Cl,3-CF₂H,4-Br) Ph(2-Cl,3-CF₂H,4-I)Ph(2-Cl,3-CF₂H,4-Me) Ph(2-Cl,3-CF₂H,4-Et) Ph(2-Cl,3-CF₂H,4-n-Pr)Ph(2-Cl,3-CF₂H,4-t-Bu) Ph(2-Cl,3-CF₂H,4-i-Pr) Ph(2-Cl,3-CF₂H,4-c-Pr)Ph(2-Cl,3-CF₂H,4-CF₃) Ph(2-Cl,3-CF₂H,4-C₂F₅) Ph(2-Cl,3-CF₂H,4-CF₂CF₂H)Ph(2-Cl,3,4-di-CF₂H) Ph(2-Cl,3-CF₂H,4-OMe) Ph(2-Cl,3-CF₂H,4-OCF₃)Ph(2-Cl,3-CF₂H,4-OCHF₂) Ph(2-Cl,3-CF₂H,4-OCF₂CF₂H)Ph(2-Cl,3-CF₂H,4-OC₂F₅) Ph(2-Cl,3-CF₂H,4-SO₂Me) Ph(2-Cl,3-CF₂H,4-TMS)Ph(2-Cl,3-CF₂H,4-CN) Ph(2-Cl,3-OMe,4-Cl) Ph(2-Cl,3-OMe,4-F)Ph(2-Cl,3-OMe,4-Br) Ph(2-Cl,3-OMe,4-I) Ph(2-Cl,3-OMe,4-Me)Ph(2-Cl,3-OMe,4-Et) Ph(2-Cl,3-OMe,4-n-Pr) Ph(2-Cl,3-OMe,4-t-Bu)Ph(2-Cl,3-OMe,4-i-Pr) Ph(2-Cl,3-OMe,4-c-Pr) Ph(2-Cl,3-OMe,4-CF₃)Ph(2-Cl,3-OMe,4-C2F5) Ph(2-Cl,3-OMe,4-CF₂CF₂H) Ph(2-Cl,3-OMe,4-CF₂H)Ph(2-Cl,3,4-di-OMe) Ph(2-Cl,3-OMe,4-OCF₃) Ph(2-Cl,3-OMe,4-OCHF₂)Ph(2-Cl,3-OMe,4-OCF₂CF₂H) Ph(2-Cl,3-OMe,4-OC₂F₅) Ph(2-Cl,3-OMe,4-SO₂Me)Ph(2-Cl,3-OMe,4-TMS) Ph(2-Cl,3-OMe,4-CN) Ph(2-Cl,3-OCF₃,4-Cl)Ph(2-Cl,3-OCF₃,4-F) Ph(2-Cl,3-OCF₃,4-Br) Ph(2-Cl,3-OCF₃,4-I)Ph(2-Cl,3-OCF₃,4-Me) Ph(2-Cl,3-OCF₃,4-Et) Ph(2-Cl,3-OCF₃,4-n-Pr)Ph(2-Cl,3-OCF₃,4-t-Bu) Ph(2-Cl,3-OCF₃,4-i-Pr) Ph(2-Cl,3-OCF₃,4-c-Pr)Ph(2-Cl,3-OCF₃,4-CF₃) Ph(2-Cl,3-OCF₃,4-C₂F₅) Ph(2-Cl,3-OCF₃,4-CF₂CF₂H)Ph(2-Cl,3-OCF₃,4-CF₂H) Ph(2-Cl,3-OCF₃,4-OMe) Ph(2-Cl,3,4-di-OCF₃)Ph(2-Cl,3-OCF₃,4-OCHF₂) Ph(2-Cl,3-OCF₃,4-OCF₂CF₂H)Ph(2-Cl,3-OCF₃,4-OC₂F₅) Ph(2-Cl,3-OCF₃,4-SO₂Me) Ph(2-Cl,3-OCF₃,4-TMS)Ph(2-Cl,3-OCF₃,4-CN) Ph(2-Cl,3-OCHF₂,4-Cl) Ph(2-Cl,3-OCHF₂,4-F)Ph(2-Cl,3-OCHF₂,4-Br) Ph(2-Cl,3-OCHF₂,4-I) Ph(2-Cl,3-OCHF₂,4-Me)Ph(2-Cl,3-OCHF₂,4-Et) Ph(2-Cl,3-OCHF₂,4-n-Pr) Ph(2-Cl,3-OCHF₂,4-t-Bu)Ph(2-Cl,3-OCHF₂,4-i-Pr) Ph(2-Cl,3-OCHF₂,4-c-Pr)Ph(2-Cl,3-OCHF₂CF₃,4-CF₃) Ph(2-Cl,3-OC₂F₅,4-C₂F₅)Ph(2-Cl,3-OCHF₂,4-CF₂CF₂H) Ph(2-Cl,3-OCHF₂,4-CF₂H)Ph(2-Cl,3-OCHF₂,4-OMe) Ph(2-Cl,3-OCHF₂,4-OCF₃) Ph(2-Cl,3,4-di-OCHF₂)Ph(2-Cl,3-OCHF₂,4-OCF₂CF₂H) Ph(2-Cl,3-OCHF₂,4-OC₂F₅)Ph(2-Cl,3-OCHF₂,4-SO₂Me) Ph(2-Cl,3-OCHF₂,4-TMS) Ph(2-Cl,3-OCHF₂,4-CN)Ph(2-Cl,3-OCF₂CF₂H,4-Cl) Ph(2-Cl,3-OCF₂CF₂H,4-F)Ph(2-Cl,3-OCF₂CF₂H,4-Br) Ph(2-Cl,3-OCF₂CF₂H,4-I)Ph(2-Cl,3-OCF₂CF₂H,4-Me) Ph(2-Cl,3-OCF₂CF₂H,4-Et)Ph(2-Cl,3-OCF₂CF₂H,4-n-Pr) Ph(2-Cl,3-OCF₂CF₂H,4-t-Bu)Ph(2-Cl,3-OCF₂CF₂H,4-i-Pr) Ph(2-Cl,3-OCF₂CF₂H,4-c-Pr)Ph(2-Cl,3-OCF₂CF₂H,4-CF₃) Ph(2-Cl,3-OCF₂CF₂H,4-C₂F₅)Ph(2-Cl,3-OCF₂CF₂H,4- CF₂CF₂H) Ph(2-Cl,3-OCF₂CF₂H,4-CF₂H)Ph(2-Cl,3-OCF₂CF₂H,4-OMe) Ph(2-Cl,3-OCF₂CF₂H,4-OCF₃)Ph(2-Cl,3-OCF₂CF₂H,4-OCHF₂) Ph(2-Cl,3,4-di-OCF₂CF₂H)Ph(2-Cl,3-OCF₂CF₂H,4-OC₂F₅) Ph(2-Cl,3-OCF₂CF₂H,4-SO₂Me)Ph(2-Cl,3-OCF₂CF₂H,4-TMS) Ph(2-Cl,3-OCF₂CF₂H,4-CN) Ph(2-Cl,3-OC₂F₅,4-Cl)Ph(2-Cl,3-OC₂F₅,4-F) Ph(2-Cl,3-OC₂F₅,4-Br) Ph(2-Cl,3-OC₂F₅,4-I)Ph(2-Cl,3-OC₂F₅,4-Me) Ph(2-Cl,3-OC₂F₅,4-Et) Ph(2-Cl,3-OC₂F₅,4-n-Pr)Ph(2-Cl,3-OC₂F₅,4-t-Bu) Ph(2-Cl,3-OC₂F₅,4-i-Pr) Ph(2-Cl,3-OC₂F₅,4-c-Pr)Ph(2-Cl,3-OC₂F₅CF₃,4-CF₃) Ph(2-Cl,3-OC₂F₅,4-CF₂CF₂H)Ph(2-Cl,3-OC₂F₅,4-CF₂H) Ph(2-Cl,3-OC₂F₅,4-OMe) Ph(2-Cl,3-OC₂F₅,4-OCF₃)Ph(2-Cl,3-OC₂F₅,4-OCHF₂) Ph(2-Cl,3-OC₂F₅,4-OCF₂CF₂H)Ph(2-Cl,3,4-di-OC₂F₅) Ph(2-Cl,3-OC₂F₅,4-SO₂Me) Ph(2-Cl,3-OC₂F₅,4-TMS)Ph(2-Cl,3-OC₂F₅,4-CN) Ph(2-Cl,3-SO₂Me,4-Cl) Ph(2-Cl,3-SO₂Me,4-F)Ph(2-Cl,3-SO₂Me,4-Br) Ph(2-Cl,3-SO₂Me,4-I) Ph(2-Cl,3-SO₂Me,4-Me)Ph(2-Cl,3-SO₂Me,4-Et) Ph(2-Cl,3-SO₂Me,4-n-Pr) Ph(2-Cl,3-SO₂Me,4-t-Bu)Ph(2-Cl,3-SO₂Me,4-i-Pr) Ph(2-Cl,3-SO₂Me,4-c-Pr)Ph(2-Cl,3-SO₂MeCF₃,4-CF₃) Ph(2-Cl,3-SO₂Me,4-C₂F₅)Ph(2-Cl,3-SO₂Me,4-CF₂CF₂H) Ph(2-Cl,3-SO₂Me,4-CF₂H)Ph(2-Cl,3-SO₂Me,4-OMe) Ph(2-Cl,3-SO₂Me,4-OCF₃) Ph(2-Cl,3-SO₂Me,4-OCHF₂)Ph(2-Cl,3-SO₂Me,4-OCF₂CF₂H) Ph(2-Cl,3-SO₂Me,4-OC₂F₅)Ph(2-Cl,3,4-di-SO₂Me) Ph(2-Cl,3-SO₂Me,4-TMS) Ph(2-Cl,3-SO₂Me,4-CN)Ph(2-Cl,3-TMS,4-Cl) Ph(2-Cl,3-TMS,4-F) Ph(2-Cl,3-TMS,4-Br)Ph(2-Cl,3-TMS,4-I) Ph(2-Cl,3-TMS,4-Me) Ph(2-Cl,3-TMS,4-Et)Ph(2-Cl,3-TMS,4-n-Pr) Ph(2-Cl,3-TMS,4-t-Bu) Ph(2-Cl,3-TMS,4-i-Pr)Ph(2-Cl,3-TMS,4-c-Pr) Ph(2-Cl,3-TMS,4-CF₃) Ph(2-Cl,3-TMS,4-C₂F₅)Ph(2-Cl,3-TMS,4-CF₂CF₂H) Ph(2-Cl,3-TMS,4-CF₂H) Ph(2-Cl,3-TMS,4-OMe)Ph(2-Cl,3-TMS,4-OCF₃) Ph(2-Cl,3-TMS,4-OCHF₂) Ph(2-Cl,3-TMS,4-OCF₂CF₂H)Ph(2-Cl,3-TMS,4-OC₂F₅) Ph(2-Cl,3-TMS,4-SO₂Me) Ph(2-Cl,3,4-di-TMS)Ph(2-Cl,3-TMS,4-CN) Ph(2-Cl,3-CN,4-Cl) Ph(2-Cl,3-CN,4-F)Ph(2-Cl,3-CN,4-Br) Ph(2-Cl,3-CN,4-I) Ph(2-Cl,3-CN,4-Me)Ph(2-Cl,3-CN,4-Et) Ph(2-Cl,3-CN,4-n-Pr) Ph(2-Cl,3-CN,4-t-Bu)Ph(2-Cl,3-CN,4-i-Pr) Ph(2-Cl,3-CN,4-c-Pr) Ph(2-Cl,3-CN,4-CF₃)Ph(2-Cl,3-CN,4-C₂F₅) Ph(2-Cl,3-CN,4-CF₂CF₂H) Ph(2-Cl,3-CN,4-CF₂H)Ph(2-Cl,3-CN,4-OMe) Ph(2-Cl,3-CN,4-OCF₃) Ph(2-Cl,3-CN,4-OCHF₂)Ph(2-Cl,3-CN,4-OCF₂CF₂H) Ph(2-Cl,3-CN,4-OC₂F₅) Ph(2-Cl,3-CN,4-SO₂Me)Ph(2 -Cl,3-CN,4-TMS) Ph(2-Cl,3,4-di-CN) Ph(2,3,5-tri-Cl)Ph(2-Cl,3-Cl,5-F) Ph(2-Cl,3-Cl,5-Br) Ph(2-Cl,3-Cl,5-I)Ph(2-Cl,3-Cl,5-Me) Ph(2-Cl,3-Cl,5-Et) Ph(2-Cl,3-Cl,5-n-Pr)Ph(2-Cl,3-Cl,5-t-Bu) Ph(2-Cl,3-Cl,5-i-Pr) Ph(2-Cl,3-Cl,5-c-Pr)Ph(2-Cl,3-Cl,5-CF₃) Ph(2-Cl,3-Cl,5-C₂F₅) Ph(2-Cl,3-Cl,5-CF₂CF₂H)Ph(2-Cl,3-Cl,5-CF₂H) Ph(2-Cl,3-Cl,5-OMe) Ph(2-Cl,3-Cl,5-OCF₃)Ph(2-Cl,3-Cl,5-OCHF₂) Ph(2-Cl,3-Cl,5-OCF₂CF₂H) Ph(2-Cl,3-Cl,5-OC₂F₅)Ph(2-Cl,3-Cl,5-SO₂Me) Ph(2-Cl,3-Cl,5-TMS) Ph(2-Cl,3-Cl,5-CN)Ph(2-Cl,3-F,5-Cl) Ph(2-Cl,3,5-di-F) Ph(2-Cl,3-F,5-Br) Ph(2-Cl,3-F,5-I)Ph(2-Cl,3-F,5-Me) Ph(2-Cl,3-F,5-Et) Ph(2-Cl,3-F,5-n-Pr)Ph(2-Cl,3-F,5-t-Bu) Ph(2-Cl,3-F,5-i-Pr) Ph(2-Cl,3-F,5-c-Pr)Ph(2-Cl,3-F,5-CF₃) Ph(2-Cl,3-F,5-C₂F₅) Ph(2-Cl,3-F,5-CF₂CF₂H)Ph(2-Cl,3-F,5-CF₂H) Ph(2-Cl,3-F,5-OMe) Ph(2-Cl,3-F,5-OCF₃)Ph(2-Cl,3-F,5-OCHF₂) Ph(2-Cl,3-F,5-OCF₂CF₂H) Ph(2-Cl,3-F,5-OC₂F₅)Ph(2-Cl,3-F,5-SO₂Me) Ph(2-Cl,3-F,5-TMS) Ph(2-Cl,3-F,5-CN)Ph(2-Cl,3-Br,5-Cl) Ph(2-Cl,3-Br,5-F) Ph(2-Cl,3,5-di-Br)Ph(2-Cl,3-Br,5-I) Ph(2-Cl,3-Br,5-Me) Ph(2-Cl,3-Br,5-Et)Ph(2-Cl,3-Br,5-n-Pr) Ph(2-Cl,3-Br,5-t-Bu) Ph(2-Cl,3-Br,5-i-Pr)Ph(2-Cl,3-Br,5-c-Pr) Ph(2-Cl,3-Br,5-CF₃) Ph(2-Cl,3-Br,5-C₂F₅)Ph(2-Cl,3-Br,5-CF₂CF₂H) Ph(2-Cl,3-Br,5-CF₂H) Ph(2-Cl,3-Br,5-OMe)Ph(2-Cl,3-Br,5-OCF₃) Ph(2-Cl,3-Br,5-OCHF₂) Ph(2-Cl,3-Br,5-OCF₂CF₂H)Ph(2-Cl,3-Br,5-OC₂F₅) Ph(2-Cl,3-Br,5-SO₂Me) Ph(2-Cl,3-Br,5-TMS)Ph(2-Cl,3-Br,5-CN) Ph(2-Cl,3-I,5-Cl) Ph(2-Cl,3-I,5-F) Ph(2-Cl,3-I,5-Br)Ph(2-Cl,3,5-di-I) Ph(2-Cl,3-I,5-Me) Ph(2-Cl,3-I,5-Et)Ph(2-Cl,3-I,5-n-Pr) Ph(2-Cl,3-I,5-t-Bu) Ph(2-Cl,3-I,5-i-Pr)Ph(2-Cl,3-I,5-c-Pr) Ph(2-Cl,3-I,5-CF₃) Ph(2-Cl,3-I,5-C₂F₅)Ph(2-Cl,3-I,5-CF₂CF₂H) Ph(2-Cl,3-I,5-CF₂H) Ph(2-Cl,3-I,5-OMe)Ph(2-Cl,3-I,5-OCF₃) Ph(2-Cl,3-I,5-OCHF₂) Ph(2-Cl,3-I,5-OCF₂CF₂H)Ph(2-Cl,3-I,5-OC₂F₅) Ph(2-Cl,3-I,5-SO₂Me) Ph(2-Cl,3-I,5-TMS)Ph(2-Cl,3-I,5-CN) Ph(2-Cl,3-Me,5-Cl) Ph(2-Cl,3-Me,5-F)Ph(2-Cl,3-Me,5-Br) Ph(2-Cl,3-Me,5-I) Ph(2-Cl,3,5-di-Me)Ph(2-Cl,3-Me,5-Et) Ph(2-Cl,3-Me,5-n-Pr) Ph(2-Cl,3-Me,5-t-Bu)Ph(2-Cl,3-Me,5-i-Pr) Ph(2-Cl,3-Me,5-c-Pr) Ph(2-Cl,3-Me,5-CF₃)Ph(2-Cl,3-Me,5-C₂F₅) Ph(2-Cl,3-Me,5-CF₂CF₂H) Ph(2-Cl,3-Me,5-CF₂H)Ph(2-Cl,3-Me,5-OMe) Ph(2-Cl,3-Me,5-OCF₃) Ph(2-Cl,3-Me,5-OCHF₂)Ph(2-Cl,3-Me,5-OCF₂CF₂H) Ph(2-Cl,3-Me,5-OC₂F₅) Ph(2-Cl,3-Me,5-SO₂Me)Ph(2-Cl,3-Me,5-TMS) Ph(2-Cl,3-Me,5-CN) Ph(2-Cl,3-Et,5-Cl)Ph(2-Cl,3-Et,5-F) Ph(2-Cl,3-Et,5-Br) Ph(2-Cl,3-Et,5-I)Ph(2-Cl,3-Et,5-Me) Ph(2-Cl,3,5-di-Et) Ph(2-Cl,3-Et,5-n-Pr)Ph(2-Cl,3-Et,5-t-Bu) Ph(2-Cl,3-Et,5-i-Pr) Ph(2-Cl,3-Et,5-c-Pr)Ph(2-Cl,3-Et,5-CF₃) Ph(2-Cl,3-Et,5-C₂F₅) Ph(2-Cl,3-Et,5-CF₂CF₂H)Ph(2-Cl,3-Et,5-CF₂H) Ph(2-Cl,3-Et,5-OMe) Ph(2-Cl,3-Et,5-OCF₃)Ph(2-Cl,3-Et,5-OCHF₂) Ph(2-Cl,3-Et,5-OCF₂CF₂H) Ph(2-Cl,3-Et,5-OC₂F₅)Ph(2-Cl,3-Et,5-SO₂Me) Ph(2-Cl,3-Et,5-TMS) Ph(2-Cl,3-Et,5-CN)Ph(2-Cl,3-n-Pr,5-Cl) Ph(2-Cl,3-n-Pr,5-F) Ph(2-Cl,3-n-Pr,5-Br)Ph(2-Cl,3-n-Pr,5-I) Ph(2-Cl,3-n-Pr,5-Me) Ph(2-Cl,3-n-Pr,5-Et)Ph(2-Cl,3,5-di-n-Pr) Ph(2-Cl,3-n-Pr,5-t-Bu) Ph(2-Cl,3-n-Pr,5-i-Pr)Ph(2-Cl,3-n-Pr,5-c-Pr) Ph(2-Cl,3-n-Pr,5-CF₃) Ph(2-Cl,3-n-Pr,5-C₂F₅)Ph(2-Cl,3-n-Pr,5-CF₂CF₂H) Ph(2-Cl,3-n-Pr,5-CF₂H) Ph(2-Cl,3-n-Pr,5-OMe)Ph(2-Cl,3-n-Pr,5-OCF₃) Ph(2-Cl,3-n-Pr,5-OCHF₂)Ph(2-Cl,3-n-Pr,5-OCF₂CF₂H) Ph(2-Cl,3-n-Pr,5-OC₂F₅)Ph(2-Cl,3-n-Pr,5-SO₂Me) Ph(2-Cl,3-n-Pr,5-TMS) Ph(2-Cl,3-n-Pr,5-CN)Ph(2-Cl,3-t-Bu,5-Cl) Ph(2-Cl,3-t-Bu,5-F) Ph(2-Cl,3-t-Bu,5-Br)Ph(2-Cl,3-t-Bu,54) Ph(2-Cl,3-t-Bu,5-Me) Ph(2-Cl,3-t-Bu,5-Et)Ph(2-Cl,3-t-Bu,5-n-Pr) Ph(2-Cl,3,5-di-t-Bu) Ph(2-Cl,3-t-Bu,5-i-Pr)Ph(2-Cl,3-t-Bu,5-c-Pr) Ph(2-Cl,3-t-Bu,5-CF₃) Ph(2-Cl,3-t-Bu,5-C₂F₅)Ph(2-Cl,3-t-Bu,5-CF₂CF₂H) Ph(2-Cl,3-t-Bu,5-CF₂H) Ph(2-Cl,3-t-Bu,5-OMe)Ph(2-Cl,3-t-Bu,5-OCF₃) Ph(2-Cl,3-t-Bu,5-OCHF₂)Ph(2-Cl,3-t-Bu,5-OCF₂CF₂H) Ph(2-Cl,3-t-Bu,5-OC₂F₅)Ph(2-Cl,3-t-Bu,5-SO₂Me) Ph(2-Cl,3-t-Bu,5-TMS) Ph(2-Cl,3-t-Bu,5-CN)Ph(2-Cl,3-i-Pr,5-Cl) Ph(2-Cl,3-i-Pr,5-F) Ph(2-Cl,3-i-Pr,5-Br)Ph(2-Cl,3-i-Pr,5-I) Ph(2-Cl,3-i-Pr,5-Me) Ph(2-Cl,3-i-Pr,5-Et)Ph(2-Cl,3-i-Pr,5-n-Pr) Ph(2-Cl,3-i-Pr,5-t-Bu) Ph(2-Cl,3,5-di-i-Pr)Ph(2-Cl,3-i-Pr,5-c-Pr) Ph(2-Cl,3-i-Pr,5-CF₃) Ph(2-Cl,3-i-Pr,5-C₂F₅)Ph(2-Cl,3-i-Pr,5-CF₂CF₂H) Ph(2-Cl,3-i-Pr,5-CF₂H) Ph(2-Cl,3-i-Pr,5-OMe)Ph(2-Cl,3-i-Pr,5-OCF₃) Ph(2-Cl,3-i-Pr,5-OCHF₂)Ph(2-Cl,3-i-Pr,5-OCF₂CF₂H) Ph(2-Cl,3-i-Pr,5-OC₂F₅)Ph(2-Cl,3-i-Pr,5-SO₂Me) Ph(2-Cl,3-i-Pr,5-TMS) Ph(2-Cl,3-i-Pr,5-CN)Ph(2-Cl,3-c-Pr,5-Cl) Ph(2-Cl,3-c-Pr,5-F) Ph(2-Cl,3-c-Pr,5-Br)Ph(2-Cl,3-c-Pr,5-I) Ph(2-Cl,3-c-Pr,5-Me) Ph(2-Cl,3-c-Pr,5-Et)Ph(2-Cl,3-c-Pr,5-n-Pr) Ph(2-Cl,3-c-Pr,5-t-Bu) Ph(2-Cl,3-c-Pr,5-i-Pr)Ph(2-Cl,3,5-di-c-Pr) Ph(2-Cl,3-c-Pr,5-CF₃) Ph(2-Cl,3-c-Pr,5-C₂F₅)Ph(2-Cl,3-c-Pr,5-CF₂CF₂H) Ph(2-Cl,3-c-Pr,5-CF₂H) Ph(2-Cl,3-c-Pr,5-OMe)Ph(2-Cl,3-c-Pr,5-OCF₃) Ph(2-Cl,3-c-Pr,5-OCHF₂)Ph(2-Cl,3-c-Pr,5-OCF₂CF₂H) Ph(2-Cl,3-c-Pr,5-OC₂F₅)Ph(2-Cl,3-c-Pr,5-SO₂Me) Ph(2-Cl,3-c-Pr,5-TMS) Ph(2-Cl,3-c-Pr,5-CN)Ph(2-Cl,3-CF3,5-Cl) Ph(2-Cl,3-CF3,5-F) Ph(2-Cl,3-CF3,5-Br)Ph(2-Cl,3-CF3,5-I) Ph(2-Cl,3-CF3,5-Me) Ph(2-Cl,3-CF₃,5-Et)Ph(2-Cl,3-CF₃,5-n-Pr) Ph(2-Cl,3-CF₃,5-t-Bu) Ph(2-Cl,3-CF₃,5-i-Pr)Ph(2-Cl,3-CF₃,5-c-Pr) Ph(2-Cl,3,5-di-CF₃) Ph(2-Cl,3-CF₃,5-C₂F₅)Ph(2-Cl,3-CF₃,5-CF₂CF₂H) Ph(2-Cl,3-CF₃,5-CF₂H) Ph(2-Cl,3-CF₃,5-OMe)Ph(2-Cl,3-CF₃,5-OCF₃) Ph(2-Cl,3-CF₃,5-OCHF₂) Ph(2-Cl,3-CF₃,5-OCF₂CF₂H)Ph(2-Cl,3-CF₃,5-OC₂F₅) Ph(2-Cl,3-CF₃,5-SO₂Me) Ph(2-Cl,3-CF₃,5-TMS)Ph(2-Cl,3-CF₃,5-CN) Ph(2-Cl,3-C₂F₅,5-Cl) Ph(2-Cl,3-C₂F₅,5-F)Ph(2-Cl,3-C₂F₅,5-Br) Ph(2-Cl,3-C₂F₅,5-I) Ph(2-Cl,3-C₂F₅,5-Me)Ph(2-Cl,3-C₂F₅,5-Et) Ph(2-Cl,3-C₂F₅,5-n-Pr) Ph(2-Cl,3-C₂F₅,5-t-Bu)Ph(2-Cl,3-C₂F₅,5-i-Pr) Ph(2-Cl,3-C₂F₅,5-c-Pr) Ph(2-Cl,3-C₂F₅CF₃,5-CF₃)Ph(2-Cl,3,5-di-C₂F₅) Ph(2-Cl,3-C₂F₅,5-CF₂CF₂H) Ph(2-Cl,3-C₂F₅,5-CF₂H)Ph(2-Cl,3-C₂F₅,5-OMe) Ph(2-Cl,3-C₂F₅,5-OCF₃) Ph(2-Cl,3-C₂F₅,5-OCHF₂)Ph(2-Cl,3-C₂F₅,5-OCF₂CF₂H) Ph(2-Cl,3-C₂F₅,5-OC₂F₅)Ph(2-Cl,3-C₂F₅,5-SO₂Me) Ph(2-Cl,3-C₂F₅,5-TMS) Ph(2-Cl,3-C₂F₅,5-CN)Ph(2-Cl,3-CF₂CF₂H,5-Cl) Ph(2-Cl,3-CF₂CF₂H,5-F) Ph(2-Cl,3-CF₂CF₂H,5-Br)Ph(2-Cl,3-CF₂CF₂H,5-I) Ph(2-Cl,3-CF₂CF₂H,5-Me) Ph(2-Cl,3-CF₂CF₂H,5-Et)Ph(2-Cl,3-CF₂CF₂H,5-n-Pr) Ph(2-Cl,3-CF₂CF₂H,5-t-Bu)Ph(2-Cl,3-CF₂CF₂H,5-i-Pr) Ph(2-Cl,3-CF₂CF₂H,5-c-Pr)Ph(2-Cl,3-CF₂CF₂H,5-CF₃) Ph(2-Cl,3-CF₂CF₂H,5-C₂F₅)Ph(2-Cl,3,5-di-CF₂CF₂H) Ph(2-Cl,3-CF₂CF₂H,5-CF₂H)Ph(2-Cl,3-CF₂CF₂H,5-OMe) Ph(2-Cl,3-CF₂CF₂H,5-OCF₃)Ph(2-Cl,3-CF₂CF₂H,5-OCHF₂) Ph(2-Cl,3-CF₂CF₂H,5- OCF₂CF₂H)Ph(2-Cl,3-CF₂CF₂H,5-OC₂F₅) Ph(2-Cl,3-CF₂CF₂H,5-SO₂Me)Ph(2-Cl,3-CF₂CF₂H,5-TMS) Ph(2-Cl,3-CF₂CF₂H,5-CN) Ph(2-Cl,3-CF₂H,5-Cl)Ph(2-Cl,3-CF₂H,5-F) Ph(2-Cl,3-CF₂H,5-Br) Ph(2-Cl,3-CF₂H,5-I)Ph(2-Cl,3-CF₂H,5-Me) Ph(2-Cl,3-CF₂H,5-Et) Ph(2-Cl,3-CF₂H,5-n-Pr)Ph(2-Cl,3-CF₂H,5-t-Bu) Ph(2-Cl,3-CF₂H,5-i-Pr) Ph(2-Cl,3-CF₂H,5-c-Pr)Ph(2-Cl,3-CF₂H,5-CF₃) Ph(2-Cl,3-CF₂H,5-C₂F₅) Ph(2-Cl,3-CF₂H,5-CF₂CF₂H)Ph(2-Cl,3,5-di-CF₂H) Ph(2-Cl,3-CF₂H,5-OMe) Ph(2-Cl,3-CF₂H,5-OCF₃)Ph(2-Cl,3-CF₂H,5-OCHF₂) Ph(2-Cl,3-CF₂H,5-OCF₂CF₂H)Ph(2-Cl,3-CF₂H,5-OC₂F5) Ph(2-Cl,3-CF₂H,5-SO₂Me) Ph(2-Cl,3-CF₂H,5-TMS)Ph(2-Cl,3-CF₂H,5-CN) Ph(2-Cl,3-OMe,5-Cl) Ph(2-Cl,3-OMe,5-F)Ph(2-Cl,3-OMe,5-Br) Ph(2-Cl,3-OMe,54) Ph(2-Cl,3-OMe,5-Me)Ph(2-Cl,3-OMe,5-Et) Ph(2-Cl,3-OMe,5-n-Pr) Ph(2-Cl,3-OMe,5-t-Bu)Ph(2-Cl,3-OMe,5-i-Pr) Ph(2-Cl,3-OMe,5-c-Pr) Ph(2-Cl,3-OMe,5-CF₃)Ph(2-Cl,3-OMe,5-C₂F₅) Ph(2-Cl,3-OMe,5-CF₂CF₂H) Ph(2-Cl,3-OMe,5-CF₂H)Ph(2-Cl,3,5-di-OMe) Ph(2-Cl,3-OMe,5-OCF₃) Ph(2-Cl,3-OMe,5-OCHF₂)Ph(2-Cl,3-OMe,5-OCF₂CF₂H) Ph(2-Cl,3-OMe,5-OC₂F₅) Ph(2-Cl,3-OMe,5-SO₂Me)Ph(2-Cl,3-OMe,5-TMS) Ph(2-Cl,3-OMe,5-CN) Ph(2-Cl,3-OCF₃,5-Cl)Ph(2-Cl,3-OCF₃,5-F) Ph(2-Cl,3-OCF₃,5-Br) Ph(2-Cl,3-OCF₃,5-I)Ph(2-Cl,3-OCF₃,5-Me) Ph(2-Cl,3-OCF₃,5-Et) Ph(2-Cl,3-OCF₃,5-n-Pr)Ph(2-Cl,3-OCF₃,5-t-Bu) Ph(2-Cl,3-OCF₃,5-i-Pr) Ph(2-Cl,3-OCF₃,5-c-Pr)Ph(2-Cl,3-OCF₃,5-CF₃) Ph(2-Cl,3-OCF₃,5-C₂F₅) Ph(2-Cl,3-OCF₃,5-CF₂CF₂H)Ph(2-Cl,3-OCF₃,5-CF₂H) Ph(2-Cl,3-OCF₃,5-OMe) Ph(2-Cl,3,5-di-OCF₃)Ph(2-Cl,3-OCF₃,5-OCHF₂) Ph(2-Cl,3-OCF₃,5-OCF₂CF₂H)Ph(2-Cl,3-OCF₃,5-OC₂F₅) Ph(2-Cl,3-OCF₃,5-SO₂Me) Ph(2-Cl,3-OCF₃,5-TMS)Ph(2-Cl,3-OCF₃,5-CN) Ph(2-Cl,3-OCHF₂,5-Cl) Ph(2-Cl,3-OCHF₂,5-F)Ph(2-Cl,3-OCHF₂,5-Br) Ph(2-Cl,3-OCHF₂,5-I) Ph(2-Cl,3-OCHF₂,5-Me)Ph(2-Cl,3-OCHF₂,5-Et) Ph(2-Cl,3-OCHF₂,5-n-Pr) Ph(2-Cl,3-OCHF₂,5-t-Bu)Ph(2-Cl,3-OCHF₂,5-i-Pr) Ph(2-Cl,3-OCHF₂,5-c-Pr)Ph(2-Cl,3-OCHF₂CF₃,5-CF₃) Ph(2-Cl,3-OC₂F₅,5-C₂F₅)Ph(2-Cl,3-OCHF₂,5-CF₂CF₂H) Ph(2-Cl,3-OCHF₂,5-CF₂H)Ph(2-Cl,3-OCHF₂,5-OMe) Ph(2-Cl,3-OCHF₂,5-OCF₃) Ph(2-Cl,3,5-di-OCHF₂)Ph(2-Cl,3-OCHF₂,5-OCF₂CF₂H) Ph(2-Cl,3-OCHF₂,5-OC₂F₅)Ph(2-Cl,3-OCHF₂,5-SO₂Me) Ph(2-Cl,3-OCHF₂,5-TMS) Ph(2-Cl,3-OCHF₂,5-CN)Ph(2-Cl,3-OCF₂CF₂H,5-Cl) Ph(2-Cl,3-OCF₂CF₂H,5-F)Ph(2-Cl,3-OCF₂CF₂H,5-Br) Ph(2-Cl,3-OCF₂CF₂H,5-I)Ph(2-Cl,3-OCF₂CF₂H,5-Me) Ph(2-Cl,3-OCF₂CF₂H,5-Et)Ph(2-Cl,3-OCF₂CF₂H,5-n-Pr) Ph(2-Cl,3-OCF₂CF₂H,5-t-Bu)Ph(2-Cl,3-OCF₂CF₂H,5-i-Pr) Ph(2-Cl,3-OCF₂CF₂H,5-c-Pr)Ph(2-Cl,3-OCF₂CF₂H,5-CF₃) Ph(2-Cl,3-OCF₂CF₂H,5-C₂F₅)Ph(2-Cl,3-OCF₂CF₂H,5- CF₂CF₂H) Ph(2-Cl,3-OCF₂CF₂H,5-CF₂H)Ph(2-Cl,3-OCF₂CF₂H,5-OMe) Ph(2-Cl,3-OCF₂CF₂H,5-OCF₃)Ph(2-Cl,3-OCF₂CF₂H,5-OCHF₂) Ph(2-Cl,3,5-di-OCF₂CF₂H)Ph(2-Cl,3-OCF₂CF₂H,5-OC₂F₅) Ph(2-Cl,3-OCF₂CF₂H,5-SO₂Me)Ph(2-Cl,3-OCF₂CF₂H,5-TMS) Ph(2-Cl,3-OCF₂CF₂H,5-CN) Ph(2-Cl,3-OC₂F₅,5-Cl)Ph(2-Cl,3-OC₂F₅,5-F) Ph(2-Cl,3-OC₂F₅,5-Br) Ph(2-Cl,3-OC₂F₅,54)Ph(2-Cl,3-OC₂F₅,5-Me) Ph(2-Cl,3-OC₂F₅,5-Et) Ph(2-Cl,3-OC₂F₅,5-n-Pr)Ph(2-Cl,3-OC₂F₅,5-t-Bu) Ph(2-Cl,3-OC₂F₅,5-i-Pr) Ph(2-Cl,3-OC₂F₅,5-c-Pr)Ph(2-Cl,3-OC₂F₅CF3,5-CF₃) Ph(2-Cl,3-OC₂F₅,5-CF₂CF₂H)Ph(2-Cl,3-OC₂F₅,5-CF₂H) Ph(2-Cl,3-OC₂F₅,5-OMe) Ph(2-Cl,3-OC₂F₅,5-OCF₃)Ph(2-Cl,3-OC₂F₅,5-OCHF₂) Ph(2-Cl,3-OC₂F₅,5-OCF₂CF₂H)Ph(2-Cl,3,5-di-OC₂F₅) Ph(2-Cl,3-OC₂F₅,5-SO₂Me) Ph(2-Cl,3-OC₂F₅,5-TMS)Ph(2-Cl,3-OC₂F₅,5-CN) Ph(2-Cl,3-SO₂Me,5-Cl) Ph(2-Cl,3-SO₂Me,5-F)Ph(2-Cl,3-SO₂Me,5-Br) Ph(2-Cl,3-SO₂Me,5-I) Ph(2-Cl,3-SO₂Me,5-Me)Ph(2-Cl,3-SO₂Me,5-Et) Ph(2-Cl,3-SO₂Me,5-n-Pr) Ph(2-Cl,3-SO₂Me,5-t-Bu)Ph(2-Cl,3-SO₂Me,5-i-Pr) Ph(2-Cl,3-SO₂Me,5-c-Pr)Ph(2-Cl,3-SO₂MeCF3,5-CF₃) Ph(2-Cl,3-SO₂Me,5-C₂F₅)Ph(2-Cl,3-SO₂Me,5-CF₂CF₂H) Ph(2-Cl,3-SO₂Me,5-CF₂H)Ph(2-Cl,3-SO₂Me,5-OMe) Ph(2-Cl,3-SO₂Me,5-OCF₃) Ph(2-Cl,3-SO₂Me,5-OCHF₂)Ph(2-Cl,3-SO₂Me,5-OCF₂CF₂H) Ph(2-Cl,3-SO₂Me,5-OC₂F₅)Ph(2-Cl,3,5-di-SO₂Me) Ph(2-Cl,3-SO₂Me,5-TMS) Ph(2-Cl,3-SO₂Me,5-CN)Ph(2-Cl,3-TMS,5-Cl) Ph(2-Cl,3-TMS,5-F) Ph(2-Cl,3-TMS,5-Br)Ph(2-Cl,3-TMS,54) Ph(2-Cl,3-TMS,5-Me) Ph(2-Cl,3-TMS,5-Et)Ph(2-Cl,3-TMS,5-n-Pr) Ph(2-Cl,3-TMS,5-t-Bu) Ph(2-Cl,3-TMS,5-i-Pr)Ph(2-Cl,3-TMS,5-c-Pr) Ph(2-Cl,3-TMS,5-CF₃) Ph(2-Cl,3-TMS,5-C₂F₅)Ph(2-Cl,3-TMS,5-CF₂CF₂H) Ph(2-Cl,3-TMS,5-CF₂H) Ph(2-Cl,3-TMS,5-OMe)Ph(2-Cl,3-TMS,5-OCF₃) Ph(2-Cl,3-TMS,5-OCHF₂) Ph(2-Cl,3-TMS,5-OCF₂CF₂H)Ph(2-Cl,3-TMS,5-OC₂F₅) Ph(2-Cl,3-TMS,5-SO₂Me) Ph(2-Cl,3,5-di-TMS)Ph(2-Cl,3-TMS,5-CN) Ph(2-Cl,3-CN,5-Cl) Ph(2-Cl,3-CN,5-F)Ph(2-Cl,3-CN,5-Br) Ph(2-Cl,3-CN,5-I) Ph(2-Cl,3-CN,5-Me)Ph(2-Cl,3-CN,5-Et) Ph(2-Cl,3-CN,5-n-Pr) Ph(2-Cl,3-CN,5-t-Bu)Ph(2-Cl,3-CN,5-i-Pr) Ph(2-Cl,3-CN,5-c-Pr) Ph(2-Cl,3-CN,5-CF₃)Ph(2-Cl,3-CN,5-C₂F₅) Ph(2-Cl,3-CN,5-CF₂CF₂H) Ph(2-Cl,3-CN,5-CF₂H)Ph(2-Cl,3-CN,5-OMe) Ph(2-Cl,3-CN,5-OCF₃) Ph(2-Cl,3-CN,5-OCHF₂)Ph(2-Cl,3-CN,5-OCF₂CF₂H) Ph(2-Cl,3-CN,5-OC₂F₅) Ph(2-Cl,3-CN,5-SO₂Me)Ph(2-Cl,3-CN,5-TMS) Ph(2-Cl,3,5-di-CN) Ph(2,4,5-tri-Cl)Ph(2-Cl,4-Cl,5-F) Ph(2-Cl,4-Cl,5-Br) Ph(2-Cl,4-Cl,5-I)Ph(2-Cl,4-Cl,5-Me) Ph(2-Cl,4-Cl,5-Et) Ph(2-Cl,4-Cl,5-n-Pr)Ph(2-Cl,4-Cl,5-t-Bu) Ph(2-Cl,4-Cl,5-i-Pr) Ph(2-Cl,4-Cl,5-c-Pr)Ph(2-Cl,4-Cl,5-CF₃) Ph(2-Cl,4-Cl,5-C₂F₅) Ph(2-Cl,4-Cl,5-CF₂CF₂H)Ph(2-Cl,4-Cl,5-CF₂H) Ph(2-Cl,4-Cl,5-OMe) Ph(2-Cl,4-Cl,5-OCF₃)Ph(2-Cl,4-Cl,5-OCHF₂) Ph(2-Cl,4-Cl,5-OCF₂CF₂H) Ph(2-Cl,4-Cl,5-OC₂F₅)Ph(2-Cl,4-Cl,5-SO₂Me) Ph(2-Cl,4-Cl,5-TMS) Ph(2-Cl,4-Cl,5-CN)Ph(2-Cl,4-F,5-Cl) Ph(2-Cl,4,5-di-F) Ph(2-Cl,4-F,5-Br) Ph(2-Cl,4-F,5-I)Ph(2-Cl,4-F,5-Me) Ph(2-Cl,4-F,5-Et) Ph(2-Cl,4-F,5-n-Pr)Ph(2-Cl,4-F,5-t-Bu) Ph(2-Cl,4-F,5-i-Pr) Ph(2-Cl,4-F,5-c-Pr)Ph(2-Cl,4-F,5-CF₃) Ph(2-Cl,4-F,5-C₂F₅) Ph(2-Cl,4-F,5-CF₂CF₂H)Ph(2-Cl,4-F,5-CF₂H) Ph(2-Cl,4-F,5-OMe) Ph(2-Cl,4-F,5-OCF₃)Ph(2-Cl,4-F,5-OCHF₂) Ph(2-Cl,4-F,5-OCF₂CF₂H) Ph(2-Cl,4-F,5-OC₂F₅)Ph(2-Cl,4-F,5-SO₂Me) Ph(2-Cl,4-F,5-TMS) Ph(2-Cl,4-F,5-CN)Ph(2-Cl,4-Br,5-Cl) Ph(2-Cl,4-Br,5-F) Ph(2-Cl,4,5-di-Br)Ph(2-Cl,4-Br,5-I) Ph(2-Cl,4-Br,5-Me) Ph(2-Cl,4-Br,5-Et)Ph(2-Cl,4-Br,5-n-Pr) Ph(2-Cl,4-Br,5-t-Bu) Ph(2-Cl,4-Br,5-i-Pr)Ph(2-Cl,4-Br,5-c-Pr) Ph(2-Cl,4-Br,5-CF₃) Ph(2-Cl,4-Br,5-C₂F₅)Ph(2-Cl,4-Br,5-CF₂CF₂H) Ph(2-Cl,4-Br,5-CF₂H) Ph(2-Cl,4-Br,5-OMe)Ph(2-Cl,4-Br,5-OCF₃) Ph(2-Cl,4-Br,5-OCHF₂) Ph(2-Cl,4-Br,5-OCF₂CF₂H)Ph(2-Cl,4-Br,5-OC₂F₅) Ph(2-Cl,4-Br,5-SO₂Me) Ph(2-Cl,4-Br,5-TMS)Ph(2-Cl,4-Br,5-CN) Ph(2-Cl,4-I,5-Cl) Ph(2-Cl,4-I,5-F) Ph(2-Cl,4-I,5-Br)Ph(2-Cl,4,5-di-I) Ph(2-Cl,4-I,5-Me) Ph(2-Cl,4-I,5-Et)Ph(2-Cl,4-I,5-n-Pr) Ph(2-Cl,4-I,5-t-Bu) Ph(2-Cl,4-I,5-i-Pr)Ph(2-Cl,4-I,5-c-Pr) Ph(2-Cl,4-I,5-CF₃) Ph(2-Cl,4-I,5-C₂F₅)Ph(2-Cl,4-I,5-CF₂CF₂H) Ph(2-Cl,4-I,5-CF₂H) Ph(2-Cl,4-I,5-OMe)Ph(2-Cl,4-I,5-OCF₃) Ph(2-Cl,4-I,5-OCHF₂) Ph(2-Cl,4-I,5-OCF₂CF₂H)Ph(2-Cl,4-I,5-OC₂F₅) Ph(2-Cl,4-I,5-SO₂Me) Ph(2-Cl,4-I,5-TMS)Ph(2-Cl,4-I,5-CN) Ph(2-Cl,4-Me,5-Cl) Ph(2-Cl,4-Me,5-F)Ph(2-Cl,4-Me,5-Br) Ph(2-Cl,4-Me,5-I) Ph(2-Cl,4,5-di-Me)Ph(2-Cl,4-Me,5-Et) Ph(2-Cl,4-Me,5-n-Pr) Ph(2-Cl,4-Me,5-t-Bu)Ph(2-Cl,4-Me,5-i-Pr) Ph(2-Cl,4-Me,5-c-Pr) Ph(2-Cl,4-Me,5-CF₃)Ph(2-Cl,4-Me,5-C₂F₅) Ph(2-Cl,4-Me,5-CF₂CF₂H) Ph(2-Cl,4-Me,5-CF₂H)Ph(2-Cl,4-Me,5-OMe) Ph(2-Cl,4-Me,5-OCF₃) Ph(2-Cl,4-Me,5-OCHF₂)Ph(2-Cl,4-Me,5-OCF₂CF₂H) Ph(2-Cl,4-Me,5-OC₂F₅) Ph(2-Cl,4-Me,5-SO₂Me)Ph(2-Cl,4-Me,5-TMS) Ph(2-Cl,4-Me,5-CN) Ph(2-Cl,4-Et,5-Cl)Ph(2-Cl,4-Et,5-F) Ph(2-Cl,4-Et,5-Br) Ph(2-Cl,4-Et,5-I)Ph(2-Cl,4-Et,5-Me) Ph(2-Cl,4,5-di-Et) Ph(2-Cl,4-Et,5-n-Pr)Ph(2-Cl,4-Et,5-t-Bu) Ph(2-Cl,4-Et,5-i-Pr) Ph(2-Cl,4-Et,5-c-Pr)Ph(2-Cl,4-Et,5-CF₃) Ph(2-Cl,4-Et,5-C₂F₅) Ph(2-Cl,4-Et,5-CF₂CF₂H)Ph(2-Cl,4-Et,5-CF₂H) Ph(2-Cl,4-Et,5-OMe) Ph(2-Cl,4-Et,5-OCF₃)Ph(2-Cl,4-Et,5-OCHF₂) Ph(2-Cl,4-Et,5-OCF₂CF₂H) Ph(2-Cl,4-Et,5-OC₂F₅)Ph(2-Cl,4-Et,5-SO₂Me) Ph(2-Cl,4-Et,5-TMS) Ph(2-Cl,4-Et,5-CN)Ph(2-Cl,4-n-Pr,5-Cl) Ph(2-Cl,4-n-Pr,5-F) Ph(2-Cl,4-n-Pr,5-Br)Ph(2-Cl,4-n-Pr,5-I) Ph(2-Cl,4-n-Pr,5-Me) Ph(2-Cl,4-n-Pr,5-Et)Ph(2-Cl,4,5-di-n-Pr) Ph(2-Cl,4-n-Pr,5-t-Bu) Ph(2-Cl,4-n-Pr,5-i-Pr)Ph(2-Cl,4-n-Pr,5-c-Pr) Ph(2-Cl,4-n-Pr,5-CF₃) Ph(2-Cl,4-n-Pr,5-C₂F₅)Ph(2-Cl,4-n-Pr,5-CF₂CF₂H) Ph(2-Cl,4-n-Pr,5-CF₂H) Ph(2-Cl,4-n-Pr,5-OMe)Ph(2-Cl,4-n-Pr,5-OCF₃) Ph(2-Cl,4-n-Pr,5-OCHF₂)Ph(2-Cl,4-n-Pr,5-OCF₂CF₂H) Ph(2-Cl,4-n-Pr,5-OC₂F₅)Ph(2-Cl,4-n-Pr,5-SO₂Me) Ph(2-Cl,4-n-Pr,5-TMS) Ph(2-Cl,4-n-Pr,5-CN)Ph(2-Cl,4-t-Bu,5-Cl) Ph(2-Cl,4-t-Bu,5-F) Ph(2-Cl,4-t-Bu,5-Br)Ph(2-Cl,4-t-Bu,5-I) Ph(2-Cl,4-t-Bu,5-Me) Ph(2-Cl,4-t-Bu,5-Et)Ph(2-Cl,4-t-Bu,5-n-Pr) Ph(2-Cl,4,5-di-t-Bu) Ph(2-Cl,4-t-Bu,5-i-Pr)Ph(2-Cl,4-t-Bu,5-c-Pr) Ph(2-Cl,4-t-Bu,5-CF₃) Ph(2-Cl,4-t-Bu,5-C₂F₅)Ph(2-Cl,4-t-Bu,5-CF₂CF₂H) Ph(2-Cl,4-t-Bu,5-CF₂H) Ph(2-Cl,4-t-Bu,5-OMe)Ph(2-Cl,4-t-Bu,5-OCF₃) Ph(2-Cl,4-t-Bu,5-OCHF₂)Ph(2-Cl,4-t-Bu,5-OCF₂CF₂H) Ph(2-Cl,4-t-Bu,5-OC₂F₅)Ph(2-Cl,4-t-Bu,5-SO₂Me) Ph(2-Cl,4-t-Bu,5-TMS) Ph(2-Cl,4-t-Bu,5-CN)Ph(2-Cl,4-i-Pr,5-Cl) Ph(2-Cl,4-i-Pr,5-F) Ph(2-Cl,4-i-Pr,5-Br)Ph(2-Cl,4-i-Pr,5-I) Ph(2-Cl,4-i-Pr,5-Me) Ph(2-Cl,4-i-Pr,5-Et)Ph(2-Cl,4-i-Pr,5-n-Pr) Ph(2-Cl,4-i-Pr,5-t-Bu) Ph(2-Cl,4,5-di-i-Pr)Ph(2-Cl,4-i-Pr,5-c-Pr) Ph(2-Cl,4-i-Pr,5-CF₃) Ph(2-Cl,4-i-Pr,5-C₂F₅)Ph(2-Cl,4-i-Pr,5-CF₂CF₂H) Ph(2-Cl,4-i-Pr,5-CF₂H) Ph(2-Cl,4-i-Pr,5-OMe)Ph(2-Cl,4-i-Pr,5-OCF₃) Ph(2-Cl,4-i-Pr,5-OCHF₂)Ph(2-Cl,4-i-Pr,5-OCF₂CF₂H) Ph(2-Cl,4-i-Pr,5-OC₂F₅)Ph(2-Cl,4-i-Pr,5-SO₂Me) Ph(2-Cl,4-i-Pr,5-TMS) Ph(2-Cl,4-i-Pr,5-CN)Ph(2-Cl,4-c-Pr,5-Cl) Ph(2-Cl,4-c-Pr,5-F) Ph(2-Cl,4-c-Pr,5-Br)Ph(2-Cl,4-c-Pr,5-I) Ph(2-Cl,4-c-Pr,5-Me) Ph(2-Cl,4-c-Pr,5-Et)Ph(2-Cl,4-c-Pr,5-n-Pr) Ph(2-Cl,4-c-Pr,5-t-Bu) Ph(2-Cl,4-c-Pr,5-i-Pr)Ph(2-Cl,4,5-di-c-Pr) Ph(2-Cl,4-c-Pr,5-CF₃) Ph(2-Cl,4-c-Pr,5-C₂F₅)Ph(2-Cl,4-c-Pr,5-CF₂CF₂H) Ph(2-Cl,4-c-Pr,5-CF₂H) Ph(2-Cl,4-c-Pr,5-OMe)Ph(2-Cl,4-c-Pr,5-OCF₃) Ph(2-Cl,4-c-Pr,5-OCHF₂)Ph(2-Cl,4-c-Pr,5-OCF₂CF₂H) Ph(2-Cl,4-c-Pr,5-OC₂F₅)Ph(2-Cl,4-c-Pr,5-SO₂Me) Ph(2-Cl,4-c-Pr,5-TMS) Ph(2-Cl,4-c-Pr,5-CN)Ph(2-Cl,4-CF3,5-Cl) Ph(2-Cl,4-CF₃,5-F) Ph(2-Cl,4-CF₃,5-Br)Ph(2-Cl,4-CF₃,5-I) Ph(2-Cl,4-CF₃,5-Me) Ph(2-Cl,4-CF₃,5-Et)Ph(2-Cl,4-CF₃,5-n-Pr) Ph(2-Cl,4-CF₃,5-t-Bu) Ph(2-Cl,4-CF₃,5-i-Pr)Ph(2-Cl,4-CF₃,5-c-Pr) Ph(2-Cl,4,5-di-CF₃) Ph(2-Cl,4-CF₃,5-C₂F₅)Ph(2-Cl,4-CF₃,5-CF₂CF₂H) Ph(2-Cl,4-CF₃,5-CF₂H) Ph(2-Cl,4-CF₃,5-OMe)Ph(2-Cl,4-CF₃,5-OCF₃) Ph(2-Cl,4-CF₃,5-OCHF₂) Ph(2-Cl,4-CF₃,5-OCF₂CF₂H)Ph(2-Cl,4-CF₃,5-OC₂F₅) Ph(2-Cl,4-CF₃,5-SO₂Me) Ph(2-Cl,4-CF₃,5-TMS)Ph(2-Cl,4-CF₃,5-CN) Ph(2-Cl,4-CF₂CF₃,5-Cl) Ph(2-Cl,4-CF₂CF₃,5-F)Ph(2-Cl,4-CF₂CF₃,5-Br) Ph(2-Cl,4-CF₂CF₃,54) Ph(2-Cl,4-CF₂CF₃,5-Me)Ph(2-Cl,4-CF₂CF₃,5-Et) Ph(2-Cl,4-CF₂CF₃,5-n-Pr) Ph(2-Cl,4-CF₂CF₃,5-t-Bu)Ph(2-Cl,4-CF₂CF₃,5-i-Pr) Ph(2-Cl,4-CF₂CF₃,5-c-Pr)Ph(2-Cl,4-C₂F₅CF₃,5-CF₃) Ph(2-Cl,4,5-di-C₂F₅)Ph(2-Cl,4-CF₂CF₃,5-CF₂CF₂H) Ph(2-Cl,4-CF₂CF₃,5-CF₂H)Ph(2-Cl,4-CF₂CF₃,5-OMe) Ph(2-Cl,4-CF₂CF₃,5-OCF₃)Ph(2-Cl,4-CF₂CF₃,5-OCHF₂) Ph(2-Cl,4-CF₂CF₃,5- OCF₂CF₂H)Ph(2-Cl,4-CF₂CF₃,5-OC₂F₅) Ph(2-Cl,4-CF₂CF₃,5-SO₂Me)Ph(2-Cl,4-CF₂CF₃,5-TMS) Ph(2-Cl,4-CF₂CF₃,5-CN) Ph(2-Cl,4-CF₂CF₂H,5-Cl)Ph(2-Cl,4-CF₂CF₂H,5-F) Ph(2-Cl,4-CF₂CF₂H,5-Br) Ph(2-Cl,4-CF₂CF₂H,5-I)Ph(2-Cl,4-CF₂CF₂H,5-Me) Ph(2-Cl,4-CF₂CF₂H,5-Et)Ph(2-Cl,4-CF₂CF₂H,5-n-Pr) Ph(2-Cl,4-CF₂CF₂H,5-t-Bu)Ph(2-Cl,4-CF₂CF₂H,5-i-Pr) Ph(2-Cl,4-CF₂CF₂H,5-c-Pr)Ph(2-Cl,4-CF₂CF₂CF₃H,5-CF₃) Ph(2-Cl,4-CF₂CF₂H,5-C₂F₅)Ph(2-Cl,4,5-di-CF₂CF₂H) Ph(2-Cl,4-CF₂CF₂H,5-CF₂H)Ph(2-Cl,4-CF₂CF₂H,5-OMe) Ph(2-Cl,4-CF₂CF₂H,5-OCF₃)Ph(2-Cl,4-CF₂CF₂H,5-OCHF₂) Ph(2-Cl,4-CF₂CF₂H,5- OCF₂CF₂H)Ph(2-Cl,4-CF₂CF₂H,5-OC₂F₅) Ph(2-Cl,4-CF₂CF₂H,5-SO₂Me)Ph(2-Cl,4-CF₂CF₂H,5-TMS) Ph(2-Cl,4-CF₂CF₂H,5-CN) Ph(2-Cl,4-CF₂H,5-Cl)Ph(2-Cl,4-CF₂H,5-F) Ph(2-Cl,4-CF₂H,5-Br) Ph(2-Cl,4-CF₂H,5-I)Ph(2-Cl,4-CF₂H,5-Me) Ph(2-Cl,4-CF₂H,5-Et) Ph(2-Cl,4-CF₂H,5-n-Pr)Ph(2-Cl,4-CF₂H,5-t-Bu) Ph(2-Cl,4-CF₂H,5-i-Pr) Ph(2-Cl,4-CF₂H,5-c-Pr)Ph(2-Cl,4-CF₂H,5-CF₃) Ph(2-Cl,4-CF₂H,5-C₂F₅) Ph(2-Cl,4-CF₂H,5-CF₂CF₂H)Ph(2-Cl,4,5-di-CF₂H) Ph(2-Cl,4-CF₂H,5-OMe) Ph(2-Cl,4-CF₂H,5-OCF₃)Ph(2-Cl,4-CF₂H,5-OCHF₂) Ph(2-Cl,4-CF₂H,5-OCF₂CF₂H)Ph(2-Cl,4-CF₂H,5-OC₂F₅) Ph(2-Cl,4-CF₂H,5-SO₂Me) Ph(2-Cl,4-CF₂H,5-TMS)Ph(2-Cl,4-CF₂H,5-CN) Ph(2-Cl,4-OMe,5-Cl) Ph(2-Cl,4-OMe,5-F)Ph(2-Cl,4-OMe,5-Br) Ph(2-Cl,4-OMe,5-I) Ph(2-Cl,4-OMe,5-Me)Ph(2-Cl,4-OMe,5-Et) Ph(2-Cl,4-OMe,5-n-Pr) Ph(2-Cl,4-OMe,5-t-Bu)Ph(2-Cl,4-OMe,5-i-Pr) Ph(2-Cl,4-OMe,5-c-Pr) Ph(2-Cl,4-OMeCF₃,5-CF₃)Ph(2-Cl,4-OMe,5-C₂F₅) Ph(2-Cl,4-OMe,5-CF₂CF₂H) Ph(2-Cl,4-OMe,5-CF₂H)Ph(2-Cl,4,5-di-OMe) Ph(2-Cl,4-OMe,5-OCF₃) Ph(2-Cl,4-OMe,5-OCHF₂)Ph(2-Cl,4-OMe,5-OCF₂CF₂H) Ph(2-Cl,4-OMe,5-OC₂F₅) Ph(2-Cl,4-OMe,5-SO₂Me)Ph(2-Cl,4-OMe,5-TMS) Ph(2-Cl,4-OMe,5-CN) Ph(2-Cl,4-OCF₃,5-Cl)Ph(2-Cl,4-OCF₃,5-F) Ph(2-Cl,4-OCF₃,5-Br) Ph(2-Cl,4-OCF₃,54)Ph(2-Cl,4-OCF₃,5-Me) Ph(2-Cl,4-OCF₃,5-Et) Ph(2-Cl,4-OCF₃,5-n-Pr)Ph(2-Cl,4-OCF₃,5-t-Bu) Ph(2-Cl,4-OCF₃,5-i-Pr) Ph(2-Cl,4-OCF₃,5-c-Pr)Ph(2-Cl,4-OCF₃,5-CF₃) Ph(2-Cl,4-OCF₃,5-C₂F₅) Ph(2-Cl,4-OCF₃,5-CF₂CF₂H)Ph(2-Cl,4-OCF₃,5-CF₂H) Ph(2-Cl,4-OCF₃,5-OMe) Ph(2-Cl,4,5-di-OCF₃)Ph(2-Cl,4-OCF₃,5-OCHF₂) Ph(2-Cl,4-OCF₃,5-OCF₂CF₂H)Ph(2-Cl,4-OCF₃,5-OC₂F₅) Ph(2-Cl,4-OCF₃,5-SO₂Me) Ph(2-Cl,4-OCF₃,5-TMS)Ph(2-Cl,4-OCF₃,5-CN) Ph(2-Cl,4-OCHF₂,5-Cl) Ph(2-Cl,4-OCHF₂,5-F)Ph(2-Cl,4-OCHF₂,5-Br) Ph(2-Cl,4-OCHF₂,5-I) Ph(2-Cl,4-OCHF₂,5-Me)Ph(2-Cl,4-OCHF₂,5-Et) Ph(2-Cl,4-OCHF₂,5-n-Pr) Ph(2-Cl,4-OCHF₂,5-t-Bu)Ph(2-Cl,4-OCHF₂,5-i-Pr) Ph(2-Cl,4-OCHF₂,5-c-Pr)Ph(2-Cl,4-OCHF₂CF₃,5-CF₃) Ph(2-Cl,4-OCF₂CF₃,5-C₂F₅)Ph(2-Cl,4-OCHF₂,5-CF₂CF₂H) Ph(2-Cl,4-OCHF₂,5-CF₂H)Ph(2-Cl,4-OCHF₂,5-OMe) Ph(2-Cl,4-OCHF₂,5-OCF₃) Ph(2-Cl,4,5-di-OCHF₂)Ph(2-Cl,4-OCHF₂,5-OCF₂CF₂H) Ph(2-Cl,4-OCHF₂,5-OC₂F₅)Ph(2-Cl,4-OCHF₂,5-SO₂Me) Ph(2-Cl,4-OCHF₂,5-TMS) Ph(2-Cl,4-OCHF₂,5-CN)Ph(2-Cl,4-OCF₂CF₂H,5-Cl) Ph(2-Cl,4-OCF₂CF₂H,5-F)Ph(2-Cl,4-OCF₂CF₂H,5-Br) Ph(2-Cl,4-OCF₂CF₂H,5-I)Ph(2-Cl,4-OCF₂CF₂H,5-Me) Ph(2-Cl,4-OCF₂CF₂H,5-Et)Ph(2-Cl,4-OCF₂CF₂H,5-n-Pr) Ph(2-Cl,4-OCF₂CF₂H,5-t-Bu)Ph(2-Cl,4-OCF₂CF₂H,5-i-Pr) Ph(2-Cl,4-OCF₂CF₂H,5-c-Pr)Ph(2-Cl,4-OCF₂CF₂CF₃H,5- CF₃) Ph(2-Cl,4-OCF₂CF₂H,5-C₂F₅)Ph(2-Cl,4-OCF₂CF₂H,5- CF₂CF₂H) Ph(2-Cl,4-OCF₂CF₂H,5-CF₂H)Ph(2-Cl,4-OCF₂CF₂H,5-OMe) Ph(2-Cl,4-OCF₂CF₂H,5-OCF₃)Ph(2-Cl,4-OCF₂CF₂H,5-OCHF₂) Ph(2-Cl,4,5-di-OCF₂CF₂H)Ph(2-Cl,4-OCF₂CF₂H,5-OC₂F₅) Ph(2-Cl,4-OCF₂CF₂H,5-SO₂Me)Ph(2-Cl,4-OCF₂CF₂H,5-TMS) Ph(2-Cl,4-OCF₂CF₂H,5-CN)Ph(2-Cl,4-OCF₂CF₃,5-Cl) Ph(2-Cl,4-OCF₂CF₃,5-F) Ph(2-Cl,4-OCF₂CF₃,5-Br)Ph(2-Cl,4-OCF₂CF₃,5-I) Ph(2-Cl,4-OCF₂CF₃,5-Me) Ph(2-Cl,4-OCF₂CF₃,5-Et)Ph(2-Cl,4-OCF₂CF₃,5-n-Pr) Ph(2-Cl,4-OCF₂CF₃,5-t-Bu)Ph(2-Cl,4-OCF₂CF₃,5-i-Pr) Ph(2-Cl,4-OCF₂CF₃,5-c-Pr)Ph(2-Cl,4-OC₂F₅CF₃,5-CF₃) Ph(2-Cl,4-OCF₂CF₃,5- CF₂CF₂H)Ph(2-Cl,4-OCF₂CF₃,5-CF₂H) Ph(2-Cl,4-OCF₂CF₃,5-OMe)Ph(2-Cl,4-OCF₂CF₃,5-OCF₃) Ph(2-Cl,4-OCF₂CF₃,5-OCHF₂)Ph(2-Cl,4-OCF₂CF₃,5- OCF₂CF₂H) Ph(2-Cl,4,5-di-OC₂F₅)Ph(2-Cl,4-OCF₂CF₃,5-SO₂Me) Ph(2-Cl,4-OCF₂CF₃,5-TMS)Ph(2-Cl,4-OCF₂CF₃,5-CN) Ph(2-Cl,4-SO₂Me,5-Cl) Ph(2-Cl,4-SO₂Me,5-F)Ph(2-Cl,4-SO₂Me,5-Br) Ph(2-Cl,4-SO₂Me,5-I) Ph(2-Cl,4-SO₂Me,5-Me)Ph(2-Cl,4-SO₂Me,5-Et) Ph(2-Cl,4-SO₂Me,5-n-Pr) Ph(2-Cl,4-SO₂Me,5-t-Bu)Ph(2-Cl,4-SO₂Me,5-i-Pr) Ph(2-Cl,4-SO₂Me,5-c-Pr)Ph(2-Cl,4-SO₂MeCF₃,5-CF₃) Ph(2-Cl,4-SO₂Me,5-C₂F₅)Ph(2-Cl,4-SO₂Me,5-CF₂CF₂H) Ph(2-Cl,4-SO₂Me,5-CF₂H)Ph(2-Cl,4-SO₂Me,5-OMe) Ph(2-Cl,4-SO₂Me,5-OCF₃) Ph(2-Cl,4-SO₂Me,5-OCHF₂)Ph(2-Cl,4-SO₂Me,5-OCF₂CF₂H) Ph(2-Cl,4-SO₂Me,5-OC₂F₅)Ph(2-Cl,4,5-di-SO₂Me) Ph(2-Cl,4-SO₂Me,5-TMS) Ph(2-Cl,4-SO₂Me,5-CN)Ph(2-Cl,4-TMS,5-Cl) Ph(2-Cl,4-TMS,5-F) Ph(2-Cl,4-TMS,5-Br)Ph(2-Cl,4-TMS,5-I) Ph(2-Cl,4-TMS,5-Me) Ph(2-Cl,4-TMS,5-Et)Ph(2-Cl,4-TMS,5-n-Pr) Ph(2-Cl,4-TMS,5-t-Bu) Ph(2-Cl,4-TMS,5-i-Pr)Ph(2-Cl,4-TMS,5-c-Pr) Ph(2-Cl,4-TMS,5-CF₃) Ph(2-Cl,4-TMS,5-C₂F₅)Ph(2-Cl,4-TMS,5-CF₂CF₂H) Ph(2-Cl,4-TMS,5-CF₂H) Ph(2-Cl,4-TMS,5-OMe)Ph(2-Cl,4-TMS,5-OCF₃) Ph(2-Cl,4-TMS,5-OCHF₂) Ph(2-Cl,4-TMS,5-OCF₂CF₂H)Ph(2-Cl,4-TMS,5-OC₂F₅) Ph(2-Cl,4-TMS,5-SO₂Me) Ph(2-Cl,4,5-di-TMS)Ph(2-Cl,4-TMS,5-CN) Ph(2-Cl,4-CN,5-Cl) Ph(2-Cl,4-CN,5-F)Ph(2-Cl,4-CN,5-Br) Ph(2-Cl,4-CN,5-I) Ph(2-Cl,4-CN,5-Me)Ph(2-Cl,4-CN,5-Et) Ph(2-Cl,4-CN,5-n-Pr) Ph(2-Cl,4-CN,5-t-Bu)Ph(2-Cl,4-CN,5-i-Pr) Ph(2-Cl,4-CN,5-c-Pr) Ph(2-Cl,4-CN,5-CF₃)Ph(2-Cl,4-CN,5-C₂F₅) Ph(2-Cl,4-CN,5-CF₂CF₂H) Ph(2-Cl,4-CN,5-CF₂H)Ph(2-Cl,4-CN,5-OMe) Ph(2-Cl,4-CN,5-OCF₃) Ph(2-Cl,4-CN,5-OCHF₂)Ph(2-Cl,4-CN,5-OCF₂CF₂H) Ph(2-Cl,4-CN,5-OC₂F₅) Ph(2-Cl,4-CN,5-SO₂Me)Ph(2-Cl,4-CN,5-TMS) Ph(2-Cl,4,5-di-CN) Ph(2-F,3,4-di-Cl)Ph(2-F,3-Cl,4-I) Ph(2-F,3-Cl,4-Me) Ph(2-F,3-Cl,4-Et) Ph(2-F,3-Cl,4-n-Pr)Ph(2-F,3-Cl,4-i-Pr) Ph(2-F,3-Cl,4-CF₃) Ph(2-F,3-Cl,4-C₂F₅)Ph(2-F,3-Cl,4-CF₂CF₂H) Ph(2-F,3-Cl,4-CF₂H) Ph(2-F,3-Cl,4-OMe)Ph(2-F,3-Cl,4-OCHF₂) Ph(2-F,3-Cl,4-OCF₂CF₂H) Ph(2-F,3-Cl,4-OC₂F₅)Ph(2,3,4-tri-F) Ph(2-F,3-F,4-Br) Ph(2-F,3-F,4-I) Ph(2-F,3-F,4-Et)Ph(2-F,3-F,4-n-Pr) Ph(2-F,3-F,4-t-Bu) Ph(2-F,3-F,4-i-Pr)Ph(2-F,3-F,4-CF₃) Ph(2-F,3-F,4-C₂F₅) Ph(2-F,3-F,4-CF₂CF₂H)Ph(2-F,3-F,4-CF₂H) Ph(2-F,3-F,4-OMe) Ph(2-F,3-F,4-OCHF₂)Ph(2-F,3-F,4-OCF₂CF₂H) Ph(2-F,3-F,4-OC₂F₅) Ph(2-F,3-Br,4-Cl)Ph(2-F,3,4-di-Br) Ph(2-F,3-Br,4-I) Ph(2-F,3-Br,4-Me) Ph(2-F,3-Br,4-Et)Ph(2-F,3-Br,4-n-Pr) Ph(2-F,3-Br,4-t-Bu) Ph(2-F,3-Br,4-i-Pr)Ph(2-F,3-Br,4-CF₃) Ph(2-F,3-Br,4-C₂F₅) Ph(2-F,3-Br,4-CF₂CF₂H)Ph(2-F,3-Br,4-CF₂H) Ph(2-F,3-Br,4-OMe) Ph(2-F,3-Br,4-OCF₂CF₂H)Ph(2-F,3-Br,4-OC₂F5) Ph(2-F,3-I,4-Cl) Ph(2-F,3-I,4-F) Ph(2-F,3-I,4-Br)Ph(2-F,3,4-di-I) Ph(2-F,3-I,4-Me) Ph(2-F,3-I,4-Et) Ph(2-F,3-I,4-n-Pr)Ph(2-F,3-I,4-t-Bu) Ph(2-F,3-I,4-i-Pr) Ph(2-F,3-I,4-c-Pr)Ph(2-F,3-I,4-CF₃) Ph(2-F,3-I,4-C₂F₅) Ph(2-F,3-I,4-CF₂CF₂H)Ph(2-F,3-I,4-CF₂H) Ph(2-F,3-I,4-OMe) Ph(2-F,3-I,4-OCF₃)Ph(2-F,3-I,4-OCHF₂) Ph(2-F,3-I,4-OCF₂CF₂H) Ph(2-F,3-I,4-OC₂F₅)Ph(2-F,3-I,4-SO₂Me) Ph(2-F,3-I,4-TMS) Ph(2-F,3-I,4-CN) Ph(2-F,3-Me,4-I)Ph(2-F,3,4-di-Me) Ph(2-F,3-Me,4-Et) Ph(2-F,3-Me,4-n-Pr)Ph(2-F,3-Me,4-i-Pr) Ph(2-F,3-Me,4-c-Pr) Ph(2-F,3-Me,4-C₂F₅)Ph(2-F,3-Me,4-CF₂CF₂H) Ph(2-F,3-Me,4-CF₂H) Ph(2-F,3-Me,4-OMe)Ph(2-F,3-Me,4-OCF₂CF₂H) Ph(2-F,3-Me,4-OC₂F₅) Ph(2-F,3-Et,4-Cl)Ph(2-F,3-Et,4-F) Ph(2-F,3-Et,4-Br) Ph(2-F,3-Et,4-I) Ph(2-F,3-Et,4-Me)Ph(2-F,3,4-di-Et) Ph(2-F,3-Et,4-n-Pr) Ph(2-F,3-Et,4-t-Bu)Ph(2-F,3-Et,4-i-Pr) Ph(2-F,3-Et,4-c-Pr) Ph(2-F,3-Et,4-CF₃)Ph(2-F,3-Et,4-C₂F₅) Ph(2-F,3-Et,4-CF₂CF₂H) Ph(2-F,3-Et,4-CF₂H)Ph(2-F,3-Et,4-OMe) Ph(2-F,3-Et,4-OCF₃) Ph(2-F,3-Et,4-OCHF₂)Ph(2-F,3-Et,4-OCF₂CF₂H) Ph(2-F,3-Et,4-OC₂F₅) Ph(2-F,3-Et,4-SO₂Me)Ph(2-F,3-Et,4-TMS) Ph(2-F,3-Et,4-CN) Ph(2-F,3-n-Pr,4-Cl)Ph(2-F,3-n-Pr,4-F) Ph(2-F,3-n-Pr,4-Br) Ph(2-F,3-n-Pr,4-I)Ph(2-F,3-n-Pr,4-Me) Ph(2-F,3-n-Pr,4-Et) Ph(2-F,3,4-di-n-Pr)Ph(2-F,3-n-Pr,4-t-Bu) Ph(2-F,3-n-Pr,4-i-Pr) Ph(2-F,3-n-Pr,4-c-Pr)Ph(2-F,3-n-Pr,4-CF₃) Ph(2-F,3-n-Pr,4-C₂F₅) Ph(2-F,3-n-Pr,4-CF₂CF₂H)Ph(2-F,3-n-Pr,4-CF₂H) Ph(2-F,3-n-Pr,4-OMe) Ph(2-F,3-n-Pr,4-OCF₃)Ph(2-F,3-n-Pr,4-OCHF₂) Ph(2-F,3-n-Pr,4-OCF₂CF₂H) Ph(2-F,3-n-Pr,4-OC₂F₅)Ph(2-F,3-n-Pr,4-SO₂Me) Ph(2-F,3-n-Pr,4-TMS) Ph(2-F,3-n-Pr,4-CN)Ph(2-F,3-t-Bu,4-I) Ph(2-F,3-t-Bu,4-Et) Ph(2-F,3-t-Bu,4-n-Pr)Ph(2-F,3,4-di-t-Bu) Ph(2-F,3-t-Bu,4-i-Pr) Ph(2-F,3-t-Bu,4-C₂F₅)Ph(2-F,3-t-Bu,4-CF₂CF₂H) Ph(2-F,3-t-Bu,4-CF₂H) Ph(2-F,3-t-Bu,4-OMe)Ph(2-F,3-t-Bu,4-OCF₂CF₂H) Ph(2-F,3-t-Bu,4-OC₂F₅) Ph(2-F,3-i-Pr,4-Cl)Ph(2-F,3-i-Pr,4-F) Ph(2-F,3-i-Pr,4-Br) Ph(2-F,3-i-Pr,4-I)Ph(2-F,3-i-Pr,4-Me) Ph(2-F,3-i-Pr,4-Et) Ph(2-F,3-i-Pr,4-n-Pr)Ph(2-F,3-i-Pr,4-t-Bu) Ph(2-F,3,4-di-i-Pr) Ph(2-F,3-i-Pr,4-c-Pr)Ph(2-F,3-i-Pr,4-CF₃) Ph(2-F,3-i-Pr,4-C₂F₅) Ph(2-F,3-i-Pr,4-CF₂CF₂H)Ph(2-F,3-i-Pr,4-CF₂H) Ph(2-F,3-i-Pr,4-OMe) Ph(2-F,3-i-Pr,4-OCF₃)Ph(2-F,3-i-Pr,4-OCHF₂) Ph(2-F,3-i-Pr,4-OCF₂CF₂H) Ph(2-F,3-i-Pr,4-OC₂F₅)Ph(2-F,3-i-Pr,4-SO₂Me) Ph(2-F,3-i-Pr,4-TMS) Ph(2-F,3-i-Pr,4-CN)Ph(2-F,3-c-Pr,4-I) Ph(2-F,3-c-Pr,4-Et) Ph(2-F,3-c-Pr,4-n-Pr)Ph(2-F,3-c-Pr,4-i-Pr) Ph(2-F,3-c-Pr,4-C₂F₅) Ph(2-F,3-c-Pr,4-CF₂CF₂H)Ph(2-F,3-c-Pr,4-CF₂H) Ph(2-F,3-c-Pr,4-OMe) Ph(2-F,3-c-Pr,4-OCF₂CF₂H)Ph(2-F,3-c-Pr,4-OC₂F₅) Ph(2-F,3-CF₃,4-I) Ph(2-F,3-CF₃,4-Et)Ph(2-F,3-CF₃,4-n-Pr) Ph(2-F,3-CF₃,4-i-Pr) Ph(2-F,3,4-di-CF₃)Ph(2-F,3-CF₃,4-C₂F₅) Ph(2-F,3-CF₃,4-CF₂CF₂H) Ph(2-F,3-CF₃,4-CF₂H)Ph(2-F,3-CF₃,4-OMe) Ph(2-F,3-CF₃,4-OCF₃) Ph(2-F,3-CF₃,4-OCHF₂)Ph(2-F,3-CF₃,4-OCF₂CF₂H) Ph(2-F,3-CF₃,4-OC₂F₅) Ph(2-F,3-CF₃,4-TMS)Ph(2-F,3-CF₃,4-CN) Ph(2-F,3-C₂F₅,4-Cl) Ph(2-F,3-C₂F₅,4-F)Ph(2-F,3-C₂F₅,4-Br) Ph(2-F,3-C₂F₅,4-I) Ph(2-F,3-C₂F₅,4-Me)Ph(2-F,3-C₂F₅,4-Et) Ph(2-F,3-C₂F₅,4-n-Pr) Ph(2-F,3-C₂F₅,4-t-Bu)Ph(2-F,3-C₂F₅,4-i-Pr) Ph(2-F,3-C₂F₅,4-c-Pr) Ph(2-F,3-C₂F₅CF3,4-CF₃)Ph(2-F,3,4-di-C₂F₅) Ph(2-F,3-C₂F₅,4-CF₂CF₂H) Ph(2-F,3-C₂F₅,4-CF₂H)Ph(2-F,3-C₂F₅,4-OMe) Ph(2-F,3-C₂F₅,4-OCF₃) Ph(2-F,3-C₂F₅,4-OCHF₂)Ph(2-F,3-C₂F₅,4-OCF₂CF₂H) Ph(2-F,3-C₂F₅,4-OC₂F₅) Ph(2-F,3-C₂F₅,4-SO₂Me)Ph(2-F,3-C₂F₅,4-TMS) Ph(2-F,3-C₂F₅,4-CN) Ph(2-F,3-CF₂CF₂H,4-Cl)Ph(2-F,3-CF₂CF₂H,4-F) Ph(2-F,3-CF₂CF₂H,4-Br) Ph(2-F,3-CF₂CF₂H,4-I)Ph(2-F,3-CF₂CF₂H,4-Me) Ph(2-F,3-CF₂CF₂H,4-Et) Ph(2-F,3-CF₂CF₂H,4-n-Pr)Ph(2-F,3-CF₂CF₂H,4-t-Bu) Ph(2-F,3-CF₂CF₂H,4-i-Pr)Ph(2-F,3-CF₂CF₂H,4-c-Pr) Ph(2-F,3-CF₂CF₂H,4-CF₃)Ph(2-F,3-CF₂CF₂H,4-C₂F₅) Ph(2-F,3,4-di-CF₂CF₂H) Ph(2-F,3-CF₂CF₂H,4-CF₂H)Ph(2-F,3-CF₂CF₂H,4-OMe) Ph(2-F,3-CF₂CF₂H,4-OCF₃)Ph(2-F,3-CF₂CF₂H,4-OCHF₂) Ph(2-F,3-CF₂CF₂H,4- OCF₂CF₂H)Ph(2-F,3-CF₂CF₂H,4-OC₂F₅) Ph(2-F,3-CF₂CF₂H,4-SO₂Me)Ph(2-F,3-CF₂CF₂H,4-TMS) Ph(2-F,3-CF₂CF₂H,4-CN) Ph(2-F,3-CF₂H,4-Cl)Ph(2-F,3-CF₂H,4-F) Ph(2-F,3-CF₂H,4-Br) Ph(2-F,3-CF₂H,4-I)Ph(2-F,3-CF₂H,4-Me) Ph(2-F,3-CF₂H,4-Et) Ph(2-F,3-CF₂H,4-n-Pr)Ph(2-F,3-CF₂H,4-t-Bu) Ph(2-F,3-CF₂H,4-i-Pr) Ph(2-F,3-CF₂H,4-c-Pr)Ph(2-F,3-CF₂H,4-CF₃) Ph(2-F,3-CF₂H,4-C₂F₅) Ph(2-F,3-CF₂H,4-CF₂CF₂H)Ph(2-F,3,4-di-CF₂H) Ph(2-F,3-CF₂H,4-OMe) Ph(2-F,3-CF₂H,4-OCF₃)Ph(2-F,3-CF₂H,4-OCHF₂) Ph(2-F,3-CF₂H,4-OCF₂CF₂H) Ph(2-F,3-CF₂H,4-OC₂F₅)Ph(2-F,3-CF₂H,4-SO₂Me) Ph(2-F,3-CF₂H,4-TMS) Ph(2-F,3-CF₂H,4-CN)Ph(2-F,3-OMe,4-Cl) Ph(2-F,3-OMe,4-F) Ph(2-F,3-OMe,4-Br)Ph(2-F,3-OMe,4-I) Ph(2-F,3-OMe,4-Me) Ph(2-F,3-OMe,4-Et)Ph(2-F,3-OMe,4-n-Pr) Ph(2-F,3-OMe,4-t-Bu) Ph(2-F,3-OMe,4-i-Pr)Ph(2-F,3-OMe,4-c-Pr) Ph(2-F,3-OMe,4-CF₃) Ph(2-F,3-OMe,4-C₂F₅)Ph(2-F,3-OMe,4-CF₂CF₂H) Ph(2-F,3-OMe,4-CF₂H) Ph(2-F,3,4-di-OMe)Ph(2-F,3-OMe,4-OCF₃) Ph(2-F,3-OMe,4-OCHF₂) Ph(2-F,3-OMe,4-OCF₂CF₂H)Ph(2-F,3-OMe,4-OC₂F₅) Ph(2-F,3-OMe,4-SO₂Me) Ph(2-F,3-OMe,4-TMS)Ph(2-F,3-OMe,4-CN) Ph(2-F,3-OCF₃,4-Cl) Ph(2-F,3-OCF₃,4-F)Ph(2-F,3-OCF₃,4-Br) Ph(2-F,3-OCF₃,4-I) Ph(2-F,3-OCF₃,4-Me)Ph(2-F,3-OCF₃,4-Et) Ph(2-F,3-OCF₃,4-n-Pr) Ph(2-F,3-OCF₃,4-t-Bu)Ph(2-F,3-OCF₃,4-i-Pr) Ph(2-F,3-OCF₃,4-CF₃) Ph(2-F,3-OCF₃,4-C₂F₅)Ph(2-F,3-OCF₃,4-CF₂CF₂H) Ph(2-F,3-OCF₃,4-CF₂H) Ph(2-F,3-OCF₃,4-OMe)Ph(2-F,3,4-di-OCF₃) Ph(2-F,3-OCF₃,4-OCF₂CF₂H) Ph(2-F,3-OCF₃,4-OC₂F₅)Ph(2-F,3-OCHF₂,4-Cl) Ph(2-F,3-OCHF₂,4-F) Ph(2-F,3-OCHF₂,4-Br)Ph(2-F,3-OCHF₂,4-I) Ph(2-F,3-OCHF₂,4-Me) Ph(2-F,3-OCHF₂,4-Et)Ph(2-F,3-OCHF₂,4-n-Pr) Ph(2-F,3-OCHF₂,4-t-Bu) Ph(2-F,3-OCHF₂,4-i-Pr)Ph(2-F,3-OCHF₂,4-c-Pr) Ph(2-F,3-OCHF₂CF₃,4-CF₃) Ph(2-F,3-OC₂F₅,4-C₂F₅)Ph(2-F,3-OCHF₂,4-CF₂CF₂H) Ph(2-F,3-OCHF₂,4-CF₂H) Ph(2-F,3-OCHF₂,4-OMe)Ph(2-F,3-OCHF₂,4-OCF₃) Ph(2-F,3,4-di-OCHF₂) Ph(2-F,3-OCHF₂,4-OCF₂CF₂H)Ph(2-F,3-OCHF₂,4-OC₂F₅) Ph(2-F,3-OCHF₂,4-SO₂Me) Ph(2-F,3-OCHF₂,4-TMS)Ph(2-F,3-OCHF₂,4-CN) Ph(2-F,3-OCF₂CF₂H,4-Cl) Ph(2-F,3-OCF₂CF₂H,4-F)Ph(2-F,3-OCF₂CF₂H,4-Br) Ph(2-F,3-OCF₂CF₂H,4-I) Ph(2-F,3-OCF₂CF₂H,4-Me)Ph(2-F,3-OCF₂CF₂H,4-Et) Ph(2-F,3-OCF₂CF₂H,4-n-Pr)Ph(2-F,3-OCF₂CF₂H,4-t-Bu) Ph(2-F,3-OCF₂CF₂H,4-i-Pr)Ph(2-F,3-OCF₂CF₂H,4-c-Pr) Ph(2-F,3-OCF₂CF₂H,4-CF₃)Ph(2-F,3-OCF₂CF₂H,4-C₂F₅) Ph(2-F,3-OCF₂CF₂H,4- CF₂CF₂H)Ph(2-F,3-OCF₂CF₂H,4-CF₂H) Ph(2-F,3-OCF₂CF₂H,4-OMe)Ph(2-F,3-OCF₂CF₂H,4-OCF₃) Ph(2-F,3-OCF₂CF₂H,4-OCHF₂)Ph(2-F,3,4-di-OCF₂CF₂H) Ph(2-F,3-OCF₂CF₂H,4-OC₂F₅)Ph(2-F,3-OCF₂CF₂H,4-SO₂Me) Ph(2-F,3-OCF₂CF₂H,4-TMS)Ph(2-F,3-OCF₂CF₂H,4-CN) Ph(2-F,3-OC₂F₅,4-Cl) Ph(2-F,3-OC₂F₅,4-F)Ph(2-F,3-OC₂F₅,4-Br) Ph(2-F,3-OC₂F₅,4-I) Ph(2-F,3-OC₂F₅,4-Me)Ph(2-F,3-OC₂F₅,4-Et) Ph(2-F,3-OC₂F₅,4-n-Pr) Ph(2-F,3-OC₂F₅,4-t-Bu)Ph(2-F,3-OC₂F₅,4-i-Pr) Ph(2-F,3-OC₂F₅,4-c-Pr) Ph(2-F,3-OC₂F₅CF₃,4-CF₃)Ph(2-F,3-OC₂F₅,4-CF₂CF₂H) Ph(2-F,3-OC₂F₅,4-CF₂H) Ph(2-F,3-OC₂F₅,4-OMe)Ph(2-F,3-OC₂F₅,4-OCF₃) Ph(2-F,3-OC₂F₅,4-OCHF₂)Ph(2-F,3-OC₂F₅,4-OCF₂CF₂H) Ph(2-F,3,4-di-OC₂F₅) Ph(2-F,3-OC₂F₅,4-SO₂Me)Ph(2-F,3-OC₂F₅,4-TMS) Ph(2-F,3-OC₂F₅,4-CN) Ph(2-F,3-SO₂Me,4-Cl)Ph(2-F,3-SO₂Me,4-Br) Ph(2-F,3-SO₂Me,4-I) Ph(2-F,3-SO₂Me,4-Me)Ph(2-F,3-SO₂Me,4-Et) Ph(2-F,3-SO₂Me,4-n-Pr) Ph(2-F,3-SO₂Me,4-t-Bu)Ph(2-F,3-SO₂Me,4-i-Pr) Ph(2-F,3-SO₂MeCF₃,4-CF₃) Ph(2-F,3-SO₂Me,4-C₂F₅)Ph(2-F,3-SO₂Me,4-CF₂CF₂H) Ph(2-F,3-SO₂Me,4-CF₂H) Ph(2-F,3-SO₂Me,4-OMe)Ph(2-F,3-SO₂Me,4-OCHF₂) Ph(2-F,3-SO₂Me,4-OCF₂CF₂H)Ph(2-F,3-SO₂Me,4-OC₂F₅) Ph(2-F,3-TMS,4-Cl) Ph(2-F,3-TMS,4-F)Ph(2-F,3-TMS,4-Br) Ph(2-F,3-TMS,4-I) Ph(2-F,3-TMS,4-Me)Ph(2-F,3-TMS,4-Et) Ph(2-F,3-TMS,4-n-Pr) Ph(2-F,3-TMS,4-t-Bu)Ph(2-F,3-TMS,4-i-Pr) Ph(2-F,3-TMS,4-c-Pr) Ph(2-F,3-TMS,4-CF₃)Ph(2-F,3-TMS,4-C₂F₅) Ph(2-F,3-TMS,4-CF₂CF₂H) Ph(2-F,3-TMS,4-CF₂H)Ph(2-F,3-TMS,4-OMe) Ph(2-F,3-TMS,4-OCF₃) Ph(2-F,3-TMS,4-OCHF₂)Ph(2-F,3-TMS,4-OCF₂CF₂H) Ph(2-F,3-TMS,4-OC₂F₅) Ph(2-F,3-TMS,4-SO₂Me)Ph(2-F,3,4-di-TMS) Ph(2-F,3-TMS,4-CN) Ph(2-F,3-CN,4-F) Ph(2-F,3-CN,4-Br)Ph(2-F,3-CN,4-I) Ph(2-F,3-CN,4-Me) Ph(2-F,3-CN,4-Et) Ph(2-F,3-CN,4-n-Pr)Ph(2-F,3-CN,4-t-Bu) Ph(2-F,3-CN,4-i-Pr) Ph(2-F,3-CN,4-c-Pr)Ph(2-F,3-CN,4-CF₃) Ph(2-F,3-CN,4-C₂F₅) Ph(2-F,3-CN,4-CF₂CF₂H)Ph(2-F,3-CN,4-CF₂H) Ph(2-F,3-CN,4-OMe) Ph(2-F,3-CN,4-OCF₃)Ph(2-F,3-CN,4-OCHF₂) Ph(2-F,3-CN,4-OCF₂CF₂H) Ph(2-F,3-CN,4-OC₂F₅)Ph(2-F,3-CN,4-TMS) Ph(2-F,3,4-di-CN) Ph(2-F,3,5-di-Cl) Ph(2-F,3-Cl,5-F)Ph(2-F,3-Cl,5-Br) Ph(2-F,3-Cl,5-I) Ph(2-F,3-Cl,5-Me) Ph(2-F,3-Cl,5-Et)Ph(2-F,3-Cl,5-n-Pr) Ph(2-F,3-Cl,5-t-Bu) Ph(2-F,3-Cl,5-i-Pr)Ph(2-F,3-Cl,5-c-Pr) Ph(2-F,3-Cl,5-CF₃) Ph(2-F,3-Cl,5-C₂F₅)Ph(2-F,3-Cl,5-CF₂CF₂H) Ph(2-F,3-Cl,5-CF₂H) Ph(2-F,3-Cl,5-OMe)Ph(2-F,3-Cl,5-OCF₃) Ph(2-F,3-Cl,5-OCHF₂) Ph(2-F,3-Cl,5-OCF₂CF₂H)Ph(2-F,3-Cl,5-OC₂F₅) Ph(2-F,3-Cl,5-SO₂Me) Ph(2-F,3-Cl,5-TMS)Ph(2-F,3-Cl,5-CN) Ph(2-F,3-F,5-Cl) Ph(2,3,5-tri-F) Ph(2-F,3-F,5-Br)Ph(2-F,3-F,5-I) Ph(2-F,3-F,5-Me) Ph(2-F,3-F,5-Et) Ph(2-F,3-F,5-n-Pr)Ph(2-F,3-F,5-t-Bu) Ph(2-F,3-F,5-i-Pr) Ph(2-F,3-F,5-c-Pr)Ph(2-F,3-F,5-CF₃) Ph(2-F,3-F,5-C₂F₅) Ph(2-F,3-F,5-CF₂CF₂H)Ph(2-F,3-F,5-CF₂H) Ph(2-F,3-F,5-OMe) Ph(2-F,3-F,5-OCF₃)Ph(2-F,3-F,5-OCHF₂) Ph(2-F,3-F,5-OCF₂CF₂H) Ph(2-F,3-F,5-OC₂F₅)Ph(2-F,3-F,5-SO₂Me) Ph(2-F,3-F,5-TMS) Ph(2-F,3-F,5-CN) Ph(2-F,3-Br,5-Cl)Ph(2-F,3-Br,5-F) Ph(2-F,3,5-di-Br) Ph(2-F,3-Br,5-I) Ph(2-F,3-Br,5-Me)Ph(2-F,3-Br,5-Et) Ph(2-F,3-Br,5-n-Pr) Ph(2-F,3-Br,5-t-Bu)Ph(2-F,3-Br,5-i-Pr) Ph(2-F,3-Br,5-c-Pr) Ph(2-F,3-Br,5-CF₃)Ph(2-F,3-Br,5-C₂F₅) Ph(2-F,3-Br,5-CF₂CF₂H) Ph(2-F,3-Br,5-CF₂H)Ph(2-F,3-Br,5-OMe) Ph(2-F,3-Br,5-OCF₃) Ph(2-F,3-Br,5-OCHF₂)Ph(2-F,3-Br,5-OCF₂CF₂H) Ph(2-F,3-Br,5-OC₂F₅) Ph(2-F,3-Br,5-SO₂Me)Ph(2-F,3-Br,5-TMS) Ph(2-F,3-Br,5-CN) Ph(2-F,3-I,5-Cl) Ph(2-F,3-I,5-F)Ph(2-F,3-I,5-Br) Ph(2-F,3,5-di-I) Ph(2-F,3-I,5-Me) Ph(2-F,3-I,5-Et)Ph(2-F,3-I,5-n-Pr) Ph(2-F,3-I,5-t-Bu) Ph(2-F,3-I,5-i-Pr)Ph(2-F,3-I,5-c-Pr) Ph(2-F,3-I,5-CF₃) Ph(2-F,3-I,5-C₂F₅)Ph(2-F,3-I,5-CF₂CF₂H) Ph(2-F,3-I,5-CF₂H) Ph(2-F,3-I,5-OMe)Ph(2-F,3-I,5-OCF₃) Ph(2-F,3-I,5-OCHF₂) Ph(2-F,3-I,5-OCF₂CF₂H)Ph(2-F,3-I,5-OC₂F₅) Ph(2-F,3-I,5-SO₂Me) Ph(2-F,3-I,5-TMS)Ph(2-F,3-I,5-CN) Ph(2-F,3-Me,5-Cl) Ph(2-F,3-Me,5-F) Ph(2-F,3-Me,5-Br)Ph(2-F,3-Me,5-I) Ph(2-F,3,5-di-Me) Ph(2-F,3-Me,5-Et) Ph(2-F,3-Me,5-n-Pr)Ph(2-F,3-Me,5-t-Bu) Ph(2-F,3-Me,5-i-Pr) Ph(2-F,3-Me,5-c-Pr)Ph(2-F,3-Me,5-CF₃) Ph(2-F,3-Me,5-C₂F₅) Ph(2-F,3-Me,5-CF₂CF₂H)Ph(2-F,3-Me,5-CF₂H) Ph(2-F,3-Me,5-OMe) Ph(2-F,3-Me,5-OCF₃)Ph(2-F,3-Me,5-OCHF₂) Ph(2-F,3-Me,5-OCF₂CF₂H) Ph(2-F,3-Me,5-OC₂F₅)Ph(2-F,3-Me,5-SO₂Me) Ph(2-F,3-Me,5-TMS) Ph(2-F,3-Me,5-CN)Ph(2-F,3-Et,5-Cl) Ph(2-F,3-Et,5-F) Ph(2-F,3-Et,5-Br) Ph(2-F,3-Et,5-I)Ph(2-F,3-Et,5-Me) Ph(2-F,3,5-di-Et) Ph(2-F,3-Et,5-n-Pr)Ph(2-F,3-Et,5-t-Bu) Ph(2-F,3-Et,5-i-Pr) Ph(2-F,3-Et,5-c-Pr)Ph(2-F,3-Et,5-CF₃) Ph(2-F,3-Et,5-C₂F₅) Ph(2-F,3-Et,5-CF₂CF₂H)Ph(2-F,3-Et,5-CF₂H) Ph(2-F,3-Et,5-OMe) Ph(2-F,3-Et,5-OCF₃)Ph(2-F,3-Et,5-OCHF₂) Ph(2-F,3-Et,5-OCF₂CF₂H) Ph(2-F,3-Et,5-OC₂F₅)Ph(2-F,3-Et,5-SO₂Me) Ph(2-F,3-Et,5-TMS) Ph(2-F,3-Et,5-CN)Ph(2-F,3-n-Pr,5-Cl) Ph(2-F,3-n-Pr,5-F) Ph(2-F,3-n-Pr,5-Br)Ph(2-F,3-n-Pr,5-I) Ph(2-F,3-n-Pr,5-Me) Ph(2-F,3-n-Pr,5-Et)Ph(2-F,3,5-di-n-Pr) Ph(2-F,3-n-Pr,5-t-Bu) Ph(2-F,3-n-Pr,5-i-Pr)Ph(2-F,3-n-Pr,5-c-Pr) Ph(2-F,3-n-Pr,5-CF₃) Ph(2-F,3-n-Pr,5-C₂F₅)Ph(2-F,3-n-Pr,5-CF₂CF₂H) Ph(2-F,3-n-Pr,5-CF₂H) Ph(2-F,3-n-Pr,5-OMe)Ph(2-F,3-n-Pr,5-OCF₃) Ph(2-F,3-n-Pr,5-OCHF₂) Ph(2-F,3-n-Pr,5-OCF₂CF₂H)Ph(2-F,3-n-Pr,5-OC₂F₅) Ph(2-F,3-n-Pr,5-SO₂Me) Ph(2-F,3-n-Pr,5-TMS)Ph(2-F,3-n-Pr,5-CN) Ph(2-F,3-t-Bu,5-Cl) Ph(2-F,3-t-Bu,5-F)Ph(2-F,3-t-Bu,5-Br) Ph(2-F,3-t-Bu,5-I) Ph(2-F,3-t-Bu,5-Me)Ph(2-F,3-t-Bu,5-Et) Ph(2-F,3-t-Bu,5-n-Pr) Ph(2-F,3,5-di-t-Bu)Ph(2-F,3-t-Bu,5-i-Pr) Ph(2-F,3-t-Bu,5-c-Pr) Ph(2-F,3-t-Bu,5-CF₃)Ph(2-F,3-t-Bu,5-C₂F₅) Ph(2-F,3-t-Bu,5-CF₂CF₂H) Ph(2-F,3-t-Bu,5-CF₂H)Ph(2-F,3-t-Bu,5-OMe) Ph(2-F,3-t-Bu,5-OCF₃) Ph(2-F,3-t-Bu,5-OCHF₂)Ph(2-F,3-t-Bu,5-OCF₂CF₂H) Ph(2-F,3-t-Bu,5-OC₂F₅) Ph(2-F,3-t-Bu,5-SO₂Me)Ph(2-F,3-t-Bu,5-TMS) Ph(2-F,3-t-Bu,5-CN) Ph(2-F,3-i-Pr,5-Cl)Ph(2-F,3-i-Pr,5-F) Ph(2-F,3-i-Pr,5-Br) Ph(2-F,3-i-Pr,5-I)Ph(2-F,3-i-Pr,5-Me) Ph(2-F,3-i-Pr,5-Et) Ph(2-F,3-i-Pr,5-n-Pr)Ph(2-F,3-i-Pr,5-t-Bu) Ph(2-F,3,5-di-i-Pr) Ph(2-F,3-i-Pr,5-c-Pr)Ph(2-F,3-i-Pr,5-CF₃) Ph(2-F,3-i-Pr,5-C₂F₅) Ph(2-F,3-i-Pr,5-CF₂CF₂H)Ph(2-F,3-i-Pr,5-CF₂H) Ph(2-F,3-i-Pr,5-OMe) Ph(2-F,3-i-Pr,5-OCF₃)Ph(2-F,3-i-Pr,5-OCHF₂) Ph(2-F,3-i-Pr,5-OCF₂CF₂H) Ph(2-F,3-i-Pr,5-OC₂F₅)Ph(2-F,3-i-Pr,5-SO₂Me) Ph(2-F,3-i-Pr,5-TMS) Ph(2-F,3-i-Pr,5-CN)Ph(2-F,3-c-Pr,5-Cl) Ph(2-F,3-c-Pr,5-F) Ph(2-F,3-c-Pr,5-Br)Ph(2-F,3-c-Pr,5-I) Ph(2-F,3-c-Pr,5-Me) Ph(2-F,3-c-Pr,5-Et)Ph(2-F,3-c-Pr,5-n-Pr) Ph(2-F,3-c-Pr,5-t-Bu) Ph(2-F,3-c-Pr,5-i-Pr)Ph(2-F,3,5-di-c-Pr) Ph(2-F,3-c-Pr,5-CF₃) Ph(2-F,3-c-Pr,5-C₂F₅)Ph(2-F,3-c-Pr,5-CF₂CF₂H) Ph(2-F,3-c-Pr,5-CF₂H) Ph(2-F,3-c-Pr,5-OMe)Ph(2-F,3-c-Pr,5-OCF₃) Ph(2-F,3-c-Pr,5-OCHF₂) Ph(2-F,3-c-Pr,5-OCF₂CF₂H)Ph(2-F,3-c-Pr,5-OC₂F₅) Ph(2-F,3-c-Pr,5-SO₂Me) Ph(2-F,3-c-Pr,5-TMS)Ph(2-F,3-c-Pr,5-CN) Ph(2-F,3-CF3,5-Cl) Ph(2-F,3-CF3,5-F)Ph(2-F,3-CF3,5-Br) Ph(2-F,3-CF3,5-I) Ph(2-F,3-CF3,5-Me)Ph(2-F,3-CF3,5-Et) Ph(2-F,3-CF3,5-n-Pr) Ph(2-F,3-CF3,5-t-Bu)Ph(2-F,3-CF3,5-i-Pr) Ph(2-F,3-CF3,5-c-Pr) Ph(2-F,3,5-di-CF₃)Ph(2-F,3-CF₃,5-C₂F₅) Ph(2-F,3-CF₃,5-CF₂CF₂H) Ph(2-F,3-CF₃,5-CF₂H)Ph(2-F,3-CF₃,5-OMe) Ph(2-F,3-CF₃,5-OCF₃) Ph(2-F,3-CF₃,5-OCHF₂)Ph(2-F,3-CF₃,5-OCF₂CF₂H) Ph(2-F,3-CF₃,5-OC₂F₅) Ph(2-F,3-CF₃,5-SO₂Me)Ph(2-F,3-CF₃,5-TMS) Ph(2-F,3-CF₃,5-CN) Ph(2-F,3-C₂F₅,5-Cl)Ph(2-F,3-C₂F₅,5-F) Ph(2-F,3-C₂F₅,5-Br) Ph(2-F,3-C₂F₅,5-I)Ph(2-F,3-C₂F₅,5-Me) Ph(2-F,3-C₂F₅,5-Et) Ph(2-F,3-C₂F₅,5-n-Pr)Ph(2-F,3-C₂F₅,5-t-Bu) Ph(2-F,3-C₂F₅,5-i-Pr) Ph(2-F,3-C₂F₅,5-c-Pr)Ph(2-F,3-C₂F₅CF3,5-CF₃) Ph(2-F,3,5-di-C₂F₅) Ph(2-F,3-C₂F₅,5-CF₂CF₂H)Ph(2-F,3-C₂F₅,5-CF₂H) Ph(2-F,3-C₂F₅,5-OMe) Ph(2-F,3-C₂F₅,5-OCF₃)Ph(2-F,3-C₂F₅,5-OCHF₂) Ph(2-F,3-C₂F₅,5-OCF₂CF₂H) Ph(2-F,3-C₂F₅,5-OC₂F₅)Ph(2-F,3-C₂F₅,5-SO₂Me) Ph(2-F,3-C₂F₅,5-TMS) Ph(2-F,3-C₂F₅,5-CN)Ph(2-F,3-CF₂CF₂H,5-Cl) Ph(2-F,3-CF₂CF₂H,5-F) Ph(2-F,3-CF₂CF₂H,5-Br)Ph(2-F,3-CF₂CF₂H,54) Ph(2-F,3-CF₂CF₂H,5-Me) Ph(2-F,3-CF₂CF₂H,5-Et)Ph(2-F,3-CF₂CF₂H,5-n-Pr) Ph(2-F,3-CF₂CF₂H,5-t-Bu)Ph(2-F,3-CF₂CF₂H,5-i-Pr) Ph(2-F,3-CF₂CF₂H,5-c-Pr)Ph(2-F,3-CF₂CF₂H,5-CF₃) Ph(2-F,3-CF₂CF₂H,5-C₂F₅) Ph(2-F,3,5-di-CF₂CF₂H)Ph(2-F,3-CF₂CF₂H,5-CF₂H) Ph(2-F,3-CF₂CF₂H,5-OMe)Ph(2-F,3-CF₂CF₂H,5-OCF₃) Ph(2-F,3-CF₂CF₂H,5-OCHF₂) Ph(2-F,3-CF₂CF₂H,5-OCF₂CF₂H) Ph(2-F,3-CF₂CF₂H,5-OC₂F₅) Ph(2-F,3-CF₂CF₂H,5-SO₂Me)Ph(2-F,3-CF₂CF₂H,5-TMS) Ph(2-F,3-CF₂CF₂H,5-CN) Ph(2-F,3-CF₂H,5-Cl)Ph(2-F,3-CF₂H,5-F) Ph(2-F,3-CF₂H,5-Br) Ph(2-F,3-CF₂H,54)Ph(2-F,3-CF₂H,5-Me) Ph(2-F,3-CF₂H,5-Et) Ph(2-F,3-CF₂H,5-n-Pr)Ph(2-F,3-CF₂H,5-t-Bu) Ph(2-F,3-CF₂H,5-i-Pr) Ph(2-F,3-CF₂H,5-c-Pr)Ph(2-F,3-CF₂H,5-CF₃) Ph(2-F,3-CF₂H,5-C₂F₅) Ph(2-F,3-CF₂H,5-CF₂CF₂H)Ph(2-F,3,5-di-CF₂H) Ph(2-F,3-CF₂H,5-OMe) Ph(2-F,3-CF₂H,5-OCF₃)Ph(2-F,3-CF₂H,5-OCHF₂) Ph(2-F,3-CF₂H,5-OCF₂CF₂H) Ph(2-F,3-CF₂H,5-OC₂F₅)Ph(2-F,3-CF₂H,5-SO₂Me) Ph(2-F,3-CF₂H,5-TMS) Ph(2-F,3-CF₂H,5-CN)Ph(2-F,3-OMe,5-Cl) Ph(2-F,3-OMe,5-F) Ph(2-F,3-OMe,5-Br)Ph(2-F,3-OMe,5-I) Ph(2-F,3-OMe,5-Me) Ph(2-F,3-OMe,5-Et)Ph(2-F,3-OMe,5-n-Pr) Ph(2-F,3-OMe,5-t-Bu) Ph(2-F,3-OMe,5-i-Pr)Ph(2-F,3-OMe,5-c-Pr) Ph(2-F,3-OMe,5-CF₃) Ph(2-F,3-OMe,5-C₂F₅)Ph(2-F,3-OMe,5-CF₂CF₂H) Ph(2-F,3-OMe,5-CF₂H) Ph(2-F,3,5-di-OMe)Ph(2-F,3-OMe,5-OCF₃) Ph(2-F,3-OMe,5-OCHF₂) Ph(2-F,3-OMe,5-OCF₂CF₂H)Ph(2-F,3-OMe,5-OC₂F₅) Ph(2-F,3-OMe,5-SO₂Me) Ph(2-F,3-OMe,5-TMS)Ph(2-F,3-OMe,5-CN) Ph(2-F,3-OCF₃,5-Cl) Ph(2-F,3-OCF₃,5-F)Ph(2-F,3-OCF₃,5-Br) Ph(2-F,3-OCF₃,54) Ph(2-F,3-OCF₃,5-Me)Ph(2-F,3-OCF₃,5-Et) Ph(2-F,3-OCF₃,5-n-Pr) Ph(2-F,3-OCF₃,5-t-Bu)Ph(2-F,3-OCF₃,5-i-Pr) Ph(2-F,3-OCF₃,5-c-Pr) Ph(2-F,3-OCF₃,5-CF₃)Ph(2-F,3-OCF₃,5-C₂F₅) Ph(2-F,3-OCF₃,5-CF₂CF₂H) Ph(2-F,3-OCF₃,5-CF₂H)Ph(2-F,3-OCF₃,5-OMe) Ph(2-F,3,5-di-OCF₃) Ph(2-F,3-OCF₃,5-OCHF₂)Ph(2-F,3-OCF₃,5-OCF₂CF₂H) Ph(2-F,3-OCF₃,5-OC₂F₅) Ph(2-F,3-OCF₃,5-SO₂Me)Ph(2-F,3-OCF₃,5-TMS) Ph(2-F,3-OCF₃,5-CN) Ph(2-F,3-OCHF₂,5-Cl)Ph(2-F,3-OCHF₂,5-F) Ph(2-F,3-OCHF₂,5-Br) Ph(2-F,3-OCHF₂,5-I)Ph(2-F,3-OCHF₂,5-Me) Ph(2-F,3-OCHF₂,5-Et) Ph(2-F,3-OCHF₂,5-n-Pr)Ph(2-F,3-OCHF₂,5-t-Bu) Ph(2-F,3-OCHF₂,5-i-Pr) Ph(2-F,3-OCHF₂,5-c-Pr)Ph(2-F,3-OCHF₂CF₃,5-CF₃) Ph(2-F,3-OC₂F₅,5-C₂F₅)Ph(2-F,3-OCHF₂,5-CF₂CF₂H) Ph(2-F,3-OCHF₂,5-CF₂H) Ph(2-F,3-OCHF₂,5-OMe)Ph(2-F,3-OCHF₂,5-OCF₃) Ph(2-F,3,5-di-OCHF₂) Ph(2-F,3-OCHF₂,5-OCF₂CF₂H)Ph(2-F,3-OCHF₂,5-OC₂F₅) Ph(2-F,3-OCHF₂,5-SO₂Me) Ph(2-F,3-OCHF₂,5-TMS)Ph(2-F,3-OCHF₂,5-CN) Ph(2-F,3-OCF₂CF₂H,5-Cl) Ph(2-F,3-OCF₂CF₂H,5-F)Ph(2-F,3-OCF₂CF₂H,5-Br) Ph(2-F,3-OCF₂CF₂H,5-I) Ph(2-F,3-OCF₂CF₂H,5-Me)Ph(2-F,3-OCF₂CF₂H,5-Et) Ph(2-F,3-OCF₂CF₂H,5-n-Pr)Ph(2-F,3-OCF₂CF₂H,5-t-Bu) Ph(2-F,3-OCF₂CF₂H,5-i-Pr)Ph(2-F,3-OCF₂CF₂H,5-c-Pr) Ph(2-F,3-OCF₂CF₂H,5-CF₃)Ph(2-F,3-OCF₂CF₂H,5-C₂F₅) Ph(2-F,3-OCF₂CF₂H,5- CF₂CF₂H)Ph(2-F,3-OCF₂CF₂H,5-CF₂H) Ph(2-F,3-OCF₂CF₂H,5-OMe)Ph(2-F,3-OCF₂CF₂H,5-OCF₃) Ph(2-F,3-OCF₂CF₂H,5-OCHF₂)Ph(2-F,3,5-di-OCF₂CF₂H) Ph(2-F,3-OCF₂CF₂H,5-OC₂F₅)Ph(2-F,3-OCF₂CF₂H,5-SO₂Me) Ph(2-F,3-OCF₂CF₂H,5-TMS)Ph(2-F,3-OCF₂CF₂H,5-CN) Ph(2-F,3-OC₂F₅,5-Cl) Ph(2-F,3-OC₂F₅,5-F)Ph(2-F,3-OC₂F₅,5-Br) Ph(2-F,3-OC₂F₅,5-I) Ph(2-F,3-OC₂F₅,5-Me)Ph(2-F,3-OC₂F₅,5-Et) Ph(2-F,3-OC₂F₅,5-n-Pr) Ph(2-F,3-OC₂F₅,5-t-Bu)Ph(2-F,3-OC₂F₅,5-i-Pr) Ph(2-F,3-OC₂F₅,5-c-Pr) Ph(2-F,3-OC₂F₅CF₃,5-CF₃)Ph(2-F,3-OC₂F₅,5-CF₂CF₂H) Ph(2-F,3-OC₂F₅,5-CF₂H) Ph(2-F,3-OC₂F₅,5-OMe)Ph(2-F,3-OC₂F₅,5-OCF₃) Ph(2-F,3-OC₂F₅,5-OCHF₂)Ph(2-F,3-OC₂F₅,5-OCF₂CF₂H) Ph(2-F,3,5-di-OC₂F₅) Ph(2-F,3-OC₂F₅,5-SO₂Me)Ph(2-F,3-OC₂F₅,5-TMS) Ph(2-F,3-OC₂F₅,5-CN) Ph(2-F,3-SO₂Me,5-Cl)Ph(2-F,3-SO₂Me,5-F) Ph(2-F,3-SO₂Me,5-Br) Ph(2-F,3-SO₂Me,5-I)Ph(2-F,3-SO₂Me,5-Me) Ph(2-F,3-SO₂Me,5-Et) Ph(2-F,3-SO₂Me,5-n-Pr)Ph(2-F,3-SO₂Me,5-t-Bu) Ph(2-F,3-SO₂Me,5-i-Pr) Ph(2-F,3-SO₂Me,5-c-Pr)Ph(2-F,3-SO₂MeCF₃,5-CF₃) Ph(2-F,3-SO₂Me,5-C₂F5)Ph(2-F,3-SO₂Me,5-CF₂CF₂H) Ph(2-F,3-SO₂Me,5-CF₂H) Ph(2-F,3-SO₂Me,5-OMe)Ph(2-F,3-SO₂Me,5-OCF₃) Ph(2-F,3-SO₂Me,5-OCHF₂)Ph(2-F,3-SO₂Me,5-OCF₂CF₂H) Ph(2-F,3-SO₂Me,5-OC₂F₅) Ph(2-F,3,5-di-SO₂Me)Ph(2-F,3-SO₂Me,5-TMS) Ph(2-F,3-SO₂Me,5-CN) Ph(2-F,3-TMS,5-Cl)Ph(2-F,3-TMS,5-F) Ph(2-F,3-TMS,5-Br) Ph(2-F,3-TMS,5-I)Ph(2-F,3-TMS,5-Me) Ph(2-F,3-TMS,5-Et) Ph(2-F,3-TMS,5-n-Pr)Ph(2-F,3-TMS,5-t-Bu) Ph(2-F,3-TMS,5-i-Pr) Ph(2-F,3-TMS,5-c-Pr)Ph(2-F,3-TMS,5-CF₃) Ph(2-F,3-TMS,5-C₂F₅) Ph(2-F,3-TMS,5-CF₂CF₂H)Ph(2-F,3-TMS,5-CF₂H) Ph(2-F,3-TMS,5-OMe) Ph(2-F,3-TMS,5-OCF₃)Ph(2-F,3-TMS,5-OCHF₂) Ph(2-F,3-TMS,5-OCF₂CF₂H) Ph(2-F,3-TMS,5-OC₂F₅)Ph(2-F,3-TMS,5-SO₂Me) Ph(2-F,3,5-di-TMS) Ph(2-F,3-TMS,5-CN)Ph(2-F,3-CN,5-Cl) Ph(2-F,3-CN,5-F) Ph(2-F,3-CN,5-Br) Ph(2-F,3-CN,5-I)Ph(2-F,3-CN,5-Me) Ph(2-F,3-CN,5-Et) Ph(2-F,3-CN,5-n-Pr)Ph(2-F,3-CN,5-t-Bu) Ph(2-F,3-CN,5-i-Pr) Ph(2-F,3-CN,5-c-Pr)Ph(2-F,3-CN,5-CF₃) Ph(2-F,3-CN,5-C₂F₅) Ph(2-F,3-CN,5-CF₂CF₂H)Ph(2-F,3-CN,5-CF₂H) Ph(2-F,3-CN,5-OMe) Ph(2-F,3-CN,5-OCF₃)Ph(2-F,3-CN,5-OCHF2) Ph(2-F,3-CN,5-OCF₂CF₂H) Ph(2-F,3-CN,5-OC₂F₅)Ph(2-F,3-CN,5-SO₂Me) Ph(2-F,3-CN,5-TMS) Ph(2-F,3,5-di-CN)Ph(2-F,4,5-di-Cl) Ph(2-F,4-Cl,5-F) Ph(2-F,4-Cl,5-Br) Ph(2-F,4-Cl,5-I)Ph(2-F,4-Cl,5-Me) Ph(2-F,4-Cl,5-Et) Ph(2-F,4-Cl,5-n-Pr)Ph(2-F,4-Cl,5-t-Bu) Ph(2-F,4-Cl,5-i-Pr) Ph(2-F,4-Cl,5-c-Pr)Ph(2-F,4-Cl,5-CF₃) Ph(2-F,4-Cl,5-C₂F₅) Ph(2-F,4-Cl,5-CF₂CF₂H)Ph(2-F,4-Cl,5-CF₂H) Ph(2-F,4-Cl,5-OMe) Ph(2-F,4-Cl,5-OCF₃)Ph(2-F,4-Cl,5-OCHF₂) Ph(2-F,4-Cl,5-OCF₂CF₂H) Ph(2-F,4-Cl,5-OC₂F₅)Ph(2-F,4-Cl,5-SO₂Me) Ph(2-F,4-Cl,5-TMS) Ph(2-F,4-Cl,5-CN)Ph(2-F,4-F,5-Cl) Ph(2,4,5-tri-F) Ph(2-F,4-F,5-Br) Ph(2-F,4-F,5-I)Ph(2-F,4-F,5-Me) Ph(2-F,4-F,5-Et) Ph(2-F,4-F,5-n-Pr) Ph(2-F,4-F,5-t-Bu)Ph(2-F,4-F,5-i-Pr) Ph(2-F,4-F,5-c-Pr) Ph(2-F,4-F,5-CF₃)Ph(2-F,4-F,5-C₂F₅) Ph(2-F,4-F,5-CF₂CF₂H) Ph(2-F,4-F,5-CF₂H)Ph(2-F,4-F,5-OMe) Ph(2-F,4-F,5-OCF₃) Ph(2-F,4-F,5-OCHF₂)Ph(2-F,4-F,5-OCF₂CF₂H) Ph(2-F,4-F,5-OC₂F₅) Ph(2-F,4-F,5-SO₂Me)Ph(2-F,4-F,5-TMS) Ph(2-F,4-F,5-CN) Ph(2-F,4-Br,5-Cl) Ph(2-F,4-Br,5-F)Ph(2-F,4,5-di-Br) Ph(2-F,4-Br,5-I) Ph(2-F,4-Br,5-Me) Ph(2-F,4-Br,5-Et)Ph(2-F,4-Br,5-n-Pr) Ph(2-F,4-Br,5-t-Bu) Ph(2-F,4-Br,5-i-Pr)Ph(2-F,4-Br,5-c-Pr) Ph(2-F,4-Br,5-CF₃) Ph(2-F,4-Br,5-C₂F₅)Ph(2-F,4-Br,5-CF₂CF₂H) Ph(2-F,4-Br,5-CF₂H) Ph(2-F,4-Br,5-OMe)Ph(2-F,4-Br,5-OCF₃) Ph(2-F,4-Br,5-OCHF₂) Ph(2-F,4-Br,5-OCF₂CF₂H)Ph(2-F,4-Br,5-OC₂F₅) Ph(2-F,4-Br,5-SO₂Me) Ph(2-F,4-Br,5-TMS)Ph(2-F,4-Br,5-CN) Ph(2-F,4-I,5-Cl) Ph(2-F,4-I,5-F) Ph(2-F,4-I,5-Br)Ph(2-F,4,5-di-I) Ph(2-F,4-I,5-Me) Ph(2-F,4-I,5-Et) Ph(2-F,4-I,5-n-Pr)Ph(2-F,4-I,5-t-Bu) Ph(2-F,4-I,5-i-Pr) Ph(2-F,4-I,5-c-Pr)Ph(2-F,4-I,5-CF₃) Ph(2-F,4-I,5-C₂F₅) Ph(2-F,4-I,5-CF₂CF₂H)Ph(2-F,4-I,5-CF₂H) Ph(2-F,4-I,5-OMe) Ph(2-F,4-I,5-OCF₃)Ph(2-F,4-I,5-OCHF₂) Ph(2-F,4-I,5-OCF₂CF₂H) Ph(2-F,4-I,5-OC₂F₅)Ph(2-F,4-I,5-SO₂Me) Ph(2-F,4-I,5-TMS) Ph(2-F,4-I,5-CN) Ph(2-F,4-Me,5-Cl)Ph(2-F,4-Me,5-F) Ph(2-F,4-Me,5-Br) Ph(2-F,4-Me,5-I) Ph(2-F,4,5-di-Me)Ph(2-F,4-Me,5-Et) Ph(2-F,4-Me,5-n-Pr) Ph(2-F,4-Me,5-t-Bu)Ph(2-F,4-Me,5-i-Pr) Ph(2-F,4-Me,5-c-Pr) Ph(2-F,4-Me,5-CF₃)Ph(2-F,4-Me,5-C₂F₅) Ph(2-F,4-Me,5-CF₂CF₂H) Ph(2-F,4-Me,5-CF₂H)Ph(2-F,4-Me,5-OMe) Ph(2-F,4-Me,5-OCF₃) Ph(2-F,4-Me,5-OCHF₂)Ph(2-F,4-Me,5-OCF₂CF₂H) Ph(2-F,4-Me,5-OC₂F₅) Ph(2-F,4-Me,5-SO₂Me)Ph(2-F,4-Me,5-TMS) Ph(2-F,4-Me,5-CN) Ph(2-F,4-Et,5-Cl) Ph(2-F,4-Et,5-F)Ph(2-F,4-Et,5-Br) Ph(2-F,4-Et,5-I) Ph(2-F,4-Et,5-Me) Ph(2-F,4,5-di-Et)Ph(2-F,4-Et,5-n-Pr) Ph(2-F,4-Et,5-t-Bu) Ph(2-F,4-Et,5-i-Pr)Ph(2-F,4-Et,5-c-Pr) Ph(2-F,4-Et,5-CF₃) Ph(2-F,4-Et,5-C₂F₅)Ph(2-F,4-Et,5-CF₂CF₂H) Ph(2-F,4-Et,5-CF₂H) Ph(2-F,4-Et,5-OMe)Ph(2-F,4-Et,5-OCF₃) Ph(2-F,4-Et,5-OCHF₂) Ph(2-F,4-Et,5-OCF₂CF₂H)Ph(2-F,4-Et,5-OC₂F₅) Ph(2-F,4-Et,5-SO₂Me) Ph(2-F,4-Et,5-TMS)Ph(2-F,4-Et,5-CN) Ph(2-F,4-n-Pr,5-Cl) Ph(2-F,4-n-Pr,5-F)Ph(2-F,4-n-Pr,5-Br) Ph(2-F,4-n-Pr,5-I) Ph(2-F,4-n-Pr,5-Me)Ph(2-F,4-n-Pr,5-Et) Ph(2-F,4,5-di-n-Pr) Ph(2-F,4-n-Pr,5-t-Bu)Ph(2-F,4-n-Pr,5-i-Pr) Ph(2-F,4-n-Pr,5-c-Pr) Ph(2-F,4-n-Pr,5-CF₃)Ph(2-F,4-n-Pr,5-C₂F₅) Ph(2-F,4-n-Pr,5-CF₂CF₂H) Ph(2-F,4-n-Pr,5-CF₂H)Ph(2-F,4-n-Pr,5-OMe) Ph(2-F,4-n-Pr,5-OCF₃) Ph(2-F,4-n-Pr,5-OCHF₂)Ph(2-F,4-n-Pr,5-OCF₂CF₂H) Ph(2-F,4-n-Pr,5-OC₂F₅) Ph(2-F,4-n-Pr,5-SO₂Me)Ph(2-F,4-n-Pr,5-TMS) Ph(2-F,4-n-Pr,5-CN) Ph(2-F,4-t-Bu,5-Cl)Ph(2-F,4-t-Bu,5-F) Ph(2-F,4-t-Bu,5-Br) Ph(2-F,4-t-Bu,5-I)Ph(2-F,4-t-Bu,5-Me) Ph(2-F,4-t-Bu,5-Et) Ph(2-F,4-t-Bu,5-n-Pr)Ph(2-F,4,5-di-t-Bu) Ph(2-F,4-t-Bu,5-i-Pr) Ph(2-F,4-t-Bu,5-c-Pr)Ph(2-F,4-t-Bu,5-CF₃) Ph(2-F,4-t-Bu,5-C₂F₅) Ph(2-F,4-t-Bu,5-CF₂CF₂H)Ph(2-F,4-t-Bu,5-CF₂H) Ph(2-F,4-t-Bu,5-OMe) Ph(2-F,4-t-Bu,5-OCF₃)Ph(2-F,4-t-Bu,5-OCHF₂) Ph(2-F,4-t-Bu,5-OCF₂CF₂H) Ph(2-F,4-t-Bu,5-OC₂F₅)Ph(2-F,4-t-Bu,5-SO₂Me) Ph(2-F,4-t-Bu,5-TMS) Ph(2-F,4-t-Bu,5-CN)Ph(2-F,4-i-Pr,5-Cl) Ph(2-F,4-i-Pr,5-F) Ph(2-F,4-i-Pr,5-Br)Ph(2-F,4-i-Pr,5-I) Ph(2-F,4-i-Pr,5-Me) Ph(2-F,4-i-Pr,5-Et)Ph(2-F,4-i-Pr,5-n-Pr) Ph(2-F,4-i-Pr,5-t-Bu) Ph(2-F,4,5-di-i-Pr)Ph(2-F,4-i-Pr,5-c-Pr) Ph(2-F,4-i-Pr,5-CF₃) Ph(2-F,4-i-Pr,5-C₂F₅)Ph(2-F,4-i-Pr,5-CF₂CF₂H) Ph(2-F,4-i-Pr,5-CF₂H) Ph(2-F,4-i-Pr,5-OMe)Ph(2-F,4-i-Pr,5-OCF₃) Ph(2-F,4-i-Pr,5-OCHF₂) Ph(2-F,4-i-Pr,5-OCF₂CF₂H)Ph(2-F,4-i-Pr,5-OC₂F₅) Ph(2-F,4-i-Pr,5-SO₂Me) Ph(2-F,4-i-Pr,5-TMS)Ph(2-F,4-i-Pr,5-CN) Ph(2-F,4-c-Pr,5-Cl) Ph(2-F,4-c-Pr,5-F)Ph(2-F,4-c-Pr,5-Br) Ph(2-F,4-c-Pr,5-I) Ph(2-F,4-c-Pr,5-Me)Ph(2-F,4-c-Pr,5-Et) Ph(2-F,4-c-Pr,5-n-Pr) Ph(2-F,4-c-Pr,5-t-Bu)Ph(2-F,4-c-Pr,5-i-Pr) Ph(2-F,4,5-di-c-Pr) Ph(2-F,4-c-Pr,5-CF₃)Ph(2-F,4-c-Pr,5-C₂F₅) Ph(2-F,4-c-Pr,5-CF₂CF₂H) Ph(2-F,4-c-Pr,5-CF₂H)Ph(2-F,4-c-Pr,5-OMe) Ph(2-F,4-c-Pr,5-OCF₃) Ph(2-F,4-c-Pr,5-OCHF₂)Ph(2-F,4-c-Pr,5-OCF₂CF₂H) Ph(2-F,4-c-Pr,5-OC₂F₅) Ph(2-F,4-c-Pr,5-SO₂Me)Ph(2-F,4-c-Pr,5-TMS) Ph(2-F,4-c-Pr,5-CN) Ph(2-F,4-CF₃,5-Cl)Ph(2-F,4-CF₃,5-F) Ph(2-F,4-CF₃,5-Br) Ph(2-F,4-CF₃,5-I)Ph(2-F,4-CF₃,5-Me) Ph(2-F,4-CF₃,5-Et) Ph(2-F,4-CF₃,5-n-Pr)Ph(2-F,4-CF₃,5-t-Bu) Ph(2-F,4-CF₃,5-i-Pr) Ph(2-F,4-CF₃,5-c-Pr)Ph(2-F,4,5-di-CF₃) Ph(2-F,4-CF₃,5-C₂F₅) Ph(2-F,4-CF₃,5-CF₂CF₂H)Ph(2-F,4-CF₃,5-CF₂H) Ph(2-F,4-CF₃,5-OMe) Ph(2-F,4-CF₃,5-OCF₃)Ph(2-F,4-CF₃,5-OCHF₂) Ph(2-F,4-CF₃,5-OCF₂CF₂H) Ph(2-F,4-CF₃,5-OC₂F₅)Ph(2-F,4-CF₃,5-SO₂Me) Ph(2-F,4-CF₃,5-TMS) Ph(2-F,4-CF₃,5-CN)Ph(2-F,4-CF₂CF₃,5-Cl) Ph(2-F,4-CF₂CF₃,5-F) Ph(2-F,4-CF₂CF₃,5-Br)Ph(2-F,4-CF₂CF₃,5-I) Ph(2-F,4-CF₂CF₃,5-Me) Ph(2-F,4-CF₂CF₃,5-Et)Ph(2-F,4-CF₂CF₃,5-n-Pr) Ph(2-F,4-CF₂CF₃,5-t-Bu) Ph(2-F,4-CF₂CF₃,5-i-Pr)Ph(2-F,4-CF₂CF₃,5-c-Pr) Ph(2-F,4-C₂F₅CF₃,5-CF₃) Ph(2-F,4,5-di-C₂F₅)Ph(2-F,4-CF₂CF₃,5-CF₂CF₂H) Ph(2-F,4-CF₂CF₃,5-CF₂H)Ph(2-F,4-CF₂CF₃,5-OMe) Ph(2-F,4-CF₂CF₃,5-OCF₃) Ph(2-F,4-CF₂CF₃,5-OCHF₂)Ph(2-F,4-CF₂CF₃,5-OCF₂CF₂H) Ph(2-F,4-CF₂CF₃,5-OC₂F₅)Ph(2-F,4-CF₂CF₃,5-SO₂Me) Ph(2-F,4-CF₂CF₃,5-TMS) Ph(2-F,4-CF₂CF₃,5-CN)Ph(2-F,4-CF₂CF₂H,5-Cl) Ph(2-F,4-CF₂CF₂H,5-F) Ph(2-F,4-CF₂CF₂H,5-Br)Ph(2-F,4-CF₂CF₂H,5-I) Ph(2-F,4-CF₂CF₂H,5-Me) Ph(2-F,4-CF₂CF₂H,5-Et)Ph(2-F,4-CF₂CF₂H,5-n-Pr) Ph(2-F,4-CF₂CF₂H,5-t-Bu)Ph(2-F,4-CF₂CF₂H,5-i-Pr) Ph(2-F,4-CF₂CF₂H,5-c-Pr)Ph(2-F,4-CF₂CF₂CF₃H,5-CF₃) Ph(2-F,4-CF₂CF₂H,5-C₂F₅)Ph(2-F,4,5-di-CF₂CF₂H) Ph(2-F,4-CF₂CF₂H,5-CF₂H) Ph(2-F,4-CF₂CF₂H,5-OMe)Ph(2-F,4-CF₂CF₂H,5-OCF₃) Ph(2-F,4-CF₂CF₂H,5-OCHF₂) Ph(2-F,4-CF₂CF₂H,5-OCF₂CF₂H) Ph(2-F,4-CF₂CF₂H,5-OC₂F₅) Ph(2-F,4-CF₂CF₂H,5-SO₂Me)Ph(2-F,4-CF₂CF₂H,5-TMS) Ph(2-F,4-CF₂CF₂H,5-CN) Ph(2-F,4-CF₂H,5-Cl)Ph(2-F,4-CF₂H,5-F) Ph(2-F,4-CF₂H,5-Br) Ph(2-F,4-CF₂H,5-I)Ph(2-F,4-CF₂H,5-Me) Ph(2-F,4-CF₂H,5-Et) Ph(2-F,4-CF₂H,5-n-Pr)Ph(2-F,4-CF₂H,5-t-Bu) Ph(2-F,4-CF₂H,5-i-Pr) Ph(2-F,4-CF₂H,5-c-Pr)Ph(2-F,4-CF₂H,5-CF₃) Ph(2-F,4-CF₂H,5-C₂F₅) Ph(2-F,4-CF₂H,5-CF₂CF₂H)Ph(2-F,4,5-di-CF₂H) Ph(2-F,4-CF₂H,5-OMe) Ph(2-F,4-CF₂H,5-OCF₃)Ph(2-F,4-CF₂H,5-OCHF₂) Ph(2-F,4-CF₂H,5-OCF₂CF₂H) Ph(2-F,4-CF₂H,5-OC₂F₅)Ph(2-F,4-CF₂H,5-SO₂Me) Ph(2-F,4-CF₂H,5-TMS) Ph(2-F,4-CF₂H,5-CN)Ph(2-F,4-OMe,5-Cl) Ph(2-F,4-OMe,5-F) Ph(2-F,4-OMe,5-Br)Ph(2-F,4-OMe,5-I) Ph(2-F,4-OMe,5-Me) Ph(2-F,4-OMe,5-Et)Ph(2-F,4-OMe,5-n-Pr) Ph(2-F,4-OMe,5-t-Bu) Ph(2-F,4-OMe,5-i-Pr)Ph(2-F,4-OMe,5-c-Pr) Ph(2-F,4-OMe,5-CF₃) Ph(2-F,4-OMe,5-C₂F₅)Ph(2-F,4-OMe,5-CF₂CF₂H) Ph(2-F,4-OMe,5-CF₂H) Ph(2-F,4,5-di-OMe)Ph(2-F,4-OMe,5-OCF₃) Ph(2-F,4-OMe,5-OCHF₂) Ph(2-F,4-OMe,5-OCF₂CF₂H)Ph(2-F,4-OMe,5-OC₂F₅) Ph(2-F,4-OMe,5-SO₂Me) Ph(2-F,4-OMe,5-TMS)Ph(2-F,4-OMe,5-CN) Ph(2-F,4-OCF₃,5-Cl) Ph(2-F,4-OCF₃,5-F)Ph(2-F,4-OCF₃,5-Br) Ph(2-F,4-OCF₃,5-I) Ph(2-F,4-OCF₃,5-Me)Ph(2-F,4-OCF₃,5-Et) Ph(2-F,4-OCF₃,5-n-Pr) Ph(2-F,4-OCF₃,5-t-Bu)Ph(2-F,4-OCF₃,5-i-Pr) Ph(2-F,4-OCF₃,5-c-Pr) Ph(2-F,4-OCF₃,5-CF₃)Ph(2-F,4-OCF₃,5-C₂F₅) Ph(2-F,4-OCF₃,5-CF₂CF₂H) Ph(2-F,4-OCF₃,5-CF₂H)Ph(2-F,4-OCF₃,5-OMe) Ph(2-F,4,5-di-OCF₃) Ph(2-F,4-OCF₃,5-OCHF₂)Ph(2-F,4-OCF₃,5-OCF₂CF₂H) Ph(2-F,4-OCF₃,5-OC₂F₅) Ph(2-F,4-OCF₃,5-SO₂Me)Ph(2-F,4-OCF₃,5-TMS) Ph(2-F,4-OCF₃,5-CN) Ph(2-F,4-OCHF₂,5-Cl)Ph(2-F,4-OCHF₂,5-F) Ph(2-F,4-OCHF₂,5-Br) Ph(2-F,4-OCHF₂,5-I)Ph(2-F,4-OCHF₂,5-Me) Ph(2-F,4-OCHF₂,5-Et) Ph(2-F,4-OCHF₂,5-n-Pr)Ph(2-F,4-OCHF₂,5-t-Bu) Ph(2-F,4-OCHF₂,5-i-Pr) Ph(2-F,4-OCHF₂,5-c-Pr)Ph(2-F,4-OCHF₂CF₃,5-CF₃) Ph(2-F,4-OCF₂CF₃,5-C₂F₅)Ph(2-F,4-OCHF₂,5-CF₂CF₂H) Ph(2-F,4-OCHF₂,5-CF₂H) Ph(2-F,4-OCHF₂,5-OMe)Ph(2-F,4-OCHF₂,5-OCF₃) Ph(2-F,4,5-di-OCHF₂) Ph(2-F,4-OCHF₂,5-OCF₂CF₂H)Ph(2-F,4-OCHF₂,5-OC₂F₅) Ph(2-F,4-OCHF₂,5-SO₂Me) Ph(2-F,4-OCHF₂,5-TMS)Ph(2-F,4-OCHF₂,5-CN) Ph(2-F,4-OCF₂CF₂H,5-Cl) Ph(2-F,4-OCF₂CF₂H,5-F)Ph(2-F,4-OCF₂CF₂H,5-Br) Ph(2-F,4-OCF₂CF₂H,5-I) Ph(2-F,4-OCF₂CF₂H,5-Me)Ph(2-F,4-OCF₂CF₂H,5-Et) Ph(2-F,4-OCF₂CF₂H,5-n-Pr)Ph(2-F,4-OCF₂CF₂H,5-t-Bu) Ph(2-F,4-OCF₂CF₂H,5-i-Pr)Ph(2-F,4-OCF₂CF₂H,5-c-Pr) Ph(2-F,4-OCF₂CF₂CF₃H,5-CF₃)Ph(2-F,4-OCF₂CF₂H,5-C₂F₅) Ph(2-F,4-OCF₂CF₂H,5- CF₂CF₂H)Ph(2-F,4-OCF₂CF₂H,5-CF₂H) Ph(2-F,4-OCF₂CF₂H,5-OMe)Ph(2-F,4-OCF₂CF₂H,5-OCF₃) Ph(2-F,4-OCF₂CF₂H,5-OCHF₂)Ph(2-F,4,5-di-OCF₂CF₂H) Ph(2-F,4-OCF₂CF₂H,5-OC₂F₅)Ph(2-F,4-OCF₂CF₂H,5-SO₂Me) Ph(2-F,4-OCF₂CF₂H,5-TMS)Ph(2-F,4-OCF₂CF₂H,5-CN) Ph(2-F,4-OCF₂CF₃,5-Cl) Ph(2-F,4-OCF₂CF₃,5-F)Ph(2-F,4-OCF₂CF₃,5-Br) Ph(2-F,4-OCF₂CF₃,5-I) Ph(2-F,4-OCF₂CF₃,5-Me)Ph(2-F,4-OCF₂CF₃,5-Et) Ph(2-F,4-OCF₂CF₃,5-n-Pr) Ph(2-F,4-OCF₂CF₃,5-t-Bu)Ph(2-F,4-OCF₂CF₃,5-i-Pr) Ph(2-F,4-OCF₂CF₃,5-c-Pr)Ph(2-F,4-OC₂F₅CF₃,5-CF₃) Ph(2-F,4-OCF₂CF₃,5-CF₂CF₂H)Ph(2-F,4-OCF₂CF₃,5-CF₂H) Ph(2-F,4-OCF₂CF₃,5-OMe)Ph(2-F,4-OCF₂CF₃,5-OCF₃) Ph(2-F,4-OCF₂CF₃,5-OCHF₂) Ph(2-F,4-OCF₂CF₃,5-OCF₂CF₂H) Ph(2-F,4,5-di-OC₂F₅) Ph(2-F,4-OCF₂CF₃,5-SO₂Me)Ph(2-F,4-OCF₂CF₃,5-TMS) Ph(2-F,4-OCF₂CF₃,5-CN) Ph(2-F,4-SO₂Me,5-Cl)Ph(2-F,4-SO₂Me,5-F) Ph(2-F,4-SO₂Me,5-Br) Ph(2-F,4-SO₂Me,54)Ph(2-F,4-SO₂Me,5-Me) Ph(2-F,4-SO₂Me,5-Et) Ph(2-F,4-SO₂Me,5-n-Pr)Ph(2-F,4-SO₂Me,5-t-Bu) Ph(2-F,4-SO₂Me,5-i-Pr) Ph(2-F,4-SO₂Me,5-c-Pr)Ph(2-F,4-SO₂MeCF₃,5-CF₃) Ph(2-F,4-SO₂Me,5-C₂F₅)Ph(2-F,4-SO₂Me,5-CF₂CF₂H) Ph(2-F,4-SO₂Me,5-CF₂H) Ph(2-F,4-SO₂Me,5-OMe)Ph(2-F,4-SO₂Me,5-OCF₃) Ph(2-F,4-SO₂Me,5-OCHF₂)Ph(2-F,4-SO₂Me,5-OCF₂CF₂H) Ph(2-F,4-SO₂Me,5-OC₂F₅) Ph(2-F,4,5-di-SO₂Me)Ph(2-F,4-SO₂Me,5-TMS) Ph(2-F,4-SO₂Me,5-CN) Ph(2-F,4-TMS,5-Cl)Ph(2-F,4-TMS,5-F) Ph(2-F,4-TMS,5-Br) Ph(2-F,4-TMS,5-I)Ph(2-F,4-TMS,5-Me) Ph(2-F,4-TMS,5-Et) Ph(2-F,4-TMS,5-n-Pr)Ph(2-F,4-TMS,5-t-Bu) Ph(2-F,4-TMS,5-i-Pr) Ph(2-F,4-TMS,5-c-Pr)Ph(2-F,4-TMS,5-CF₃) Ph(2-F,4-TMS,5-C₂F₅) Ph(2-F,4-TMS,5-CF₂CF₂H)Ph(2-F,4-TMS,5-CF₂H) Ph(2-F,4-TMS,5-OMe) Ph(2-F,4-TMS,5-OCF₃)Ph(2-F,4-TMS,5-OCHF2) Ph(2-F,4-TMS,5-OCF₂CF₂H) Ph(2-F,4-TMS,5-OC₂F₅)Ph(2-F,4-TMS,5-SO₂Me) Ph(2-F,4,5-di-TMS) Ph(2-F,4-TMS,5-CN)Ph(2-F,4-CN,5-Cl) Ph(2-F,4-CN,5-F) Ph(2-F,4-CN,5-Br) Ph(2-F,4-CN,5-I)Ph(2-F,4-CN,5-Me) Ph(2-F,4-CN,5-Et) Ph(2-F,4-CN,5-n-Pr)Ph(2-F,4-CN,5-t-Bu) Ph(2-F,4-CN,5-i-Pr) Ph(2-F,4-CN,5-c-Pr)Ph(2-F,4-CN,5-CF₃) Ph(2-F,4-CN,5-C₂F₅) Ph(2-F,4-CN,5-CF₂CF₂H)Ph(2-F,4-CN,5-CF₂H) Ph(2-F,4-CN,5-OMe) Ph(2-F,4-CN,5-OCF₃)Ph(2-F,4-CN,5-OCHF₂) Ph(2-F,4-CN,5-OCF₂CF₂H) Ph(2-F,4-CN,5-OC₂F₅)Ph(2-F,4-CN,5-SO₂Me) Ph(2-F,4-CN,5-TMS) Ph(2-F,4,5-di-CN)Ph(3,4,5-tri-Cl) Ph(3-Cl,4-F,5-Cl) Ph(3-Cl,4-Br,5-Cl) Ph(3-Cl,4-I,5-Cl)Ph(3-Cl,4-Me,5-Cl) Ph(3-Cl,4-Et,5-Cl) Ph(3-Cl,4-n-Pr,5-Cl)Ph(3-Cl,4-t-Bu,5-Cl) Ph(3-Cl,4-i-Pr,5-Cl) Ph(3-Cl,4-c-Pr,5-Cl)Ph(3-Cl,4-CF₃,5-Cl) Ph(3-Cl,4-C₂F₅,5-Cl) Ph(3-Cl,4-CF₂CF₂H,5-Cl)Ph(3-Cl,4-CF₂H,5-Cl) Ph(3-Cl,4-OMe,5-Cl) Ph(3-Cl,4-OCF₃,5-Cl)Ph(3-Cl,4-OCHF₂,5-Cl) Ph(3-Cl,4-OCF₂CF₂H,5-Cl) Ph(3-Cl,4-OC₂F₅,5-Cl)Ph(3-Cl,4-SO₂Me,5-Cl) Ph(3-Cl,4-TMS,5-Cl) Ph(3-Cl,4-CN,5-Cl)Ph(3-F,4-Cl,5-F) Ph(3,4,5-tri-F) Ph(3-F,4-Br,5-F) Ph(3-F,4-I,5-F)Ph(3-F,4-Me,5-F) Ph(3-F,4-Et,5-F) Ph(3-F,4-n-Pr,5-F) Ph(3-F,4-t-Bu,5-F)Ph(3-F,4-i-Pr,5-F) Ph(3-F,4-c-Pr,5-F) Ph(3-F,4-CF₃,5-F)Ph(3-F,4-C₂F₅,5-F) Ph(3-F,4-CF₂CF₂H,5-F) Ph(3-F,4-CF₂H,5-F)Ph(3-F,4-OMe,5-F) Ph(3-F,4-OCF₃,5-F) Ph(3-F,4-OCHF₂,5-F)Ph(3-F,4-OCF₂CF₂H,5-F) Ph(3-F,4-OC₂F5,5-F) Ph(3-F,4-SO₂Me,5-F)Ph(3-F,4-TMS,5-F) Ph(3-F,4-CN,5-F) Ph(3-Br,4-Cl,5-Br) Ph(3-Br,4-F,5-Br)Ph(3,4,5-tri-Br) Ph(3-Br,4-I,5-Br) Ph(3-Br,4-Me,5-Br) Ph(3-Br,4-Et,5-Br)Ph(3-Br,4-n-Pr,5-Br) Ph(3-Br,4-t-Bu,5-Br) Ph(3-Br,4-i-Pr,5-Br)Ph(3-Br,4-c-Pr,5-Br) Ph(3-Br,4-CF₃,5-Br) Ph(3-Br,4-C₂F₅,5-Br)Ph(3-Br,4-CF₂CF₂H,5-Br) Ph(3-Br,4-CF₂H,5-Br) Ph(3-Br,4-OMe,5-Br)Ph(3-Br,4-OCF₃,5-Br) Ph(3-Br,4-OCHF₂,5-Br) Ph(3-Br,4-OCF₂CF₂H,5-Br)Ph(3-Br,4-OC₂F₅,5-Br) Ph(3-Br,4-SO₂Me,5-Br) Ph(3-Br,4-TMS,5-Br)Ph(3-Br,4-CN,5-Br) Ph(3-Me,4-Cl,5-Me) Ph(3-Me,4-F,5-Me)Ph(3-Me,4-Br,5-Me) Ph(3-Me,4-I,5-Me) Ph(3,4-tri-Me) Ph(3-Me,4-Et,5-Me)Ph(3-Me,4-n-Pr,5-Me) Ph(3-Me,4-t-Bu,5-Me) Ph(3-Me,4-i-Pr,5-Me)Ph(3-Me,4-c-Pr,5-Me) Ph(3-Me,4-CF₃,5-Me) Ph(3-Me,4-C₂F₅,5-Me)Ph(3-Me,4-CF₂CF₂H,5-Me) Ph(3-Me,4-CF₂H,5-Me) Ph(3-Me,4-OMe,5-Me)Ph(3-Me,4-OCF₃,5-Me) Ph(3-Me,4-OCHF₂,5-Me) Ph(3-Me,4-OCF₂CF₂H,5-Me)Ph(3-Me,4-OC₂F₅,5-Me) Ph(3-Me,4-SO₂Me,5-Me) Ph(3-Me,4-TMS,5-Me)Ph(3-Me,4-CN,5-Me) Ph(3-CF₃,4-Cl,5-CF₃) Ph(3-CF₃,4-F,5-CF₃)Ph(3-CF₃,4-Br,5-CF₃) Ph(3-CF₃,4-I,5-CF₃) Ph(3-CF₃,4-Me,5-CF₃)Ph(3-CF₃,4-Et,5-CF₃) Ph(3-CF₃,4-n-Pr,5-CF₃) Ph(3-CF₃,4-t-Bu,5-CF₃)Ph(3-CF₃,4-i-Pr,5-CF₃) Ph(3-CF₃,4-c-Pr,5-CF₃) Ph(3,4,5-tri-CF₃)Ph(3-CF₃,4-C₂F₅,5-CF₃) Ph(3-CF₃,4-CF₂CF₂H,5-CF₃) Ph(3-CF₃,4-CF₂H,5-CF₃)Ph(3-CF₃,4-OMe,5-CF₃) Ph(3-CF₃,4-OCF₃,5-CF₃) Ph(3-CF₃,4-OCHF₂,5-CF₃)Ph(3-CF₃,4-OCF₂CF₂H,5-CF₃) Ph(3,5-di-CF₃,4-OC₂F5)Ph(3-CF₃,4-SO₂Me,5-CF₃) Ph(3-CF₃,4-TMS,5-CF₃) Ph(3-CF₃,4-CN,5-CF3)Ph(3-OCHF₂,4-Cl,5-OCHF₂) Ph(3-OCHF₂,4-F,5-OCHF₂)Ph(3-OCHF₂,4-Br,5-OCHF₂) Ph(3-OCHF₂,4-I,5-OCHF₂)Ph(3-OCHF₂,4-Me,5-OCHF2) Ph(3-OCHF₂,4-Et,5-OCHF₂)Ph(3-OCHF2,4-n-Pr,5-OCHF₂) Ph(3-OCHF2,4-t-Bu,5-OCHF₂)Ph(3-OCHF₂,4-i-Pr,5-OCHF₂) Ph(3-OCHF₂,4-c-Pr,5-OCHF₂)Ph(3,5-di-OCHF₂CF₃,4-CF₃,) Ph(3-OC₂F₅,4-C₂F₅,5-OCHF₂)Ph(3,5-di-OCHF₂,4-CF₂CF₂H) Ph(3-OCHF₂,4-CF₂H,5-OCHF₂)Ph(3-OCHF₂,4-OMe,5-OCHF₂) Ph(3-OCHF₂,4-OCF₃,5-OCHF₂) Ph(3,4,5-tri-OCHF₂)Ph(3,5-di-OCHF₂,4-OCF₂CF₂H) Ph(3,5-di-OCHF₂,4-OC₂F₅)Ph(3,5-di-OCHF₂,4-SO₂Me) Ph(3-OCHF₂,4-TMS,5-OCHF₂)Ph(3-OCHF₂,4-CN,5-OCHF₂) Ph(2,3,4,5-tetra-Cl) Ph(2-Cl,3-Cl,4-F,5-Cl)Ph(2-Cl,3-Cl,4-Br,5-Cl) Ph(2-Cl,3-Cl,4-I,5-Cl) Ph(2-Cl,3-Cl,4-Me,5-Cl)Ph(2-Cl,3-Cl,4-Et,5-Cl) Ph(2-Cl,3-Cl,4-n-Pr,5-Cl)Ph(2-Cl,3-Cl,4-t-Bu,5-Cl) Ph(2-Cl,3-Cl,4-i-Pr,5-Cl)Ph(2-Cl,3-Cl,4-c-Pr,5-Cl) Ph(2-Cl,3-Cl,4-CF₃,5-Cl)Ph(2-Cl,3,5-di-Cl,4-C₂F₅) Ph(2-Cl,3-Cl,4-CF₂CF₂H,5-Cl)Ph(2-Cl,3-Cl,4-CF₂H,5-Cl) Ph(2-Cl,3-Cl,4-OMe,5-Cl)Ph(2-Cl,3-Cl,4-OCF₃,5-Cl) Ph(2-Cl,3-Cl,4-OCHF₂,5-Cl)Ph(2-Cl,3-Cl,4-OCF₂CF₂H,5-Cl) Ph(2-Cl,3,5-di-Cl,4-OC₂F₅)Ph(2-Cl,3-Cl,4-SO₂Me,5-Cl) Ph(2-Cl,3-Cl,4-TMS,5-Cl)Ph(2-Cl,3-Cl,4-CN,5-Cl) Ph(2-Cl,3-F,4-Cl,5-F) Ph(2-Cl,3,4,5-tri-F)Ph(2-Cl,3-F,4-Br,5-F) Ph(2-Cl,3-F,4-I,5-F) Ph(2-Cl,3-F,4-Me,5-F)Ph(2-Cl,3-F,4-Et,5-F) Ph(2-Cl,3-F,4-n-Pr,5-F) Ph(2-Cl,3-F,4-t-Bu,5-F)Ph(2-Cl,3-F,4-i-Pr,5-F) Ph(2-Cl,3-F,4-c-Pr,5-F) Ph(2-Cl,3-F,4-CF₃,5-F)Ph(2-Cl,3-F,4-C₂F₅,5-F) Ph(2-Cl,3-F,4-CF₂CF₂H,5-F)Ph(2-Cl,3-F,4-CF₂H,5-F) Ph(2-Cl,3-F,4-OMe,5-F) Ph(2-Cl,3-F,4-OCF₃,5-F)Ph(2-Cl,3-F,4-OCHF₂,5-F) Ph(2-Cl,3-F,4-OCF₂CF₂H,5-F)Ph(2-Cl,3,5-di-F,4-OC₂F₅,) Ph(2-Cl,3-F,4-SO₂Me,5-F)Ph(2-Cl,3-F,4-TMS,5-F) Ph(2-Cl,3-F,4-CN,5-F) Ph(2-Cl,3-Br,4-Cl,5-Br)Ph(2-Cl,3-Br,4-F,5-Br) Ph(2-Cl,3,4,5-tri-Br) Ph(2-Cl,3-Br,4-I,5-Br)Ph(2-Cl,3-Br,4-Me,5-Br) Ph(2-Cl,3-Br,4-Et,5-Br)Ph(2-Cl,3-Br,4-n-Pr,5-Br) Ph(2-Cl,3-Br,4-t-Bu,5-Br)Ph(2-Cl,3-Br,4-i-Pr,5-Br) Ph(2-Cl,3-Br,4-c-Pr,5-Br)Ph(2-Cl,3-Br,4-CF₃,5-Br) Ph(2-Cl,3,5-di-Br,4-C₂F₅)Ph(2-Cl,3-Br,4-CF₂CF₂H,5-Br) Ph(2-Cl,3-Br,4-CF₂H,5-Br)Ph(2-Cl,3-Br,4-OMe,5-Br) Ph(2-Cl,3-Br,4-OCF₃,5-Br)Ph(2-Cl,3-Br,4-OCHF₂,5-Br) Ph(2-Cl,3-Br,4-OCF₂CF₂H,5-Br)Ph(2-Cl,3,5-di-Br,4-OC₂F₅) Ph(2-Cl,3-Br,4-SO₂Me,5-Br)Ph(2-Cl,3-Br,4-TMS,5-Br) Ph(2-Cl,3-Br,4-CN,5-Br) Ph(2-Cl,3-Me,4-Cl,5-Me)Ph(2-Cl,3-Me,4-F,5-Me) Ph(2-Cl,3-Me,4-Br,5-Me) Ph(2-Cl,3-Me,4-I,5-Me)Ph(2-Cl,3,4-tri-Me) Ph(2-Cl,3-Me,4-Et,5-Me) Ph(2-Cl,3-Me,4-n-Pr,5-Me)Ph(2-Cl,3-Me,4-t-Bu,5-Me) Ph(2-Cl,3-Me,4-i-Pr,5-Me)Ph(2-Cl,3-Me,4-c-Pr,5-Me) Ph(2-Cl,3-Me,4-CF₃,5-Me)Ph(2-Cl,3,5-di-Me,4-C₂F₅) Ph(2-Cl,3-Me,4-CF₂CF₂H,5-Me)Ph(2-Cl,3-Me,4-CF₂H,5-Me) Ph(2-Cl,3-Me,4-OMe,5-Me)Ph(2-Cl,3-Me,4-OCF₃,5-Me) Ph(2-Cl,3-Me,4-OCHF₂,5-Me)Ph(2-Cl,3,5-di-Me,4-OCF₂CF₂H) Ph(2-Cl,3-Me,4-OC₂F₅,5-Me)Ph(2-Cl,3,5-di-Me,4-SO₂Me) Ph(2-Cl,3-Me,4-TMS,5-Me)Ph(2-Cl,3-Me,4-CN,5-Me) Ph(2-Cl,3-CF₃,4-Cl,5-CF₃)Ph(2-Cl,3-CF₃,4-F,5-CF₃) Ph(2-Cl,3-CF₃,4-Br,5-CF₃)Ph(2-Cl,3-CF₃,4-I,5-CF₃) Ph(2-Cl,3-CF₃,4-Me,5-CF₃)Ph(2-Cl,3-CF₃,4-Et,5-CF₃) Ph(2-Cl,3-CF₃,4-n-Pr,5-CF₃)Ph(2-Cl,3-CF₃,4-t-Bu,5-CF₃) Ph(2-Cl,3-CF₃,4-i-Pr,5-CF₃)Ph(2-Cl,3-CF₃,4-c-Pr,5-CF₃) Ph(2-Cl,3,4,5-tri-CF₃)Ph(2-Cl,3,5-di-CF₃,4-C₂F₅) Ph(2-Cl,3,5-di-CF₃,4-CF₂CF₂H)Ph(2-Cl,3-CF₃,4-CF₂H,5-CF₃) Ph(2-Cl,3-CF₃,4-OMe,5-CF₃)Ph(2-Cl,3-CF₃,4-OCF₃,5-CF₃) Ph(2-Cl,3-CF₃,4-OCHF₂,5-CF₃)Ph(2-Cl,3,5-di-CF₃,4- OCF₂CF₂H-) Ph(2-Cl,3,5-di-CF₃,4-OC₂F₅)Ph(2-Cl,3,5-di-CF₃,4-SO₂Me) Ph(2-Cl,3,5-di-CF₃,4-TMS)Ph(2-Cl,3-CF₃,4-CN,5-CF₃) Ph(2-Cl,3,5-di-OCHF₂,4-Cl)Ph(2-Cl,3-OCHF₂,4-F,5-OCHF₂) Ph(2-Cl,3,5-di-OCHF₂,4-Br)Ph(2-Cl,3-OCHF₂,4-I,5-OCHF₂) Ph(2-Cl,3,5-di-OCHF₂,4-Me)Ph(2-Cl,3,5-di-OCHF₂,4-Et) Ph(2-Cl,3,5-di-OCHF₂,4-n-Pr)Ph(2-Cl,3,5-di-OCHF₂,4-t-Bu) Ph(2-Cl,3,5-di-OCHF₂,4-i-Pr)Ph(2-Cl,3,5-di-OCHF₂,4-c-Pr) Ph(2-Cl,3,5-di-OCHF₂CF₃,4- CF₃)Ph(2-Cl,3-OC₂F₅,4-C₂F₅,5- OCHF₂) Ph(2-Cl,3,5-di-OCHF₂,4- CF₂CF₂H)Ph(2-Cl,3-OCHF₂,4-CF₂H,5- OCHF₂) Ph(2-Cl,3,5-di OCHF₂,4-OMe)Ph(2-Cl,3,5-di-OCHF₂,4-OCF₃) Ph(2-Cl,3,4,5-tri-OCHF₂) Ph(2-Cl,3-OCHF₂,4-OCF₂CF₂H,5-OCHF₂) Ph(2-Cl,3-OCHF₂,4-OC₂F₅,5- OCHF₂)Ph(2-Cl,3,5-di-OCHF₂,4-SO₂Me) Ph(2-Cl,3,5-di-OCHF₂,4-TMS)Ph(2-Cl,3,5-di-OCHF₂,4-CN) Ph(2-F,3,4,5-tri-Cl) Ph(2-F,3-Cl,4-F,5-Cl)Ph(2-F,3-Cl,4-Br,5-Cl) Ph(2-F,3-Cl,4-I,5-Cl) Ph(2-F,3-Cl,4-Me,5-Cl)Ph(2-F,3-Cl,4-Et,5-Cl) Ph(2-F,3-Cl,4-n-Pr,5-Cl) Ph(2-F,3-Cl,4-t-Bu,5-Cl)Ph(2-F,3-Cl,4-i-Pr,5-Cl) Ph(2-F,3-Cl,4-c-Pr,5-Cl)Ph(2-F,3-Cl,4-CF₃,5-Cl) Ph(2-F,3-Cl,4-C₂F₅,5-Cl)Ph(2-F,3-Cl,4-CF₂CF₂H,5-Cl) Ph(2-F,3-Cl,4-CF₂H,5-Cl)Ph(2-F,3-Cl,4-OMe,5-Cl) Ph(2-F,3-Cl,4-OCF₃,5-Cl)Ph(2-F,3-Cl,4-OCHF₂,5-Cl) Ph(2-F,3-Cl,4-OCF₂CF₂H,5-Cl)Ph(2-F,3,5-di-Cl,4-OC₂F₅) Ph(2-F,3-Cl,4-SO₂Me,5-Cl)Ph(2-F,3-Cl,4-TMS,5-Cl) Ph(2-F,3-Cl,4-CN,5-Cl) Ph(2-F,3-F,4-Cl,5-F)Ph(2,3,4,5-tetra-F) Ph(2-F,3-F,4-Br,5-F) Ph(2-F,3-F,4-I,5-F)Ph(2-F,3-F,4-Me,5-F) Ph(2-F,3-F,4-Et,5-F) Ph(2-F,3-F,4-n-Pr,5-F)Ph(2-F,3-F,4-t-Bu,5-F) Ph(2-F,3-F,4-i-Pr,5-F) Ph(2-F,3-F,4-c-Pr,5-F)Ph(2-F,3-F,4-CF₃,5-F) Ph(2-F,3-F,4-C₂F₅,5-F) Ph(2-F,3-F,4-CF₂CF₂H,5-F)Ph(2-F,3-F,4-CF₂H,5-F) Ph(2-F,3-F,4-OMe,5-F) Ph(2-F,3-F,4-OCF₃,5-F)Ph(2-F,3-F,4-OCHF₂,5-F) Ph(2-F,3-F,4-OCF₂CF₂H,5-F)Ph(2-F,3-F,4-OC₂F₅,5-F) Ph(2-F,3-F,4-SO₂Me,5-F) Ph(2-F,3-F,4-TMS,5-F)Ph(2-F,3-F,4-CN,5-F) Ph(2-F,3-Br,4-Cl,5-Br) Ph(2-F,3-Br,4-F,5-Br)Ph(2-F,3,4,5-tri-Br) Ph(2-F,3-Br,4-I,5-Br) Ph(2-F,3-Br,4-Me,5-Br)Ph(2-F,3-Br,4-Et,5-Br) Ph(2-F,3-Br,4-n-Pr,5-Br) Ph(2-F,3-Br,4-t-Bu,5-Br)Ph(2-F,3-Br,4-i-Pr,5-Br) Ph(2-F,3-Br,4-c-Pr,5-Br)Ph(2-F,3-Br,4-CF₃,5-Br) Ph(2-F,3,5-di-Br,4-C₂F₅)Ph(2-F,3-Br,4-CF₂CF₂H,5-Br) Ph(2-F,3-Br,4-CF₂H,5-Br)Ph(2-F,3-Br,4-OMe,5-Br) Ph(2-F,3-Br,4-OCF₃,5-Br)Ph(2-F,3-Br,4-OCHF₂,5-Br) Ph(2-F,3-Br,4-OCF₂CF₂H,5-Br)Ph(2-F,3-Br,4-OC₂F₅,5-Br) Ph(2-F,3-Br,4-SO₂Me,5-Br)Ph(2-F,3-Br,4-TMS,5-Br) Ph(2-F,3-Br,4-CN,5-Br) Ph(2-F,3-Me,4-Cl,5-Me)Ph(2-F,3-Me,4-F,5-Me) Ph(2-F,3-Me,4-Br,5-Me) Ph(2-F,3-Me,4-I,5-Me)Ph(2-F,3,4-tri-Me) Ph(2-F,3-Me,4-Et,5-Me) Ph(2-F,3-Me,4-n-Pr,5-Me)Ph(2-F,3-Me,4-t-Bu,5-Me) Ph(2-F,3-Me,4-i-Pr,5-Me)Ph(2-F,3-Me,4-c-Pr,5-Me) Ph(2-F,3-Me,4-CF₃,5-Me)Ph(2-F,3-Me,4-C₂F₅,5-Me) Ph(2-F,3-Me,4-CF₂CF₂H,5-Me)Ph(2-F,3-Me,4-CF₂H,5-Me) Ph(2-F,3-Me,4-OMe,5-Me)Ph(2-F,3-Me,4-OCF₃,5-Me) Ph(2-F,3-Me,4-OCHF₂,5-Me)Ph(2-F,3-Me,4-OCF₂CF₂H,5-Me) Ph(2-F,3-Me,4-OC₂F₅,5-Me)Ph(2-F,3-Me,4-SO₂Me,5-Me) Ph(2-F,3-Me,4-TMS,5-Me) Ph(2-F,3-Me,4-CN,5-Me)Ph(2-F,3-CF₃,4-Cl,5-CF₃) Ph(2-F,3-CF₃,4-F,5-CF₃)Ph(2-F,3-CF₃,4-Br,5-CF₃) Ph(2-F,3-CF₃,4-I,5-CF₃)Ph(2-F,3-CF₃,4-Me,5-CF₃) Ph(2-F,3-CF₃,4-Et,5-CF₃)Ph(2-F,3-CF₃,4-n-Pr,5-CF₃) Ph(2-F,3-CF₃,4-t-Bu,5-CF₃)Ph(2-F,3-CF₃,4-i-Pr,5-CF₃) Ph(2-F,3-CF₃,4-c-Pr,5-CF₃)Ph(2-F,3,4,5-tri-CF₃) Ph(2-F,3-CF₃,4-C₂F₅,5-CF₃)Ph(2-F,3-CF₃,4-CF₂CF₂H,5-CF₃) Ph(2-F,3-CF₃,4-CF₂H,5-CF₃)Ph(2-F,3-CF₃,4-OMe,5-CF₃) Ph(2-F,3-CF₃,4-OCF₃,5-CF₃)Ph(2-F,3-CF₃,4-OCHF₂,5-CF₃) Ph(2-F,3-CF₃,4-OCF₂CF₂H,5- CF₃)Ph(2-F,3-CF₃,4-OC₂F₅,5-CF₃) Ph(2-F,3-CF₃,4-SO₂Me,5-CF₃)Ph(2-F,3-CF₃,4-TMS,5-CF₃) Ph(2-F,3-CF₃,4-CN,5-CF₃)Ph(2-F,3-OCHF₂,4-Cl,5-OCHF₂) Ph(2-F,3-OCHF₂,4-F,5-OCHF₂)Ph(2-F,3-OCHF₂,4-Br,5-OCHF₂) Ph(2-F,3-OCHF₂,4-I,5-OCHF₂)Ph(2-F,3-OCHF₂,4-Me,5- OCHF₂) Ph(2-F,3-OCHF₂,4-Et,5-OCHF₂)Ph(2-F,3-OCHF₂,4-n-Pr,5- OCHF₂) Ph(2-F,3-OCHF₂,4-t-Bu,5- OCHF₂)Ph(2-F,3-OCHF₂,4-i-Pr,5- OCHF₂) Ph(2-F,3,5-di-OCHF₂,4-c-Pr)Ph(2-F,3-OCHF₂CF₃,4-CF₃,5- OCHF₂) Ph(2-F,3-OC₂F₅,4-C₂F₅,5- OCHF₂)Ph(2-F,3,5-di-OCHF₂,4- CF₂CF₂H) Ph(2-F,3-OCHF₂,4-CF₂H,5- OCHF₂)Ph(2-F,3-OCHF₂,4-OMe,5- OCHF₂) Ph(2-F,3-OCHF₂,4-OCF₃,5- OCHF₂)Ph(2-F,3,4,5-tri-OCHF₂) Ph(2-F,3-OCHF₂,4- OCF₂CF₂H,5-OCHF₂)Ph(2-F,3-OCHF₂,4-OC₂F₅,5- OCHF₂) Ph(2-F,3-OCHF₂,4-SO₂Me,5- OCHF₂)Ph(2-F,3-OCHF₂,4-TMS,5- OCHF₂) Ph(2-F,3-OCHF₂,4-CN,5- OCHF₂)1H-Imidazol-2-yl(1-CF₂CF₂H,5- Cl) 1H-Imidazol-2-yl(1-CF₂CF₂H,5- F)1H-Imidazol-2-yl(1-CH₂CF₃,5- Cl) 1H-Imidazol-2-yl(1-CH₂CF₃,5-F)1H-Imidazol-2-yl(1-Me,5-CF₂H) 1H-Imidazol-2-yl(1-CF₂CF₂H,5- CF₂H)1H-Imidazol-2-yl(1-CH₂CF₃,5- CF₂H) 1H-Imidazol-2-yl(1-Me,5-CF₃)1H-Imidazol-2-yl(1-CF₂CF₂H,5- CF₃) 1H-Imidazol-2-yl(1-CH₂CF₃,5- CF₃)1,3-Benzodioxo1-4-yl 1,3-Benzodioxo1-4-yl(2,2-di-Me)1,4-Benzodioxo1-4-yl(2,3- dihydro) 1,4-Benzodioxo1-4-yl(2,2,3,3-tetrafluoro) 1H-Pyrazol-3-yl(1-CH₂CF₃,4-F)1H-Pyrazol-3-yl(1-CH₂CF₃,4-Cl) 1H-Pyrazol-3-yl(1-CF₂CF₂H,4-F)1H-Pyrazol-3-yl(1-CF₂CF₂H,4- Cl) 1,3-Benzodioxo1-4-yl(2,2-di-F)

Table 2 is constructed in the same manner except that the Row Heading“Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F); and Q¹ is”is replaced with the Row Heading listed for Table 2 below (i.e. “Y¹ isO; Y¹ is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-F); and Q¹ is”).Therefore the first entry in Table 2 is a compound of Formula 1 whereinY¹ is O, R² is H, R⁴ is H, R⁵ is H, Q² is Ph(2,3-F); and Q¹ is Ph(3-Cl)(i.e. 3-chlorophenyl).

Tables 3 through 1699 are constructed similarly. Table Row Heading 2 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is3 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-F); andQ¹ is 4 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,5-di-F);and Q¹ is 5 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2,3,4-tri-F); and Q¹ is 6 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2,3,5-tri-F); and Q¹ is 7 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 8 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 9 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 10 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Br,4-F); and Q¹is 11 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me);and Q¹ is 12 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-Me,4-F); and Q¹ is 13 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 14 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-F,3-Cl); and Q¹ is 15 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Cl); and Q¹ is 16 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 17 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is 18Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹is 19 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-OMe,4-F); and Q¹ is 20 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 21 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 22 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 23 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 24Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂); and Q¹is 25 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-NO₂,4-F); and Q¹ is 26 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 27 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 28 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 29 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹ is 30 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Me); and Q¹ is 31Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-F); and Q¹is 32 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Cl);and Q¹ is 33 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CF₃,4-Cl); and Q¹ is 34 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 35 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-CF₂H); and Q¹ is 36 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-F); and Q¹ is 37 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 38 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-F); and Q¹ is 39Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Cl); andQ¹ is 40 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CF₂H,4-Cl); and Q¹ is 41 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 42 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-Me); and Q¹ is 43 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 44 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 45 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹ is 46 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-CF₃); and Q¹ is 47Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-Cl);and Q¹ is 48 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Me,3-Cl,4-F); and Q¹ is 49 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 50 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 51 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is 52 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 53 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is54 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et); and Q¹is 55 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-F);and Q¹ is 56 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Et,3-Cl); and Q¹ is 57 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-Et,4-F); and Q¹ is 58 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 59 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr); and Q¹ is 60 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 61 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 62 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is63 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-i-Pr,3,4-di-F); and Q¹ is 64 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-c-Pr); and Q¹ is 65 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹ is 66 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 67 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹ is 68 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is69 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂); and Q¹is 70 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-F);and Q¹ is 71 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-NO₂,3-Cl); and Q¹ is 72 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-NO₂,4-F); and Q¹ is 73 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 74 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃); and Q¹ is 75 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,3-F); and Q¹ is 76 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is 77 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 78Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹is 79 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Cl,3-Me,4-F); and Q¹ is 80 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2,3-di-Cl); and Q¹ is 81 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2,4-di-Cl); and Q¹ is 82 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 83 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is 84 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,5-F); and Q¹ is 85 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is86 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,5-di-F);and Q¹ is 87 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-OCF₂H); and Q¹ is 88 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 89 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 90 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 91 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 92 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 93Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F);and Q¹ is 94 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-OCF₂CF₂H,4-F); and Q¹ is 95 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-Br); and Q¹ is 96 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-Br,3-F); and Q¹ is 97 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-Br,4-F); and Q¹ is 98 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 99 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I); and Q¹ is 100 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 101 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is102 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3,4-di-F);and Q¹ is 103 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CN); and Q¹ is 104 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q²is Ph(2-CN,3-Me); and Q¹ is 105 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-CN,3-F); and Q¹ is 106 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 107 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 108 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹ is 109 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹ is110 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl; andQ¹ is 111 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is2-Pyridinyl,3-F; and Q¹ is 112 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is 2-Pyridinyl,4-F; and Q¹ is 113 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 114 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 115 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-Cl; and Q¹ is116 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is2-Pyridinyl,3-Cl,4-F; and Q¹ is 117 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 118 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 119 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 120 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 121Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,5-F); andQ¹ is 122 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂Me,3,4-di-F); and Q¹ is 123 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 124 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 125 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is126 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂); andQ¹ is 127 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂NH₂,3-F); and Q¹ is 128 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 129 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 130 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 131 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F);and Q¹ is 132 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-F); and Q¹ is 133 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q²is Ph(3,4-di-F); and Q¹ is 134 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(3,5-di-F); and Q¹ is 135 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(3,4,5-tri-F); and Q¹ is 136 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(3-F,4-Cl); and Q¹ is 137 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 138 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is 139 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 140Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,5-F); and Q¹is 141 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-CF₃,4,5-di-F); and Q¹ is 142 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(3-SO₂Me); and Q¹ is 143 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 144 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 145 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is146 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,5-F);and Q¹ is 147 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-SO₂NH₂); and Q¹ is 148 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 149 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 150 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 151 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is152 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me); and Q¹is 153 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-F);and Q¹ is 154 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-Me,4-Cl); and Q¹ is 155 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(3-Me,5-F); and Q¹ is 156 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 157 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl); and Q¹ is 158 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4-F); and Q¹ is 159 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-Cl); and Q¹ is 160 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 161Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F);and Q¹ is 162 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3,5-di-Cl); and Q¹ is 163 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(4-F); and Q¹ is 164 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(4-Cl); and Q¹ is 165 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 166 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl;and Q¹ is 167 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 168 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 169 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-4-yl;and Q¹ is 170 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is1,3-benzodioxol-5-yl; and Q¹ is 171 Y¹ is S; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-F); and Q¹ is 172 Y¹ is S; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is 173 Y¹ is S; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-F); and Q¹ is 174 Y¹ is S; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2,5-di-F); and Q¹ is 175 Y¹ is S; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4-tri-F); and Q¹ is 176 Y¹ isS; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,5-tri-F); and Q¹ is177 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2,3,4,5-tetra-F); and Q¹ is 178 Y¹ is S; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 179 Y¹ is S; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 180 Y¹ is S; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 181Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹is 182 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-Me,4-F); and Q¹ is 183 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 184 Y¹ is S; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl); and Q¹ is 185 Y¹ is S; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Cl); and Q¹ is 186 Y¹ is S; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 187 Y¹is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is188 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe);and Q¹ is 189 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-OMe,4-F); and Q¹ is 190 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 191 Y¹ is S; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 192 Y¹ is S; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 193 Y¹ is S;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is194 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂);and Q¹ is 195 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-NO₂,4-F); and Q¹ is 196 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 197 Y¹ is S; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 198 Y¹ is S; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 199 Y¹ is S; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹ is 200 Y¹is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Me); and Q¹is 201 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-F);and Q¹ is 202 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CF₃,3-Cl); and Q¹ is 203 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 204 Y¹ is S; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 205 Y¹ is S; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H); and Q¹ is 206 Y¹ is S; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-F); and Q¹ is 207 Y¹ isS; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is208 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-F);and Q¹ is 209 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CF₂H,3-Cl); and Q¹ is 210 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 211 Y¹ is S; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 212 Y¹ is S; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me); and Q¹ is 213 Y¹ is S; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 214 Y¹ isS; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 215Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹is 216 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Me,3-CF₃); and Q¹ is 217 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 218 Y¹ is S; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 219 Y¹ is S; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 220 Y¹ is S;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 221 Y¹is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is222 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Me,3,4-di-F); and Q¹ is 223 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 224 Y¹ is S; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-Et); and Q¹ is 225 Y¹ is S; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-F); and Q¹ is 226 Y¹ is S; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-Cl); and Q¹ is 227 Y¹ is S;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹ is 228 Y¹is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3,4-di-F); andQ¹ is 229 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr);and Q¹ is 230 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-i-Pr,3-F); and Q¹ is 231 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 232 Y¹ is S; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is 233 Y¹ is S; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 234 Y¹ is S;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 235 Y¹is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹is 236 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-c-Pr,3-Cl); and Q¹ is 237 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-c-Pr,4-F); and Q¹ is 238 Y¹ is S; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 239 Y¹ is S; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is 240 Y¹ is S; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-F); and Q¹ is 241 Y¹ isS; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is242 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,4-F);and Q¹ is 243 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-NO₂,3,4-di-F); and Q¹ is 244 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-OCF₃); and Q¹ is 245 Y¹ is S; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-OCF₃,3-F); and Q¹ is 246 Y¹ is S; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is 247 Y¹ is S; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 248 Y¹ is S; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 249 Y¹is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); andQ¹ is 250 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2,3-di-Cl); and Q¹ is 251 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2,4-di-Cl); and Q¹ is 252 Y¹ is S; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 253 Y¹ is S; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is 254 Y¹ is S; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,5-F); and Q¹ is 255 Y¹ is S; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 256 Y¹is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,5-di-F); andQ¹ is 257 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-OCF₂H); and Q¹ is 258 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 259 Y¹ is S; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 260 Y¹ is S; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 261 Y¹ is S; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 262 Y¹is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H); and Q¹is 263 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-OCF₂CF₂H,3-F); and Q¹ is 264 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 265 Y¹ is S; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-Br); and Q¹ is 266 Y¹ is S; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3-F); and Q¹ is 267 Y¹ is S; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,4-F); and Q¹ is 268 Y¹ is S; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 269Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I); and Q¹ is270 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3-F); andQ¹ is 271 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-I,4-F); and Q¹ is 272 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-I,3,4-di-F); and Q¹ is 273 Y¹ is S; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-CN); and Q¹ is 274 Y¹ is S; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-CN,3-Me); and Q¹ is 275 Y¹ is S; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-F); and Q¹ is 276 Y¹ is S; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 277 Y¹ is S;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 278Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹is 279 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CN,3,4-di-F); and Q¹ is 280 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is 2-Pyridinyl; and Q¹ is 281 Y¹ is S; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is 2-Pyridinyl,3-F; and Q¹ is 282 Y¹ is S; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-F; and Q¹ is 283 Y¹ is S; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 284Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; andQ¹ is 285 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is2-Pyridinyl,4-Cl; and Q¹ is 286 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 287 Y¹ is S; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 288 Y¹ is S; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 289 Y¹ is S;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is290 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-F);and Q¹ is 291 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂Me,5-F); and Q¹ is 292 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 293 Y¹ is S; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 294 Y¹ is S; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 295 Y¹is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl,4-F);and Q¹ is 296 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂NH₂); and Q¹ is 297 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 298 Y¹ is S; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 299 Y¹ is S; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 300 Y¹ is S;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is301 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂NH₂,3,4-di-F); and Q¹ is 302 Y¹ is S; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(3-F); and Q¹ is 303 Y¹ is S; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(3,4-di-F); and Q¹ is 304 Y¹ is S; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-F); and Q¹ is 305 Y¹ is S; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4,5-tri-F); and Q¹ is 306 Y¹ is S; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F,4-Cl); and Q¹ is 307 Y¹ isS; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 308 Y¹is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is309 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-Cl);and Q¹ is 310 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-CF₃,5-F); and Q¹ is 311 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 312 Y¹ is S; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 313 Y¹ is S; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 314 Y¹ is S; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 315 Y¹is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F);and Q¹ is 316 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-SO₂Me,5-F); and Q¹ is 317 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(3-SO₂NH₂); and Q¹ is 318 Y¹ is S; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 319 Y¹ is S; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 320 Y¹ is S;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is321 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,5-F);and Q¹ is 322 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-Me); and Q¹ is 323 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q²is Ph(3-Me,4-F); and Q¹ is 324 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(3-Me,4-Cl); and Q¹ is 325 Y¹ is S; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is 326 Y¹ is S; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 327 Y¹ is S; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl); and Q¹ is 328 Y¹ is S; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4-F); and Q¹ is 329 Y¹ isS; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-Cl); and Q¹ is330 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,5-F); andQ¹ is 331 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-Cl,4,5-di-F); and Q¹ is 332 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(3,5-di-Cl); and Q¹ is 333 Y¹ is S; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(4-F); and Q¹ is 334 Y¹ is S; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(4-Cl); and Q¹ is 335 Y¹ is S; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 336Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 337 Y¹ is S; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 338 Y¹is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 339 Y¹ is S; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 340 Y¹ is S; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is341 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F); and Q¹is 342 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-F);and Q¹ is 343 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2,4-di-F); and Q¹ is 344 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2,5-di-F); and Q¹ is 345 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2,3,4-tri-F); and Q¹ is 346 Y¹ is O; Y² is S; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2,3,5-tri-F); and Q¹ is 347 Y¹ is O; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 348 Y¹ isO; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹is 349 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-Cl,4-F); and Q¹ is 350 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 351 Y¹ is O; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹ is 352 Y¹ is O; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 353 Y¹ is O;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is354 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl); andQ¹ is 355 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,4-Cl); and Q¹ is 356 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 357 Y¹ is O; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is 358 Y¹ is O; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹ is 359 Y¹ is O; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 360 Y¹ isO; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹is 361 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-CF₂H); and Q¹ is 362 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-F,3-CF₃); and Q¹ is 363 Y¹ is O; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 364 Y¹ is O; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂); and Q¹ is 365 Y¹ is O; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 366Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me); andQ¹ is 367 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-SO₂Me,4-F); and Q¹ is 368 Y¹ is O; Y² is S; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 369 Y¹ is O; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹ is 370 Y¹ is O; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Me); and Q¹ is 371 Y¹ is O; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-F); and Q¹ is 372 Y¹ isO; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Cl); and Q¹ is373 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-Cl);and Q¹ is 374 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CF₃,3,4-di-F); and Q¹ is 375 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-CF₂H); and Q¹ is 376 Y¹ is O; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-CF₂H,3-F); and Q¹ is 377 Y¹ is O; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 378 Y¹ is O; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-F); and Q¹ is 379 Y¹ isO; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is380 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-Cl);and Q¹ is 381 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CF₂H,3,4-di-F); and Q¹ is 382 Y¹ is O; Y² is S; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-Me); and Q¹ is 383 Y¹ is O; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 384 Y¹ is O; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 385 Y¹ is O; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹ is 386 Y¹ is O;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-CF₃); and Q¹ is 387Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-Cl);and Q¹ is 388 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Me,3-Cl,4-F); and Q¹ is 389 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 390 Y¹ is O; Y² is S; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 391 Y¹ is O; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is 392 Y¹ is O; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 393 Y¹ isO; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,5-di-F); and Q¹is 394 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et); andQ¹ is 395 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Et,3-F); and Q¹ is 396 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-Et,3-Cl); and Q¹ is 397 Y¹ is O; Y² is S; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹ is 398 Y¹ is O; Y² is S; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 399 Y¹ is O; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr); and Q¹ is 400 Y¹ is O; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 401 Y¹is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹is 402 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-i-Pr,4-F); and Q¹ is 403 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 404 Y¹ is O; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 405 Y¹ is O; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹ is 406 Y¹ is O; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 407 Y¹is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹is 408 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-c-Pr,3,4-di-F); and Q¹ is 409 Y¹ is O; Y² is S; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is 410 Y¹ is O; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-NO₂,3-F); and Q¹ is 411 Y¹ is O; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 412 Y¹ is O; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,4-F); and Q¹ is 413 Y¹ isO; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F); and Q¹is 414 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃);and Q¹ is 415 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-OCF₃,3-F); and Q¹ is 416 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-OCF₃,4-F); and Q¹ is 417 Y¹ is O; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 418 Y¹ is O; Y² is S; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 419 Y¹ is O; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 420 Y¹ is O;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Cl); and Q¹ is 421Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-Cl); and Q¹is 422 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-F);and Q¹ is 423 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Cl,4-F); and Q¹ is 424 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-Cl,5-F); and Q¹ is 425 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 426 Y¹ is O; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 427 Y¹ is O; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H); and Q¹ is 428 Y¹ is O;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is429 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl);and Q¹ is 430 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-OCF₂H,3-F); and Q¹ is 431 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 432 Y¹ is O; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 433 Y¹ is O; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 434 Y¹ is O; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 435Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br); and Q¹ is436 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3-F); andQ¹ is 437 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Br,4-F); and Q¹ is 438 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-Br,3,4-di-F); and Q¹ is 439 Y¹ is O; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-I); and Q¹ is 440 Y¹ is O; Y² is S; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 441 Y¹ is O; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is 442 Y¹ is O; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3,4-di-F); and Q¹ is 443 Y¹ isO; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN); and Q¹ is 444 Y¹is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Me); and Q¹ is445 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-F); andQ¹ is 446 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CN,4-F); and Q¹ is 447 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-CN,3-Cl); and Q¹ is 448 Y¹ is O; Y² is S; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹ is 449 Y¹ is O; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 450 Y¹ is O; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl; and Q¹ is 451 Y¹ is O;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-F; and Q¹ is 452Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-F; andQ¹ is 453 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is2-Pyridinyl,3,4-di-F; and Q¹ is 454 Y¹ is O; Y² is S; R² is H; R⁴ is H;R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 455 Y¹ is O; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 456 Y¹ is O; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is457 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me); andQ¹ is 458 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂Me,3-F); and Q¹ is 459 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 460 Y¹ is O; Y² is S; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 461 Y¹ is O; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 462 Y¹ is O; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is463 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl);and Q¹ is 464 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂Me,4-Cl); and Q¹ is 465 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 466 Y¹ is O; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂); and Q¹ is 467 Y¹ is O; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 468 Y¹ isO; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹is 469 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂NH₂,4-F); and Q¹ is 470 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 471 Y¹ is O; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 472 Y¹ is O; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F); and Q¹ is 473 Y¹ is O;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-F); and Q¹ is 474 Y¹is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-F); and Q¹ is475 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4,5-tri-F);and Q¹ is 476 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-F,4-Cl); and Q¹ is 477 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(3-CF₃); and Q¹ is 478 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(3-CF₃,4-F); and Q¹ is 479 Y¹ is O; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 480 Y¹ is O; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,5-F); and Q¹ is 481 Y¹ is O; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 482 Y¹is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is483 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl);and Q¹ is 484 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-SO₂Me,4-F); and Q¹ is 485 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 486 Y¹ is O; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 487 Y¹ is O; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂); and Q¹ is 488 Y¹ is O; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 489Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-SO₂NH₂,4,5-di-F); and Q¹ is 490 Y¹ is O; Y² is S; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 491 Y¹ is O; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 492 Y¹ is O; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me); and Q¹ is 493 Y¹ is O;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-F); and Q¹ is 494 Y¹is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-Cl); and Q¹ is495 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,5-F); andQ¹ is 496 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-Me,4,5-di-F); and Q¹ is 497 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(3-Cl); and Q¹ is 498 Y¹ is O; Y² is S; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(3-Cl,4-F); and Q¹ is 499 Y¹ is O; Y² is S; R² is H; R⁴is H; R⁵ is H; Q² is Ph(3,4-di-Cl); and Q¹ is 500 Y¹ is O; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 501 Y¹ is O; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 502 Y¹is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-Cl); and Q¹ is503 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(4-F); and Q¹is 504 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(4-Cl); andQ¹ is 505 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 506 Y¹ is O; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 507 Y¹is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 508 Y¹ is O; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 509 Y¹is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-4-yl;and Q¹ is 510 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is1,3-benzodioxol-5-yl; and Q¹ is 511 Y¹ is S; Y² is S; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-F); and Q¹ is 512 Y¹ is S; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is 513 Y¹ is S; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-F); and Q¹ is 514 Y¹ is S; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2,5-di-F); and Q¹ is 515 Y¹ is S; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4-tri-F); and Q¹ is 516 Y¹ isS; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,5-tri-F); and Q¹ is517 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2,3,4,5-tetra-F); and Q¹ is 518 Y¹ is S; Y² is S; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 519 Y¹ is S; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 520 Y¹ is S; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 521Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹is 522 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-Me,4-F); and Q¹ is 523 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 524 Y¹ is S; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl); and Q¹ is 525 Y¹ is S; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Cl); and Q¹ is 526 Y¹ is S; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 527 Y¹is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is528 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe);and Q¹ is 529 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-OMe,4-F); and Q¹ is 530 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 531 Y¹ is S; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 532 Y¹ is S; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 533 Y¹ is S;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is534 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂);and Q¹ is 535 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-NO₂,4-F); and Q¹ is 536 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 537 Y¹ is S; Y² is S; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 538 Y¹ is S; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 539 Y¹ is S; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹ is 540 Y¹is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Me); and Q¹is 541 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-F);and Q¹ is 542 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CF₃,3-Cl); and Q¹ is 543 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 544 Y¹ is S; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 545 Y¹ is S; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H); and Q¹ is 546 Y¹ is S; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-F); and Q¹ is 547 Y¹ isS; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is548 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-F);and Q¹ is 549 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CF₂H,3-Cl); and Q¹ is 550 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 551 Y¹ is S; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 552 Y¹ is S; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me); and Q¹ is 553 Y¹ is S; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 554 Y¹ isS; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 555Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹is 556 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Me,3-CF₃); and Q¹ is 557 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 558 Y¹ is S; Y² is S; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 559 Y¹ is S; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 560 Y¹ is S;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 561 Y¹is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is562 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Me,3,4-di-F); and Q¹ is 563 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 564 Y¹ is S; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-Et); and Q¹ is 565 Y¹ is S; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-F); and Q¹ is 566 Y¹ is S; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-Cl); and Q¹ is 567 Y¹ is S;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹ is 568 Y¹is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3,4-di-F); andQ¹ is 569 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr);and Q¹ is 570 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-i-Pr,3-F); and Q¹ is 571 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 572 Y¹ is S; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is 573 Y¹ is S; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 574 Y¹ is S;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 575 Y¹is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹is 576 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-c-Pr,3-Cl); and Q¹ is 577 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-c-Pr,4-F); and Q¹ is 578 Y¹ is S; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 579 Y¹ is S; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is 580 Y¹ is S; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-F); and Q¹ is 581 Y¹ isS; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is582 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,4-F);and Q¹ is 583 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-NO₂,3,4-di-F); and Q¹ is 584 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-OCF₃); and Q¹ is 585 Y¹ is S; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-OCF₃,3-F); and Q¹ is 586 Y¹ is S; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is 587 Y¹ is S; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 588 Y¹ is S; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 589 Y¹is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); andQ¹ is 590 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2,3-di-Cl); and Q¹ is 591 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2,4-di-Cl); and Q¹ is 592 Y¹ is S; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 593 Y¹ is S; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is 594 Y¹ is S; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,5-F); and Q¹ is 595 Y¹ is S; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 596 Y¹is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,5-di-F); andQ¹ is 597 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-OCF₂H); and Q¹ is 598 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 599 Y¹ is S; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 600 Y¹ is S; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 601 Y¹ is S; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 602 Y¹is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H); and Q¹is 603 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-OCF₂CF₂H,3-F); and Q¹ is 604 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 605 Y¹ is S; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-Br); and Q¹ is 606 Y¹ is S; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3-F); and Q¹ is 607 Y¹ is S; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,4-F); and Q¹ is 608 Y¹ is S; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 609Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I); and Q¹ is610 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3-F); andQ¹ is 611 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-I,4-F); and Q¹ is 612 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-I,3,4-di-F); and Q¹ is 613 Y¹ is S; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-CN); and Q¹ is 614 Y¹ is S; Y² is S; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-CN,3-Me); and Q¹ is 615 Y¹ is S; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-F); and Q¹ is 616 Y¹ is S; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 617 Y¹ is S;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 618Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹is 619 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CN,3,4-di-F); and Q¹ is 620 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is 2-Pyridinyl; and Q¹ is 621 Y¹ is S; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is 2-Pyridinyl,3-F; and Q¹ is 622 Y¹ is S; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-F; and Q¹ is 623 Y¹ is S; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 624Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; andQ¹ is 625 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is2-Pyridinyl,4-Cl; and Q¹ is 626 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 627 Y¹ is S; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 628 Y¹ is S; Y² is S;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 629 Y¹ is S;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is630 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-F);and Q¹ is 631 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂Me,5-F); and Q¹ is 632 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 633 Y¹ is S; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 634 Y¹ is S; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 635 Y¹is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl,4-F);and Q¹ is 636 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂NH₂); and Q¹ is 637 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 638 Y¹ is S; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 639 Y¹ is S; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 640 Y¹ is S;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is641 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂NH₂,3,4-di-F); and Q¹ is 642 Y¹ is S; Y² is S; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(3-F); and Q¹ is 643 Y¹ is S; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(3,4-di-F); and Q¹ is 644 Y¹ is S; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-F); and Q¹ is 645 Y¹ is S; Y² is S; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4,5-tri-F); and Q¹ is 646 Y¹ is S; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F,4-Cl); and Q¹ is 647 Y¹ isS; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 648 Y¹is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is649 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-Cl);and Q¹ is 650 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-CF₃,5-F); and Q¹ is 651 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 652 Y¹ is S; Y² is S; R² is H; R⁴is H; R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 653 Y¹ is S; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 654 Y¹ is S; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 655 Y¹is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F);and Q¹ is 656 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-SO₂Me,5-F); and Q¹ is 657 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(3-SO₂NH₂); and Q¹ is 658 Y¹ is S; Y² is S; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 659 Y¹ is S; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 660 Y¹ is S;Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is661 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,5-F);and Q¹ is 662 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-Me); and Q¹ is 663 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q²is Ph(3-Me,4-F); and Q¹ is 664 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(3-Me,4-Cl); and Q¹ is 665 Y¹ is S; Y² is S; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is 666 Y¹ is S; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 667 Y¹ is S; Y² isS; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl); and Q¹ is 668 Y¹ is S; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4-F); and Q¹ is 669 Y¹ isS; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-Cl); and Q¹ is670 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,5-F); andQ¹ is 671 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-Cl,4,5-di-F); and Q¹ is 672 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵is H; Q² is Ph(3,5-di-Cl); and Q¹ is 673 Y¹ is S; Y² is S; R² is H; R⁴is H; R⁵ is H; Q² is Ph(4-F); and Q¹ is 674 Y¹ is S; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(4-Cl); and Q¹ is 675 Y¹ is S; Y² is S; R² isH; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 676Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 677 Y¹ is S; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 678 Y¹is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 679 Y¹ is S; Y² is S; R² is H;R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 680 Y¹ is S; Y²is S; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is681 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F); and Q¹is 682 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-F);and Q¹ is 683 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2,4-di-F); and Q¹ is 684 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2,5-di-F); and Q¹ is 685 Y¹ is NH; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2,3,4-tri-F); and Q¹ is 686 Y¹ is NH; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,5-tri-F); and Q¹ is 687 Y¹ is NH;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is688 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-Cl,4-Br); and Q¹ is 689 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 690 Y¹ is NH; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 691 Y¹ is NH; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹ is 692 Y¹ isNH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-F); and Q¹is 693 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-Me,4-Cl); and Q¹ is 694 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-F,3-Cl); and Q¹ is 695 Y¹ is NH; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-F,4-Cl); and Q¹ is 696 Y¹ is NH; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 697 Y¹ is NH;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is 698 Y¹is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹is 699 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-OMe,4-F); and Q¹ is 700 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 701 Y¹ is NH; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 702 Y¹ is NH; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 703 Y¹ isNH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹is 704 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-NO₂); and Q¹ is 705 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 706 Y¹ is NH; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 707 Y¹ is NH; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 708 Y¹is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is709 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-F);and Q¹ is 710 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CF₃,3-Me); and Q¹ is 711 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-CF₃,4-F); and Q¹ is 712 Y¹ is NH; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 713 Y¹ is NH; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 714 Y¹ is NH; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 715 Y¹is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H); and Q¹ is716 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-F);and Q¹ is 717 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CF₂H,3-Me); and Q¹ is 718 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-CF₂H,4-F); and Q¹ is 719 Y¹ is NH; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 720 Y¹ is NH; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 721 Y¹ isNH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3,4-di-F); andQ¹ is 722 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me);and Q¹ is 723 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2,3-di-Me); and Q¹ is 724 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-Me,3-F); and Q¹ is 725 Y¹ is NH; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹ is 726 Y¹ is NH; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-CF₃); and Q¹ is 727 Y¹ is NH; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 728 Y¹is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); andQ¹ is 729 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Me,4-Cl); and Q¹ is 730 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-Me,4-F); and Q¹ is 731 Y¹ is NH; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is 732 Y¹ is NH; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 733 Y¹ is NH; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 734Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et); and Q¹ is735 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-F);and Q¹ is 736 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Et,3-Cl); and Q¹ is 737 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-Et,4-F); and Q¹ is 738 Y¹ is NH; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 739 Y¹ is NH; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr); and Q¹ is 740 Y¹ is NH; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 741 Y¹ isNH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is742 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,4-F);and Q¹ is 743 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-i-Pr,3,4-di-F); and Q¹ is 744 Y¹ is NH; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 745 Y¹ is NH; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹ is 746 Y¹ is NH; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 747 Y¹ is NH;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹ is 748Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3,4-di-F);and Q¹ is 749 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-NO₂); and Q¹ is 750 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H;Q² is Ph(2-NO₂,3-F); and Q¹ is 751 Y¹ is NH; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 752 Y¹ is NH; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,4-F); and Q¹ is 753 Y¹ is NH; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 754 Y¹ isNH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃); and Q¹ is 755Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,3-F); andQ¹ is 756 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-OCF₃,4-F); and Q¹ is 757 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-Cl); and Q¹ is 758 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 759 Y¹ is NH; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 760 Y¹ is NH; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Cl); and Q¹ is 761 Y¹ is NH;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-Cl); and Q¹ is 762Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹is 763 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,4-F);and Q¹ is 764 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Cl,5-F); and Q¹ is 765 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 766 Y¹ is NH; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 767 Y¹ is NH; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H); and Q¹ is 768 Y¹ is NH; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 769Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl);and Q¹ is 770 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-OCF₂H,3-F); and Q¹ is 771 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 772 Y¹ is NH; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 773 Y¹ is NH; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 774 Y¹ isNH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹is 775 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br); andQ¹ is 776 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-Br,3-F); and Q¹ is 777 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-Br,4-F); and Q¹ is 778 Y¹ is NH; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 779 Y¹ is NH; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I); and Q¹ is 780 Y¹ is NH; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 781 Y¹ is NH; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is 782 Y¹ isNH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3,4-di-F); and Q¹is 783 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN); andQ¹ is 784 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-CN,3-Me); and Q¹ is 785 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(2-CN,3-F); and Q¹ is 786 Y¹ is NH; Y² is O; R² is H; R⁴ isH; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 787 Y¹ is NH; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 788 Y¹ is NH; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹ is 789 Y¹ isNH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹is 790 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl;and Q¹ is 791 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is2-Pyridinyl,3-F; and Q¹ is 792 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is 2-Pyridinyl,4-F; and Q¹ is 793 Y¹ is NH; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 794 Y¹ is NH; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 795Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-Cl;and Q¹ is 796 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is2-Pyridinyl,3-Cl,4-F; and Q¹ is 797 Y¹ is NH; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 798 Y¹ is NH; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 799 Y¹ is NH; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 800 Y¹ isNH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-F); and Q¹ is801 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,5-F);and Q¹ is 802 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂Me,3,4-di-F); and Q¹ is 803 Y¹ is NH; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 804 Y¹ is NH; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 805 Y¹ is NH; Y²is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is806 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂);and Q¹ is 807 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂NH₂,3-F); and Q¹ is 808 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 809 Y¹ is NH; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 810 Y¹ is NH; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 811 Y¹is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F);and Q¹ is 812 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-F); and Q¹ is 813 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q²is Ph(3,4-di-F); and Q¹ is 814 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(3,5-di-F); and Q¹ is 815 Y¹ is NH; Y² is O; R² is H; R⁴is H; R⁵ is H; Q² is Ph(3,4,5-tri-F); and Q¹ is 816 Y¹ is NH; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F,4-Cl); and Q¹ is 817 Y¹ is NH;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 818 Y¹ isNH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is819 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-Cl);and Q¹ is 820 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-CF₃,5-F); and Q¹ is 821 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ isH; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 822 Y¹ is NH; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 823 Y¹ is NH; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 824 Y¹ is NH;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 825Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-SO₂Me,4,5-di-F); and Q¹ is 826 Y¹ is NH; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 827 Y¹ is NH; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂); and Q¹ is 828 Y¹ is NH; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 829 Y¹is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F);and Q¹ is 830 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-SO₂NH₂,4-Cl); and Q¹ is 831 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 832 Y¹ is NH; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(3-Me); and Q¹ is 833 Y¹ is NH; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-F); and Q¹ is 834 Y¹ is NH; Y² isO; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-Cl); and Q¹ is 835 Y¹ isNH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is836 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(3-Me,4,5-di-F); and Q¹ is 837 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵is H; Q² is Ph(3-Cl); and Q¹ is 838 Y¹ is NH; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is Ph(3-Cl,4-F); and Q¹ is 839 Y¹ is NH; Y² is O; R² is H;R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-Cl); and Q¹ is 840 Y¹ is NH; Y² is O;R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 841 Y¹ is NH;Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is842 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-Cl);and Q¹ is 843 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² isPh(4-F); and Q¹ is 844 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q²is Ph(4-Cl); and Q¹ is 845 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H;Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 846 Y¹ is NH; Y² is O; R²is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is847 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 848 Y¹ is NH; Y² is O; R² isH; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 849Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is1,3-benzodioxol-4-yl; and Q¹ is 850 Y¹ is NH; Y² is O; R² is H; R⁴ is H;R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 851 Y¹ is O; Y² is O; R²is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F); and Q¹ is 852 Y¹ is O; Y² is O;R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is 853 Y¹ is O;Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-F); and Q¹ is 854Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,5-di-F); and Q¹is 855 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2,3,4-tri-F); and Q¹ is 856 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(2,3,5-tri-F); and Q¹ is 857 Y¹ is O; Y² is O; R² is Me;R⁴ is H; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 858 Y¹ is O; Y²is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 859Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-F);and Q¹ is 860 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-Br,4-F); and Q¹ is 861 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(2-F,3-Me); and Q¹ is 862 Y¹ is O; Y² is O; R² is Me; R⁴is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 863 Y¹ is O; Y² is O;R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 864 Y¹ isO; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl); and Q¹ is865 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Cl);and Q¹ is 866 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-F,3,4-di-Cl); and Q¹ is 867 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(2-F,4-Br); and Q¹ is 868 Y¹ is O; Y² is O; R² is Me; R⁴is H; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹ is 869 Y¹ is O; Y² is O; R²is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 870 Y¹ is O;Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is871 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₂H);and Q¹ is 872 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-CF₃); and Q¹ is 873 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ isH; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 874 Y¹ is O; Y² is O; R² is Me; R⁴is H; R⁵ is H; Q² is Ph(2-F,3-NO₂); and Q¹ is 875 Y¹ is O; Y² is O; R²is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 876 Y¹ is O;Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is877 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-F,3-SO₂Me,4-F); and Q¹ is 878 Y¹ is O; Y² is O; R² is Me; R⁴ is H;R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 879 Y¹ is O; Y² is O; R² is Me; R⁴is H; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹ is 880 Y¹ is O; Y² is O; R²is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Me); and Q¹ is 881 Y¹ is O; Y²is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-F); and Q¹ is 882 Y¹is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Cl); and Q¹is 883 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-CF₃,4-Cl); and Q¹ is 884 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ isH; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 885 Y¹ is O; Y² is O; R² is Me;R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H); and Q¹ is 886 Y¹ is O; Y² is O; R²is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-F); and Q¹ is 887 Y¹ is O; Y²is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 888Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-F); andQ¹ is 889 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-CF₂H,3-Cl); and Q¹ is 890 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 891 Y¹ is O; Y² is O; R² is Me;R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 892 Y¹ is O; Y²is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me); and Q¹ is 893 Y¹ is O;Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 894Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹is 895 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-Me,3-Cl); and Q¹ is 896 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ isH; Q² is Ph(2-Me,3-CF₃); and Q¹ is 897 Y¹ is O; Y² is O; R² is Me; R⁴ isH; R⁵ is H; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 898 Y¹ is O; Y² is O; R²is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 899 Y¹ is O;Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 900Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹is 901 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,5-F);and Q¹ is 902 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-Me,3,4-di-F); and Q¹ is 903 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 904 Y¹ is O; Y² is O; R² is Me;R⁴ is H; R⁵ is H; Q² is Ph(2-Et); and Q¹ is 905 Y¹ is O; Y² is O; R² isMe; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-F); and Q¹ is 906 Y¹ is O; Y² isO; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-Cl); and Q¹ is 907 Y¹ isO; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹ is908 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-Et,3,4-di-F); and Q¹ is 909 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(2-i-Pr); and Q¹ is 910 Y¹ is O; Y² is O; R² is Me; R⁴ isH; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 911 Y¹ is O; Y² is O; R² isMe; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 912 Y¹ is O; Y²is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is 913 Y¹is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3,4-di-F);and Q¹ is 914 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-c-Pr); and Q¹ is 915 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H;Q² is Ph(2-c-Pr,3-F); and Q¹ is 916 Y¹ is O; Y² is O; R² is Me; R⁴ is H;R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 917 Y¹ is O; Y² is O; R² isMe; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹ is 918 Y¹ is O; Y² isO; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 919Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is920 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-F);and Q¹ is 921 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-NO₂,3-Cl); and Q¹ is 922 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ isH; Q² is Ph(2-NO₂,4-F); and Q¹ is 923 Y¹ is O; Y² is O; R² is Me; R⁴ isH; R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 924 Y¹ is O; Y² is O; R²is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃); and Q¹ is 925 Y¹ is O; Y² isO; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,3-F); and Q¹ is 926 Y¹ isO; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is927 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl); and Q¹is 928 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-Cl,3-Me); and Q¹ is 929 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ isH; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 930 Y¹ is O; Y² is O; R² is Me; R⁴is H; R⁵ is H; Q² is Ph(2,3-di-Cl); and Q¹ is 931 Y¹ is O; Y² is O; R²is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-Cl); and Q¹ is 932 Y¹ is O; Y²is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 933 Y¹is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is934 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,5-F);and Q¹ is 935 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-Cl,3,4-di-F); and Q¹ is 936 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 937 Y¹ is O; Y² is O; R² is Me;R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H); and Q¹ is 938 Y¹ is O; Y² is O; R²is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 939 Y¹ is O;Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is940 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-F);and Q¹ is 941 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-OCF₂H,4-F); and Q¹ is 942 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 943 Y¹ is O; Y² is O; R² is Me; R⁴is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 944 Y¹ is O; Y² is O;R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 945 Y¹is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Br); and Q¹ is 946Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3-F); and Q¹is 947 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,4-F);and Q¹ is 948 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-Br,3,4-di-F); and Q¹ is 949 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(2-I); and Q¹ is 950 Y¹ is O; Y² is O; R² is Me; R⁴ is H;R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 951 Y¹ is O; Y² is O; R² is Me; R⁴is H; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is 952 Y¹ is O; Y² is O; R² isMe; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3,4-di-F); and Q¹ is 953 Y¹ is O; Y²is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CN); and Q¹ is 954 Y¹ is O;Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Me); and Q¹ is 955Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-F); and Q¹is 956 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-F);and Q¹ is 957 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-CN,3-Cl); and Q¹ is 958 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ isH; Q² is Ph(2-CN,4-Cl); and Q¹ is 959 Y¹ is O; Y² is O; R² is Me; R⁴ isH; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 960 Y¹ is O; Y² is O; R²is Me; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl; and Q¹ is 961 Y¹ is O; Y² isO; R² is Me; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-F; and Q¹ is 962 Y¹is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-F; and Q¹is 963 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is2-Pyridinyl,3,4-di-F; and Q¹ is 964 Y¹ is O; Y² is O; R² is Me; R⁴ is H;R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 965 Y¹ is O; Y² is O; R² isMe; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 966 Y¹ is O; Y²is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is967 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me); andQ¹ is 968 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂Me,3-F); and Q¹ is 969 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 970 Y¹ is O; Y² is O; R² is Me;R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 971 Y¹ is O; Y² is O;R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 972 Y¹ isO; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3,4-di-F); andQ¹ is 973 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂Me,3-Cl); and Q¹ is 974 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 975 Y¹ is O; Y² is O; R² is Me;R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 976 Y¹ is O; Y²is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂); and Q¹ is 977 Y¹is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-F); andQ¹ is 978 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(2-SO₂NH₂,3-Cl); and Q¹ is 979 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 980 Y¹ is O; Y² is O; R² is Me;R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 981 Y¹ is O; Y² isO; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is982 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-F); and Q¹is 983 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-F);and Q¹ is 984 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(3,5-di-F); and Q¹ is 985 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ isH; Q² is Ph(3,4,5-tri-F); and Q¹ is 986 Y¹ is O; Y² is O; R² is Me; R⁴is H; R⁵ is H; Q² is Ph(3-F,4-Cl); and Q¹ is 987 Y¹ is O; Y² is O; R² isMe; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 988 Y¹ is O; Y² is O;R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is 989 Y¹ is O;Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 990Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,5-F); andQ¹ is 991 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(3-CF₃,4,5-di-F); and Q¹ is 992 Y¹ is O; Y² is O; R² is Me; R⁴ is H;R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 993 Y¹ is O; Y² is O; R² is Me; R⁴is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 994 Y¹ is O; Y² is O;R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 995 Y¹ isO; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F); andQ¹ is 996 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(3-SO₂Me,5-F); and Q¹ is 997 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(3-SO₂NH₂); and Q¹ is 998 Y¹ is O; Y² is O; R² is Me; R⁴is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 999 Y¹ is O; Y² is O;R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 1000Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl);and Q¹ is 1001 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(3-SO₂NH₂,5-F); and Q¹ is 1002 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵is H; Q² is Ph(3-Me); and Q¹ is 1003 Y¹ is O; Y² is O; R² is Me; R⁴ isH; R⁵ is H; Q² is Ph(3-Me,4-F); and Q¹ is 1004 Y¹ is O; Y² is O; R² isMe; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-Cl); and Q¹ is 1005 Y¹ is O; Y² isO; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is 1006 Y¹ isO; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹is 1007 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl);and Q¹ is 1008 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² isPh(3-Cl,4-F); and Q¹ is 1009 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ isH; Q² is Ph(3,4-di-Cl); and Q¹ is 1010 Y¹ is O; Y² is O; R² is Me; R⁴ isH; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 1011 Y¹ is O; Y² is O; R² isMe; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 1012 Y¹ is O;Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-Cl); and Q¹ is 1013Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(4-F); and Q¹ is1014 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(4-Cl); andQ¹ is 1015 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 1016 Y¹ is O; Y² is O; R² isMe; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is1017 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 1018 Y¹ is O; Y² is O; R² isMe; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is1019 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is1,3-benzodioxol-4-yl; and Q¹ is 1020 Y¹ is O; Y² is O; R² is Me; R⁴ isH; R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 1021 Y¹ is O; Y² is O;R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F); and Q¹ is 1022 Y¹ is O; Y² isO; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is 1023 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2,4-di-F); and Q¹ is1024 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2,5-di-F);and Q¹ is 1025 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2,3,4-tri-F); and Q¹ is 1026 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵is H; Q² is Ph(2,3,5-tri-F); and Q¹ is 1027 Y¹ is O; Y² is O; R² is H;R⁴ is Br; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 1028 Y¹ is O; Y²is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is1029 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-F,3-Cl,4-F); and Q¹ is 1030 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 1031 Y¹ is O; Y² is O; R² is H;R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹ is 1032 Y¹ is O; Y² is O;R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 1033 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹is 1034 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-F,3-Cl); and Q¹ is 1035 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ isH; Q² is Ph(2-F,4-Cl); and Q¹ is 1036 Y¹ is O; Y² is O; R² is H; R⁴ isBr; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 1037 Y¹ is O; Y² is O;R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is 1038 Y¹ is O;Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹ is 1039Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-OMe,4-F);and Q¹ is 1040 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-F,3-OMe,4-Cl); and Q¹ is 1041 Y¹ is O; Y² is O; R² is H; R⁴ is Br;R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 1042 Y¹ is O; Y² is O; R² is H;R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 1043 Y¹ is O; Y² is O;R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 1044 Y¹is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-NO₂); and Q¹is 1045 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-F,3-NO₂,4-F); and Q¹ is 1046 Y¹ is O; Y² is O; R² is H; R⁴ is Br;R⁵ is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 1047 Y¹ is O; Y² is O; R² isH; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 1048 Y¹ is O;Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 1049 Y¹is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹is 1050 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-CF₃,3-Me); and Q¹ is 1051 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵is H; Q² is Ph(2-CF₃,4-F); and Q¹ is 1052 Y¹ is O; Y² is O; R² is H; R⁴is Br; R⁵ is H; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 1053 Y¹ is O; Y² is O;R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 1054 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₃,3,4-di-F); and Q¹is 1055 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₂H);and Q¹ is 1056 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-CF₂H,3-F); and Q¹ is 1057 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 1058 Y¹ is O; Y² is O; R² is H;R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₂H,4-F); and Q¹ is 1059 Y¹ is O; Y² isO; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 1060 Y¹is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₂H,4-Cl); and Q¹is 1061 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-CF₂H,3,4-di-F); and Q¹ is 1062 Y¹ is O; Y² is O; R² is H; R⁴ is Br;R⁵ is H; Q² is Ph(2-Me); and Q¹ is 1063 Y¹ is O; Y² is O; R² is H; R⁴ isBr; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 1064 Y¹ is O; Y² is O; R² isH; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 1065 Y¹ is O; Y² isO; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹ is 1066 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,3-CF₃); and Q¹ is1067 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-Me,3,4-di-Cl); and Q¹ is 1068 Y¹ is O; Y² is O; R² is H; R⁴ is Br;R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 1069 Y¹ is O; Y² is O; R² isH; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 1070 Y¹ is O; Y² isO; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 1071 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is1072 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-Me,3,4-di-F); and Q¹ is 1073 Y¹ is O; Y² is O; R² is H; R⁴ is Br;R⁵ is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 1074 Y¹ is O; Y² is O; R² isH; R⁴ is Br; R⁵ is H; Q² is Ph(2-Et); and Q¹ is 1075 Y¹ is O; Y² is O;R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Et,3-F); and Q¹ is 1076 Y¹ is O;Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Et,3-Cl); and Q¹ is 1077Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹is 1078 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-Et,3,4-di-F); and Q¹ is 1079 Y¹ is O; Y² is O; R² is H; R⁴ is Br;R⁵ is H; Q² is Ph(2-i-Pr); and Q¹ is 1080 Y¹ is O; Y² is O; R² is H; R⁴is Br; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 1081 Y¹ is O; Y² is O;R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 1082 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is1083 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-i-Pr,3,4-di-F); and Q¹ is 1084 Y¹ is O; Y² is O; R² is H; R⁴ is Br;R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 1085 Y¹ is O; Y² is O; R² is H; R⁴is Br; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹ is 1086 Y¹ is O; Y² is O;R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 1087 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹ is1088 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-c-Pr,3,4-di-F); and Q¹ is 1089 Y¹ is O; Y² is O; R² is H; R⁴ is Br;R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is 1090 Y¹ is O; Y² is O; R² is H; R⁴is Br; R⁵ is H; Q² is Ph(2-NO₂,3-F); and Q¹ is 1091 Y¹ is O; Y² is O; R²is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 1092 Y¹ is O;Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-NO₂,4-F); and Q¹ is 1093Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F);and Q¹ is 1094 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-OCF₃); and Q¹ is 1095 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H;Q² is Ph(2-OCF₃,3-F); and Q¹ is 1096 Y¹ is O; Y² is O; R² is H; R⁴ isBr; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is 1097 Y¹ is O; Y² is O; R²is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 1098 Y¹ is O; Y² isO; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 1099 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); and Q¹is 1100 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2,3-di-Cl); and Q¹ is 1101 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ isH; Q² is Ph(2,4-di-Cl); and Q¹ is 1102 Y¹ is O; Y² is O; R² is H; R⁴ isBr; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 1103 Y¹ is O; Y² is O; R² isH; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is 1104 Y¹ is O; Y² isO; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl,5-F); and Q¹ is 1105 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹is 1106 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-Cl,3,5-di-F); and Q¹ is 1107 Y¹ is O; Y² is O; R² is H; R⁴ is Br;R⁵ is H; Q² is Ph(2-OCF₂H); and Q¹ is 1108 Y¹ is O; Y² is O; R² is H; R⁴is Br; R⁵ is H; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 1109 Y¹ is O; Y² is O;R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 1110 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₂H,3-F); and Q¹ is1111 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-OCF₂H,4-F); and Q¹ is 1112 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 1113 Y¹ is O; Y² is O; R² is H; R⁴is Br; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 1114 Y¹ is O; Y² isO; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 1115Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Br); and Q¹ is1116 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Br,3-F);and Q¹ is 1117 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-Br,4-F); and Q¹ is 1118 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ isH; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 1119 Y¹ is O; Y² is O; R² is H; R⁴is Br; R⁵ is H; Q² is Ph(2-I); and Q¹ is 1120 Y¹ is O; Y² is O; R² is H;R⁴ is Br; R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 1121 Y¹ is O; Y² is O;R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is 1122 Y¹ is O;Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-I,3,4-di-F); and Q¹ is1123 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CN); andQ¹ is 1124 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-CN,3-Me); and Q¹ is 1125 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ isH; Q² is Ph(2-CN,3-F); and Q¹ is 1126 Y¹ is O; Y² is O; R² is H; R⁴ isBr; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 1127 Y¹ is O; Y² is O; R² isH; R⁴ is Br; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 1128 Y¹ is O; Y² isO; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹ is 1129 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹is 1130 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 2-Pyridinyl;and Q¹ is 1131 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is2-Pyridinyl,3-F; and Q¹ is 1132 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵is H; Q² is 2-Pyridinyl,4-F; and Q¹ is 1133 Y¹ is O; Y² is O; R² is H;R⁴ is Br; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 1134 Y¹ is O;Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is1135 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is2-Pyridinyl,4-Cl; and Q¹ is 1136 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 1137 Y¹ is O; Y² is O; R² isH; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 1138 Y¹ is O; Y² isO; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 1139 Y¹is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); andQ¹ is 1140 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-SO₂Me,4-F); and Q¹ is 1141 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵is H; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 1142 Y¹ is O; Y² is O; R² is H;R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 1143 Y¹ is O;Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is1144 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-SO₂Me,4-Cl); and Q¹ is 1145 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 1146 Y¹ is O; Y² is O; R² isH; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂NH₂); and Q¹ is 1147 Y¹ is O; Y² isO; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 1148 Y¹is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-Cl); andQ¹ is 1149 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(2-SO₂NH₂,4-F); and Q¹ is 1150 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 1151 Y¹ is O; Y² is O; R² is H;R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 1152 Y¹ is O;Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-F); and Q¹ is 1153 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3,4-di-F); and Q¹ is1154 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3,5-di-F);and Q¹ is 1155 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(3,4,5-tri-F); and Q¹ is 1156 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵is H; Q² is Ph(3-F,4-Cl); and Q¹ is 1157 Y¹ is O; Y² is O; R² is H; R⁴is Br; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 1158 Y¹ is O; Y² is O; R² isH; R⁴ is Br; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is 1159 Y¹ is O; Y² isO; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 1160 Y¹is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-CF₃,5-F); and Q¹is 1161 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(3-CF₃,4,5-di-F); and Q¹ is 1162 Y¹ is O; Y² is O; R² is H; R⁴ is Br;R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 1163 Y¹ is O; Y² is O; R² is H; R⁴is Br; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 1164 Y¹ is O; Y² is O;R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 1165 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F); andQ¹ is 1166 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(3-SO₂Me,5-F); and Q¹ is 1167 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵is H; Q² is Ph(3-SO₂NH₂); and Q¹ is 1168 Y¹ is O; Y² is O; R² is H; R⁴is Br; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 1169 Y¹ is O; Y² is O;R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 1170Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl);and Q¹ is 1171 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(3-SO₂NH₂,5-F); and Q¹ is 1172 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵is H; Q² is Ph(3-Me); and Q¹ is 1173 Y¹ is O; Y² is O; R² is H; R⁴ isBr; R⁵ is H; Q² is Ph(3-Me,4-F); and Q¹ is 1174 Y¹ is O; Y² is O; R² isH; R⁴ is Br; R⁵ is H; Q² is Ph(3-Me,4-Cl); and Q¹ is 1175 Y¹ is O; Y² isO; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is 1176 Y¹ isO; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹is 1177 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-Cl);and Q¹ is 1178 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² isPh(3-Cl,4-F); and Q¹ is 1179 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ isH; Q² is Ph(3,4-di-Cl); and Q¹ is 1180 Y¹ is O; Y² is O; R² is H; R⁴ isBr; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 1181 Y¹ is O; Y² is O; R² isH; R⁴ is Br; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 1182 Y¹ is O;Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3,5-di-Cl); and Q¹ is 1183Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(4-F); and Q¹ is1184 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(4-Cl); andQ¹ is 1185 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 1186 Y¹ is O; Y² is O; R² is H;R⁴ is Br; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 1187Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 1188 Y¹ is O; Y² is O; R² isH; R⁴ is Br; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is1189 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is1,3-benzodioxol-4-yl; and Q¹ is 1190 Y¹ is O; Y² is O; R² is H; R⁴ isBr; R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 1191 Y¹ is O; Y² isO; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F); and Q¹ is 1192 Y¹ is O; Y²is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is 1193 Y¹is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2,4-di-F); and Q¹ is1194 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2,5-di-F);and Q¹ is 1195 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2,3,4-tri-F); and Q¹ is 1196 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵is H; Q² is Ph(2,3,5-tri-F); and Q¹ is 1197 Y¹ is O; Y² is O; R² is H;R⁴ is Cl; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 1198 Y¹ is O; Y²is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is1199 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-F,3-Cl,4-F); and Q¹ is 1200 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 1201 Y¹ is O; Y² is O; R² is H;R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹ is 1202 Y¹ is O; Y² is O;R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 1203 Y¹ isO; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹is 1204 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-F,3-Cl); and Q¹ is 1205 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ isH; Q² is Ph(2-F,4-Cl); and Q¹ is 1206 Y¹ is O; Y² is O; R² is H; R⁴ isCl; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 1207 Y¹ is O; Y² is O;R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is 1208 Y¹ is O;Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹ is 1209Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-OMe,4-F);and Q¹ is 1210 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-F,3-OMe,4-Cl); and Q¹ is 1211 Y¹ is O; Y² is O; R² is H; R⁴ is Cl;R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 1212 Y¹ is O; Y² is O; R² is H;R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 1213 Y¹ is O; Y² is O;R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 1214 Y¹is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-NO₂); and Q¹is 1215 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-F,3-NO₂,4-F); and Q¹ is 1216 Y¹ is O; Y² is O; R² is H; R⁴ is Cl;R⁵ is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 1217 Y¹ is O; Y² is O; R² isH; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 1218 Y¹ is O;Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 1219 Y¹is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹is 1220 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-CF₃,3-Me); and Q¹ is 1221 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵is H; Q² is Ph(2-CF₃,4-F); and Q¹ is 1222 Y¹ is O; Y² is O; R² is H; R⁴is Cl; R⁵ is H; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 1223 Y¹ is O; Y² is O;R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 1224 Y¹ isO; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₃,3,4-di-F); and Q¹is 1225 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₂H);and Q¹ is 1226 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-CF₂H,3-F); and Q¹ is 1227 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 1228 Y¹ is O; Y² is O; R² is H;R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₂H,4-F); and Q¹ is 1229 Y¹ is O; Y² isO; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 1230 Y¹is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₂H,4-Cl); and Q¹is 1231 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-CF₂H,3,4-di-F); and Q¹ is 1232 Y¹ is O; Y² is O; R² is H; R⁴ is Cl;R⁵ is H; Q² is Ph(2-Me); and Q¹ is 1233 Y¹ is O; Y² is O; R² is H; R⁴ isCl; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 1234 Y¹ is O; Y² is O; R² isH; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 1235 Y¹ is O; Y² isO; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹ is 1236 Y¹ isO; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,3-CF₃); and Q¹ is1237 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-Me,3,4-di-Cl); and Q¹ is 1238 Y¹ is O; Y² is O; R² is H; R⁴ is Cl;R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 1239 Y¹ is O; Y² is O; R² isH; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 1240 Y¹ is O; Y² isO; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 1241 Y¹ isO; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is1242 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-Me,3,4-di-F); and Q¹ is 1243 Y¹ is O; Y² is O; R² is H; R⁴ is Cl;R⁵ is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 1244 Y¹ is O; Y² is O; R² isH; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Et); and Q¹ is 1245 Y¹ is O; Y² is O;R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Et,3-F); and Q¹ is 1246 Y¹ is O;Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Et,3-Cl); and Q¹ is 1247Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹is 1248 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-Et,3,4-di-F); and Q¹ is 1249 Y¹ is O; Y² is O; R² is H; R⁴ is Cl;R⁵ is H; Q² is Ph(2-i-Pr); and Q¹ is 1250 Y¹ is O; Y² is O; R² is H; R⁴is Cl; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 1251 Y¹ is O; Y² is O;R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 1252 Y¹ isO; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is1253 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-i-Pr,3,4-di-F); and Q¹ is 1254 Y¹ is O; Y² is O; R² is H; R⁴ is Cl;R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 1255 Y¹ is O; Y² is O; R² is H; R⁴is Cl; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹ is 1256 Y¹ is O; Y² is O;R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 1257 Y¹ isO; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹ is1258 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-c-Pr,3,4-di-F); and Q¹ is 1259 Y¹ is O; Y² is O; R² is H; R⁴ is Cl;R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is 1260 Y¹ is O; Y² is O; R² is H; R⁴is Cl; R⁵ is H; Q² is Ph(2-NO₂,3-F); and Q¹ is 1261 Y¹ is O; Y² is O; R²is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 1262 Y¹ is O;Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-NO₂,4-F); and Q¹ is 1263Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F);and Q¹ is 1264 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-OCF₃); and Q¹ is 1265 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H;Q² is Ph(2-OCF₃,3-F); and Q¹ is 1266 Y¹ is O; Y² is O; R² is H; R⁴ isCl; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is 1267 Y¹ is O; Y² is O; R²is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 1268 Y¹ is O; Y² isO; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 1269 Y¹ isO; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); and Q¹is 1270 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2,3-di-Cl); and Q¹ is 1271 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ isH; Q² is Ph(2,4-di-Cl); and Q¹ is 1272 Y¹ is O; Y² is O; R² is H; R⁴ isCl; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 1273 Y¹ is O; Y² is O; R² isH; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is 1274 Y¹ is O; Y² isO; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl,5-F); and Q¹ is 1275 Y¹ isO; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹is 1276 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-Cl,3,5-di-F); and Q¹ is 1277 Y¹ is O; Y² is O; R² is H; R⁴ is Cl;R⁵ is H; Q² is Ph(2-OCF₂H); and Q¹ is 1278 Y¹ is O; Y² is O; R² is H; R⁴is Cl; R⁵ is H; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 1279 Y¹ is O; Y² is O;R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 1280 Y¹ isO; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₂H,3-F); and Q¹ is1281 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-OCF₂H,4-F); and Q¹ is 1282 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 1283 Y¹ is O; Y² is O; R² is H; R⁴is Cl; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 1284 Y¹ is O; Y² isO; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 1285Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Br); and Q¹ is1286 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Br,3-F);and Q¹ is 1287 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-Br,4-F); and Q¹ is 1288 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ isH; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 1289 Y¹ is O; Y² is O; R² is H; R⁴is Cl; R⁵ is H; Q² is Ph(2-I); and Q¹ is 1290 Y¹ is O; Y² is O; R² is H;R⁴ is Cl; R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 1291 Y¹ is O; Y² is O;R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is 1292 Y¹ is O;Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-I,3,4-di-F); and Q¹ is1293 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CN); andQ¹ is 1294 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-CN,3-Me); and Q¹ is 1295 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ isH; Q² is Ph(2-CN,3-F); and Q¹ is 1296 Y¹ is O; Y² is O; R² is H; R⁴ isCl; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 1297 Y¹ is O; Y² is O; R² isH; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 1298 Y¹ is O; Y² isO; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹ is 1299 Y¹ isO; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹is 1300 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 2-Pyridinyl;and Q¹ is 1301 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is2-Pyridinyl,3-F; and Q¹ is 1302 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵is H; Q² is 2-Pyridinyl,4-F; and Q¹ is 1303 Y¹ is O; Y² is O; R² is H;R⁴ is Cl; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 1304 Y¹ is O;Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is1305 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is2-Pyridinyl,4-Cl; and Q¹ is 1306 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 1307 Y¹ is O; Y² is O; R² isH; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 1308 Y¹ is O; Y² isO; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 1309 Y¹is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); andQ¹ is 1310 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-SO₂Me,4-F); and Q¹ is 1311 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵is H; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 1312 Y¹ is O; Y² is O; R² is H;R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 1313 Y¹ is O;Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is1314 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-SO₂Me,4-Cl); and Q¹ is 1315 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 1316 Y¹ is O; Y² is O; R² isH; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂NH₂); and Q¹ is 1317 Y¹ is O; Y² isO; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 1318 Y¹is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-Cl); andQ¹ is 1319 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(2-SO₂NH₂,4-F); and Q¹ is 1320 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 1321 Y¹ is O; Y² is O; R² is H;R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 1322 Y¹ is O;Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-F); and Q¹ is 1323 Y¹ isO; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3,4-di-F); and Q¹ is1324 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3,5-di-F);and Q¹ is 1325 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(3,4,5-tri-F); and Q¹ is 1326 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵is H; Q² is Ph(3-F,4-Cl); and Q¹ is 1327 Y¹ is O; Y² is O; R² is H; R⁴is Cl; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 1328 Y¹ is O; Y² is O; R² isH; R⁴ is Cl; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is 1329 Y¹ is O; Y² isO; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 1330 Y¹is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-CF₃,5-F); and Q¹is 1331 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(3-CF₃,4,5-di-F); and Q¹ is 1332 Y¹ is O; Y² is O; R² is H; R⁴ is Cl;R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 1333 Y¹ is O; Y² is O; R² is H; R⁴is Cl; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 1334 Y¹ is O; Y² is O;R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 1335 Y¹ isO; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F); andQ¹ is 1336 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(3-SO₂Me,5-F); and Q¹ is 1337 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵is H; Q² is Ph(3-SO₂NH₂); and Q¹ is 1338 Y¹ is O; Y² is O; R² is H; R⁴is Cl; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 1339 Y¹ is O; Y² is O;R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 1340Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl);and Q¹ is 1341 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(3-SO₂NH₂,5-F); and Q¹ is 1342 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵is H; Q² is Ph(3-Me); and Q¹ is 1343 Y¹ is O; Y² is O; R² is H; R⁴ isCl; R⁵ is H; Q² is Ph(3-Me,4-F); and Q¹ is 1344 Y¹ is O; Y² is O; R² isH; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Me,4-Cl); and Q¹ is 1345 Y¹ is O; Y² isO; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is 1346 Y¹ isO; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹is 1347 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Cl);and Q¹ is 1348 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² isPh(3-Cl,4-F); and Q¹ is 1349 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ isH; Q² is Ph(3,4-di-Cl); and Q¹ is 1350 Y¹ is O; Y² is O; R² is H; R⁴ isCl; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 1351 Y¹ is O; Y² is O; R² isH; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 1352 Y¹ is O;Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3,5-di-Cl); and Q¹ is 1353Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(4-F); and Q¹ is1354 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(4-Cl); andQ¹ is 1355 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 1356 Y¹ is O; Y² is O; R² is H;R⁴ is Cl; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 1357Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 1358 Y¹ is O; Y² is O; R² isH; R⁴ is Cl; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is1359 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is1,3-benzodioxol-4-yl; and Q¹ is 1360 Y¹ is O; Y² is O; R² is H; R⁴ isCl; R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 1361 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F); and Q¹ is 1362 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2,3-di-F); and Q¹ is 1363 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2,4-di-F); and Q¹ is1364 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2,5-di-F);and Q¹ is 1365 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2,3,4-tri-F); and Q¹ is 1366 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(2,3,5-tri-F); and Q¹ is 1367 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 1368 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is1369 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-F,3-Cl,4-F); and Q¹ is 1370 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 1371 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-Me); and Q¹ is 1372 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 1373 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-Me,4-Cl); and Q¹is 1374 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-F,3-Cl); and Q¹ is 1375 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isBr; Q² is Ph(2-F,4-Cl); and Q¹ is 1376 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is Br; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 1377 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,4-Br); and Q¹ is 1378 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-OMe); and Q¹ is 1379Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-OMe,4-F);and Q¹ is 1380 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-F,3-OMe,4-Cl); and Q¹ is 1381 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is Br; Q² is Ph(2-F,3-CF₂H); and Q¹ is 1382 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-CF₃); and Q¹ is 1383 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 1384Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-NO₂); andQ¹ is 1385 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-F,3-NO₂,4-F); and Q¹ is 1386 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 1387 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 1388 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₃); and Q¹ is 1389 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₃,3-F); and Q¹ is1390 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₃,3-Me);and Q¹ is 1391 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-CF₃,4-F); and Q¹ is 1392 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isBr; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 1393 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is Br; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 1394 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 1395 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₂H); and Q¹ is1396 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₂H,3-F);and Q¹ is 1397 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-CF₂H,3-Me); and Q¹ is 1398 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(2-CF₂H,4-F); and Q¹ is 1399 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 1400 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 1401 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₂H,3,4-di-F);and Q¹ is 1402 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-Me); and Q¹ is 1403 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br;Q² is Ph(2,3-di-Me); and Q¹ is 1404 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is Br; Q² is Ph(2-Me,3-F); and Q¹ is 1405 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,3-Cl); and Q¹ is 1406 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,3-CF₃); and Q¹ is 1407 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,3,4-di-Cl); and Q¹is 1408 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-Me,3-Cl,4-F); and Q¹ is 1409 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(2-Me,4-Cl); and Q¹ is 1410 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is Br; Q² is Ph(2-Me,4-F); and Q¹ is 1411 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,5-F); and Q¹ is 1412 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,3,4-di-F); and Q¹ is1413 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-Me,3,5-di-F); and Q¹ is 1414 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(2-Et); and Q¹ is 1415 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is Br; Q² is Ph(2-Et,3-F); and Q¹ is 1416 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Br; Q² is Ph(2-Et,3-Cl); and Q¹ is 1417 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Et,4-F); and Q¹ is 1418 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Et,3,4-di-F); and Q¹is 1419 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-i-Pr);and Q¹ is 1420 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-i-Pr,3-F); and Q¹ is 1421 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isBr; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 1422 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is Br; Q² is Ph(2-i-Pr,4-F); and Q¹ is 1423 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 1424 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-c-Pr); and Q¹ is1425 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-c-Pr,3-F);and Q¹ is 1426 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-c-Pr,3-Cl); and Q¹ is 1427 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(2-c-Pr,4-F); and Q¹ is 1428 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 1429 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-NO₂); and Q¹ is 1430 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-NO₂,3-F); and Q¹ is1431 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-NO₂,3-Cl);and Q¹ is 1432 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-NO₂,4-F); and Q¹ is 1433 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isBr; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 1434 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₃); and Q¹ is 1435 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₃,3-F); and Q¹ is 1436 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₃,4-F); and Q¹ is1437 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Cl); andQ¹ is 1438 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-Cl,3-Me); and Q¹ is 1439 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isBr; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 1440 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(2,3-di-Cl); and Q¹ is 1441 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2,4-di-Cl); and Q¹ is 1442 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Cl,3-F); and Q¹ is 1443Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Cl,4-F); and Q¹is 1444 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-Cl,5-F); and Q¹ is 1445 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isBr; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 1446 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 1447 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₂H); and Q¹ is 1448 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₂H,3-Me); andQ¹ is 1449 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-OCF₂H,3-Cl); and Q¹ is 1450 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 1451 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 1452 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 1453 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₂CF₂H,3-F); andQ¹ is 1454 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-OCF₂CF₂H,4-F); and Q¹ is 1455 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is Br; Q² is Ph(2-Br); and Q¹ is 1456 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is Br; Q² is Ph(2-Br,3-F); and Q¹ is 1457 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Br,4-F); and Q¹ is 1458 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Br,3,4-di-F); and Q¹ is1459 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-I); and Q¹is 1460 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-I,3-F);and Q¹ is 1461 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-I,4-F); and Q¹ is 1462 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isBr; Q² is Ph(2-I,3,4-di-F); and Q¹ is 1463 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is Br; Q² is Ph(2-CN); and Q¹ is 1464 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Br; Q² is Ph(2-CN,3-Me); and Q¹ is 1465 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CN,3-F); and Q¹ is 1466 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CN,4-F); and Q¹ is1467 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CN,3-Cl);and Q¹ is 1468 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-CN,4-Cl); and Q¹ is 1469 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isBr; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 1470 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is 2-Pyridinyl; and Q¹ is 1471 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Br; Q² is 2-Pyridinyl,3-F; and Q¹ is 1472 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 2-Pyridinyl,4-F; and Q¹ is1473 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is2-Pyridinyl,3,4-di-F; and Q¹ is 1474 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is Br; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 1475 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Br; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 1476 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is1477 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me);and Q¹ is 1478 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-SO₂Me,3-F); and Q¹ is 1479 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 1480 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 1481 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 1482 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me,3,4-di-F);and Q¹ is 1483 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-SO₂Me,3-Cl); and Q¹ is 1484 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 1485 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 1486 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂NH₂); and Q¹ is 1487Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂NH₂,3-F);and Q¹ is 1488 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(2-SO₂NH₂,3-Cl); and Q¹ is 1489 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 1490 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 1491 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is1492 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-F); and Q¹is 1493 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(3,4-di-F); and Q¹ is 1494 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isBr; Q² is Ph(3,5-di-F); and Q¹ is 1495 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is Br; Q² is Ph(3,4,5-tri-F); and Q¹ is 1496 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-F,4-Cl); and Q¹ is 1497 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-CF₃); and Q¹ is 1498 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-CF₃,4-F); and Q¹ is1499 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-CF₃,4-Cl);and Q¹ is 1500 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(3-CF₃,5-F); and Q¹ is 1501 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isBr; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 1502 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂Me); and Q¹ is 1503 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 1504 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂Me,4-F); and Q¹ is1505 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(3-SO₂Me,4,5-di-F); and Q¹ is 1506 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is Br; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 1507 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂NH₂); and Q¹ is 1508 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 1509 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂NH₂,4,5-di-F);and Q¹ is 1510 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(3-SO₂NH₂,4-Cl); and Q¹ is 1511 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 1512 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is Ph(3-Me); and Q¹ is 1513 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Me,4-F); and Q¹ is 1514 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Me,4-Cl); and Q¹ is 1515 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Me,5-F); and Q¹ is1516 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(3-Me,4,5-di-F); and Q¹ is 1517 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(3-Cl); and Q¹ is 1518 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is Br; Q² is Ph(3-Cl,4-F); and Q¹ is 1519 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Br; Q² is Ph(3,4-di-Cl); and Q¹ is 1520 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Cl,5-F); and Q¹ is 1521 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Cl,4,5-di-F); and Q¹is 1522 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² isPh(3,5-di-Cl); and Q¹ is 1523 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isBr; Q² is Ph(4-F); and Q¹ is 1524 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Br; Q² is Ph(4-Cl); and Q¹ is 1525 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is Br; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 1526 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 1527 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Br; Q² is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 1528Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 1529 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Br; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 1530 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 1,3-benzodioxol-5-yl; andQ¹ is 1531 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F);and Q¹ is 1532 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2,3-di-F); and Q¹ is 1533 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isCl; Q² is Ph(2,4-di-F); and Q¹ is 1534 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is Cl; Q² is Ph(2,5-di-F); and Q¹ is 1535 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Cl; Q² is Ph(2,3,4-tri-F); and Q¹ is 1536 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2,3,5-tri-F); and Q¹ is 1537Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2,3,4,5-tetra-F);and Q¹ is 1538 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-F,3-Cl,4-Br); and Q¹ is 1539 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 1540 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 1541 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-Me); and Q¹ is 1542 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-Me,4-F); and Q¹is 1543 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-F,3-Me,4-Cl); and Q¹ is 1544 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is Ph(2-F,3-Cl); and Q¹ is 1545 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is Cl; Q² is Ph(2-F,4-Cl); and Q¹ is 1546 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 1547 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,4-Br); and Q¹ is1548 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-OMe);and Q¹ is 1549 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-F,3-OMe,4-F); and Q¹ is 1550 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 1551 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-CF₂H); and Q¹ is 1552 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-CF₃); and Q¹ is 1553 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-CF₃,4-F); andQ¹ is 1554 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-F,3-NO₂); and Q¹ is 1555 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isCl; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 1556 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 1557 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 1558Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₃); and Q¹ is1559 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₃,3-F);and Q¹ is 1560 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-CF₃,3-Me); and Q¹ is 1561 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isCl; Q² is Ph(2-CF₃,4-F); and Q¹ is 1562 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is Cl; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 1563 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 1564 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is1565 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₂H); andQ¹ is 1566 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-CF₂H,3-F); and Q¹ is 1567 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isCl; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 1568 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is Cl; Q² is Ph(2-CF₂H,4-F); and Q¹ is 1569 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 1570 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is1571 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-CF₂H,3,4-di-F); and Q¹ is 1572 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is Cl; Q² is Ph(2-Me); and Q¹ is 1573 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is Cl; Q² is Ph(2,3-di-Me); and Q¹ is 1574 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,3-F); and Q¹ is 1575 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,3-Cl); and Q¹ is 1576 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,3-CF₃); and Q¹is 1577 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-Me,3,4-di-Cl); and Q¹ is 1578 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is Cl; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 1579 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,4-Cl); and Q¹ is 1580 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,4-F); and Q¹ is 1581 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,5-F); and Q¹ is1582 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-Me,3,4-di-F); and Q¹ is 1583 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 1584 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Et); and Q¹ is 1585 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Et,3-F); and Q¹ is 1586 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Et,3-Cl); and Q¹ is 1587Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Et,4-F); and Q¹is 1588 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-Et,3,4-di-F); and Q¹ is 1589 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is Ph(2-i-Pr); and Q¹ is 1590 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is Cl; Q² is Ph(2-i-Pr,3-F); and Q¹ is 1591 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 1592 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-i-Pr,4-F); and Q¹ is1593 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-i-Pr,3,4-di-F); and Q¹ is 1594 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is Cl; Q² is Ph(2-c-Pr); and Q¹ is 1595 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is Cl; Q² is Ph(2-c-Pr,3-F); and Q¹ is 1596 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 1597 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-c-Pr,4-F); and Q¹ is1598 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-c-Pr,3,4-di-F); and Q¹ is 1599 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is Cl; Q² is Ph(2-NO₂); and Q¹ is 1600 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is Cl; Q² is Ph(2-NO₂,3-F); and Q¹ is 1601 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 1602 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-NO₂,4-F); and Q¹ is 1603Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-NO₂,3,4-di-F);and Q¹ is 1604 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-OCF₃); and Q¹ is 1605 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl;Q² is Ph(2-OCF₃,3-F); and Q¹ is 1606 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is Cl; Q² is Ph(2-OCF₃,4-F); and Q¹ is 1607 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl); and Q¹ is 1608 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl,3-Me); and Q¹ is 1609 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is1610 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2,3-di-Cl);and Q¹ is 1611 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2,4-di-Cl); and Q¹ is 1612 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isCl; Q² is Ph(2-Cl,3-F); and Q¹ is 1613 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is Cl; Q² is Ph(2-Cl,4-F); and Q¹ is 1614 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl,5-F); and Q¹ is 1615 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 1616Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl,3,5-di-F);and Q¹ is 1617 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-OCF₂H); and Q¹ is 1618 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isCl; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 1619 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is Cl; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 1620 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 1621 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₂H,4-F); and Q¹ is1622 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₂CF₂H);and Q¹ is 1623 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-OCF₂CF₂H,3-F); and Q¹ is 1624 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is Cl; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 1625 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Br); and Q¹ is 1626 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Br,3-F); and Q¹ is 1627 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Br,4-F); and Q¹ is1628 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-Br,3,4-di-F); and Q¹ is 1629 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is Ph(2-I); and Q¹ is 1630 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is Cl; Q² is Ph(2-I,3-F); and Q¹ is 1631 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Cl; Q² is Ph(2-I,4-F); and Q¹ is 1632 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-I,3,4-di-F); and Q¹ is 1633 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CN); and Q¹ is 1634Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CN,3-Me); andQ¹ is 1635 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-CN,3-F); and Q¹ is 1636 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isCl; Q² is Ph(2-CN,4-F); and Q¹ is 1637 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is Cl; Q² is Ph(2-CN,3-Cl); and Q¹ is 1638 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CN,4-Cl); and Q¹ is 1639 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 1640Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 2-Pyridinyl; and Q¹is 1641 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is2-Pyridinyl,3-F; and Q¹ is 1642 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is 2-Pyridinyl,4-F; and Q¹ is 1643 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Cl; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 1644 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 2-Pyridinyl,3-Cl; and Q¹ is1645 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is2-Pyridinyl,4-Cl; and Q¹ is 1646 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 1647 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me); and Q¹ is 1648 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 1649Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me,3-Me);and Q¹ is 1650 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-SO₂Me,4-F); and Q¹ is 1651 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 1652 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 1653 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is1654 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-SO₂Me,4-Cl); and Q¹ is 1655 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 1656 Y¹ is O; Y² is O; R²is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂NH₂); and Q¹ is 1657 Y¹ is O; Y²is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 1658Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂NH₂,3-Cl);and Q¹ is 1659 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(2-SO₂NH₂,4-F); and Q¹ is 1660 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 1661 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 1662 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-F); and Q¹ is 1663 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3,4-di-F); and Q¹ is1664 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3,5-di-F);and Q¹ is 1665 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(3,4,5-tri-F); and Q¹ is 1666 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is Ph(3-F,4-Cl); and Q¹ is 1667 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is Cl; Q² is Ph(3-CF₃); and Q¹ is 1668 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Cl; Q² is Ph(3-CF₃,4-F); and Q¹ is 1669 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 1670 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-CF₃,5-F); and Q¹is 1671 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(3-CF₃,4,5-di-F); and Q¹ is 1672 Y¹ is O; Y² is O; R² is H; R⁴ is H;R⁵ is Cl; Q² is Ph(3-SO₂Me); and Q¹ is 1673 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 1674 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 1675 Y¹is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂Me,4,5-di-F);and Q¹ is 1676 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(3-SO₂Me,5-F); and Q¹ is 1677 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is Ph(3-SO₂NH₂); and Q¹ is 1678 Y¹ is O; Y² is O; R² is H; R⁴is H; R⁵ is Cl; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 1679 Y¹ is O; Y² is O;R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 1680Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂NH₂,4-Cl);and Q¹ is 1681 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(3-SO₂NH₂,5-F); and Q¹ is 1682 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵is Cl; Q² is Ph(3-Me); and Q¹ is 1683 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is Cl; Q² is Ph(3-Me,4-F); and Q¹ is 1684 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Me,4-Cl); and Q¹ is 1685 Y¹ is O; Y² isO; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Me,5-F); and Q¹ is 1686 Y¹ isO; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Me,4,5-di-F); and Q¹is 1687 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Cl);and Q¹ is 1688 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² isPh(3-Cl,4-F); and Q¹ is 1689 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ isCl; Q² is Ph(3,4-di-Cl); and Q¹ is 1690 Y¹ is O; Y² is O; R² is H; R⁴ isH; R⁵ is Cl; Q² is Ph(3-Cl,5-F); and Q¹ is 1691 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 1692 Y¹ is O;Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3,5-di-Cl); and Q¹ is 1693Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(4-F); and Q¹ is1694 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(4-Cl); andQ¹ is 1695 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 1696 Y¹ is O; Y² is O; R² is H;R⁴ is H; R⁵ is Cl; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 1697Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 1698 Y¹ is O; Y² is O; R² isH; R⁴ is H; R⁵ is Cl; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is1699 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is1,3-benzodioxol-4-yl; and Q¹ is

Table 1700

Table 1700 is constructed the same way as Table 1 above, except thestructure is replaced with the following:

Tables 1701 Through 3399

This disclosure also includes Tables 1701 through 3399, each Table isconstructed in the same fashion as Tables 2 through 1699 above, exceptthat the structure is replaced with the structure in Table 1700 above.

Table 3400

Table 3400 is constructed the same way as Table 1 above, except thestructure is replaced with the following:

Tables 3401 Through 5099

This disclosure also includes Tables 3401 through 5099, each Table isconstructed in the same fashion as Tables 2 through 1699 above, exceptthat the structure is replaced with the structure in Table 3400 above.

Table 5100

Table 5100 is constructed the same way as Table 1 above, except thestructure is replaced with the following:

Tables 5101 Through 6799

This disclosure also includes Tables 5101 through 6799, each Table isconstructed in the same fashion as Tables 2 through 1699 above, exceptthat the structure is replaced with the structure in Table 5100 above.

TABLE I

The present disclosure also includes the intermediate compounds listedin Table I. Table 1 is constructed using the above Table I structure,combined with the individual values listed for Q¹ from Table 1.

TABLE II

The present disclosure also includes the intermediate compounds listedin Table II. Table II is constructed using the above Table II structure,combined with the individual values listed for Q¹ from Table 1.

TABLE III

The present disclosure also includes the intermediate compounds listedin Table III. Table III is constructed using the above Table IIIstructure, combined with the individual values listed for Q¹ from Table1.

TABLE IV

The present disclosure also includes the intermediate compounds listedin Table IV. Table IV is constructed using the above Table IV structure,combined with the individual values listed for Q¹ from Table 1.

Formulation/Utility

A compound of this invention will generally be used as a herbicidalactive ingredient in a composition, i.e. formulation, with at least oneadditional component selected from the group consisting of surfactants,solid diluents and liquid diluents, which serves as a carrier. Theformulation or composition ingredients are selected to be consistentwith the physical properties of the active ingredient, mode ofapplication and environmental factors such as soil type, moisture andtemperature.

Useful formulations include both liquid and solid compositions. Liquidcompositions include solutions (including emulsifiable concentrates),suspensions, emulsions (including microemulsions, oil-in-wateremulsions, flowable concentrates and/or suspoemulsions) and the like,which optionally can be thickened into gels. The general types ofaqueous liquid compositions are soluble concentrate, suspensionconcentrate, capsule suspension, concentrated emulsion, microemulsion,oil-in-water emulsion, flowable concentrate and suspo-emulsion. Thegeneral types of nonaqueous liquid compositions are emulsifiableconcentrate, microemulsifiable concentrate, dispersible concentrate andoil dispersion.

The general types of solid compositions are dusts, powders, granules,pellets, prills, pastilles, tablets, filled films (including seedcoatings) and the like, which can be water-dispersible (“wettable”) orwater-soluble. Films and coatings formed from film-forming solutions orflowable suspensions are particularly useful for seed treatment. Activeingredient can be (micro)encapsulated and further formed into asuspension or solid formulation; alternatively the entire formulation ofactive ingredient can be encapsulated (or “overcoated”). Encapsulationcan control or delay release of the active ingredient. An emulsifiablegranule combines the advantages of both an emulsifiable concentrateformulation and a dry granular formulation. High-strength compositionsare primarily used as intermediates for further formulation.

Sprayable formulations are typically extended in a suitable mediumbefore spraying. Such liquid and solid formulations are formulated to bereadily diluted in the spray medium, usually water, but occasionallyanother suitable medium like an aromatic or paraffinic hydrocarbon orvegetable oil. Spray volumes can range from about from about one toseveral thousand liters per hectare, but more typically are in the rangefrom about ten to several hundred liters per hectare. Sprayableformulations can be tank mixed with water or another suitable medium forfoliar treatment by aerial or ground application, or for application tothe growing medium of the plant. Liquid and dry formulations can bemetered directly into drip irrigation systems or metered into the furrowduring planting.

The formulations will typically contain effective amounts of activeingredient, diluent and surfactant within the following approximateranges which add up to 100 percent by weight.

Weight Percent Active Ingredient Diluent Surfactant Water-Dispersibleand Water- 0.001-90 0-99.999 0-15 soluble Granules, Tablets and PowdersOil Dispersions, Suspensions,    1-50 40-99    0-50 Emulsions, Solutions(including Emulsifiable Concentrates) Dusts    1-25 70-99    0-5 Granules and Pellets 0.001-99 5-99.999 0-15 High Strength Compositions  90-99 0-10    0-2 

Solid diluents include, for example, clays such as bentonite,montmorillonite, attapulgite and kaolin, gypsum, cellulose, titaniumdioxide, zinc oxide, starch, dextrin, sugars (e.g., lactose, sucrose),silica, talc, mica, diatomaceous earth, urea, calcium carbonate, sodiumcarbonate and bicarbonate, and sodium sulfate. Typical solid diluentsare described in Watkins et al., Handbook of Insecticide Dust Diluentsand Carriers, 2nd Ed., Dorland Books, Caldwell, N.J.

Liquid diluents include, for example, water, N,N-dimethylalkanamides(e.g., N,N-dimethylformamide), limonene, dimethyl sulfoxide,N-alkylpyrrolidones (e.g., N-methylpyrrolidinone), alkyl phosphates(e.g., triethyl phosphate), ethylene glycol, triethylene glycol,propylene glycol, dipropylene glycol, polypropylene glycol, propylenecarbonate, butylene carbonate, paraffins (e.g., white mineral oils,normal paraffins, isoparaffins), alkylbenzenes, alkylnaphthalenes,glycerine, glycerol triacetate, sorbitol, aromatic hydrocarbons,dearomatized aliphatics, alkylbenzenes, alkylnaphthalenes, ketones suchas cyclohexanone, 2-heptanone, isophorone and4-hydroxy-4-methyl-2-pentanone, acetates such as isoamyl acetate, hexylacetate, heptyl acetate, octyl acetate, nonyl acetate, tridecyl acetateand isobornyl acetate, other esters such as alkylated lactate esters,dibasic esters, alkyl and aryl benzoates and γ-butyrolactone, andalcohols, which can be linear, branched, saturated or unsaturated, suchas methanol, ethanol, n-propanol, isopropyl alcohol, n-butanol, isobutylalcohol, n-hexanol, 2-ethylhexanol, n-octanol, decanol, isodecylalcohol, isooctadecanol, cetyl alcohol, lauryl alcohol, tridecylalcohol, oleyl alcohol, cyclohexanol, tetrahydrofurfuryl alcohol,diacetone alcohol, cresol and benzyl alcohol. Liquid diluents alsoinclude glycerol esters of saturated and unsaturated fatty acids(typically C₆-C₂₂), such as plant seed and fruit oils (e.g., oils ofolive, castor, linseed, sesame, corn (maize), peanut, sunflower,grapeseed, safflower, cottonseed, soybean, rapeseed, coconut and palmkernel), animal-sourced fats (e.g., beef tallow, pork tallow, lard, codliver oil, fish oil), and mixtures thereof. Liquid diluents also includealkylated fatty acids (e.g., methylated, ethylated, butylated) whereinthe fatty acids may be obtained by hydrolysis of glycerol esters fromplant and animal sources, and can be purified by distillation. Typicalliquid diluents are described in Marsden, Solvents Guide, 2nd Ed.,Interscience, New York, 1950.

The solid and liquid compositions of the present invention often includeone or more surfactants. When added to a liquid, surfactants (also knownas “surface-active agents”) generally modify, most often reduce, thesurface tension of the liquid. Depending on the nature of thehydrophilic and lipophilic groups in a surfactant molecule, surfactantscan be useful as wetting agents, dispersants, emulsifiers or defoamingagents.

Surfactants can be classified as nonionic, anionic or cationic. Nonionicsurfactants useful for the present compositions include, but are notlimited to: alcohol alkoxylates such as alcohol alkoxylates based onnatural and synthetic alcohols (which may be branched or linear) andprepared from the alcohols and ethylene oxide, propylene oxide, butyleneoxide or mixtures thereof amine ethoxylates, alkanolamides andethoxylated alkanolamides; alkoxylated triglycerides such as ethoxylatedsoybean, castor and rapeseed oils; alkylphenol alkoxylates such asoctylphenol ethoxylates, nonylphenol ethoxylates, dinonyl phenolethoxylates and dodecyl phenol ethoxylates (prepared from the phenolsand ethylene oxide, propylene oxide, butylene oxide or mixturesthereof); block polymers prepared from ethylene oxide or propylene oxideand reverse block polymers where the terminal blocks are prepared frompropylene oxide; ethoxylated fatty acids; ethoxylated fatty esters andoils; ethoxylated methyl esters; ethoxylated tristyrylphenol (includingthose prepared from ethylene oxide, propylene oxide, butylene oxide ormixtures thereof); fatty acid esters, glycerol esters, lanolin-basedderivatives, polyethoxylate esters such as polyethoxylated sorbitanfatty acid esters, polyethoxylated sorbitol fatty acid esters andpolyethoxylated glycerol fatty acid esters; other sorbitan derivativessuch as sorbitan esters; polymeric surfactants such as randomcopolymers, block copolymers, alkyd peg (polyethylene glycol) resins,graft or comb polymers and star polymers; polyethylene glycols (pegs);polyethylene glycol fatty acid esters; silicone-based surfactants; andsugar-derivatives such as sucrose esters, alkyl polyglycosides and alkylpolysaccharides.

Useful anionic surfactants include, but are not limited to: alkylarylsulfonic acids and their salts; carboxylated alcohol or alkylphenolethoxylates; diphenyl sulfonate derivatives; lignin and ligninderivatives such as lignosulfonates; maleic or succinic acids or theiranhydrides; olefin sulfonates; phosphate esters such as phosphate estersof alcohol alkoxylates, phosphate esters of alkylphenol alkoxylates andphosphate esters of styryl phenol ethoxylates; protein-basedsurfactants; sarcosine derivatives; styryl phenol ether sulfate;sulfates and sulfonates of oils and fatty acids; sulfates and sulfonatesof ethoxylated alkylphenols; sulfates of alcohols; sulfates ofethoxylated alcohols; sulfonates of amines and amides such asN,N-alkyltaurates; sulfonates of benzene, cumene, toluene, xylene, anddodecyl and tridecylbenzenes; sulfonates of condensed naphthalenes;sulfonates of naphthalene and alkyl naphthalene; sulfonates offractionated petroleum; sulfosuccinamates; and sulfosuccinates and theirderivatives such as dialkyl sulfosuccinate salts.

Useful cationic surfactants include, but are not limited to: amides andethoxylated amides; amines such as N-alkyl propanediamines,tripropylenetriamines and dipropylenetetramines, and ethoxylated amines,ethoxylated diamines and propoxylated amines (prepared from the aminesand ethylene oxide, propylene oxide, butylene oxide or mixturesthereof); amine salts such as amine acetates and diamine salts;quaternary ammonium salts such as quaternary salts, ethoxylatedquaternary salts and diquaternary salts; and amine oxides such asalkyldimethylamine oxides and bis-(2-hydroxyethyl)-alkylamine oxides.

Also useful for the present compositions are mixtures of nonionic andanionic surfactants or mixtures of nonionic and cationic surfactants.Nonionic, anionic and cationic surfactants and their recommended usesare disclosed in a variety of published references includingMcCutcheon's Emulsifiers and Detergents, annual American andInternational Editions published by McCutcheon's Division, TheManufacturing Confectioner Publishing Co.; Sisely and Wood, Encyclopediaof Surface Active Agents, Chemical Publ. Co., Inc., New York, 1964; andA. S. Davidson and B. Milwidsky, Synthetic Detergents, Seventh Edition,John Wiley and Sons, New York, 1987.

Compositions of this invention may also contain formulation auxiliariesand additives, known to those skilled in the art as formulation aids(some of which may be considered to also function as solid diluents,liquid diluents or surfactants). Such formulation auxiliaries andadditives may control: pH (buffers), foaming during processing(antifoams such polyorganosiloxanes), sedimentation of activeingredients (suspending agents), viscosity (thixotropic thickeners),in-container microbial growth (antimicrobials), product freezing(antifreezes), color (dyes/pigment dispersions), wash-off (film formersor stickers), evaporation (evaporation retardants), and otherformulation attributes. Film formers include, for example, polyvinylacetates, polyvinyl acetate copolymers, polyvinylpyrrolidone-vinylacetate copolymer, polyvinyl alcohols, polyvinyl alcohol copolymers andwaxes. Examples of formulation auxiliaries and additives include thoselisted in McCutcheon's Volume 2: Functional Materials, annualInternational and North American editions published by McCutcheon'sDivision, The Manufacturing Confectioner Publishing Co.; and PCTPublication WO 03/024222.

The compound of Formula 1 and any other active ingredients are typicallyincorporated into the present compositions by dissolving the activeingredient in a solvent or by grinding in a liquid or dry diluent.Solutions, including emulsifiable concentrates, can be prepared bysimply mixing the ingredients. If the solvent of a liquid compositionintended for use as an emulsifiable concentrate is water-immiscible, anemulsifier is typically added to emulsify the active-containing solventupon dilution with water. Active ingredient slurries, with particlediameters of up to 2,000 μm can be wet milled using media mills toobtain particles with average diameters below 3 μm. Aqueous slurries canbe made into finished suspension concentrates (see, for example, U.S.Pat. No. 3,060,084) or further processed by spray drying to formwater-dispersible granules. Dry formulations usually require dry millingprocesses, which produce average particle diameters in the 2 to 10 μmrange. Dusts and powders can be prepared by blending and usuallygrinding (such as with a hammer mill or fluid-energy mill). Granules andpellets can be prepared by spraying the active material upon preformedgranular carriers or by agglomeration techniques. See Browning,“Agglomeration”, Chemical Engineering, Dec. 4, 1967, pp 147-48, Perry'sChemical Engineer's Handbook, 4th Ed., McGraw-Hill, New York, 1963,pages 8-57 and following, and WO 91/13546. Pellets can be prepared asdescribed in U.S. Pat. No. 4,172,714. Water-dispersible andwater-soluble granules can be prepared as taught in U.S. Pat. Nos.4,144,050, 3,920,442 and DE 3,246,493. Tablets can be prepared as taughtin U.S. Pat. Nos. 5,180,587, 5,232,701 and 5,208,030. Films can beprepared as taught in GB 2,095,558 and U.S. Pat. No. 3,299,566.

For further information regarding the art of formulation, see T. S.Woods, “The Formulator's Toolbox—Product Forms for Modern Agriculture”in Pesticide Chemistry and Bioscience, The Food-Environment Challenge,T. Brooks and T. R. Roberts, Eds., Proceedings of the 9th InternationalCongress on Pesticide Chemistry, The Royal Society of Chemistry,Cambridge, 1999, pp. 120-133. See also U.S. 3,235,361, Col. 6, line 16through Col. 7, line 19 and Examples 10-41; U.S. 3,309,192, Col. 5, line43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58,132, 138-140, 162-164, 166, 167 and 169-182; U.S. Pat. No. 2,891,855,Col. 3, line 66 through Col. 5, line 17 and Examples 1-4; Klingman, WeedControl as a Science, John Wiley and Sons, Inc., New York, 1961, pp81-96; Hance et al., Weed Control Handbook, 8th Ed., BlackwellScientific Publications, Oxford, 1989; and Developments in formulationtechnology, PJB Publications, Richmond, UK, 2000.

In the following Examples, all percentages are by weight and allformulations are prepared in conventional ways. Compound numbers referto compounds in Index Tables A-C. Without further elaboration, it isbelieved that one skilled in the art using the preceding description canutilize the present invention to its fullest extent. The followingExamples are, therefore, to be construed as merely illustrative, and notlimiting of the disclosure in any way whatsoever. Percentages are byweight except where otherwise indicated.

Example A

High Strength Concentrate Compound 17 98.5% silica aerogel 0.5%synthetic amorphous fine silica 1.0%

Example B

Wettable Powder Compound 79 65.0% dodecylphenol polyethylene glycolether 2.0% sodium ligninsulfonate 4.0% sodium silicoaluminate 6.0%montmorillonite (calcined) 23.0%

Example C

Granule Compound 80 10.0% attapulgite granules (low volatile matter,90.0% 0.71/0.30 mm; U.S.S. No. 25-50 sieves)

Example D

Extruded Pellet Compound 5 25.0% anhydrous sodium sulfate 10.0% crudecalcium ligninsulfonate 5.0% sodium alkylnaphthalenesulfonate 1.0%calcium/magnesium bentonite 59.0%

Example E

Emulsifiable Concentrate Compound 17 10.0% polyoxyethylene sorbitolhexoleate 20.0% C₆-C₁₀fatty acid methyl ester 70.0%

Example F

Microemulsion Compound 79 5.0% polyvinylpyrrolidone-vinyl acetatecopolymer 30.0% alkylpolyglycoside 30.0% glyceryl monooleate 15.0% water20.0%

Example G

Suspension Concentrate Compound 80  35% butylpolyoxyethylene/polypropylene block copolymer 4.0% stearicacid/polyethylene glycol copolymer 1.0% styrene acrylic polymer 1.0%xanthan gum 0.1% propylene glycol 5.0% silicone based defoamer 0.1%1,2-benzisothiazolin-3-one 0.1% water 53.7% 

Example H

Emulsion in Water Compound 5 10.0% butyl polyoxyethylene/polypropyleneblock copolymer 4.0% stearic acid/polyethylene glycol copolymer 1.0%styrene acrylic polymer 1.0% xanthan gum 0.1% propylene glycol 5.0%silicone based defoamer 0.1% 1,2-benzisothiazolin-3-one 0.1% aromaticpetroleum based hydrocarbon 20.0 water 58.7%

Example I

Oil Dispersion Compound 17 25% polyoxyethylene sorbitol hexaoleate 15%organically modified bentonite clay 2.5%  fatty acid methyl ester 57.5% 

Example J

Suspoemulsion Compound 79 10.0% imidacloprid 5.0% butylpolyoxyethylene/polypropylene block copolymer 4.0% stearicacid/polyethylene glycol copolymer 1.0% styrene acrylic polymer 1.0%xanthan gum 0.1% propylene glycol 5.0% silicone based defoamer 0.1%1,2-benzisothiazolin-3-one 0.1% aromatic petroleum based hydrocarbon20.0% water 53.7%

Test results indicate that the compounds of the present invention arehighly active preemergent and/or postemergent herbicides and/or plantgrowth regulants. The compounds of the invention generally show highestactivity for early postemergence weed control (i.e. applied soon afterweed seedlings emerge from the soil) and preemergence weed control (i.e.applied before weed seedlings emerge from the soil). Many of them haveutility for broad-spectrum pre- and/or postemergence weed control inareas where complete control of all vegetation is desired such as aroundfuel storage tanks, industrial storage areas, parking lots, drive-intheaters, air fields, river banks, irrigation and other waterways,around billboards and highway and railroad structures. Many of thecompounds of this invention, by virtue of selective metabolism in cropsversus weeds, or by selective activity at the locus of physiologicalinhibition in crops and weeds, or by selective placement on or withinthe environment of a mixture of crops and weeds, are useful for theselective control of grass and broadleaf weeds within a crop/weedmixture. One skilled in the art will recognize that the preferredcombination of these selectivity factors within a compound or group ofcompounds can readily be determined by performing routine biologicaland/or biochemical assays. Compounds of this invention may showtolerance to important agronomic crops including, but is not limited to,alfalfa, barley, cotton, wheat, rape, sugar beets, corn (maize),sorghum, soybeans, rice, oats, peanuts, vegetables, tomato, potato,perennial plantation crops including coffee, cocoa, oil palm, rubber,sugarcane, citrus, grapes, fruit trees, nut trees, banana, plantain,pineapple, hops, tea and forests such as eucalyptus and conifers (e.g.,loblolly pine), and turf species (e.g., Kentucky bluegrass, St.Augustine grass, Kentucky fescue and Bermuda grass). Compounds of thisinvention can be used in crops genetically transformed or bred toincorporate resistance to herbicides, express proteins toxic toinvertebrate pests (such as Bacillus thuringiensis toxin), and/orexpress other useful traits. Those skilled in the art will appreciatethat not all compounds are equally effective against all weeds.Alternatively, the subject compounds are useful to modify plant growth.

As the compounds of the invention have (both preemergent andpostemergent herbicidal) activity, to control undesired vegetation bykilling or injuring the vegetation or reducing its growth, the compoundscan be usefully applied by a variety of methods involving contacting aherbicidally effective amount of a compound of the invention, or acomposition comprising said compound and at least one of a surfactant, asolid diluent or a liquid diluent, to the foliage or other part of theundesired vegetation or to the environment of the undesired vegetationsuch as the soil or water in which the undesired vegetation is growingor which surrounds the seed or other propagule of the undesiredvegetation.

A herbicidally effective amount of the compounds of this invention isdetermined by a number of factors. These factors include: formulationselected, method of application, amount and type of vegetation present,growing conditions, etc. In general, a herbicidally effective amount ofcompounds of this invention is about 0.005 to 20 kg/ha with a preferredrange of about 0.01 to 1 kg/ha. One skilled in the art can easilydetermine the herbicidally effective amount necessary for the desiredlevel of weed control.

Compounds of the invention are useful in treating all plants and plantparts. Plant varieties and cultivars can be obtained by conventionalpropagation and breeding methods or by genetic engineering methods.Genetically modified plants (transgenic plants) are those in which aheterologous gene (transgene) has been stably integrated into theplant's genome. A transgene that is defined by its particular locationin the plant genome is called a transformation or transgenic event.

Genetically modified plant cultivars which can be treated according tothe invention include those that are resistant against one or morebiotic stresses (pests such as nematodes, insects, mites, fungi, etc.)or abiotic stresses (drought, cold temperature, soil salinity, etc.), orthat contain other desirable characteristics. Plants can be geneticallymodified to exhibit traits of, for example, herbicide tolerance,insect-resistance, modified oil profiles or drought tolerance. Usefulgenetically modified plants containing single gene transformation eventsor combinations of transformation events are listed in Table 3.Additional information for the genetic modifications listed in Table 3can be obtained from publicly available databases maintained, forexample, by the U.S. Department of Agriculture.

The following abbreviations, T1 through T37, are used in Table 3 fortraits. A “−” means the entry is not available.

Trait Description T1 Glyphosate tolerance T2 High lauric acid oil T3Glufosinate tolerance T4 Phytate breakdown T5 Oxynil tolerance T6Disease resistance T7 Insect resistance T9 Modified flower color T11 ALSHerbicide Tol. T12 Dicamba Tolerance T13 Anti-allergy T14 Salt toleranceT15 Cold tolerance T16 Imidazolinone herb. tol. T17 Modifiedalpha-amylase T18 Pollination control T19 2,4-D tolerance T20 Increasedlysine T21 Drought tolerance T22 Delayed ripening/senescence T23Modified product quality T24 High cellulose T25 Modifiedstarch/carbohydrate T26 Insect & disease resist. T27 High tryptophan T28Erect leaves semidwarf T29 Semidwarf T30 Low iron tolerance T31 Modifiedoil/fatty acid T32 HPPD tolerance T33 High oil T34 Aryloxyalkanoate tol.T35 Mesotrione tolerance T36 Reduced nicotine T37 Modified product

TABLE 3 Crop Event Name Event Code Trait(s) Gene(s) Alfalfa J101MON-00101-8 T1 cp4 epsps (aroA:CP4) Alfalfa J163 MON-ØØ163-7 T1 cp4epsps (aroA:CP4) Canola* 23-18-17 (Event 18) CGN-89465-2 T2 te Canola*23-198 (Event 23) CGN-89465-2 T2 te Canola* 61061 DP-Ø61Ø61-7 T1 gat4621Canola* 73496 DP-Ø73496-4 T1 gat4621 Canola* GT200 (RT200) MON-89249-2T1 cp4 epsps (aroA:CP4); goxv247 Canola* GT73 (RT73) MON-ØØØ73-7 T1 cp4epsps (aroA:CP4); goxv247 Canola* HCN10 (Topas 19/2) — T3 bar Canola*HCN28 (T45) ACS-BNØØ8-2 T3 pat (syn) Canola* HCN92 (Topas 19/2)ACS-BNØØ7-1 T3 bar Canola* MON88302 MON-883Ø2-9 T1 cp4 epsps (aroA:CP4)Canola* MPS961 — T4 phyA Canola* MPS962 — T4 phyA Canola* MPS963 — T4phyA Canola* MPS964 — T4 phyA Canola* MPS965 — T4 phyA Canola* MS1(B91-4) ACS-BNØØ4-7 T3 bar Canola* MS8 ACS-BNØØ5-8 T3 bar Canola*OXY-235 ACS-BNØ11-5 T5 bxn Canola* PHY14 — T3 bar Canola* PHY2 3 — T3bar Canola* PHY35 — T3 bar Canola* PHY36 — T3 bar Canola* RF1 (B93-101)ACS-BNØØ1-4 T3 bar Canola* RF2 (B94-2) ACS-BNØØ2-5 T3 bar Canola* RF3ACS-BNØØ3-6 T3 bar Bean EMBRAPA 5.1 EMB-PV051-1 T6 ac1 (sense andantisense) Brinjal # EE-1 — T7 cry1Ac Cotton 19-51a DD-Ø1951A-7 T11S4-HrA Cotton 281-24-236 DAS-24236-5 T3, T7 pat (syn); cry1F Cotton3006-210-23 DAS-21Ø23-5 T3, T7 pat (syn); cry1Ac Cotton 31707 — T5, T7bxn; cry1Ac Cotton 31803 — T5, T7 bxn; cry1Ac Cotton 31807 — T5, T7 bxn;cry1Ac Cotton 31808 — T5, T7 bxn; cry1Ac Cotton 42317 — T5, T7 bxn;cry1Ac Cotton BNLA-601 — T7 cry1Ac Cotton BXN10211 BXN10211-9 T5 bxn;cry1Ac Cotton BXN10215 BXN10215-4 T5 bxn; cry1Ac Cotton BXN10222BXN10222-2 T5 bxn; cry1Ac Cotton BXN10224 BXN10224-4 T5 bxn; cry1AcCotton COT102 SYN-IR102-7 T7 vip3A(a) Cotton COT67B SYN-IR67B-1 T7cry1Ab Cotton COT202 — T7 vip3A Cotton Event 1 — T7 cry1Ac Cotton GMFCry1A GTL-GMF311-7 T7 cry1Ab-Ac Cotton GHB119 BCS-GH005-8 T7 crY2 AeCotton GHB614 BCS-GH002-5 T1 2mepsps Cotton GK12 — T7 cry1Ab-Ac CottonLLCotton25 ACS-GH001-3 T3 bar Cotton MLS 9124 — T7 cry1C Cotton MON1076MON-89924-2 T7 cry1Ac Cotton MON1445 MON-01445-2 T1 cp4 epsps (aroA:CP4)Cotton MON15985 MON-15985-7 T7 cry1Ac; crY2 Ab2 Cotton MON1698MON-89383-1 T7 cp4 epsps (aroA:CP4) Cotton MON531 MON-00531-6 T7 cry1AcCotton MON757 MON-00757-7 T7 cry1Ac Cotton MON88913 MON-88913-8 T1 cp4epsps (aroA:CP4) Cotton Nqwe Chi 6 Bt — T7 — Cotton SKG321 — T7 cry1A;CpTI Cotton T303-3 BCS-GH003-6 T3, T7 cry1Ab; bar Cotton T304-40BCS-GH004-7 T3, T7 cry1Ab; bar Cotton CE43-67B — T7 cry1Ab CottonCE46-02A — T7 cry1Ab Cotton CE44-69D — T7 cry1Ab Cotton 1143-14A — T7cry1Ab Cotton 1143-51B — T7 cry1Ab Cotton T342-142 — T7 cry1Ab CottonPV-GHGT07 (1445) — T1 cp4 epsps (aroA:CP4) Cotton EE-GH3 — T1 mepspsCotton EE-GH5 — T7 cry1Ab Cotton MON88701 MON-88701-3 T3, T12 Modifieddmo; bar Cotton OsCr11 — T13 Modified Cry j Flax FP967 CDC-FL001-2 T11als Lentil RH44 — T16 als Maize 3272 SYN-E3272-5 T17 amy797E Maize 5307SYN-05307-1 T7 ecry3.1Ab Maize 59122 DAS-59122-7 T3, T7 cry34Ab1;cry35Ab1; pat Maize 676 PH-000676-7 T3, T18 pat; dam Maize 678PH-000678-9 T3, T18 pat; dam Maize 680 PH-000680-2 T3, T18 pat; damMaize 98140 DP-098140-6 T1, T11 gat4621; zm-hra Maize Bt10 — T3, T7cry1Ab; pat Maize Bt176 (176) SYN-EV176-9 T3, T7 cry1Ab; bar MaizeBVLA430101 — T4 phyA2 Maize CBH-351 ACS-ZM004-3 T3, T7 cry9C; bar MaizeDAS40278-9 DAS40278-9 T19 aad-1 Maize DBT418 DKB-89614-9 T3, T7 cry1Ac;pinII; bar Maize DLL25 (B16) DKB-89790-5 T3 bar Maize GA21 MON-00021-9T1 mepsps Maize GG25 — T1 mepsps Maize GJ11 — T1 mepsps Maize Fl117 — T1mepsps Maize GAT-ZM1 — T3 pat Maize LY038 REN-00038-3 T20 cordapA MaizeMIR162 SYN-IR162-4 T7 vip3Aa20 Maize MIR604 SYN-IR604-5 T7 mcry3A MaizeMON801 (MON80100) MON801 T1, T7 cry1Ab; cp4 epsps (aroA:CP4); goxv247Maize MON802 MON-80200-7 T1, T7 cry1Ab; cp4 epsps (aroA:CP4); goxv247Maize MON809 PH-MON-809-2 T1, T7 cry1Ab; cp4 epsps (aroA:CP4); goxv247Maize MON810 MON-00810-6 T1, T7 cry1Ab; cp4 epsps (aroA:CP4); goxv247Maize MON832 — T1 cp4 epsps (aroA:CP4); goxv247 Maize MON863 MON-00863-5T7 cry3Bb1 Maize MON87427 MON-87427-7 T1 cp4 epsps (aroA:CP4) MaizeMON87460 MON-87460-4 T21 cspB Maize MON88017 MON-88017-3 T1, T7 cry3Bb1;cp4 epsps (aroA:CP4) Maize MON89034 MON-89034-3 T7 crY2 Ab2; cry1A.105Maize MS3 ACS-ZM001-9 T3, T18 bar; barnase Maize MS6 ACS-ZM005-4 T3, T18bar; barnase Maize NK603 MON-00603-6 T1 cp4 epsps (aroA:CP4) Maize T14ACS-ZM002-1 T3 pat (syn) Maize T25 ACS-ZM003-2 T3 pat (syn) Maize TC1507DAS-01507-1 T3, T7 cry1Fa2; pat Maize TC6275 DAS-06275-8 T3, T7 mocry1F;bar Maize VIP1034 — T3, T7 vip3A; pat Maize 43A47 DP-043A47-3 T3, T7cry1F; cry34Ab1; cry35Ab1; pat Maize 40416 DP-040416-8 T3, T7 cry1F;cry34Ab1; cry35Ab1; pat Maize 32316 DP-032316-8 T3, T7 cry1F; cry34Ab1;cry35Ab1; pat Maize 4114 DP-004114-3 T3, T7 cry1F; cry34Ab1; cry35Ab1;pat Melon Melon A — T22 sam-k Melon Melon B — T22 sam-k Papaya 55-1CUH-CP551-8 T6 prsv cp Papaya 63-1 CUH-CP631-7 T6 prsv cp Papaya HuanongNo. 1 — T6 prsv rep Papaya X17-2 UFL-X17CP-6 T6 prsv cp Plum C-5ARS-PLMC5-6 T6 ppv cp Canola** ZSR5 00 — T1 cp4 epsps (aroA:CP4);goxv247 Canola** ZSR5 02 — T1 cp4 epsps (aroA:CP4); goxv247 Canola**ZSR5 03 — T1 cp4 epsps (aroA:CP4); goxv247 Rice 7Crp#242-95-7 — T13 7crpRice 7Crp#10 — T13 7crp Rice GM Shanyou 63 — T7 cry1Ab; cry1Ac RiceHuahui-1/TT51-1 — T7 cry1Ab; cry1Ac Rice LLRICE06 ACS-OS001-4 T3 barRice LLRICE601 BCS-OS003-7 T3 bar Rice LLRICE62 ACS-OS002-5 T3 bar RiceTarom molaii + cry1Ab — T7 cry1Ab (truncated) Rice GAT-OS2 — T3 bar RiceGAT-OS3 — T3 bar Rice PE-7 — T7 Cry1Ac Rice 7Crp#10 — T13 7crp RiceKPD627-8 — T27 OASA1D Rice KPD722-4 — T27 OASA1D Rice KA317 — T27 OASA1DRice HW5 — T27 OASA1D Rice HW1 — T27 OASA1D Rice B-4-1-18 — T28 Δ OsBRI1Rice G-3-3-22 — T29 OSGA2ox1 Rice AD77 — T6 DEF Rice AD51 — T6 DEF RiceAD48 — T6 DEF Rice AD41 — T6 DEF Rice 13pNasNa800725atAprt1 — T30HvNAS1; HvNAAT-A; APRT Rice 13pAprt1 — T30 APRT Rice gHvNAS1-gHvNAAT-1 —T30 HvNAS1; HvNAAT-A; HvNAAT-B Rice gHvIDS3-1 — T30 HvIDS3 Rice gHvNAAT1— T30 HvNAAT-A; HvNAAT-B Rice gHvNAS1-1 — T30 HvNAS1 Rice NIA-OS006-4 —T6 WRKY45 Rice NIA-OS005-3 — T6 WRKY45 Rice NIA-OS004-2 — T6 WRKY45 RiceNIA-OS003-1 — T6 WRKY45 Rice NIA-OS002-9 — T6 WRKY45 Rice NIA-OS001-8 —T6 WRKY45 Rice OsCr11 — T13 Modified Cry j Rice 17053 — T1 cp4 epsps(aroA:CP4) Rice 17314 — T1 cp4 epsps (aroA:CP4) Rose WKS82/130-4-1IFD-52401-4 T9 5AT; bp40 (f3'5'h) Rose WKS92/130-9-1 IFD-52901-9 T9 5AT;bp40 (f3'5'h) Soybean 260-05 (G94-1, G94-19, — T9 gm-fad2-1 (silencinglocus) G168) Soybean A2704-12 ACS-GM005-3 T3 pat Soybean A2704-21ACS-GM004-2 T3 pat Soybean A5547-127 ACS-GM006-4 T3 pat Soybean A5547-35ACS-GM008-6 T3 pat Soybean CV127 BPS-CV127-9 T16 csr1-2 SoybeanDAS68416-4 DAS68416-4 T3 pat Soybean DP305423 DP-305423-1 T11, T31gm-fad2-1 (silencing locus); gm-hra Soybean DP356043 DP-356043-5 T1, T31gm-fad2-1 (silencing locus); gat4601 Soybean FG72 MST-FG072-3 T32, T12mepsps; hppdPF W336 Soybean GTS 40-3-2 (40-3-2) MON-04032-6 T1 cp4epsps (aroA:CP4) Soybean GU262 ACS-GM003-1 T3 pat Soybean MON87701MON-87701-2 T7 cry1Ac Soybean MON87705 MON-87705-6 T1, T31 fatb1-A(sense & antisense); fad2- 1A (sense & antisense); cp4 epsps (aroA:CP4)Soybean MON87708 MON-87708-9 T1, T12 dmo; cp4 epsps (aroA:CP4) SoybeanMON87769 MON-87769-7 T1, T31 Pj.D6D; Nc.Fad3; cp4 epsps (aroA:CP4)Soybean MON89788 MON-89788-1 T1 cp4 epsps (aroA:CP4) Soybean W62ACS-GM002-9 T3 bar Soybean W98 ACS-GM001-8 T3 bar Soybean MON87754MON-87754-1 T33 dgat2A Soybean DAS21606 DAS-21606 T34, T3 Modifiedaad-12; pat Soybean DAS44406 DAS-44406-6 T1, T3, T34 Modified aad-12;2mepsps; pat Soybean SYHT04R SYN-0004R-8 T35 Modified avhppd Soybean9582.814.19.1 — T3, T7 cry1Ac, cry1F, PAT Squash CZW3 SEM-ØCZW3-2 T6 cmvcp, zymv cp, wmv cp Squash ZW20 SEM-0ZW20-7 T6 zymv cp, wmv cp SugarBeet GTSB77 (T9100152) SY-GTSB77-8 T1 cp4 epsps (aroA:CP4); goxv247Sugar Beet H7-1 KM-000H71-4 T1 cp4 epsps (aroA:CP4) Sugar Beet T120-7ACS-BV001-3 T3 pat Sugar Beet T227-1 — T1 cp4 epsps (aroA:CP4) SugarcaneNXI-1T — T21 EcbetA Sunflower X81359 — T16 als Pepper PK-SP01 — T6 cmvcp Tobacco C/F/93/08-02 — T5 bxn Tobacco Vector 21-41 — T36 NtQPT1(antisense) Sunflower X81359 — T16 als Wheat MON71800 MON-718ØØ-3 T1 cp4epsps (aroA:CP4) *Argentine (Brassica napus), **Polish (B. rapa), #Eggplant

Treatment of genetically modified plants with compounds of the inventionmay result in super-additive or synergistic effects. For example,reduction in application rates, broadening of the activity spectrum,increased tolerance to biotic/abiotic stresses or enhanced storagestability may be greater than expected from just simple additive effectsof the application of compounds of the invention on genetically modifiedplants.

Compounds of this invention can also be mixed with one or more otherbiologically active compounds or agents including herbicides, herbicidesafeners, fungicides, insecticides, nematocides, bactericides,acaricides, growth regulators such as insect molting inhibitors androoting stimulants, chemosterilants, semiochemicals, repellents,attractants, pheromones, feeding stimulants, plant nutrients, otherbiologically active compounds or entomopathogenic bacteria, virus orfungi to form a multi-component pesticide giving an even broaderspectrum of agricultural protection. Mixtures of the compounds of theinvention with other herbicides can broaden the spectrum of activityagainst additional weed species, and suppress the proliferation of anyresistant biotypes. Thus the present invention also pertains to acomposition comprising a compound of Formula 1 (in a herbicidallyeffective amount) and at least one additional biologically activecompound or agent (in a biologically effective amount) and can furthercomprise at least one of a surfactant, a solid diluent or a liquiddiluent. The other biologically active compounds or agents can beformulated in compositions comprising at least one of a surfactant,solid or liquid diluent.

For mixtures of the present invention, one or more other biologicallyactive compounds or agents can be formulated together with a compound ofFormula 1, to form a premix, or one or more other biologically activecompounds or agents can be formulated separately from the compound ofFormula 1, and the formulations combined together before application(e.g., in a spray tank) or, alternatively, applied in succession.

A mixture of one or more of the following herbicides with a compound ofthis invention may be particularly useful for weed control: acetochlor,acifluorfen and its sodium salt, aclonifen, acrolein (2-propenal),alachlor, alloxydim, ametryn, amicarbazone, amidosulfuron,aminocyclopyrachlor and its esters (e.g., methyl, ethyl) and salts(e.g., sodium, potassium), aminopyralid, amitrole, ammonium sulfamate,anilofos, asulam, atrazine, azimsulfuron, beflubutamid, benazolin,benazolin-ethyl, bencarbazone, benfluralin, benfuresate,bensulfuron-methyl, bensulide, bentazone, benzobicyclon, benzofenap,bicyclopyrone, bifenox, bilanafos, bispyribac and its sodium salt,bromacil, bromobutide, bromofenoxim, bromoxynil, bromoxynil octanoate,butachlor, butafenacil, butamifos, butralin, butroxydim, butylate,cafenstrole, carbetamide, carfentrazone-ethyl, catechin, chlomethoxyfen,chloramben, chlorbromuron, chlorflurenol-methyl, chloridazon,chlorimuron-ethyl, chlorotoluron, chlorpropham, chlorsulfuron,chlorthal-dimethyl, chlorthiamid, cinidon-ethyl, cinmethylin,cinosulfuron, clacyfos, clefoxydim, clethodim, cyclopyrimorate,clodinafop-propargyl, clomazone, clomeprop, clopyralid,clopyralid-olamine, cloransulam-methyl, cumyluron, cyanazine, cycloate,cyclopyrimorate, cyclosulfamuron, cycloxydim, cyhalofop-butyl, 2,4-D andits butotyl, butyl, isoctyl and isopropyl esters and itsdimethylammonium, diolamine and trolamine salts, daimuron, dalapon,dalapon-sodium, dazomet, 2,4-DB and its dimethylammonium, potassium andsodium salts, desmedipham, desmetryn, dicamba and its diglycolammonium,dimethylammonium, potassium and sodium salts, dichlobenil, dichlorprop,diclofop-methyl, diclosulam, difenzoquat metilsulfate, diflufenican,diflufenzopyr, dimefuron, dimepiperate, dimethachlor, dimethametryn,dimethenamid, dimethenamid-P, dimethipin, dimethylarsinic acid and itssodium salt, dinitramine, dinoterb, diphenamid, diquat dibromide,dithiopyr, diuron, DNOC, endothal, EPTC, esprocarb, ethalfluralin,ethametsulfuron-methyl, ethiozin, ethofumesate, ethoxyfen,ethoxysulfuron, etobenzanid, fenoxaprop-ethyl, fenoxaprop-P-ethyl,fenoxasulfone, fenquinotrione, fentrazamide, fenuron, fenuron-TCA,flamprop-methyl, flamprop-M-isopropyl, flamprop-M-methyl, flazasulfuron,florasulam, fluazifop-butyl, fluazifop-P-butyl, fluazolate,flucarbazone, flucetosulfuron, fluchloralin, flufenacet, flufenpyr,flufenpyr-ethyl, flumetsulam, flumiclorac-pentyl, flumioxazin,fluometuron, fluoroglycofen-ethyl, flupoxam, flupyrsulfuron-methyl andits sodium salt, flurenol, flurenol-butyl, fluridone, flurochloridone,fluroxypyr, flurtamone, fluthiacet-methyl, fomesafen, foramsulfuron,fosamine-ammonium, glufosinate, glufosinate-ammonium, glufosinate-P,glyphosate and its salts such as ammonium, isopropylammonium, potassium,sodium (including sesquisodium) and trimesium (alternatively namedsulfosate), halauxifen, halauxifen-methyl, halosulfuron-methyl,haloxyfop-etotyl, haloxyfop-methyl, hexazinone, imazamethabenz-methyl,imazamox, imazapic, imazapyr, imazaquin, imazaquin-ammonium,imazethapyr, imazethapyr-ammonium, imazosulfuron, indanofan, indaziflam,iofensulfuron, iodosulfuron-methyl, ioxynil, ioxynil octanoate,ioxynil-sodium, ipfencarbazone, isoproturon, isouron, isoxaben,isoxaflutole, isoxachlortole, lactofen, lenacil, linuron, maleichydrazide, MCPA and its salts (e.g., MCPA-dimethylammonium,MCPA-potassium and MCPA-sodium, esters (e.g., MCPA-2-ethylhexyl,MCPA-butotyl) and thioesters (e.g., MCPA-thioethyl), MCPB and its salts(e.g., MCPB-sodium) and esters (e.g., MCPB-ethyl), mecoprop, mecoprop-P,mefenacet, mefluidide, mesosulfuron-methyl, mesotrione, metam-sodium,metamifop, metamitron, metazachlor, metazosulfuron, methabenzthiazuron,methylarsonic acid and its calcium, monoammonium, monosodium anddisodium salts, methyldymron, metobenzuron, metobromuron, metolachlor,S-metolachlor, metosulam, metoxuron, metribuzin, metsulfuron-methyl,molinate, monolinuron, naproanilide, napropamide, napropamide-M,naptalam, neburon, nicosulfuron, norflurazon, orbencarb,orthosulfamuron, oryzalin, oxadiargyl, oxadiazon, oxasulfuron,oxaziclomefone, oxyfluorfen, paraquat dichloride, pebulate, pelargonicacid, pendimethalin, penoxsulam, pentanochlor, pentoxazone, perfluidone,pethoxamid, pethoxyamid, phenmedipham, picloram, picloram-potassium,picolinafen, pinoxaden, piperophos, pretilachlor, primisulfuron-methyl,prodiamine, profoxydim, prometon, prometryn, propachlor, propanil,propaquizafop, propazine, propham, propisochlor, propoxycarbazone,propyrisulfuron, propyzamide, prosulfocarb, prosulfuron, pyraclonil,pyraflufen-ethyl, pyrasulfotole, pyrazogyl, pyrazolynate, pyrazoxyfen,pyrazosulfuron-ethyl, pyribenzoxim, pyributicarb, pyridate, pyriftalid,pyriminobac-methyl, pyrimisulfan, pyrithiobac, pyrithiobac-sodium,pyroxasulfone, pyroxsulam, quinclorac, quinmerac, quinoclamine,quizalofop-ethyl, quizalofop-P-ethyl, quizalofop-P-tefuryl, rimsulfuron,saflufenacil, sethoxydim, siduron, simazine, simetryn, sulcotrione,sulfentrazone, sulfometuron-methyl, sulfosulfuron, 2,3,6-TBA, TCA,TCA-sodium, tebutam, tebuthiuron, tefuryltrione, tembotrione,tepraloxydim, terbacil, terbumeton, terbuthylazine, terbutryn,thenylchlor, thiazopyr, thiencarbazone, thifensulfuron-methyl,thiobencarb, tiafenacil, tiocarbazil, topramezone, tralkoxydim,tri-allate, triafamone, triasulfuron, triaziflam, tribenuron-methyl,triclopyr, triclopyr-butotyl, triclopyr-triethylammonium, tridiphane,trietazine, trifloxysulfuron, trifluralin, triflusulfuron-methyl,tritosulfuron, vernolate,3-(2-chloro-3,6-difluorophenyl)-4-hydroxy-1-methyl-1,5-naphthyridin-2(1H)-one,5-chloro-3-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-1-(4-methoxyphenyl)-2(1H)-quinoxalinone,2-chloro-N-(1-methyl-1H-tetrazol-5-yl-6-(trifluoromethyl)-3-pyridinecarboxamide,7-(3,5-dichloro-4-pyridinyl)-5-(2,2-difluoroethyl)-8-hydroxypyrido[2,3-b]pyrazin-6(5H)-one),4-(2,6-diethyl-4-methylphenyl)-5-hydroxy-2,6-dimethyl-3(2H)-pyridazinone),5-[[(2,6-difluorophenyl)methoxy]methyl]-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)isoxazole(previously methioxolin),3-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl]dihydro-1,5-dimethyl-6-thioxo-1,3,5-triazine-2,4(1H,3H)-dione,4-(4-fluorophenyl)-6-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-2-methyl-1,2,4-triazine-3,5(2H,4H)-dione,methyl4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-2-pyridinecarboxylate,2-methyl-3-(methylsulfonyl)-N-(1-methyl-1H-tetrazol-5-yl-4-(trifluoromethyl)benzamide,and2-methyl-N-(4-methyl-1,2,5-oxadiazol-3-yl-3-(methylsulfinyl)-4-(trifluoromethyenzamide. Other herbicides also include bioherbicides such as Alternariadestruens Simmons, Colletotrichum gloeosporiodes (Penz.) Penz. & Sacc.,Drechsiera monoceras (MTB-951), Myrothecium verrucaria (Albertini &Schweinitz) Ditmar: Fries, Phytophthora palmivora (Butl.) Butl. andPuccinia thlaspeos Schub.

Compounds of this invention can also be used in combination with plantgrowth regulators such as aviglycine, N-(phenylmethyl)-1H-purin-6-amine,epocholeone, gibberellic acid, gibberellin A₄ and A₇, harpin protein,mepiquat chloride, prohexadione calcium, prohydrojasmon, sodiumnitrophenolate and trinexapac-methyl, and plant growth modifyingorganisms such as Bacillus cereus strain BP01.

General references for agricultural protectants (i.e. herbicides,herbicide safeners, insecticides, fungicides, nematocides, acaricidesand biological agents) include The Pesticide Manual, 13th Edition, C. D.S. Tomlin, Ed., British Crop Protection Council, Farnham, Surrey, U.K.,2003 and The BioPesticide Manual, 2nd Edition, L. G. Copping, Ed.,British Crop Protection Council, Farnham, Surrey, U.K., 2001.

For embodiments where one or more of these various mixing partners areused, the weight ratio of these various mixing partners (in total) tothe compound of Formula 1 is typically between about 1:3000 and about3000:1. Of note are weight ratios between about 1:300 and about 300:1(for example ratios between about 1:30 and about 30:1). One skilled inthe art can easily determine through simple experimentation thebiologically effective amounts of active ingredients necessary for thedesired spectrum of biological activity. It will be evident thatincluding these additional components may expand the spectrum of weedscontrolled beyond the spectrum controlled by the compound of Formula 1alone.

In certain instances, combinations of a compound of this invention withother biologically active (particularly herbicidal) compounds or agents(i.e. active ingredients) can result in a greater-than-additive (i.e.synergistic) effect on weeds and/or a less-than-additive effect (i.e.safening) on crops or other desirable plants. Reducing the quantity ofactive ingredients released in the environment while ensuring effectivepest control is always desirable. Ability to use greater amounts ofactive ingredients to provide more effective weed control withoutexcessive crop injury is also desirable. When synergism of herbicidalactive ingredients occurs on weeds at application rates givingagronomically satisfactory levels of weed control, such combinations canbe advantageous for reducing crop production cost and decreasingenvironmental load. When safening of herbicidal active ingredientsoccurs on crops, such combinations can be advantageous for increasingcrop protection by reducing weed competition.

Of note is a combination of a compound of the invention with at leastone other herbicidal active ingredient. Of particular note is such acombination where the other herbicidal active ingredient has differentsite of action from the compound of the invention. In certain instances,a combination with at least one other herbicidal active ingredienthaving a similar spectrum of control but a different site of action willbe particularly advantageous for resistance management. Thus, acomposition of the present invention can further comprise (in aherbicidally effective amount) at least one additional herbicidal activeingredient having a similar spectrum of control but a different site ofaction.

Compounds of this invention can also be used in combination withherbicide safeners such as allidochlor, benoxacor, cloquintocet-mexyl,cumyluron, cyometrinil, cyprosulfonamide, daimuron, dichlormid,dicyclonon, dietholate, dimepiperate, fenchlorazole-ethyl, fenclorim,flurazole, fluxofenim, furilazole, isoxadifen-ethyl, mefenpyr-diethyl,mephenate, methoxyphenone naphthalic anhydride (1,8-naphthalicanhydride), oxabetrinil, N-(aminocarbonyl)-2-methylbenzenesulfonamide,N-(aminocarbonyl)-2-fluorobenzenesulfonamide,1-bromo-4-[(chloromethyl)sulfonyl]benzene (BCS),4-(dichloroacetyl)-1-oxa-4-azospiro[4.5]decane (MON 4660),2-(dichloromethyl)-2-methyl-1,3-dioxolane (MG 191), ethyl1,6-dihydro-1-(2-methoxyphenyl)-6-oxo-2-phenyl-5-pyrimidinecarboxylate,2-hydroxy-N,N-dimethyl-6-(trifluoromethyl)pyridine-3-carboxamide, and3-oxo-1-cyclohexen-1-yl1-(3,4-dimethylphenyl)-1,6-dihydro-6-oxo-2-phenyl-5-pyrimidinecarboxylateto increase safety to certain crops. Antidotally effective amounts ofthe herbicide safeners can be applied at the same time as the compoundsof this invention, or applied as seed treatments. Therefore an aspect ofthe present invention relates to a herbicidal mixture comprising acompound of this invention and an antidotally effective amount of aherbicide safener. Seed treatment is particularly useful for selectiveweed control, because it physically restricts antidoting to the cropplants. Therefore a particularly useful embodiment of the presentinvention is a method for selectively controlling the growth ofundesired vegetation in a crop comprising contacting the locus of thecrop with a herbicidally effective amount of a compound of thisinvention wherein seed from which the crop is grown is treated with anantidotally effective amount of safener. Antidotally effective amountsof safeners can be easily determined by one skilled in the art throughsimple experimentation.

Of note is a composition comprising a compound of the invention (in aherbicidally effective amount), at least one additional activeingredient selected from the group consisting of other herbicides andherbicide safeners (in an effective amount), and at least one componentselected from the group consisting of surfactants, solid diluents andliquid diluents.

Preferred for better control of undesired vegetation (e.g., lower userate such as from synergism, broader spectrum of weeds controlled, orenhanced crop safety) or for preventing the development of resistantweeds are mixtures of a compound of this invention with anotherherbicide. Table A1 lists particular combinations of Component (a) (i.e.a specific compound of the present invention) with another herbicide asComponent (b) illustrative of the mixtures, compositions and methods ofthe present invention. Compound 17 in the Component (a) column isidentified in Index Table A. The second column of Table A1 lists thespecific Component (b) compound (e.g., “2,4-D” in the first line). Thethird, fourth and fifth columns of Table A1 lists ranges of weightratios for rates at which the Component (a) compound is typicallyapplied to a field-grown crop relative to Component (b) (i.e. (a):(b)).Thus, for example, the first line of Table A1 specifically discloses thecombination of Component (a) (i.e. Compound 17 in Index Table A) with2,4-D is typically applied in a weight ratio between 1:192-6:1. Theremaining lines of Table A1 are to be construed similarly.

TABLE A1 Component (a) Typical More Typical Most Typical (Compound #)Component (b) Weight Ratio Weight Ratio Weight Ratio 17 2,4-D 1:192-6:11:64-2:1 1:24-1:3 17 Acetochlor 1:768-2:1 1:256-1:2   1:96-1:11 17Acifluorfen  1:96-12:1 1:32-4:1 1:12-1:2 17 Aclonifen 1:857-2:11:285-1:3  1:107-1:12 17 Alachlor 1:768-2:1 1:256-1:2   1:96-1:11 17Ametryn 1:384-3:1 1:128-1:1  1:48-1:6 17 Amicarbazone 1:192-6:1 1:64-2:11:24-1:3 17 Amidosulfuron   1:6-168:1  1:2-56:1  1:1-11:1 17Aminocyclopyrachlor  1:48-24:1 1:16-8:1  1:6-2:1 17 Aminopyralid 1:20-56:1  1:6-19:1  1:2-4:1 17 Amitrole 1:768-2:1 1:256-1:2  1:96-1:11 17 Anilofos  1:96-12:1 1:32-4:1 1:12-1:2 17 Asulam 1:960-2:11:320-1:3  1:120-1:14 17 Atrazine 1:192-6:1 1:64-2:1 1:24-1:3 17Azimsulfuron   1:6-168:1  1:2-56:1  1:1-11:1 17 Beflubutamid 1:342-4:11:114-2:1  1:42-1:5 17 Benfuresate 1:617-2:1 1:205-1:2  1:77-1:9 17Bensulfuron-methyl  1:25-45:1  1:8-15:1  1:3-3:1 17 Bentazone 1:192-6:11:64-2:1 1:24-1:3 17 Benzobicyclon  1:85-14:1 1:28-5:1 1:10-1:2 17Benzofenap 1:257-5:1 1:85-2:1 1:32-1:4 17 Bicyclopyrone  1:42-27:11:14-9:1  1:5-2:1 17 Bifenox 1:257-5:1 1:85-2:1 1:32-1:4 17Bispyribac-sodium   1:10-112:1  1:3-38:1  1:1-7:1 17 Bromacil 1:384-3:11:128-1:1  1:48-1:6 17 Bromobutide 1:384-3:1 1:128-1:1  1:48-1:6 17Bromoxynil  1:96-12:1 1:32-4:1 1:12-1:2 17 Butachlor 1:768-2:11:256-1:2   1:96-1:11 17 Butafenacil  1:42-27:1 1:14-9:1  1:5-2:1 17Butylate 1:1542-1:2  1:514-1:5  1:192-1:22 17 Cafenstrole 1:192-6:11:64-2:1 1:24-1:3 17 Carfentrazone-ethyl 1:128-9:1 1:42-3:1 1:16-1:2 17Chlorimuron-ethyl   1:8-135:1  1:2-45:1  1:1-9:1 17 Chlorotoluron1:768-2:1 1:256-1:2   1:96-1:11 17 Chlorsulfuron   1:6-168:1  1:2-56:1 1:1-11:1 17 Cinosulfuron  1:17-68:1  1:5-23:1  1:2-5:1 17 Cinidon-ethyl1:384-3:1 1:128-1:1  1:48-1:6 17 Cinmethylin  1:34-34:1  1:11-12:1 1:4-3:1 17 Clacyfos  1:34-34:1  1:11-12:1  1:4-3:1 17 Clethodim 1:48-24:1 1:16-8:1  1:6-2:1 17 Clodinafop-propargyl  1:20-56:1 1:6-19:1  1:2-4:1 17 Clomazone 1:384-3:1 1:128-1:1  1:48-1:6 17Clomeprop 1:171-7:1 1:57-3:1 1:21-1:3 17 Clopyralid 1:192-6:1 1:64-2:11:24-1:3 17 Cloransulam-methyl  1:12-96:1  1:4-32:1  1:1-6:1 17Cumyluron 1:384-3:1 1:128-1:1  1:48-1:6 17 Cyanazine 1:384-3:11:128-1:1  1:48-1:6 17 Cyclopyrimorate  1:17-68:1  1:5-23:1  1:2-5:1 17Cyclosulfamuron  1:17-68:1  1:5-23:1  1:2-5:1 17 Cycloxydim  1:96-12:11:32-4:1 1:12-1:2 17 Cyhalofop  1:25-45:1  1:8-15:1  1:3-3:1 17 Daimuron1:192-6:1 1:64-2:1 1:24-1:3 17 Desmedipham 1:322-4:1 1:107-2:1  1:40-1:517 Dicamba 1:192-6:1 1:64-2:1 1:24-1:3 17 Dichlobenil 1:1371-1:2 1:457-1:4  1:171-1:20 17 Dichlorprop 1:925-2:1 1:308-1:3  1:115-1:13 17Diclofop-methyl 1:384-3:1 1:128-1:1  1:48-1:6 17 Diclosulam   1:10-112:1 1:3-38:1  1:1-7:1 17 Difenzoquat 1:288-4:1 1:96-2:1 1:36-1:4 17Diflufenican 1:857-2:1 1:285-1:3  1:107-1:12 17 Diflufenzopyr  1:12-96:1 1:4-32:1  1:1-6:1 17 Dimethachlor 1:768-2:1 1:256-1:2   1:96-1:11 17Dimethametryn 1:192-6:1 1:64-2:1 1:24-1:3 17 Dimethenamid-P 1:384-3:11:128-1:1  1:48-1:6 17 Dithiopyr 1:192-6:1 1:64-2:1 1:24-1:3 17 Diuron1:384-3:1 1:128-1:1  1:48-1:6 17 EPTC 1:768-2:1 1:256-1:2   1:96-1:11 17Esprocarb 1:1371-1:2  1:457-1:4  1:171-1:20 17 Ethalfluralin 1:384-3:11:128-1:1  1:48-1:6 17 Ethametsulfuron-methyl  1:17-68:1  1:5-23:1 1:2-5:1 17 Ethoxyfen   1:8-135:1  1:2-45:1  1:1-9:1 17 Ethoxysulfuron 1:20-56:1  1:6-19:1  1:2-4:1 17 Etobenzanid 1:257-5:1 1:85-2:1 1:32-1:417 Fenoxaprop-ethyl  1:120-10:1 1:40-4:1 1:15-1:2 17 Fenoxasulfone 1:85-14:1 1:28-5:1 1:10-1:2 17 Fenquinotrione  1:17-68:1  1:5-23:1 1:2-5:1 17 Fentrazamide  1:17-68:1  1:5-23:1  1:2-5:1 17 Flazasulfuron 1:17-68:1  1:5-23:1  1:2-5:1 17 Florasulam   1:2-420:1   1:1-140:1 2:1-27:1 17 Fluazifop-butyl 1:192-6:1 1:64-2:1 1:24-1:3 17 Flucarbazone  1:8-135:1  1:2-45:1  1:1-9:1 17 Flucetosulfuron   1:8-135:1  1:2-45:1 1:1-9:1 17 Flufenacet 1:257-5:1 1:85-2:1 1:32-1:4 17 Flumetsulam 1:24-48:1  1:8-16:1  1:3-3:1 17 Flumiclorac-pentyl   1:10-112:1 1:3-38:1  1:1-7:1 17 Flumioxazin  1:25-45:1  1:8-15:1  1:3-3:1 17Fluometuron 1:384-3:1 1:128-1:1  1:48-1:6 17 Flupyrsulfuron-methyl  1:3-336:1   1:1-112:1  2:1-21:1 17 Fluridone 1:384-3:1 1:128-1:1 1:48-1:6 17 Fluroxypyr  1:96-12:1 1:32-4:1 1:12-1:2 17 Flurtamone1:857-2:1 1:285-1:3  1:107-1:12 17 Fluthiacet-methyl  1:48-42:1 1:16-14:1  1:3-3:1 17 Fomesafen  1:96-12:1 1:32-4:1 1:12-1:2 17Foramsulfuron  1:13-84:1  1:4-28:1  1:1-6:1 17 Glufosinate 1:288-4:11:96-2:1 1:36-1:4 17 Glyphosate 1:288-4:1 1:96-2:1 1:36-1:4 17Halauxifen  1:20-56:1  1:6-19:1  1:2-4:1 17 Halauxifen-methyl  1:20-56:1 1:6-19:1  1:2-4:1 17 Halosulfuron-methyl  1:17-68:1  1:5-23:1  1:2-5:117 Haloxyfop-methyl  1:34-34:1  1:11-12:1  1:4-3:1 17 Hexazinone1:192-6:1 1:64-2:1 1:24-1:3 17 Imazamox  1:13-84:1  1:4-28:1  1:1-6:1 17Imazapic  1:20-56:1  1:6-19:1  1:2-4:1 17 Imazapyr  1:85-14:1 1:28-5:11:10-1:2 17 Imazaquin  1:34-34:1  1:11-12:1  1:4-3:1 17Imazethabenz-methyl 1:171-7:1 1:57-3:1 1:21-1:3 17 Imazethapyr 1:24-48:1  1:8-16:1  1:3-3:1 17 Imazosulfuron  1:27-42:1  1:9-14:1 1:3-3:1 17 Indanofan 1:342-4:1 1:114-2:1  1:42-1:5 17 Indaziflam 1:25-45:1  1:8-15:1  1:3-3:1 17 Iodosulfuron-methyl   1:3-336:1  1:1-112:1  2:1-21:1 17 Ioxynil 1:192-6:1 1:64-2:1 1:24-1:3 17Ipfencarbazone  1:85-14:1 1:28-5:1 1:10-1:2 17 Isoproturon 1:384-3:11:128-1:1  1:48-1:6 17 Isoxaben 1:288-4:1 1:96-2:1 1:36-1:4 17Isoxaflutole  1:60-20:1 1:20-7:1  1:7-2:1 17 Lactofen  1:42-27:11:14-9:1  1:5-2:1 17 Lenacil 1:384-3:1 1:128-1:1  1:48-1:6 17 Linuron1:384-3:1 1:128-1:1  1:48-1:6 17 MCPA 1:192-6:1 1:64-2:1 1:24-1:3 17MCPB 1:288-4:1 1:96-2:1 1:36-1:4 17 Mecoprop 1:768-2:1 1:256-1:2  1:96-1:11 17 Mefenacet 1:384-3:1 1:128-1:1  1:48-1:6 17 Mefluidide1:192-6:1 1:64-2:1 1:24-1:3 17 Mesosulfuron-methyl   1:5-224:1  1:1-75:1 1:1-14:1 17 Mesotrione  1:42-27:1 1:14-9:1  1:5-2:1 17 Metamifop 1:42-27:1 1:14-9:1  1:5-2:1 17 Metazachlor 1:384-3:1 1:128-1:1 1:48-1:6 17 Metazosulfuron  1:25-45:1  1:8-15:1  1:3-3:1 17Methabenzthiazuron 1:768-2:1 1:256-1:2   1:96-1:11 17 Metolachlor1:768-2:1 1:256-1:2   1:96-1:11 17 Metosulam   1:8-135:1  1:2-45:1 1:1-9:1 17 Metribuzin 1:192-6:1 1:64-2:1 1:24-1:3 17 Metsulfuron-methyl  1:2-560:1   1:1-187:1  3:1-35:1 17 Molinate 1:1028-2:1  1:342-1:3 1:128-1:15 17 Napropamide 1:384-3:1 1:128-1:1  1:48-1:6 17 Napropamide-M1:192-6:1 1:64-2:1 1:24-1:3 17 Naptalam 1:192-6:1 1:64-2:1 1:24-1:3 17Nicosulfuron  1:12-96:1  1:4-32:1  1:1-6:1 17 Norflurazon 1:1152-1:1 1:384-1:3  1:144-1:16 17 Orbencarb 1:1371-1:2  1:457-1:4  1:171-1:20 17Orthosulfamuron  1:20-56:1  1:6-19:1  1:2-4:1 17 Oryzalin 1:514-3:11:171-1:2  1:64-1:8 17 Oxadiargyl 1:384-3:1 1:128-1:1  1:48-1:6 17Oxadiazon 1:548-3:1 1:182-1:2  1:68-1:8 17 Oxasulluron  1:27-42:1 1:9-14:1  1:3-3:1 17 Oxaziclomefone  1:42-27:1 1:14-9:1  1:5-2:1 17Oxyfluorfen 1:384-3:1 1:128-1:1  1:48-1:6 17 Paraquat 1:192-6:1 1:64-2:11:24-1:3 17 Pendimethalin 1:384-3:1 1:128-1:1  1:48-1:6 17 Penoxsulam  1:10-112:1  1:3-38:1  1:1-7:1 17 Penthoxamid 1:384-3:1 1:128-1:1 1:48-1:6 17 Pentoxazone  1:102-12:1 1:34-4:1 1:12-1:2 17 Phenmedipham 1:102-12:1 1:34-4:1 1:12-1:2 17 Picloram  1:96-12:1 1:32-4:1 1:12-1:217 Picolinafen  1:34-34:1  1:11-12:1  1:4-3:1 17 Pinoxaden  1:25-45:1 1:8-15:1  1:3-3:1 17 Pretilachlor 1:192-6:1 1:64-2:1 1:24-1:3 17Primisulfuron-methyl   1:8-135:1  1:2-45:1  1:1-9:1 17 Prodiamine1:384-3:1 1:128-1:1  1:48-1:6 17 Profoxydim  1:42-27:1 1:14-9:1  1:5-2:117 Prometryn 1:384-3:1 1:128-1:1  1:48-1:6 17 Propachlor 1:1152-1:1 1:384-1:3  1:144-1:16 17 Propanil 1:384-3:1 1:128-1:1  1:48-1:6 17Propaquizafop  1:48-24:1 1:16-8:1  1:6-2:1 17 Propoxycarbazone 1:17-68:1  1:5-23:1  1:2-5:1 17 Propyrisulfuron  1:17-68:1  1:5-23:1 1:2-5:1 17 Propyzamide 1:384-3:1 1:128-1:1  1:48-1:6 17 Prosulfocarb1:1200-1:2  1:400-1:4  1:150-1:17 17 Prosulfuron   1:6-168:1  1:2-56:1 1:1-11:1 17 Pyraclonil  1:42-27:1 1:14-9:1  1:5-2:1 17 Pyraflufen-ethyl  1:5-224:1  1:1-75:1  1:1-14:1 17 Pyrasulfotole  1:13-84:1  1:4-28:1 1:1-6:1 17 Pyrazolynate 1:857-2:1 1:285-1:3  1:107-1:12 17Pyrazosulfuron-ethyl   1:10-112:1  1:3-38:1  1:1-7:1 17 Pyrazoxyfen  1:5-224:1  1:1-75:1  1:1-14:1 17 Pyribenzoxim   1:10-112:1  1:3-38:1 1:1-7:1 17 Pyributicarb 1:384-3:1 1:128-1:1  1:48-1:6 17 Pyridate1:288-4:1 1:96-2:1 1:36-1:4 17 Pyriftalid   1:10-112:1  1:3-38:1 1:1-7:1 17 Pyriminobac-methyl  1:20-56:1  1:6-19:1  1:2-4:1 17Pyrimisulfan  1:17-68:1  1:5-23:1  1:2-5:1 17 Pyrithiobac  1:24-48:1 1:8-16:1  1:3-3:1 17 Pyroxasulfone  1:85-14:1 1:28-5:1 1:10-1:2 17Pyroxsulam   1:5-224:1  1:1-75:1  1:1-14:1 17 Quinclorac 1:192-6:11:64-2:1 1:24-1:3 17 Quizalofop-ethyl  1:42-27:1 1:14-9:1  1:5-2:1 17Rimsulfuron  1:13-84:1  1:4-28:1  1:1-6:1 17 Saflufenacil  1:25-45:1 1:8-15:1  1:3-3:1 17 Sethoxydim  1:96-12:1 1:32-4:1 1:12-1:2 17Simazine 1:384-3:1 1:128-1:1  1:48-1:6 17 Sulcotrione  1:120-10:11:40-4:1 1:15-1:2 17 Sulfentrazone 1:147-8:1 1:49-3:1 1:18-1:3 17Sulfometuron-methyl  1:34-34:1  1:11-12:1  1:4-3:1 17 Sulfosulfuron  1:8-135:1  1:2-45:1  1:1-9:1 17 Tebuthiuron 1:384-3:1 1:128-1:1 1:48-1:6 17 Tefmyltrione  1:42-27:1 1:14-9:1  1:5-2:1 17 Tembotrione 1:31-37:1  1:10-13:1  1:3-3:1 17 Tepraloxydim  1:25-45:1  1:8-15:1 1:3-3:1 17 Terbacil 1:288-4:1 1:96-2:1 1:36-1:4 17 Terbuthylazine1:857-2:1 1:285-1:3  1:107-1:12 17 Terbutryn 1:192-6:1 1:64-2:1 1:24-1:317 Thenylchlor  1:85-14:1 1:28-5:1 1:10-1:2 17 Thiazopyr 1:384-3:11:128-1:1  1:48-1:6 17 Thiencarbazone   1:3-336:1   1:1-112:1  2:1-21:117 Thifensulfuron-methyl   1:5-224:1  1:1-75:1  1:1-14:1 17 Tiafenacil 1:17-68:1  1:5-23:1  1:2-5:1 17 Thiobencarb 1:768-2:1 1:256-1:2  1:96-1:11 17 Topramezone   1:6-168:1  1:2-56:1  1:1-11:1 17 Tralkoxydim 1:68-17:1 1:22-6:1  1:8-2:1 17 Triallate 1:768-2:1 1:256-1:2  1:96-1:11 17 Triasulfuron   1:5-224:1  1:1-75:1  1:1-14:1 17 Triaziflam1:171-7:1 1:57-3:1 1:21-1:3 17 Tribenuron-methyl   1:3-336:1   1:1-112:1 2:1-21:1 17 Triclopyr 1:192-6:1 1:64-2:1 1:24-1:3 17 Trifloxysulfuron  1:2-420:1   1:1-140:1  2:1-27:1 17 Trifluralin 1:288-4:1 1:96-2:11:36-1:4 17 Triflusulfuron-methyl  1:17-68:1  1:5-23:1  1:2-5:1 17Tritosulfuron  1:13-84:1  1:4-28:1  1:1-6:1

Table A2 is constructed the same as Table A1 above except that entriesbelow the “Component (a)” column heading are replaced with therespective Component (a) Column Entry shown below. Compound 79 in theComponent (a) column is identified in Index Table A. Thus, for example,in Table A2 the entries below the “Component (a)” column heading allrecite “Compound 79” (i.e. Compound 79 identified in Index Table A), andthe first line below the column headings in Table A2 specificallydiscloses a mixture of Compound 79 with 2,4-D. Tables A3 and A4 areconstructed similarly.

Table Number Component (a) Column Entries A2 Compound 79 A3 Compound 80A4 Compound 5 A5 Compound 3 A6 Compound 5 A7 Compound 80 A8 Compound 101A9 Compound 103 A10 Compound 156 A11 Compound 202 A12 Compound 204 A13Compound 206 A14 Compound 232 A15 Compound 263 A16 Compound 271 A17Compound 304 A18 Compound 306 A19 Compound 315 A20 Compound 319 A21Compound 323 A22 Compound 351

Preferred for better control of undesired vegetation (e.g., lower userate such as from synergism, broader spectrum of weeds controlled, orenhanced crop safety) or for preventing the development of resistantweeds are mixtures of a compound of this invention with a herbicideselected from the group consisting of chlorimuron-ethyl, nicosulfuron,mesotrione, thifensulfuron-methyl, flupyrsulfuron-methyl, tribenuron,pyroxasulfone, pinoxaden, tembotrione, pyroxsulam, metolachlor andS-metolachlor.

The following Tests demonstrate the control efficacy of compounds ofthis invention on specific pathogens. The pathogen control protectionafforded by the compounds is not limited, however, to these species. SeeIndex Tables A-C for compound descriptions. The following abbreviationsare used in the Index Tables which follow: Me is methyl, Ph is phenyl,OMe is methoxy, —CN is cyano, —NO₂ is nitro, t-Boc istertiary-butoxycarbonyl, and TMS is trimethylsilyl. The abbreviation“Ex.” stands for “Example” and is followed by a number indicating inwhich example the compound is prepared. Mass spectra are reported as themolecular weight of the highest isotopic abundance parent ion (M+1)formed by addition of H⁺ (molecular weight of 1) to the molecule, or(M−1) formed by the loss of H⁺ (molecular weight of 1) from themolecule, observed by using liquid chromatography coupled to a massspectrometer (LCMS) using either atmospheric pressure chemicalionization (AP⁺) or electrospray ionization (ESI⁺).

TABLE A ⁽¹⁾ INDEX

Cmpd. No. Q¹ Q² m.p. (° C.) M − 1 M + 1 1 Ph(3-F) Ph(2-F) 317 2 Ph(3-F)Ph(2-CF₃) 367 3 Ph(3-CF₃) Ph(2-F) 367 4 Ph(3-CF₃) Ph(2-CF₃) 417 5Ph(3,4-di-F) Ph(2-F) 335 6 Ph(3,4-di-F) Ph(2-CF₃) 385 12 Ph(3,4-di-F)Ph(3-F) 335 13 Ph(3,4-di-F) Ph(3-CF₃) 385 14 Ph(3,4-di-Cl) Ph(2-F) 36715 Ph(3,4-di-Cl) Ph(2-CN) 376 16 Ph(4-F) Ph(2-F) 317 17 Ph(3,4-di-F)Ph(2,3-di-F) 198-200 18 Ph(3,4-di-F) Ph(3-Cl) 165-167 19 Ph(3,4-di-F)Ph(2-Me) 158-160 20 Ph(3,4-di-F) Ph(2-NO₂) 173-175 21 Ph(3,4-di-F)Ph(2-SO₂Me) 203-205 22 Ph(3,4-di-F) 4-pyridinyl(2-F) 210-212 23Ph(3,4-di-F) Ph(2,4-di-F) 188-190 25 Ph(3,4-di-Cl) Ph(2,3-di-F) 171-17326 Ph(3,4-di-Cl) Ph(2-CF₃) 170-172 27 Ph(3,4-di-Cl) Ph(3-F) 174-176 283-thienyl Ph(2-CF₃) 146-148 29 3-thienyl Ph(2-F) ** 30 Ph(3,4-di-F) Ph184-186 31 Ph(3,4-di-F) 1H-pyrazol-3-yl(1-Me) 181-183 32 Ph(3,4-di-Cl)Ph(2-OCF₃) 432 33 Ph(3,4,5-tri-F) Ph(2-CF₃) 160-162 34 Ph(3,4,5-tri-F)Ph(2-F) 196-198 35 Ph(3,4,5-tri-F) Ph(2-Me) 170-172 36 Ph(3-OMe) Ph(2-F)329 38 Ph(3-Me) Ph(2-F) 313 39 Ph(3,4-di-Cl) Ph(2-NO₂) 178-180 40Ph(3,4-di-Cl) Ph(2-Me) 194-196 41 pyridin-3-yl(6-Cl) Ph(2-F) 200-204 42pyridin-3-yl(6-Cl) Ph(2-CF₃) 43 Ph(3,4-di-Cl) Ph(2-SO₂Me) 219-221 45Ph(3,4-di-F) 2-pyridinyl 316 318 46 Ph(3,4-di-F) 3-pyridinyl(2-OMe) 346348 47 Ph(3,4-di-F) 2-pyridinyl(1-oxido) 334 48 Ph(3,4,5-tri-F)Ph(2,3-di-F) 371 49 Ph(3,4,5-tri-F) Ph(3-NO₂) 380 50 Ph(2,4,5-tri-F)Ph(2,3-di-F) 371 51 Ph(2,4,5-tri-F) Ph(2-F) 353 52 Ph(3-F,4-Cl)Ph(2,3-di-F) 369 53 Ph(3-F,4-Cl) Ph(2-F) 351 54 Ph(3,4-di-F) Ph(2-OCF₃)399 401 55 Ph(3,4-di-F) Ph(2-Br) 393 395 56 Ph(3,4-di-F) Ph(3-Me) 329331 57 Ph(3,4-di-F) 1,3-benzodioxol- 395 397 4-yl(2,2-di-F) 58Ph(3,4-di-F) 2-pyridinyl(6-OMe) 346 348 59 Ph(3-Cl,4-F) Ph(2,3-di-F) 36960 Ph(3-Cl,4-F) Ph(2-F) 351 62 1,3-benzodioxol- Ph(2,3-di-F) 3975-yl(2,2-di-F) 63 1,3-benzodioxol- Ph(2-F) 379 5-yl(2,2-di-F) 64Ph(3-Br) Ph(2,3-di-F) 395 65 Ph Ph(2,3-di-F) 317 66 Ph(3-Br) Ph(2-F) 37767 Ph(3,4-di-F) Ph(2-CF₃,3-F) 401 403 68 Ph(3-OCF₃) Ph(2,3-di-F) 401 69Ph(3-OCF₃) Ph(2-F) 383 70 Ph(3-NH-t-Boc) Ph(2,3-di-F) 432 72 Ph(3-CN)Ph(2-F) 324 73 Ph(3-CN) Ph(2,3-di-F) 342 74 (Ex. 1) Ph(3-Cl,4-F)Ph(2-CF₃) 401 75 1,3-benzodioxol- Ph(2-CF₃) 429 5-yl(2,2-di-F) 76Ph(3-CF₃,4-F) Ph(2-F) 385 77 Ph(3-CF₃,4-F) Ph(2,3-di-F) 403 78Ph(3-CF₃,4-F) Ph(2-CF₃) 435 79 Ph(4-CF₃) Ph(2-F) 367 80 Ph(4-CF₃)Ph(2,3-di-F) 385 81 Ph Ph(2-F) 158-159 82 Ph Ph(2-CF₃) 159-160 83 PhPh(2-Cl) 154-155 84 Ph Ph(2-F,4-Br) 184-186 85 Ph(2-F) Ph(2-F) ** 86 PhPh(2-CN) ** 87 Ph(4-Cl) Ph(2-F) 189-192 88 Ph(2-Cl) Ph(2-F) 163-165 89Ph(3-Cl) Ph(2-F) 164-166 90 Ph(3,5-di-Cl) Ph(2-F) 199-203 91Ph(2,4-di-Cl) Ph(2-F) 192-194 96 Ph(3,4-F) 2-pyridin-6-one 334 97Ph(3,4-F) 3-pyridin-2-one 334 98 Ph(3,4-F) 3-pyridinyl(2-CF₃) 170-173 99Ph(3,4-F) Ph(2-Cl) 155-158 100 Ph(3,4-F) Ph(3-Cl,2-Me) 198-201 101Ph(3,4-F) Ph(2,3-di-F) 170-172 102(3S,4R) Ph(3,4-F) Ph(2-F) 180-182103(3R,4S) Ph(3,4-F) Ph(2-F) 179-181 104 Ph(3,4-F) Ph(3-Cl,2-F) 196-198105 Ph(3,4-F) 3-pyridinyl(2-F) 171-174 106 Ph(3,4-F) Ph(3-F,2-Me)200-202 107 Ph(3,4-F) Ph(2,3-di-F) 171-173 108 Ph(3,4-F) Ph(2-Cl,3-F)219-223 109 Ph(3-CF₃) Ph(2-Me) 163-165 110 Ph(3-CF₃) 2-pyridinyl 175-177111 Ph(3-CF₃) 1,3,4-thiadiazol-2-yl 357.3 112 Ph(3-CF₃)1,3,4-thiadiazol-2-yl(5- 425.3 CF₃) 113 Ph(3-CF₃) 1,3-thiazol-2-yl(5-Cl)390.3 114 Ph(3-CF₃) oxazol-2-yl(4-CF₃) 408.4 115 2-naphthyl Ph(2-F) 349116 2-naphthyl Ph(2,3-di-F) 367 117 2-naphthyl Ph(2-CF₃) 399 118 Ph(4-F)Ph(2-OCHF₂) 363.3 119 Ph(4-F) Ph(2,3-di-F) 335.3 120 Ph(4-F)Ph(2,3,4-tri-F) 353.5 121 Ph(3-OCF₂CHF₂) Ph(2-F) 415 122 Ph(3-OCF₂CHF₂)Ph(2,4-di-F) 433 123 Ph(3-OCF₂CHF₂) Ph(2,3-di-F) 433 124 Ph(3-OCF₂CHF₂)Ph(2,3,4-tri-F) 451 125 Ph(3-OCF₂CHF₂) Ph(2-Cl) 431 126 Ph(OCH₂CF₃)Ph(2-F) 397 127 Ph(OCH₂CF₃) Ph(2,4-di-F) 415 128 Ph(OCH₂CF₃)Ph(2,3-di-F) 415 129 Ph(OCH₂CF₃) Ph(2,3,4-tri-F) 433 130 Ph(OCH₂CF₃)Ph(2-Cl) 413 131 Ph(3-OMe,4-F) Ph(2,4-di-F) 365 132 Ph(3-OMe,4-F)Ph(2,3,4-tri-F) 383 133 Ph(3-OMe,4-F) Ph(2-Cl) 363 134 Ph(3-SO₂Me)Ph(2-F) 377 135 Ph(3-SO₂Me) Ph(2,4-di-F) 395 136 Ph(3-SO₂Me)Ph(2,3-di-F) 395 137 Ph(3-SO₂Me) Ph(2,3,4-tri-F) 413 138 Ph(3-SO₂Me)Ph(2-Cl) 393 139 Ph(4-F,3-Me) Ph(2-F) 331 140 Ph(4-F,3-Me) Ph(2,4-di-F)349 141 Ph(4-F,3-Me) Ph(2,3-di-F) 349 142 Ph(4-F,3-Me) Ph(2,3,4-tri-F)367 143 Ph(4-F,3-Me) Ph(2-Cl) 347 144 Ph(3-F,4-Me) Ph(2-F) 331 145Ph(3-F,4-Me) Ph(2,4-di-F) 349 146 Ph(3-F,4-Me) Ph(2,3-di-F) 349 147Ph(3-F,4-Me) Ph(2,3,4-tri-F) 367 148 Ph(3-F,4-Me) Ph(2-Cl) 347 149Ph(4-Me) Ph(2-F) 313 150 Ph(4-Me) Ph(2,4-di-F) 331 151 Ph(4-Me)Ph(2,3-di-F) 331 152 Ph(4-Me) Ph(2-Cl) 329 153 Ph(4-Me) Ph(3-F) 313 154Ph(3-CF₃) Ph(2-Cl) 397.5 155 Ph(3,5-di-F) Ph(2-F) 335 156 Ph(3,5-di-F)Ph(2,4-di-F) 353 157 Ph(3,5-di-F) Ph(2,3-di-F) 353 158 Ph(3,5-di-F)Ph(2,3,4-tri-F) 371 159 Ph(3,5-di-F) Ph(2-Cl) 351 160 Ph(3-CF₃)Ph(2-SO₂Me) 427 161 1,3-benzodioxo1-5-yl(2,2- Ph(2-F) 379 di-F) 1621,3-benzodioxo1-5-yl(2,2- Ph(2,3,4-tri-F) 415 di-F) 163 Ph(3-CHF₂)Ph(2-F) 349 164 Ph(3-CHF₂) Ph(2,3-di-F) 367 165 Ph(3-CHF₂)Ph(2,3,4-tri-F) 385 166 Ph(3-c-Pr) Ph(2-F) 339 167 Ph(3-c-Pr)Ph(2,3-di-F) 357 168 Ph(3-c-Pr) Ph(2,3,4-tri-F) 375 169 Ph(3-Et) Ph(2-F)327 170 Ph(3-Et) Ph(2,3-di-F) 345 171 Ph(3-Et) Ph(2,3,4-tri-F) 363 172Ph(4-OCF₂CHF₂) Ph(2,3-di-F) 433 173 Ph(4-OCF₂CHF₂) Ph(2,4-di-F) 433 174Ph(4-OCF₂CHF₂) Ph(2,3,4-di-F) 451 176 Ph(4-Cl) Ph(2,3-di-F) 351 177Ph(4-Cl) Ph(2,4-di-F) 351 178 Ph(4-Cl) Ph(2-F) 333 179 Ph(4-Cl) Ph(3-F)333 180 Ph(4-Cl) Ph(2-Cl) 350 183 Ph(3-CF₃) Ph(2-F,5-Me) 381 184Ph(3-CF₃) Ph(2-F,3-Me) 381 185 Ph(3-CF₃) Ph(4-F,3-Me) 381 186 Ph(3-CF₃)Ph(5-CF₃,4-Me) 431 187 Ph(3-CF₃) Ph(4-OMe,2-F) 397 188 Ph(3-CF₃)Ph(4-OMe,3-F) 397 189 Ph(3-CF₃) Ph(2-Cl) 383 190 Ph(3-CF₃) Ph(2-Br)428.9 191 1H-pyrazol-3-yl(1-Me) Ph(2-CF₃) 141-143 1921H-pyrazol-3-yl(1-Me) Ph(2,3-di-F) 188-190 193 Ph(3,4-di-F) Ph(4-F)162-164 194 Ph(3-OMe,4-F) Ph(2-F) 347 195 Ph(3-OMe,4-F) Ph(2,3-di-F) 365196 Ph(3-OMe,4-F) Ph(2-CF₃) 397 197 Ph(4-OMe,3-F) Ph(2-F) 347 198Ph(4-OMe,3-F) Ph(2,3-di-F) 365 199 Ph(4-OMe,3-F) Ph(2-CF₃) 397 200Ph(3-t-Bu) Ph(2,3-di-F) 373 201 Ph(3-t-Bu) Ph(2-CF₃) 405 202 Ph(4-CF₃)Ph(2,3-di-F) 385.5 203(3S,4R) Ph(3-CF₃) Ph(2-F) 138-140 204(3R,4S)Ph(3-CF₃) Ph(2-F) 135-137 205(3S,4R) Ph(3-CF₃) Ph(2,3-di-F) 121-123206(3R,4S) Ph(3-CF₃) Ph(2,3-di-F) 120-122 207 Ph(3-CF₃) Ph(2,4-di-F)164-166 208 Ph(3-CF₃) Ph(3-F) 123-125 209 Ph(3-CF₃,4-OCH₃) Ph(2-F) 397210 Ph(3-CHF₂) Ph(2-F) 349 211 Ph(3-CHF₂) Ph(2,3-di-F) 367 212Ph(3-CHF₂) Ph(2-CF₃) 399 213 Ph(3-SF₅) Ph(2-F) 425 214 Ph(3-SF₅)Ph(2,3-di-F) 443 215 Ph(3-SF₅) Ph(2-CF₃) 475 216 naphthalen-1-yl Ph(2-F)349 217 Ph(4-Cl) Ph(2-F) 333 218 Ph(4-Cl) Ph(2,3-di-F) 351 219 Ph(4-Cl)Ph(2-CF₃) 383 220 Ph(4-Cl) Ph(2-Cl) 349 221 Ph(4-Cl) Ph(2,3-di-Cl) 383222 Ph(3-OCHF₂) Ph(2-CF₃) 415.1 223 Ph(3-OCHF₂) Ph(2-F) 365.1 224Ph(3-OCHF₂) Ph(2,3-di-F) 383.1 225 Ph(4-OCHF₂) Ph(2-Br) 427 226Ph(4-OCHF₂) Ph(2-Cl) 381 227 Ph(4-OCHF₂) Ph(2-Me) 361.1 228 Ph(3-OCHF₂)Ph(2-Br) 427 229 Ph(3-OCHF₂) Ph(2-Cl) 381.1 230 Ph(3-OCHF₂) Ph(2-Me)361.1 231(3R,4S) Ph(4-CF₃) Ph(2-F) 367.5 232 Ph(4-CF₃) Ph(2,3,4-tri-F)403.5 233 Ph(4-CF₃) Ph(2-Cl) 383.5 234 Ph(3-CF₃,4-OMe) Ph(2,3-di-F) 415235 Ph(4-Ph(2-F)) Ph(2,3-di-F) 131.6-136.5 236 Ph(4-Ph(2-CF₃))Ph(2,3-di-F) 177.9-191.1 237 Ph(3-Ph(2-CF₃)) Ph(2-CF₃) 57.1-66.2 238Ph(3-Ph(2-F)) Ph(2-CF₃) 152.7-157.5 239 Ph(4-F) Ph(2-F) 317.4 240Ph(3-CF₃,4-OMe) Ph(2-CF₃) 447 241 Ph(3-CF₃) Ph(2,3-di-F) 385 242Ph(3-CF₃) Ph(2-CF₃,3-F) 436 244 Ph(3,4-di-F) 2-pyridinyl(6-F) 337.3 245Ph(3,4-di-F) 2-pyridinyl(6-CF₃) 386.4 246 Ph(4-CF₃,3-F) Ph(2-F) 385 247Ph(4-CF₃,3-F) Ph(2,3-di-F) 403 248 Ph(4-CF₃,3-F) Ph(2-CF₃) 435 249Ph(4-CF₃,3-Cl) Ph(2-F) 401 250 Ph(4-CF₃,3-Cl) Ph(2,3-di-F) 419 251Ph(4-CF₃,3-Cl) Ph(2-CF₃) 451 252 1H-imidazol-2-yl(1-Me) Ph(2,3-di-F)170-174 253 1H-pyrazol-4-yl(1-Me) Ph(2,3-di-F) 165-168 2541H-pyrazol-4-yl(1-Me) Ph(2-F) 189-193 255 1H-imidazol-2-yl(1-Me) Ph(2-F)167-170 256 Ph(4-OCF₃) Ph(2-F) 383 257 Ph(4-OCF₃) Ph(2,3-di-F) 401 258Ph(4-OCF₃) Ph(2-CF₃) 433 259 Ph(4-CF₃,2-F) Ph(2-F) 385 260 Ph(4-CF₃,2-F)Ph(2,3-di-F) 403 261 Ph(4-CF₃,2-F) Ph(2-CF₃) 435 262 3-pyridinyl(6-CF₃)Ph(2-F) 368 263 3-pyridinyl(6-CF₃) Ph(2,3-di-F) 386 2643-pyridinyl(6-CF₃) Ph(2-CF₃) 418 267 Ph(3-CF₃,4-Cl) Ph(2-F) 401 268Ph(3-CF₃,4-Cl) Ph(2,3-di-F) 419 269 Ph(3-CF₃,4-Cl) Ph(2-CF₃) 451 272Ph(3,4-di-Cl) Ph(2,4-di-F) 385 273 Ph(3,4-di-Cl) Ph(2-Cl) 383 275Ph(3-Cl) Ph(2,3-di-F) 351.4 278 Ph(3,5-di-F) Ph(2,4-di-F) 353 279Ph(3,5-di-F) Ph(2,3-di-F) 353 280 Ph(3,5-di-F) Ph(2-Cl) 351 2812-benzofuranyl Ph(2-F) 339 282 2-benzofuranyl Ph(2,3-di-F) 357 2832-benzofuranyl Ph(2-CF₃) 389 284 2-furanyl(5-Cl) Ph(2-F) 323 2852-furanyl(5-Cl) Ph(2,3-di-F) 341 286 Ph(3,4-di-Cl) Ph(2,3,4-tri-F) 403287 Ph(3-SMe) Ph(2-F) 345 288 Ph(3-SMe) Ph(2,4-di-F) 363 289 Ph(3-SMe)Ph(2,3-di-F) 363 290 Ph(3-SMe) Ph(2,3,4-tri-F) 381 291 Ph(3-SMe)Ph(2-Cl) 361 292 2-thienyl(5-Cl) Ph(2-F) 339 293 2-thienyl(5-Cl)Ph(2-CF₃) 389 294 2-thienyl(5-Cl) Ph(2,3-di-F) 357 295 2-benzothiophenylPh(2-F) 355 296 2-benzothiophenyl Ph(2,3-di-F) 373 297 2-benzothiophenylPh(2-CF₃) 405 298 1H-pyrazol-4-yl(1- Ph(2-F) 371 CH₂CF₃) 2991H-pyrazol-4-yl(1- Ph(2,3-di-F) 389 CH₂CF₃) 300 1H-pyrazol-4-yl(1-Ph(2-CF₃) 421 CH₂CF₃) 307 Ph(3-Br) Ph(2-F) 378 308 Ph(3-Br) Ph(2,4-di-F)394 309 Ph(3-Br) Ph(2,3-di-F) 396 310 Ph(3-Br) Ph(2,3,4-tri-F) 412 311Ph(3-Br) Ph(2-Cl) 394 312 Ph(3-CF₃) Ph(2-Cl) 383 313 Ph(3-CF₃) Ph(3-CF₃)417 314 Ph(3-CF₃) Ph(2,5-di-F) 385 315 Ph(3-CF₃) Ph(2,3,4-tri-F) 403 316Ph(3-CF₃) Ph(3-Cl,2-F) 401 317 Ph(3-CF₃) Ph(3-Me) 363 318 Ph(3-i-Pr)Ph(2-F) 341 319 Ph(3-i-Pr) Ph(2,3-di-F) 359 320 Ph(3-i-Pr) Ph(2-CF₃) 391321 Ph(4-SCF₃) Ph(2-F) 399 322 Ph(4-SCF₃) Ph(2,3,4-tri-F) 435 323Ph(3-OCHF₂) Ph(2-F) 365 324 Ph(3-OCHF₂) Ph(2,3-di-F) 383 325 Ph(3-OCHF₂)Ph(2,3,4-tri-F) 401 326 Ph(3-(1H-pyrazol-1-yl(3- Ph(2,3-di-F)190.8-193.9 CF₃))) 327 Ph(3-I) Ph(2,3-di-F) 152.7-160.9 328 Ph(3-I)Ph(2-CF₃) 106.8-110.4 329 Ph(3-(1H-pyrazol-1-yl(3- Ph(2-CF₃) 174.8-179.8CF₃))) 330 Ph(3-OPh) Ph(2-F) 391 331 Ph(3-OPh) Ph(2,4-di-F) 409 332Ph(3-OPh) Ph(2,3-di-F) 409 333 Ph(3-OPh) Ph(2,3,4-tri-F) 427 334Ph(3-OPh) Ph(2-Cl) 407 337 Ph(3-(1H-pyrazol-1-yl)) Ph(2,3-di-F) 383.5338 Ph(3-(1H-pyrazol-1-yl)) Ph(2-CF₃) 415.5 339 Ph(3,4-di-Br) Ph(2-F)457 340 Ph(3,4-di-Br) Ph(2,4-di-F) 475 341 Ph(3,4-di-Br) Ph(2,3-di-F)475 342 Ph(3,4-di-Br) Ph(2,3,4-tri-F) 493 343 Ph(3,4-di-Br) Ph(2-Cl) 473344 Ph(3-CF₃) Ph(3-Cl,2-F) 155-156 345 Ph(3-CF₃) Ph(2,3,4-tri-F) 156158346 Ph(3,4-di-F) Ph(2,3,4-tri-F) 205-207 347 Ph(3-t-Bu) Ph(2-F) 355 348Ph(4-OCHF₂) Ph(2-CF₃) 143-144 349 Ph(4-OCHF₂) Ph(2-F) 161-162 350Ph(4-OCHF₂) Ph(2,3-di-F) 167-168 ⁽¹⁾ Substituents in the 3 and 4positions of the pyrrolidinone ring, i.e. C(O)N(Q²)(R⁶) and Q¹,respectively, are predominately in the trans configuration. In someinstances the presence of minor amounts of the cis isomer can bedetected by NMR. * See synthesis example for ¹H NMR data. ** See IndexTable D for ¹H NMR data.

INDEX TABLE B

Cmpd. No. R² R³ Q¹ Q² M + 1 7(Diastereomer Mixture A) Me H Ph(3,4-di-F)Ph(2-F) 349 8(Diastereomer Mixture B) Me H Ph(3,4-di-F) Ph(2-F) 3499(Diastereomer Mixture A) Me H Ph(3,4-di-F) Ph(2-CF₃) 39910(Diastereomer Mixture B) Me H Ph(3,4-di-F) Ph(2-CF₃) 399 11 Me MePh(3,4-di-F) Ph(2-F) 363

TABLE C INDEX

Cmpd. No. R¹ Q¹ R⁴ R⁵ R⁶ Q² Y¹ m.p. (° C.) M − 1 M + 1  24 HPh(3,4-di-F) H H Me Ph(2-F) O 171-172  37 t-Boc Ph(3-Me) H H H Ph(2-F) O70.2-73.4 44 (Ex. 3) OH Ph(3,4-di-F) H H H Ph(2-F) O 351  61 HPh(3-Cl,4-F) H Me H Ph(2,3-di-F) O 383  71 H Ph(3,4-di-F) H H OH Ph O331 92 (Ex. 2) H Ph H Br H Ph(2-F) O * 93 (Ex. 2) H Ph Br H H Ph(2-F)O *  94 H Ph H Br H Ph(2-F,4-Br) O ** 95 (Ex. 4) H Ph(3,4-di-F) H H HPh(2-F) NH * 175 H Ph(3,4-F) H H OMe Ph(2-F,5-NO₂) O 170-175 181 n-PrPh(4-CF₃) H H H Ph(2-F) O 409.5 182 n-Pr Ph(4-CF₃) H H H Ph(2,3-di-F) O427.5 243 H Ph(3,4-di-F) H H OMe Ph(2-NO₂) O 155-159 265 H Ph(3,4-di-F)H H propargyl Ph(2-NO₂) O 226-230 266 H Ph(3,4-di-F) H H allyl Ph(2-NO₂)O 206-210 270 Me Ph(4-F) H H H Ph(2-F) O 331 271 Me Ph(4-F) H H HPh(2,3-di-F) O 349 274 H Ph(3-CF₃) H H H Ph(2-F) S 383 276 i-Pr Ph(4-F)H H H Ph(2,3-di-F) O 377.5 277 Me Ph(3-CF₃) H H H Ph(2-F) O 381.5 301 HPh CH₃ H H Ph(2-F) O 313.1 302 Me Ph(3,4-di-F) H H H Ph(2-F) O 349.3 303Me Ph(3,4-di-F) H H H Ph(2,3-di-F) O 367.3 304 Me Ph(4-CF₃) H H HPh(2-F) O 381.5 305 Me Ph(3-CF₃) H H H Ph(2,3-di-F) O 399.5 306 MePh(4-CF₃) H H H Ph(2,3-di-F) O 399.5 335 Et Ph(4-CF₃) H H H Ph(2-F) O395 336 Et Ph(4-CF₃) H H H Ph(2,3-di-F) O 413 351(3S,4S)(Ex. 6) MePh(3-CF₃) H H H Ph(2-F) O * *See synthesis example for ¹H NMR data.**See Index Table D for ¹H NMR data.

INDEX TABLE D ¹H NMR Data (CDCl₃ Cmpd. No. solution unless indicatedotherwise)^(a) 29 δ 9.65 (br s, 1H), 8.28 (m, 1H), 7.37 (m, 1H), 7.25(m, 1H), 7.10 (m, 4H), 6.18 (br s, 1H), 4.36 (m, 1H), 3.84 (m, 1H), 3.53(m, 2H). 85 δ 9.80 (br s, 1H), 8.25 (t, 1H), 7.40 (t, 1H), 7.25 (m, 1H),7.15 (m, 1H), 7.05 (m, 4H), 6.35 (br s, 1H), 4.10 (q, 1H), 3.80 (m, 2H),3.50 (t, 1H). 86 δ 10.3 (br s, 1H), 8.20 (br s, 1H), 7.80 (d, 1H), 7.70(d, 1H), 7.65 (t, 1H), 7.40-7.20 (m, 6H), 4.00 (q, 1H), 3.85 (d, 1H),3.70 (t, 1H), 3.30 (t, 1H) 94 δ 9.55 (br s, 1H), 8.25 (t, 1H), 7.48 (d,2H), 7.38 (m, 3H), 7.11 (m, 3H), 6.85 (br s, 1H), 4.45 (m, 1H), 3.77 (m,1H), 3.65 (m, 1H). ^(a1)H NMR data are in ppm downfield fromtetramethylsilane. Couplings are designated by (s)-singlet, (d)-doublet,(t)-triplet, (m)-multiplet, (br s)-broad singlet.

Biological Examples of the Invention

Test A

Seeds of plant species selected from barnyardgrass (Echinochloacrus-galli), Kochia (Kochia scoparia), ragweed (common ragweed, Ambrosiaelation), ryegrass, Italian (Italian ryegrass, Lolium multiflorum),crabgrass, large (large crabgrass Digitaria sanguinalis), giant foxtail(Setaria faberii), morningglory (Ipomoea spp.), pigweed (Amaranthusretroflexus), velvetleaf (Abutilon theophrasti), wheat (Triticumaestivum), and corn (Zea mays) were planted into a blend of loam soiland sand and treated preemergence with a directed soil spray using testchemicals formulated in a non-phytotoxic solvent mixture which includeda surfactant.

At the same time, plants selected from these crop and weed species andalso blackgrass (Alopecurus myosuroides), and galium (catchweedbedstraw, Galium aparine) were planted in pots containing the same blendof loam soil and sand and treated with postemergence applications oftest chemicals formulated in the same manner. Plants ranged in heightfrom 2 to 10 cm and were in the one- to two-leaf stage for thepostemergence treatment. Treated plants and untreated controls weremaintained in a greenhouse for approximately 10 days, after which timeall treated plants were compared to untreated controls and visuallyevaluated for injury. Plant response ratings, summarized in Table A, arebased on a 0 to 100 scale where 0 is no effect and 100 is completecontrol. A dash (−) response means no test result.

TABLE A 1000 g ai/ha Compounds Postemergence 17 18 19 20 21 22 23 24 2526 27 30 31 33 Barnyardgrass 90 50  90 80  90 0 90  0 80 70  70  90  60 90 Blackgrass — — — — — — — — — — — — — — Corn 60 0  0 0  0 0 0 0  0 0 00 30  40 Crabgrass, Large 90 70  90 90  80 0 80  30  80 60  70  80  20 90 Foxtail, Giant 90 70  80 80  80 0 80  0 90 70  60  80  20  90 Galium— — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — —Morningglory  0 0  0 0  0 0 0 0 10 0 0 0 0 20 Pigweed 40 0  0 0 — 0 0 0 0 0 0 0 0  0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — —— — — — — — — — — — — — Velvetleaf 50 0 10 0 60 0 40  0 10 0 0 0 0 20Wheat 60 0 30 20  30 0 0 0  0 0 0 0 0 60 1000 g ai/ha CompoundsPostemergence 34 35 39 40 43 44 71 96 98 99 100 104 105 106Barnyardgrass 90 90 50 80 40 60  50  0 50 90 80 80  90 90 Blackgrass — —— — — — — — — — — — — — Corn 50 20  0 20  0 0 0 0  0 20 40 0  0 50Crabgrass, Large 90 90 80 90 20 50  80  0 90 90 90 80  90 90 Foxtail,Giant 90 90 70 90 50 30  60  0 60 90 80 70  80 90 Galium — — — — — — — —— — — — — — Kochia — — — — — — — — — — — — — — Morningglory 20  0 10 1010 0 — 0  0 10  0 0 10 20 Pigweed  0  0 50  0 20 0 0 0  0  0  0 0  0  0Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — —— — — — — Velvetleaf 20  0 10  0 30 0 0 0 10 10  0 10  10 40 Wheat 70 4040 20  0 0 0 0 20 20 30 0  0 30 1000 g ai/ha Compounds Postemergence 108191 192 193 237 238 243 252 253 254 255 265 266 274 Barnyardgrass 90 0 090  20  30  60  0 0 0 0 0 0 90 Blackgrass — — — — 0 20  — — — — — — — 50Corn  0 0 0 0 0 0 0 0 0 0 0 0 0 70 Crabgrass, Large 90 0 0 90  — — 0 020  0 0 0 0 — Foxtail, Giant 80 0 0 80  0 30  20  0 20  0 0 0 0 90Galium — — — — 0 20  — — — — — — —  0 Kochia — — — — 0 0 — — — — — — —40 Morningglory 10 0 0 0 — — 0 0 10  0 0 0 0 — Pigweed  0 0 0 0 0 0 0 00 0 0 0 0 20 Ragweed — — — — 0 0 — — — — — — — 30 Ryegrass, Italian — —— — 0 0 — — — — — — — 20 Velvetleaf 10 0 0 0 — — 0 0 0 0 0 0 0 — Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 40 500 g ai/ha Compounds Postemergence 1 2 34 5 6 7 8 9 10 11 12 13 14 Barnyardgrass 80  60  80 70 90  80 70  60 50  40  50  90 30  80  Blackgrass — — — — — — — — — — — — — — Corn 0 060 50 0  0 0 0 0 0 0  0 0 0 Crabgrass, Large 80  70  80 80 80  80 80 70  70  60  50  90 60  90  Foxtail, Giant 60  60  80 70 80  80 50  50 70  30  — 80 0 80  Galium — — — — — — — — — — — — — — Kochia — — — — — —— — — — — — — — Morningglory 0 0 30 30 10   0 0 0 0 0 0  0 0 0 Pigweed 00 50 50 0 10 0 0 0 0 0  0 0 0 Ragweed — — — — — — — — — — — — — —Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0  0  0 0 100 0 0 0 0 20 0 90  Wheat 0 0 50 50 0  0 0 0 0 0 0 20 0 0 500 g ai/haCompounds Postemergence 15 16 28 29 32 36 37 38 41 42 45 46 47 48Barnyardgrass 0 90 0 0 0 80  50  30  50  40  80 0 0 90 Blackgrass — — —— — — — — — — — — — — Corn 0 30 0 0 0 0 0 0 0 0 — — — 50 Crabgrass,Large 0 90 40  0 30  20  20  50  60  70  80 60  0 80 Foxtail, Giant 0 900 0 40  20  20  20  0 20  70 40  0 80 Galium — — — — — — — — — — — — — —Kochia — — — — — — — — — — — — — — Morningglory 0 10 0 0 0 0 0 0 0 0 500 20  20 Pigweed 0  0 0 0 0 0 0 0 30  0  0 0 0  0 Ragweed — — — — — — —— — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 30  50   0 0 0 20 Wheat 0 50 0 0 0 0 0 0 0 0  0 0 0 40500 g ai/ha Compounds Postemergence 49 50 51 52 53 54 55 56 57 58 59 6061 62 Barnyardgrass 20  80  20  80 80  0 90  50  80  0 90 90 20  80Blackgrass — — — — — — — — — — — — — — Corn 0 0 0 30 0 0 0 0 0 0 30 60 070 Crabgrass, Large 70  80  80  80 80  80  80  80  70  80  90 90 70  90Foxtail, Giant 40  80  30  80 80  70  80  60  60  70  80 80 30  80Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — —Morningglory 0 0 0  0 0 0 0 0 0 0  0  0 0  0 Pigweed 0 0 0 40 0 0 0 0 00 40  0 0 70 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — —— — — — — — — — — — — Velvetleaf 0 0 0  0 0 0 0 0 0 0  0  0 0  0 Wheat 00 0 30 0 0 0 0 0 0 60 50 0 60 500 g ai/ha Compounds Postemergence 63 6465 66 67 68 69 70 72 73 74 75 76 77 Barnyardgrass 80 80 70 80 60  80 8060 60  80 80 70 90 80 Blackgrass — — — — — — — — — — — — — — Corn 50 4020 80 0 90 90  0 0  0 50  0 70 70 Crabgrass, Large 90 80 90 80 90  90 9070 70  80 90 80 90 80 Foxtail, Giant 90 80 90 80 90  80 80 80 50  80 9080 80 80 Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — —— — — Morningglory  0  0 20  0 0  0  0  0 10  20  0  0 40 30 Pigweed  030  0  0 20  60 30 20 0  0  0  0 60 50 Ragweed — — — — — — — — — — — — —— Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf  0 30 30  0 020 30 20 0 30 50 20 60 40 Wheat 30 40 20 30 0 20 40 40 0  0 60 30 60 60500 g ai/ha Compounds Postemergence 78 79 80 81 82 83 84 85 86 87 88 8990 91 Barnyardgrass 70 90 80 80  50 60  0 20  20  80 40  80 70 20 Blackgrass — — — — — — — — — — — — — — Corn 50 70 60 0  0 0 0 0 0  0 030 30 0 Crabgrass, Large 80 90 90 80  70 70  20  50  60  80 60  80 7050  Foxtail, Giant 80 80 80 70  70 50  0 0 10  80 0 80 70 20  Galium — —— — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory 0 10  0 0 10 0 0 0 0 10 0 10  0 0 Pigweed 50 70 70 0  0 0 0 0 0 20 0 2020 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — —— — — — — — — Velvetleaf 60 60 60 0 20 0 0 0 0  0 0  0  0 0 Wheat 50 5050 0 10 0 0 0 0 20 0 20  0 0 500 g ai/ha Compounds Postemergence 92 9394 95 97 101 102 103 107 109 110 111 112 113 Barnyardgrass 70  60  0 90 0 90 0 90 80 90 90 0 0 0 Blackgrass — — — — — — — — — 80 70 0 0 0 Corn 00 0 0 0 50 0 20  0 80 20 0 0 0 Crabgrass, Large 70  80  0 90  0 80 0 9070 — — — — — Foxtail, Giant 10  60  0 80  0 90 0 90 70 90 90 0 0 0Galium — — — — — — — — — 60 40 0 0 0 Kochia — — — — — — — — —  0  0 0 00 Morningglory 0 0 0 0 0 60 0  0 40 — — — — — Pigweed 0 0 0 0 0 70 0 2030  0  0 0 0 0 Ragweed — — — — — — — — —  0  0 0 0 0 Ryegrass, Italian —— — — — — — — — 30 40 0 0 0 Velvetleaf 0 0 0 0 0 70 0  0 20 — — — — —Wheat 0 0 0 0 0 60 0 20  0 60 20 0 0 0 500 g ai/ha CompoundsPostemergence 114 115 116 117 118 119 120 121 122 123 124 125 126 127Barnyardgrass 60 50  40  30  60  90 90 80 80 80 70 70 80  70 Blackgrass30 — — — 0 50 50 70 70 70 70 50 30  40 Corn 20 0 20  20  0 70 80 70 6080 50  0 0 20 Crabgrass, Large — 50  30  60  — — — — — — — — — —Foxtail, Giant 70 10  20  50  80  90 90 90 80 90 90 80 80  80 Galium 20— — — 60  50 60 70 80 70 80 60 30  60 Kochia 20 — — — 50  50 70 60 70 7080 60 0 60 Morningglory — 0 0 0 — — — — — — — — — — Pigweed  0 0 0 0 030 50  0 80 90 70 20 0  0 Ragweed  0 — — — 0 30 50 30 70 70 70  0 0  0Ryegrass, Italian 60 — — — 0 40 50 50 40 50 50  0 0  0 Velvetleaf — 0 00 — — — — — — — — — — Wheat 20 0 0 0 0 70 60 60 60 60 50  0 0  0 500 gai/ha Compounds Postemergence 128 129 130 131 132 133 139 140 141 142143 144 145 146 Barnyardgrass 60 70 70  60  80  80  90  80  90 90 90  9090 90 Blackgrass 50 50 0 0 0 0 20  20  50 30 0 30 30 70 Corn 20 30 0 0 00 0 0 50  0 0 20  0 50 Crabgrass, Large — — — — — — — — — — — — — —Foxtail, Giant 80 80 70  50  70  50  30  50  50 50 30  70 70 70 Galium 0 60 0 0 0 0 30  30  50 40 40  70 50 70 Kochia  0  0 0 0 10  0 0 0 20 0 0  0 20 70 Morningglory — — — — — — — — — — — — — — Pigweed 50  0 0 00 0 0 0  0  0 0  0  0  0 Ragweed  0  0 0 0 0 0 0 0 40  0 0  0 20 60Ryegrass, Italian  0 50 0 0 0 0 0 0 40 20 0 40  0 60 Velvetleaf — — — —— — — — — — — — — — Wheat 40 40 0 0 0 0 0 0 30 20 0  0  0 70 500 g ai/haCompounds Postemergence 147 148 149 150 151 152 153 154 156 157 160 161162 163 Barnyardgrass 90 90  80 80 90 80 80 80 80 80 80 90 90 90Blackgrass 60 0 40 10 70 50 30 70 20 30 70 50 50 60 Corn 50 0 70 30 50 0  0 70 30 80 70 60 60 40 Crabgrass, Large — — — — — — — — — — — — — —Foxtail, Giant 70 30  70 70 70 60 60 80 80 80 90 90 90 80 Galium 60 40 60 60 70 70 60 60 30 40 70 60 70 60 Kochia 60 0 60 60 80 60 60 50 20 3080 60 70  0 Morningglory — — — — — — — — — — — — — — Pigweed 10 0  0 2060 20 50 30 20 30 80 60 70 20 Ragweed 50 0 40 20 70 50 10  0 30 40 60 3040 20 Ryegrass, Italian 50 0 50  0 50 50  0 50 30 30 10 50 50 30Velvetleaf — — — — — — — — — — — — — — Wheat 40 0 20  0 60  0  0 50 4070 50 40 50 60 500 g ai/ha Compounds Postemergence 164 165 166 167 168169 170 171 172 174 175 181 182 183 Barnyardgrass 90 90 80 90 90 90 9090 20  20  0 0 0 0 Blackgrass 70 70 60 60 60 60 60 60 0 0 0 50  0 0 Corn80 80 80 70 70 50 70 70 0 0 0 0 0 0 Crabgrass, Large — — — — — — — — — —— — — — Foxtail, Giant 90 90 90 90 90 90 90 80 30  30  0 0 10  0 Galium60 50 60 60 70 50 60 70 0 0 0 0 0 0 Kochia 70 70 70 50 60 40 50 30 0 0 070  0 0 Morningglory — — — — — — — — — — — — — — Pigweed 60 50 50  0 40 0 30 40 0 0 0 50  0 0 Ragweed 50 50  0 50 20  0 50 30 0 0 0 0 0 0Ryegrass, Italian 50 50 50 40 50 40 60 30 0 0 0 0 0 0 Velvetleaf — — — —— — — — — — — — — — Wheat 80 70 50 50 40 50 60 50 0 0 0 0 0 0 500 gai/ha Compounds Postemergence 184 185 186 188 189 190 194 195 196 197198 199 200 201 Barnyardgrass 80 80  0 0 90  90 80  90  80  70  80  70 90  30  Blackgrass 20 20  0 0 — — — — — — — — 0 0 Corn 20 20  0 0 60  400 0 0 0 0 0 20  0 Crabgrass, Large — — — — 80  90 80  80  80  70  80 80  — — Foxtail, Giant 80 80  0 0 90  80 50  70  70  40  60  50  40  0Galium 20 0 0 0 — — — — — — — — 0 0 Kochia  0 0 0 0 — — — — — — — — 0 0Morningglory — — — — 0 10 0 0 0 10  0 0 — — Pigweed  0 0 0 0 0  0 0 0 00 0 0 0 0 Ragweed  0 0 0 0 — — — — — — — — 0 0 Ryegrass, Italian 20 0 00 — — — — — — — — 0 0 Velvetleaf — — — — 0 10 0 0 0 0 0 40  — — Wheat 4020  0 0 0  0 0 30  0 0 0 0 20  0 500 g ai/ha Compounds Postemergence 202203 204 205 206 207 208 209 210 211 212 213 214 215 Barnyardgrass 90 80 90 70 90 90 80 80  90 90 90 70 70 60 Blackgrass 50 30  80 70 80 70 6020  60 70 60 60 70 50 Corn 90 0 80  0 80 70 50 0 60 70 50 50 50  0Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 70  90 9090 90 90 70  90 90 90 90 90 80 Galium 60 0 60 60 80 50 50 0 60 70 60  070 60 Kochia 90 0 60 40 70  0 60 0 60 60 20  0 40  0 Morningglory — — —— — — — — — — — — — — Pigweed 80 0 20 30 70  0  0 0 20 50  0  0 50 60Ragweed 50 20   0  0 50  0 20 0  0 30 20 30  0 10 Ryegrass, Italian 40 050  0 60 50 40 20  50 60  0 50 30  0 Velvetleaf — — — — — — — — — — — —— — Wheat 50 20  80 40 80 60 40 0 50 80 70 50 50  0 500 g ai/haCompounds Postemergence 216 217 218 219 220 221 222 223 224 225 226 227228 229 Barnyardgrass 0 90 90 50  80 0 90 80 90 60 80 80  80 80Blackgrass 0 50 40 50  40 0 60 70 70 30 30 40  40 70 Corn 0 30 30 0 20 060 50 80 20  0 0 30  0 Crabgrass, Large — — — — — — — — — — — — — —Foxtail, Giant 10  90 90 80  80 30  90 90 80 70 80 80  90 90 Galium 0 5060 60  30 0 60 60 70 30 20 0 40 70 Kochia 0 70 60 10  40 0 40 70 90  050 40  30 60 Morningglory — — — — — — — — — — — — — — Pigweed 0  0 40 0 0 0 20 60 80  0  0 0  0  0 Ragweed 0 30 50 0  0 0 40 30 60  0  0 0 2060 Ryegrass, Italian 0 30 30 0 20 0 30 40 60  0 20 20  20 40 Velvetleaf— — — — — — — — — — — — — — Wheat 0 30 50 0 20 0 30 50 60 20  0 0 20  0500 g ai/ha Compounds Postemergence 230 231 232 233 234 235 236 239 240241 242 244 245 246 Barnyardgrass 90 90 90 90 90 20 0 90 90  90 80 90 5070 Blackgrass 50 60 50 60 30 20 0 20 0 — — — — — Corn 40 40 80 20 60 200  0 20  80 70 20  0 30 Crabgrass, Large — — — — — — — — — 80 80 80 3060 Foxtail, Giant 90 90 90 90 80 50 0 90 80  90 80 80 30 80 Galium 50 5060 50 50 70 0 30 0 — — — — — Kochia 40 90 90 80 30 20 0 20 0 — — — — —Morningglory — — — — — — — — — 30 30  0  0  0 Pigweed  0 40 90 20  0 500  0 0 20 20 40 40  0 Ragweed 30 50 50 50  0  0 0  0 0 — — — — —Ryegrass, Italian 20 40 50 40 30  0 0 20 0 — — — — — Velvetleaf — — — —— — — — — 20 20 30 40  0 Wheat 20 30 50 20 40  0 0 20 20  70 20 20 40 30500 g ai/ha Compounds Postemergence 247 248 249 250 251 256 257 258 259260 261 262 263 264 Barnyardgrass 80 50  50  50  30  20  80 80 70  80 5070  80 80 Blackgrass — — — — — — — — — — — — — — Corn 20 20  0 0 0 0 2020 0  0  0 0 60  0 Crabgrass, Large 70 70  40  40  30  90  90 90 90  9080 80  90 90 Foxtail, Giant 80 50  40  50  20  70  90 80 70  90 60 70 90 80 Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — —— — Morningglory  0 0 0 0 0 0  0  0 0 50  0 0 60  0 Pigweed  0 0 0 0 20 0  0  0 0 70 40 0 70 60 Ragweed — — — — — — — — — — — — — — Ryegrass,Italian — — — — — — — — — — — — — — Velvetleaf  0 0 0 0 0 0  0  0 0 — 30— — 30 Wheat 30 0 0 0 0 20  30 30 0  0  0 0 60  0 500 g ai/ha CompoundsPostemergence 267 268 269 270 271 272 273 275 276 277 278 279 280 281Barnyardgrass 80 70 70 90 90 80 30  90 0 90 90  90 90  70  Blackgrass —— — 20 60 30 0 60 0 50 60  70 0 0 Corn 70 40 20 30 60 10 0 90 0 90 0 700 0 Crabgrass, Large 90 80 80 — — — — — — — — — — — Foxtail, Giant 80 9080 90 90 80 70  90 0 90 80  90 80  0 Galium — — — 50 70 50 50  70 0 7050  50 0 0 Kochia — — — 30 80 60 0 80 0 30 0 40 0 0 Morningglory 60  0 0 — — — — — — — — — — — Pigweed 60 80 60  0 20 20 0 40 0 30 10   0 0 0Ragweed — — —  0 60  0 0 30 0 30 0  0 0 0 Ryegrass, Italian — — — 20 40 0 0 50 0 40 0  0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat  0  0 0 20 80  0 0 70 0 70 0 60 0 0 500 g ai/ha Compounds Postemergence 282283 284 285 286 287 288 289 290 291 292 293 294 295 Barnyardgrass 90 60  50  70  60  80  80  70  80  60  70  70  90 50  Blackgrass 20  0 0 00 0 0 0 0 0 0 10  30 0 Corn 0 0 0 0 0 0 0 0 0 0 0 0  0 0 Crabgrass,Large — — — — — — — — — — — — — — Foxtail, Giant 30  10  10  0 70  0 30 60  60  50  60  70  80 0 Galium 40  0 60  0 0 0 0 0 0 0 20  60  30 10 Kochia 0 0 0 0 20  0 20  0 0 0 0 0 50 0 Morningglory — — — — — — — — — —— — — — Pigweed 0 0 0 0 0 0 0 0 10  0 0 0  0 0 Ragweed 0 0 0 0 0 0 0 0 00 0 0 20 0 Ryegrass, Italian 0 0 0 0 20  0 0 0 0 0 0 0 20 0 Velvetleaf —— — — — — — — — — — — — — Wheat 0 0 0 0 0 0 0 0 0 0 0 0 20 0 500 g ai/haCompounds Postemergence 296 297 298 299 300 301 302 303 304 305 306 307308 309 Barnyardgrass 20  0 0 70  0 0 90 90 90 90 80 90  70  90Blackgrass 0 10  0 0 0 0 60 70 70 70 60 70  70  70 Corn 0 0 0 0 0 0 4070 70 70 70 60  10  80 Crabgrass, Large — — — — — — — — — — — — — —Foxtail, Giant 0 0 0 50  0 0 80 80 80 80 80 80  80  90 Galium 0 0 0 0 00 60 70 60 70 70 0 0 70 Kochia 0 0 0 0 0 0 60 80 80 70 70 0 0  0Morningglory — — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 10 60 60 7080 0 0  0 Ragweed 0 0 0 0 0 0  0 40 20  0 40 0 0  0 Ryegrass, Italian 00 0 0 0 0 60 60 50 70 60 0 0 30 Velvetleaf — — — — — — — — — — — — — —Wheat 0 0 0 0 0 0 50 60 60 70 60 30  20  60 500 g ai/ha CompoundsPostemergence 310 311 312 313 314 315 316 317 318 319 320 321 322 323Barnyardgrass 90 80  90 80  80  90 90 90  90 90 90 50  60  90 Blackgrass50 30  50 0 0 50 40 20  40 50 20 0 0 60 Corn 50 0 80 0 0 80 80 20  50 80 0 0 20  90 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant90 70  90 70  80  90 90 90  70 90 70 50  60  90 Galium 20 0 50 0 0 50 400 40 50  0 0 0 60 Kochia 30 0 40 0 0 70 40 0 30 50 20 0 0 90Morningglory — — — — — — — — — — — — — — Pigweed  0 0 30 0 0 50 20 0 2020  0 0 0 30 Ragweed 30 0 40 0 0 40 30 0 30 40 30 0 0 20 Ryegrass,Italian 30 0 40 0 0 50 30 0 40 50 30 0 0 30 Velvetleaf — — — — — — — — —— — — — — Wheat 50 0 70 0 0 70 40 20  30 50  0 0 0 80 500 g ai/haCompounds Postemergence 324 325 326 327 328 329 330 331 332 333 334 335336 337 Barnyardgrass 90 90 20  80 80 0 60  70  50 60 0 60  60  50 Blackgrass 70 50 0 40 40 0 0 30   0 30 0 20  0 0 Corn 90 80 0 30  0 0 00  0 20 0 0 0 0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail,Giant 90 90 50  80 80 30  80  80  80 80 10  90  70  40  Galium 60 60 060 50 0 30  30  20 40 0 0 0 0 Kochia 80 80 30  40 20 0 0 20  20 20 0 0 030  Morningglory — — — — — — — — — — — — — — Pigweed 70 50 0 20  0 0 0 0 0 20 0 0 0 0 Ragweed 50 60 0 20  0 0 0 0  0 20 0 0 0 0 Ryegrass,Italian 50 50 0 20 20 0 0 0 20 30 0 0 0 0 Velvetleaf — — — — — — — — — —— — — — Wheat 80 80 0 20  0 0 0 0 20 20 0 20  0 0 500 g ai/ha CompoundsPostemergence 338 339 340 341 342 343 344 345 346 347 348 349 350Barnyardgrass 30  60  50 50 60 30  90  90 90 50  50 90 90 Blackgrass 0 020  0  0 0 0 60 50 0 30 40 50 Corn 0 0  0 30 40 0 0 90 40 0  0 20 40Crabgrass, Large — — — — — — — — — — — — — Foxtail, Giant 60  60  90 7050 60  90  90 90 20  90 90 90 Galium 0 0 30 30 20 0 0 70 50 0 40 50 70Kochia 0 0 30 70 70 20  0 70  0 0 40 60 80 Morningglory — — — — — — — —— — — — — Pigweed 0 0 20 50 50 0 0 70 20 0 20 20 70 Ragweed 0 0  0 20  00 0 30 20 0  0 20 30 Ryegrass, Italian 0 0 20 20  0 0 0 70 30 0  0  0 30Velvetleaf — — — — — — — — — — — — — Wheat 0 0  0 20 20 0 0 70 40 0 2030 50 125 g ai/ha Compounds Postemergence 1 2 3 4 5 6 7 8 9 10 11 12 1314 Barnyardgrass 50  30  70  60 60  40  20  20  30  0 0 60  0 60 Blackgrass — — — — — — — — — — — — — — Corn 0 0 0  0 0 0 0 0 0 0 0 0 0 0Crabgrass, Large 30  50  70  60 70  60  30  60  40  20  0 80  0 80 Foxtail, Giant 20  30  60  60 80  70  0 0 0 0 0 60  0 60  Galium — — — —— — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory 0 030  20 0 0 0 0 0 0 0 0 0 0 Pigweed 0 0 0 40 0 0 0 0 0 0 0 0 0 0 Ragweed— — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — —— Velvetleaf 0 0 0  0 0 0 0 0 0 0 0 0 0 0 Wheat 0 0 0 30 0 0 0 0 0 0 0 00 0 125 g ai/ha Compounds Postemergence 15 16 28 29 32 36 37 38 41 42 4546 47 48 Barnyardgrass 0 70  0 0 0 0 0 0 0 0 50 0 0 80  Blackgrass — — —— — — — — — — — — — — Corn 0 0 0 0 0 0 0 0 0 0 — — — 0 Crabgrass, Large0 90  20  0 0 0 0 0 30  0 60 30  0 80  Foxtail, Giant 0 60  0 0 0 0 0 00 0 20 0 0 80  Galium — — — — — — — — — — — — — — Kochia — — — — — — — —— — — — — — Morningglory 0 0 0 0 0 0 0 0 0 0 40 0 0 0 Pigweed 0 0 0 0 00 0 0 0 0  0 0 0 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian— — — — — — — — — — — — — — Velvetleaf 0 0 — 0 0 0 0 0 0 30   0 0 0 0Wheat 0 20  0 0 0 0 0 0 0 0  0 0 0 20  125 g ai/ha CompoundsPostemergence 49 50 51 52 53 54 55 56 57 58 59 60 61 62 Barnyardgrass 080  0 80  30  0 30  0 70  0 70  80  0 70 Blackgrass — — — — — — — — — —— — — — Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 40 Crabgrass, Large 20  80  20 80  80  70  80  50  50  40  70  80  0 80 Foxtail, Giant 0 80  0 80  30 60  70  20  50  20  80  80  0 80 Galium — — — — — — — — — — — — — —Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 0 0 0 00  0 Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 30 Ragweed — — — — — — — — — — —— — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 0 00 0 0 0 0 0 0 0  0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 20 125 g ai/haCompounds Postemergence 63 64 65 66 67 68 69 70 72 73 74 75 76 77Barnyardgrass 60  60  20  80  40  70 70 20  20  70  60  40  80 70Blackgrass — — — — — — — — — — — — — — Corn 0 30  0 20  0 20 20 0 0 0 00 40 50 Crabgrass, Large 80  80  90  80  50  90 70 20  30  50  80  60 90 80 Foxtail, Giant 70  70  50  70  80  80 80 20  10  30  80  70  80 80Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — —Morningglory 0 0 0 0 0  0  0 0 0 0 0 0 20  0 Pigweed 0 0 0 0 0 40 20 0 0— 0 0 50 40 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — —— — — — — — — — — — — Velvetleaf 0 0 0 0 0 20 20 0 0 0 30  10  20 20Wheat 0 0 0 0 0  0  0 0 0 0 0 0 50 50 125 g ai/ha CompoundsPostemergence 78 79 80 81 82 83 84 85 86 87 88 89 90 91 Barnyardgrass 5080 80 30  0 — 0 0 0 50  0 60  30  0 Blackgrass — — — — — — — — — — — — —— Corn 20 20 30 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 70 80 80 50  50 20  0 0 0 60  0 60  50  30  Foxtail, Giant 80 80 80 20  0 0 0 0 0 50  060  40  0 Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — —— — — — Morningglory  0  0  0 0 0 0 0 0 0 0 0 0 0 0 Pigweed 50 70 60 0 00 0 0 0 0 0 0 0 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian— — — — — — — — — — — — — — Velvetleaf 20 10 10 0 0 0 0 0 0 0 0 0 0 0Wheat 40 30 40 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Postemergence92 93 94 95 97 101 102 103 107 109 110 111 112 113 Barnyardgrass 20  10 0 80  0 80 0 90 50  90 50  0 0 0 Blackgrass — — — — — — — — — 50 0 0 0 0Corn 0 0 0 0 0  0 0 20 0 50 0 0 0 0 Crabgrass, Large 20  50  0 80  0 800 90 60  — — — — — Foxtail, Giant 0 10  0 70  0 80 0 90 10  90 80  0 0 0Galium — — — — — — — — — 30 20  0 0 0 Kochia — — — — — — — — —  0 0 0 00 Morningglory 0 0 0 0 0 30 0  0 0 — — — — — Pigweed 0 0 0 0 0 20 0 20 0 0 0 0 0 0 Ragweed — — — — — — — — —  0 0 0 0 0 Ryegrass, Italian — — —— — — — — — 20 20  0 0 0 Velvetleaf 0 0 0 0 0 50 0  0 0 — — — — — Wheat0 0 0 0 0 50 0  0 0 20 0 0 0 0 125 g ai/ha Compounds Postemergence 114115 116 117 118 119 120 121 122 123 124 125 126 127 Barnyardgrass 20 10  — 0 0 90 80 70 70 70 60 60  60  60  Blackgrass 20  — — — 0 30 40 6050 60 40 20  0 30  Corn 0 0 0 0 0 30 20 50 40 50  0 0 0 0 Crabgrass,Large — 0 20  30  — — — — — — — — — — Foxtail, Giant 40  0 0 20  50  9080 80 80 80 80 70  70  70  Galium 0 — — — 50  30 50 60 70 60 70 0 0 20 Kochia 0 — — — 10  40 60 50 70 60 70 20  0 20  Morningglory — 0 0 0 — —— — — — — — — — Pigweed 0 0 0 0 0 30 20  0 60 80 60 0 0 0 Ragweed 0 — —— 0 20 30  0 30 50 40 0 0 0 Ryegrass, Italian 0 — — — 0 20 30 40  0 4030 0 0 0 Velvetleaf — 0 0 0 — — — — — — — — — — Wheat 0 0 0 0 0 20 20 5050 50 30 0 0 0 125 g ai/ha Compounds Postemergence 128 129 130 131 132133 139 140 141 142 143 144 145 146 Barnyardgrass 50  60  50  50  60 30  80  70  80  80  50  90  70  90  Blackgrass 30  30  0 0 0 0 0 0 0 0 00 0 30  Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large — — — — — — —— — — — — — — Foxtail, Giant 70  70  60  50  50  20  30  0 0 0 20  40 40  0 Galium 0 40  0 0 0 0 0 0 20  0 0 10  20  40  Kochia 0 0 0 0 0 0 00 0 0 0 0 0 0 Morningglory — — — — — — — — — — — — — — Pigweed 30  0 0 00 0 0 0 0 0 0 0 0 0 Ragweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ryegrass,Italian 0 30  0 0 0 0 0 0 0 0 0 0 0 20  Velvetleaf — — — — — — — — — — —— — — Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha CompoundsPostemergence 147 148 149 150 151 152 153 154 156 157 160 161 162 163Barnyardgrass 90 50  70 80  80 70 60  70 80  70 70 90 70 90 Blackgrass40 0 30 0 40  0 40  60 0 30 60 50 50 50 Corn  0 0 10 0  0  0 0 60 20  5040 10 30 10 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant40 20  40 30  60 50 50  80 80  80 80 90 90 70 Galium 50 0 50 50  60 60 0 0 20  40 60 50 30 20 Kochia 40 0 50 30  70 50 60  40 0 20 70 20 40  0Morningglory — — — — — — — — — — — — — — Pigweed  0 0  0 0 50  0 40  200  0 60 20 20  0 Ragweed  0 0 30 0 60 40 0  0 0 20 50  0  0  0 Ryegrass,Italian 20 0 10 0 30 10 0 30 20  30  0 20  0  0 Velvetleaf — — — — — — —— — — — — — — Wheat  0 0  0 0  0  0 0  0 0 40  0 20  0 20 125 g ai/haCompounds Postemergence 164 165 166 167 168 169 170 171 172 174 175 181182 183 Barnyardgrass 90 90 80 90 90 90  90 90 0 0 0 0 0 0 Blackgrass 5060 50 50 40 30  50 50 0 0 0 40  0 0 Corn 50 60 30  0 30 0 20 20 0 0 0 00 0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 70 70 8090 90 60  60 60 0 20  0 0 0 0 Galium 50 40 20 50 60 20  60 50 0 0 0 0 00 Kochia 60 50 30 30 40 0 20  0 0 0 0 10  0 0 Morningglory — — — — — — —— — — — — — — Pigweed 20 30 40  0  0 0 20  0 0 0 0 0 0 0 Ragweed 20 20 0 20  0 0 20  0 0 0 0 0 0 0 Ryegrass, Italian 40 40  0 20 20 20  20 200 0 0 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat 40 30 20  0  00  0  0 0 0 0 0 0 0 125 g ai/ha Compounds Postemergence 184 185 186 188189 190 194 195 196 197 198 199 200 201 Barnyardgrass 70  40  0 0 90 70  50  80  30  30  50  50  70  0 Blackgrass 0 0 0 0 — — — — — — — — 0 0Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large — — — — 60  70  60 80  70  50  50  60  — — Foxtail, Giant 70  20  0 0 70  70  10  30  20  010  0 20  0 Galium 0 0 0 0 — — — — — — — — 0 0 Kochia 0 0 0 0 — — — — —— — — 0 0 Morningglory — — — — 0 0 0 0 0 0 0 0 — — Pigweed 0 0 0 0 0 0 00 0 0 0 0 0 0 Ragweed 0 0 0 0 — — — — — — — — 0 0 Ryegrass, Italian 0 00 0 — — — — — — — — 0 0 Velvetleaf — — — — 0 0 0 0 0 0 0 0 — — Wheat 0 00 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Postemergence 202 203 204205 206 207 208 209 210 211 212 213 214 215 Barnyardgrass 80 40  90 40 90 80  50  60  80  90 60  60  60 50  Blackgrass 50 0 70 0 70 70  20  030  50 40  50  40 30  Corn 80 0 60 0 60 50  0 0 0 30 0 0 30 0 Crabgrass,Large — — — — — — — — — — — — — — Foxtail, Giant 90 50  90 70  90 90 90  40  50  70 60  80  80 80  Galium 60 0 50 30  70 0 0 0 30  60 50  040 40  Kochia 80 0 20 0 70 0 0 0 20  40 0 0  0 0 Morningglory — — — — —— — — — — — — — — Pigweed 70 0  0 0 50 0 0 0 0  0 0 0  0 50  Ragweed 300  0 0  0 0 0 0 0  0 0 0  0 0 Ryegrass, Italian 30 0 30 0 50 0 0 0 0 300 40  10 0 Velvetleaf — — — — — — — — — — — — — — Wheat 40 0 60 0 70 0 00 0 30 0 0  0 0 125 g ai/ha Compounds Postemergence 216 217 218 219 220221 222 223 224 225 226 227 228 229 Barnyardgrass 0 70 60 40  40  0 7080 80 30  30  20  60 70 Blackgrass 0 20 20 40  0 0 30 60 60 0 20  0 2040 Corn 0 20 20 0 0 0 20  0 60 0 0 0 20  0 Crabgrass, Large — — — — — —— — — — — — — — Foxtail, Giant 0 80 60 60  50  0 80 80 80 40  70  30  7080 Galium 0 30 40 30  0 0 30 50 70 20  20  0 30 60 Kochia 0 20 50 0 0 0 0 50 80 0 30  0 20 10 Morningglory — — — — — — — — — — — — — — Pigweed0  0  0 0 0 0  0 40 60 0 0 0  0  0 Ragweed 0  0  0 0 0 0  0  0 40 0 0 0 0 20 Ryegrass, Italian 0  0  0 0 0 0 20  0 50 0 0 0  0 30 Velvetleaf —— — — — — — — — — — — — — Wheat 0 20 20 0 0 0 20 40 50 0 0 0  0  0 125 gai/ha Compounds Postemergence 230 231 232 233 234 235 236 239 240 241242 244 245 246 Barnyardgrass 60 80 80 70 60  10  0 50  30  80 70  80 3070  Blackgrass 20 40 50 60 0 0 0 20  0 — — — — — Corn 20 30 80 20 0 0 00 0 50 0  0  0 20  Crabgrass, Large — — — — — — — — — 70 70  80 20 50 Foxtail, Giant 70 70 90 90 40  10  0 50  40  80 80  80 20 40  Galium 2040 60 20 30  50  0 0 0 — — — — — Kochia  0 70 80 60 0 0 0 0 0 — — — — —Morningglory — — — — — — — — — 20 0 20  0 0 Pigweed  0  0 80  0 0 0 0 00  0 0 20 40 0 Ragweed  0 20 20 30 0 0 0 0 0 — — — — — Ryegrass, Italian 0 20 40 20 20  0 0 0 0 — — — — — Velvetleaf — — — — — — — — —  0 0 3020 0 Wheat 20 20 30  0 0 0 0 0 0 30 0 20  0 0 125 g ai/ha CompoundsPostemergence 247 248 249 250 251 256 257 258 259 260 261 262 263 264Barnyardgrass 60  20  30  30  0 0 50  40  50  70 0 60  70 30  Blackgrass— — — — — — — — — — — — — — Corn 0 0 0 0 0 0 0 0 0  0 0 0 40 0Crabgrass, Large 50  50  0 0 0 70  90  80  80  90 70  70  80 80 Foxtail, Giant 50  30  20  30  0 40  80  60  50  80 0 60  80 60  Galium— — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — —Morningglory 0 0 0 0 0 0 0 0 0  0 0 0 20 0 Pigweed 0 0 0 0 0 0 0 0 0 600 0 40 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — —— — — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 0 — 0 — — 30  Wheat 0 0 0 00 0 20  0 0  0 0 0 40 0 125 g ai/ha Compounds Postemergence 267 268 269270 271 272 273 275 276 277 278 279 280 281 Barnyardgrass 70 50 50 90 90 50  10  90 0 90 80  80 80  40  Blackgrass — — — 0 50 0 0 50 0 50 30 60 0 0 Corn 40  0  0 0 20 0 0 40 0 90 0 40 0 0 Crabgrass, Large 80 70 60— — — — — — — — — — — Foxtail, Giant 70 80 70 60  90 60  20  90 0 90 80 80 70  0 Galium — — — 20  40 30  0 60 0 70 40  40 0 0 Kochia — — — 0 6020  0 50 0 30 0  0 0 0 Morningglory 20  0  0 — — — — — — — — — — —Pigweed 50 70 40 0  0 0 0 30 0 30 0  0 0 0 Ragweed — — — 0 40 0 0 30 030 0  0 0 0 Ryegrass, Italian — — — 0  0 0 0 30 0 30 0  0 0 0 Velvetleaf— — — — — — — — — — — — — — Wheat  0  0  0 0  0 0 0 40 0 60 0 40 0 0 125g ai/ha Compounds Postemergence 282 283 284 285 286 287 288 289 290 291292 293 294 295 Barnyardgrass 50  0 0 20  60  50  20  50  50  40  50 50  60  0 Blackgrass 0 0 0 0 0 0 0 0 0 0 0 0 20  0 Corn 0 0 0 0 0 0 0 00 0 0 0 0 0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant0 0 0 0 60  0 20  30  30  20  50  50  30  0 Galium 0 0 0 0 0 0 0 0 0 20 10  20  0 0 Kochia 0 0 0 0 0 0 0 0 0 0 0 0 30  0 Morningglory — — — — —— — — — — — — — — Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed 0 0 0 0 00 0 0 0 0 0 0 0 0 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 0 0 0 0Velvetleaf — — — — — — — — — — — — — — Wheat 0 0 0 0 0 0 0 0 0 0 0 0 20 0 125 g ai/ha Compounds Postemergence 296 297 298 299 300 301 302 303304 305 306 307 308 309 Barnyardgrass 0 0 0 30  0 0 90  80 80 80 80 70 70  80 Blackgrass 0 0 0 0 0 0 40  60 50 60 50 30  50  60 Corn 0 0 0 0 00 0 50 30 70 50 0 0 30 Crabgrass, Large — — — — — — — — — — — — — —Foxtail, Giant 0 0 0 0 0 0 80  80 80 80 80 70  70  80 Galium 0 0 0 0 0 060  60 20 50 60 0 0 60 Kochia 0 0 0 0 0 0 10  50 10 30 30 0 0  0Morningglory — — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 0 40 40 6070 0 0  0 Ragweed 0 0 0 0 0 0 0 20  0  0 20 0 0  0 Ryegrass, Italian 0 00 0 0 0 0 40 50 60 50 0 0 10 Velvetleaf — — — — — — — — — — — — — —Wheat 0 0 0 0 0 0 0 50 40 60 50 0 0 40 125 g ai/ha CompoundsPostemergence 310 311 312 313 314 315 316 317 318 319 320 321 322 323Barnyardgrass 90 60  80 20  30  90 80 80  90 90 50  0 0 90 Blackgrass 300 40 0 0 40 30 0 30 40 0 0 0 40 Corn 20 0 60 0 0 70 60 0 20 40 0 0 0 70Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 60  8040  60  90 90 80  40 50 30  0 0 90 Galium 20 0 30 0 0 40 20 0 30 30 0 00 40 Kochia 30 0 20 0 0 50 30 0 20 30 20  0 0 40 Morningglory — — — — —— — — — — — — — — Pigweed  0 0 20 0 0 30  0 0 20  0 0 0 0 20 Ragweed 200 20 0 0 20 20 0  0 20 0 0 0  0 Ryegrass, Italian 30 0 20 0 0 20 20 0 2030 0 0 0 30 Velvetleaf — — — — — — — — — — — — — — Wheat 30 0 40 0 0 6020 0 20 20 0 0 0 40 125 g ai/ha Compounds Postemergence 324 325 326 327328 329 330 331 332 333 334 335 336 337 Barnyardgrass 90 90 0 40 30  060  20  40  20  0 20  30  0 Blackgrass 60 50 0 30 30  0 0 0 0 0 0 0 0 0Corn 50 80 0  0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large — — — — — — — — — —— — — — Foxtail, Giant 90 90 20  40 70  0 80  20  30  50  0 70  70  0Galium 40 50 0 40 20  0 20  0 0 0 0 0 0 0 Kochia 50 60 0 30 0 0 0 0 0 00 0 0 0 Morningglory — — — — — — — — — — — — — — Pigweed 40 40 0  0 0 00 0 0 0 0 0 0 0 Ragweed 20 20 0  0 0 0 0 0 0 0 0 0 0 0 Ryegrass, Italian30 30 0 20 0 0 0 0 0 0 0 0 0 0 Velvetleaf — — — — — — — — — — — — — —Wheat 30 60 0  0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Postemergence338 339 340 341 342 343 344 345 346 347 348 349 350 Barnyardgrass 0 40 30  30  30  0 60  70 80 50  20  80  70 Blackgrass 0 0 0 0 0 0 0 50 20 020  20  50 Corn 0 0 0 0 0 0 0 80 20 0 0 0 20 Crabgrass, Large — — — — —— — — — — — — — Foxtail, Giant 20  60  30  50  40  30  80  90 80 20  70 60  80 Galium 0 0 0 0 0 0 0 60 30 0 0 20  60 Kochia 0 0 0 0 20  0 0 50 0 0 20  40  70 Morningglory — — — — — — — — — — — — — Pigweed 0 0 0 0 00 0 20  0 0 0 0 20 Ragweed 0 0 0 0 0 0 0  0  0 0 0 0  0 Ryegrass,Italian 0 0 0 0 0 0 0 50 20 0 0 0  0 Velvetleaf — — — — — — — — — — — —— Wheat 0 0 0 0 0 0 0 50  0 0 0 0 20 1000 g ai/ha Compounds Preemergence17 18 19 20 21 22 23 24 25 26 27 30 31 33 Barnyardgrass 90 80  90  90 900 90 0 80  70  70  90  50 90 Corn 60 0 0 0  0 0  0 0 0 0 0 0 20  0Crabgrass, Large 90 80  90  90 90 70  90 70  90  90  90  90  80 90Foxtail, Giant 90 80  90  90 90 30  90 40  90  90  90  90  80 90 Kochia— — — — — — — — — — — — — — Morningglory 30 0 0 0 40 0  0 0 0 0 0 0 — —Pigweed 50 0 0 0 40 — — 0 0 0 0 0  0  0 Ragweed — — — — — — — — — — — —— — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 40 0 0 3050 0 40 60  0 0 0 0  0  0 Wheat 70 0 0 0 20 0  0 0 0 0 0 0 50 50 1000 gai/ha Compounds Preemergence 34 35 39 40 43 44 71 96 98 99 100 104 105106 Barnyardgrass 90 90 70  90 20  40  50  0 50 90 90 80 90  90 Corn 3020 0 30 0 0 0 0 20 20 20 20 0 30 Crabgrass, Large 90 90 90  90 90  90 80  0 90 90 90 90 90  90 Foxtail, Giant 90 90 80  90 80  70  60  0 90 9090 90 90  90 Kochia — — — — — — — — — — — — — — Morningglory — 0 0  0 00 — 0 0  0  0  0 0  0 Pigweed  0 0 0  0 0 0 0 0 0  0  0  0 0  0 Ragweed— — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — —— Velvetleaf  0 0 0  0 0 0 0 0 0  0  0  0 0  0 Wheat 60 0 0 20 0 0 0 0 020 20 20 0 50 1000 g ai/ha Compounds Preemergence 108 191 192 193 237238 243 252 253 254 255 265 266 274 Barnyardgrass 90  0 0 80  60  50 80  20  0 0 60  0 0 90 Corn 0 0 0 0 — — 0 0 0 0 0 0 0 — Crabgrass, Large90  0 0 100  — — 90  40  0 70  90  0 0 — Foxtail, Giant 90  0 0 90  80 90  90  20  0 40  70  0 0 90 Kochia — — — — 0 0 — — — — — — — 40Morningglory 0 0 0 0 — — 0 0 0 0 0 0 0 — Pigweed 0 0 0 0 0 0 0 — 0 0 0 00  0 Ragweed — — — — 0 0 — — — — — — — 20 Ryegrass, Italian — — — — 0 0— — — — — — — 40 Velvetleaf 0 0 0 0 — — 0 0 0 0 0 0 0 — Wheat 0 0 0 0 —— 0 0 0 0 0 0 0 — 500 g ai/ha Compounds Preemergence 1 2 3 4 5 6 7 8 910 11 12 13 14 Barnyardgrass 90 60  80 80 90  80  80  60 60  40  20  9050  90 Corn 20 0 50 0 0 0 0 20 0 0 0 0 0 0 Crabgrass, Large 90 90  90 9090  90  90  90 90  90  90  90 80  90 Foxtail, Giant 90 90  90 90 100 90  90  90 90  90  50  90 30  90 Kochia — — — — — — — — — — — — — —Morningglory 0 0  0 0 0 0 0 0 0 0 0 0 0 0 Pigweed 0 0  0 0 0 0 0 0 0 0 00 0 20 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — —— — — — — — — — Velvetleaf 0 0  0 0 0 0 0 0 0 0 0 0 0 0 Wheat 0 0 60 700 0 0 0 0 0 0 20 0 0 500 g ai/ha Compounds Preemergence 15 16 28 29 3236 37 38 41 42 45 46 47 48 Barnyardgrass 0 90 20  50  0 80 80 80  60  6080  50  0 90 Corn 0 30 0 0 0 0 0 0 0  0 0 0 0 20 Crabgrass, Large 80  9080  70  80  80 80 80  90  90 90  90  60  90 Foxtail, Giant 50  90 20  080  70 20 30  70  80 80  80  0 90 Kochia — — — — — — — — — — — — — —Morningglory 0 0 0 0 0 0 0 0 — — 0 0 0  0 Pigweed 0 0 0 0 0 0 0 0 0 30 00 0  0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — —— — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 0  0 0 0 0  0 Wheat 0 0 0 0 020 30 0 0  0 0 0 0 50 500 g ai/ha Compounds Preemergence 49 50 51 52 5354 55 56 57 58 59 60 61 62 Barnyardgrass 20  90  0 90 90 20 80  40  80 20  90  90  0 80 Corn 0 0 0  0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 90 90  90  90 90 90 90  90  90  90  90  90  80  90 Foxtail, Giant 70  90 90  90 90 90 90  50  80  80  90  90  0 90 Kochia — — — — — — — — — — — —— — Morningglory 0 0 0  0 0 0 0 0 0 0 0 0 0 0 Pigweed 0 0 0 40 0 0 0 0 00 0 0 0 30 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — —— — — — — — — — — — Velvetleaf 0 0 0 20 0 0 0 0 0 0 0 0 0 0 Wheat 0 0 0 0 20 20 0 0 0 0 0 0 0 0 500 g ai/ha Compounds Preemergence 63 64 65 6667 68 69 70 72 73 74 75 76 77 Barnyardgrass 80  90 90  90 70  90 90 9050  80  90 70 80 90 Corn 0 20 0 20 0  0  0 0 0 0 0 0 40 30 Crabgrass,Large 90  90 90  90 90  90 90 90 90  90  90 90 90 90 Foxtail, Giant 90 90 90  90 90  90 90 90 80  90  90 90 90 90 Kochia — — — — — — — — — — —— — — Morningglory 0 0 0  0 0  0  0 0 0 0 0 0 50 60 Pigweed 0 0 0  0 030 20 0 0 0 50 0 50 70 Ragweed — — — — — — — — — — — — — — Ryegrass,Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0  0 0  0  0 0 0 0 00  0  0 Wheat 0 0 0 20 0 20 20 20 0 0 0 30  0 30 500 g ai/ha CompoundsPreemergence 78 79 80 81 82 83 84 85 86 87 88 89 90 91 Barnyardgrass 9090 80 80 50  50  0 30  40 80 50 80 70  20  Corn  0  0  0  0 0 0 0 0 20 00 0 0 0 Crabgrass, Large 90 90 90 90 90  90  50  80  80 90 80 90 80  60 Foxtail, Giant 90 90 90 90 70  70  0 50  60 90 30 90 70  40  Kochia — —— — — — — — — — — — — — Morningglory  0  0  0 20 0 0 0 0 0 0 0 0 0 0Pigweed 60 80 80  0 0 0 0 0 0 0 30 0 0 0 Ragweed — — — — — — — — — — — —— — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 30 30 30  00 0 0 0 0 0 0 0 0 0 Wheat  0 20 20 20 0 0 0 0 0 10 0 10 0 0 500 g ai/haCompounds Preemergence 92 93 94 95 97 101 102 103 107 109 110 111 112113 Barnyardgrass 90  90  0 90  0 90 0 90 70 90  90  0 0 0 Corn 0 0 0 00  0 0 0 0 — — — — — Crabgrass, Large 90  90  50  90  0 100  0 100 90 —— — — — Foxtail, Giant 90  90  0 90  0 90 0 90 80 90  90  0 0 0 Kochia —— — — — — — — — 0 0 0 0 0 Morningglory 0 0 0 0 0 50 0 0 0 — — — — —Pigweed 0 0 — 0 0 70 0 20 20 0 0 0 0 0 Ragweed — — — — — — — — — 0 0 0 00 Ryegrass, Italian — — — — — — — — — 50  0 0 0 0 Velvetleaf 0 0 — 0 040 0 0 0 — — — — — Wheat 0 0 0 0 0 70 0 0 0 — — — — — 500 g ai/haCompounds Preemergence 114 115 116 117 118 119 120 121 122 123 124 125126 127 Barnyardgrass 50  50  50  20  70  90 90 90 90 90 80 90 90  90 Corn — 0 0 0 — — — — — — — — — — Crabgrass, Large — 80  80  80  — — — —— — — — — — Foxtail, Giant 70  20  30  70  90  90 90 90 90 90 90 90 90 90  Kochia 0 — — — 0 60 80 70 70 90 70 70 10  60  Morningglory — 0 0 0 —— — — — — — — — — Pigweed 0 0 0 0 0 40 40 70 80 80 80  0 0 0 Ragweed 0 —— — 0 80 80 70 60 80 50  0 0 0 Ryegrass, Italian 30  — — — 0 60 50  0  060 40 20 0 0 Velvetleaf — 0 0 0 — — — — — — — — — — Wheat — 0 0 0 — — —— — — — — — — 500 g ai/ha Compounds Preemergence 128 129 130 131 132 133139 140 141 142 143 144 145 146 Barnyardgrass 80 80 70  60  90  30  9090  90 90  90  90  90  90 Corn — — — — — — — — — — — — — — Crabgrass,Large — — — — — — — — — — — — — — Foxtail, Giant 90 90 90  60  80  90 90 90  90 90  90  80  90  90 Kochia 60 70 0 0 0 0 30 0 20 0 30  0 0 30Morningglory — — — — — — — — — — — — — — Pigweed  0  0 0 0 0 0 20 0  0 00 0 0  0 Ragweed —  0 0 0 0 0  0 0  0 0 0 0 0 30 Ryegrass, Italian  0 600 0 0 0  0 0 20 0 0 20  0 40 Velvetleaf — — — — — — — — — — — — — —Wheat — — — — — — — — — — — — — — 500 g ai/ha Compounds Preemergence 147148 149 150 151 152 153 154 156 157 160 161 162 163 Barnyardgrass 90 90 90 90 90 90 90 80 90 90 90 90 90 90 Corn — — — — — — — — — — — — — —Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 90  90 9090 90 80 90 90 90 90 90 90 90 Kochia 80 30  70 90 90 60 80 70 40 70 9060 60 50 Morningglory — — — — — — — — — — — — — — Pigweed  0 0  0  0  010  0 30  0 50 90 70 80 40 Ragweed 50 0 80 50 90 70 80  0  0 50 80 70 6040 Ryegrass, Italian 40 0 70 50 60 30  0 50 30 60 70 50 50  0 Velvetleaf— — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 500 gai/ha Compounds Preemergence 164 165 166 167 168 169 170 171 172 174 175181 182 183 Barnyardgrass 90 90 90 90 90 90 90 90 20  20  0 0 0 0 Corn —— — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — —Foxtail, Giant 90 90 90 90 90 90 90 90 30  50  0 70  70  0 Kochia 80 7070 60 60 60 70 70 30  20  0 80  0 0 Morningglory — — — — — — — — — — — —— — Pigweed 70 70 10 50 50 20 50 40 0 0 0 0 0 0 Ragweed 60 80 50 50 5020 60 30 0 0 0 0 0 0 Ryegrass, Italian 50 20 60 70 40 20 50 30 0 0 0 0 00 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — —— 500 g ai/ha Compounds Preemergence 184 185 186 188 189 190 194 195 196197 198 199 200 201 Barnyardgrass 90  70 0 0 90 90 80  90  70  70  90 60  90  20  Corn — — — — 0 0 0 0 0 0 0 0 — — Crabgrass, Large — — — — 9090 100  90  100  100  100  100  — — Foxtail, Giant 90  90 0 0 90 90 90 90  90  80  80  90  80  30  Kochia 20  40 0 0 — — — — — — — — 0 0Morningglory — — — — 0 0 0 0 0 0 0 0 — — Pigweed 0 20 0 0 0 0 0 0 0 0 00 0 0 Ragweed 0  0 0 0 — — — — — — — — 0 0 Ryegrass, Italian 0 20 0 0 —— — — — — — — 0 0 Velvetleaf — — — — 0 0 0 0 0 0 0 0 — — Wheat — — — —20 30 0 0 0 0 0 0 — — 500 g ai/ha Compounds Preemergence 202 203 204 205206 207 208 209 210 211 212 213 214 215 Barnyardgrass 90 60  90 80 90 9090 60 90 90 90 80  80 80 Corn — — — — — — — — — — — — — — Crabgrass,Large — — — — — — — — — — — — — — Foxtail, Giant 90 80  90 90 90 90 9090 90 90 90 90  90 90 Kochia 80 0 80 50 80 30 20 20 30 70 20 0 80  0Morningglory — — — — — — — — — — — — — — Pigweed 70 0 50 20 80 20  0 2050 70  0 0 70 50 Ragweed 90 0 80 30 70 20  0  0 30 80 50 0  0  0Ryegrass, Italian 60 0 50 20 80 40 20 20 50 40 30 40   0 10 Velvetleaf —— — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 500 g ai/haCompounds Preemergence 216 217 218 219 220 221 222 223 224 225 226 227228 229 Barnyardgrass 60  90 90 60  80 0 90 90 90 30 90 50 80 90 Corn —— — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — —Foxtail, Giant 50  90 90 90  90 80  90 90 90 90 90 90 90 90 Kochia 0 7070 70  40 0 50 80 90 30 30 20 20 70 Morningglory — — — — — — — — — — — —— — Pigweed 0 40 70 0 20 0 30 50 80  0 30 20  0  0 Ragweed 0 50 50 0  00 20 50 90  0  0  0 20 — Ryegrass, Italian 0 60 60 0 30 0 50 60 70 40 2030 40 20 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — —— — — — — 500 g ai/ha Compounds Preemergence 230 231 232 233 234 235 236239 240 241 242 244 245 246 Barnyardgrass 90 90 90 90 90 60  0 90 50  9090 90 20 90  Corn — — — — — — — — — 50 20 0 0 0 Crabgrass, Large — — — —— — — — — 90 90 100 80 90  Foxtail, Giant 90 90 90 90 90 80  0 90 90  9090 90 70 90  Kochia 30 90 80 80 50 0 0 70 0 — — — — — Morningglory — — —— — — — — —  0  0 0 0 0 Pigweed 20 70 60 30 20 0 0  0 0 30 20 50 30 0Ragweed 20 90 90 50 20 0 30  90 0 — — — — — Ryegrass, Italian 30 60 8060 30 0 50   0 0 — — — — — Velvetleaf — — — — — — — — —  0  0 0 0 0Wheat — — — — — — — — — 30 30 0 0 — 500 g ai/ha Compounds Preemergence247 248 249 250 251 256 257 258 259 260 261 262 263 264 Barnyardgrass90  80  80  80  80 20  80  90  80  80 0 90 90 90 Corn 0 0 0 0 0 0 0 0 010 0 0 70 0 Crabgrass, Large 90  90  90  90  90 90  90  90  90  90 90 90 100 100 Foxtail, Giant 90  90  90  80  80 60  90  90  90  90 70  90100 90 Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 050 0 0 0 0 Pigweed 0 0 0 0 30 0 0 0 0 80 0 70 100 80 Ragweed — — — — — —— — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf0 0 0 0 0 0 0 0 0 40 0 0 50 0 Wheat 0 0 0 0 0 0 0 0 0  0 0 0 60 0 500 gai/ha Compounds Preemergence 267 268 269 270 271 272 273 275 276 277 278279 280 281 Barnyardgrass 80 80 80 90 90 90 80  90 0 90 90  90 80  70 Corn 0 80 0 — — — — — — — — — — — Crabgrass, Large 90 90 90 — — — — — —— — — — — Foxtail, Giant 90 80 80 90 90 90 90  90 0 90 90  90 90  70 Kochia — — — 80 80 20 70  80 0 60 0 80 0 0 Morningglory 0 60 0 — — — — —— — — — — — Pigweed 50 60 70 20 80 30 0 30 0 30 0 40 0 0 Ragweed — — —20 80  0 0 40 0 20 0  0 0 0 Ryegrass, Italian — — —  0 30  0 0 60 0 30 060 0 0 Velvetleaf 0  0 0 — — — — — — — — — — — Wheat 0  0 0 — — — — — —— — — — — 500 g ai/ha Compounds Preemergence 282 283 284 285 286 287 288289 290 291 292 293 294 295 Barnyardgrass 90  0 60 0 60 80  70 80  80 60 80  70  90 70  Corn — — — — — — — — — — — — — — Crabgrass, Large — —— — — — — — — — — — — — Foxtail, Giant 70  0 70 10  80 80  90 90  80  8060  90  90 20  Kochia 50  0 30 0 40 0 50 0 0 20 80  0 90 0 Morningglory— — — — — — — — — — — — — — Pigweed 0 0 40 0 30 0  0 0 0  0 0 0 20 0Ragweed 0 0  0 0  0 0  0 0 0  0 0 —  0 0 Ryegrass, Italian 0 0  0 0 20 020 0 0 30 0 0 30 0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — —— — — — — — — — — — 500 g ai/ha Compounds Preemergence 296 297 298 299300 301 302 303 304 305 306 307 308 309 Barnyardgrass 0 50  0 70  0 0 9090 90 90 90 90  80  80 Corn — — — — — — — — — — — — — — Crabgrass, Large— — — — — — — — — — — — — — Foxtail, Giant 0 70  0 80  0 0 90 90 90 9090 90  90  90 Kochia 0 0 0 0 0 0 70 80 70 70 80 0 0  0 Morningglory — —— — — — — — — — — — — — Pigweed 0 0 0 0 0 0 60 50 80 40 90 0 0  0Ragweed 0 0 0 0 0 0 30 — — 50 80 0 0 — Ryegrass, Italian 0 0 0 0 0 0 6040  0 90 80 0 0 20 Velvetleaf — — — — — — — — — — — — — — Wheat — — — —— — — — — — — — — — 500 g ai/ha Compounds Preemergence 310 311 312 313314 315 316 317 318 319 320 321 322 323 Barnyardgrass 90 80  90 80  80 90 90 90  90 90 80 30  40  90 Corn — — — — — — — — — — — — — —Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 90  9080  90  90 90 90  90 90 90 50  70  90 Kochia 70 0 70 0 0 60 30 0 70 8020 0 0 80 Morningglory — — — — — — — — — — — — — — Pigweed 40 0 20 0 030 20 0 20 20  0 0 0 30 Ragweed  0 0 30 0 0 30 30 0 40 40 30 0 0 80Ryegrass, Italian 40 0 60 0 0 70 50 0 60 60 50 0 0 30 Velvetleaf — — — —— — — — — — — — — — Wheat — — — — — — — — — — — — — — 500 g ai/haCompounds Preemergence 324 325 326 327 328 329 330 331 332 333 334 335336 337 Barnyardgrass 90 90 30 80 80 0 70 80 80  90  0 50 60 20  Corn —— — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — —Foxtail, Giant 90 90 60 90 90 60  80 90 90  90  50  90 90 30  Kochia 8080 50 70 20 0 20  0 0 0 0 60 60 0 Morningglory — — — — — — — — — — — — —— Pigweed 60 60  0 20  0 0 20 20 0 0 0 30 20 0 Ragweed 60 50  0 30  0 0 0 20 0 0 0  0  0 0 Ryegrass, Italian 40 50 40 40 40 0 40 20 0 20  0  020 0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — —— — — 500 g ai/ha Compounds Preemergence 338 339 340 341 342 343 344 345346 347 348 349 350 Barnyardgrass 20  80  80  80  80 80  90  90 90 90 60 90 90 Corn — — — — — — — — — — — — — Crabgrass, Large — — — — — — — —— — — — — Foxtail, Giant 80  80  90  90  90 80  90  90 90 40  90 90 90Kochia 20  0 0 0  0 0 0 80 80 0 70 80 80 Morningglory — — — — — — — — —— — — — Pigweed 0 0 0 0 50 0 0 70 30 0 50 40 80 Ragweed 0 0 0 0  0 0 0 0  0 0 30 40 30 Ryegrass, Italian 0 20  20  0 20 0 30  40 30 0  0  0  0Velvetleaf — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — 125g ai/ha Compounds Preemergence 1 2 3 4 5 6 7 8 9 10 11 12 13 14Barnyardgrass 30  30  60 60 70  50  20  20  20  0 0 60  0 80  Corn 0 0 00 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 90  90  90 90 80  80  80  80  80 90  70  90  50  90  Foxtail, Giant 70  90  90 80 90  90  70  60  70  60 20  70  0 80  Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 00 0 0 0 0 0 0 0 0 Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed — — — — —— — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — —Velvetleaf 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Wheat 0 0 40 60 0 0 0 0 0 0 0 0 00 125 g ai/ha Compounds Preemergence 15 16 28 29 32 36 37 38 41 42 45 4647 48 Barnyardgrass 0 80  0 0 0 40  0 0 30  0 10  0 0 80  Corn 0 0 0 0 00 0 0 0 0 0 0 0 0 Crabgrass, Large 60  90  30  30  80  20  0 70  60  80 80  70  10  90  Foxtail, Giant 20  90  0 0 70  20  0 0 10  20  50  40  080  Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 — —0 0 0 0 Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed — — — — — — — — — —— — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 00 0 0 0 0 0 0 0 0 0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 g ai/haCompounds Preemergence 49 50 51 52 53 54 55 56 57 58 59 60 61 62Barnyardgrass 0 30  0 80  80  0 20  0 40  0 80  80  0 80  Corn 0 0 0 0 00 0 0 0 0 0 0 0 0 Crabgrass, Large 70  90  90  90  90  90  80  60  80 70  90  90  0 90  Foxtail, Giant 20  90  30  80  90  90  70  20  60  20 80  90  0 80  Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 00 0 0 0 0 0 0 0 0 Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed — — — — —— — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — —Velvetleaf 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0125 g ai/ha Compounds Preemergence 63 64 65 66 67 68 69 70 72 73 74 7576 77 Barnyardgrass 50  80 40  80 30  80  80  20  0 50  60  50  80  80Corn 0 20 0 20 0 0 0 0 0 0 0 0 0  0 Crabgrass, Large 90  80 90  80 90 90  90  80  80  80  90  90  90  90 Foxtail, Giant 70  80 80  80 80  90 90  70  60  80  90  80  90  90 Kochia — — — — — — — — — — — — — —Morningglory 0 0 0 0 0 0 0 0 0 0 0 0 0 20 Pigweed 0 0 0 0 0 0 0 0 0 0 00 0 40 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — —— — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 0 0 0 0 0  0 Wheat 0 0 0 0 00 0 0 0 0 0 0 0  0 125 g ai/ha Compounds Preemergence 78 79 80 81 82 8384 85 86 87 88 89 90 91 Barnyardgrass 80 80 80 40  0 0 0 0 0 20  0 60 30  0 Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 90 90 90 80  80 70  0 30  60  80  40  80  70  40  Foxtail, Giant 90 90 90 30  20  0 0 020  60  0 80  60  0 Kochia — — — — — — — — — — — — — — Morningglory 0 00 0 — 0 0 0 0 0 0 0 0 0 Pigweed 10 80 60 0 0 0 0 0 0 0 0 0 0 0 Ragweed —— — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — —Velvetleaf 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0125 g ai/ha Compounds Preemergence 92 93 94 95 97 101 102 103 107 109110 111 112 113 Barnyardgrass 60  50  0 60  0 90 0 80  20  80  70  0 0 0Corn 0 0 0 0 0  0 0 0 0 — — — — — Crabgrass, Large 80  90  0 90  0 90 090  80  — — — — — Foxtail, Giant 0 80  0 80  0 90 0 90  70  90  60  0 00 Kochia — — — — — — — — — 0 0 0 0 0 Morningglory 0 0 0 0 0  0 0 0 0 — —— — — Pigweed 0 0 0 0 0 10 0 0 0 0 0 0 0 0 Ragweed — — — — — — — — — 0 00 0 0 Ryegrass, Italian — — — — — — — — — 0 0 0 0 0 Velvetleaf 0 0 0 0 030 0 0 0 — — — — — Wheat 0 0 0 0 0 60 0 0 0 — — — — — 125 g ai/haCompounds Preemergence 114 115 116 117 118 119 120 121 122 123 124 125126 127 Barnyardgrass 20  0 0 0 50  90 90 80 80 80 70 80  70  70  Corn —0 0 0 — — — — — — — — — — Crabgrass, Large — 70  70  60  — — — — — — — —— — Foxtail, Giant 20  20  0 20  90  90 90 90 90 90 80 80  90  90 Kochia 0 — — — 0 40 60 60 60 80 60 30  0 40  Morningglory — 0 0 0 — — —— — — — — — — Pigweed 0 0 0 0 0 30 30 50 50 70 70 0 0 0 Ragweed 0 — — —0 70 60 70  0 70 40 0 0 0 Ryegrass, Italian 0 — — — 0 20 30  0  0 40  00 0 0 Velvetleaf — 0 0 0 — — — — — — — — — — Wheat — 0 0 0 — — — — — — —— — — 125 g ai/ha Compounds Preemergence 128 129 130 131 132 133 139 140141 142 143 144 145 146 Barnyardgrass 60  80  60  50  70  20  70  80 90  90  60  90  80  90  Corn — — — — — — — — — — — — — — Crabgrass,Large — — — — — — — — — — — — — — Foxtail, Giant 80  80  80  50  70  30 50  50  50  70  30  60  70  80  Kochia 10  50  0 0 0 0 0 0 0 0 30  0 0 0Morningglory — — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 0 0 0 0 0 00 0 Ragweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ryegrass, Italian 0 0 0 0 0 0 00 0 0 0 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — —— — — — — — — 125 g ai/ha Compounds Preemergence 147 148 149 150 151 152153 154 156 157 160 161 162 163 Barnyardgrass 90  30  90 80  90 90 80 80 90  90 80 90 90 80  Corn — — — — — — — — — — — — — — Crabgrass, Large— — — — — — — — — — — — — — Foxtail, Giant 80  40  70 70  80 70 60  9090  90 80 90 80 90  Kochia 30  30  10 60  90 30 60  40 20  50 80 20 50 0Morningglory — — — — — — — — — — — — — — Pigweed 0 0  0 0  0  0 0  0 0 0 70 20 60 40  Ragweed 0 0 60 0 90 50 0  0 0 30 70 20  0 0 Ryegrass,Italian 0 0 20 0 10  0 0 40 0 30 60  0  0 0 Velvetleaf — — — — — — — — —— — — — — Wheat — — — — — — — — — — — — — — 125 g ai/ha CompoundsPreemergence 164 165 166 167 168 169 170 171 172 174 175 181 182 183Barnyardgrass 90 90 80 90 90 90  90 90 0 0 0 0 0 0 Corn — — — — — — — —— — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant90 90 90 90 90 80  80 90 20  30  0 10  50  0 Kochia 60 70 30 20 40 40 50 60 30  0 0 50  0 0 Morningglory — — — — — — — — — — — — — — Pigweed50 50  0 50 40 0 50 20 0 0 0 0 0 0 Ragweed 20  0  0  0  0 0  0  0 0 0 00 0 0 Ryegrass, Italian 20  0 20 20  0 0  0  0 0 0 0 0 0 0 Velvetleaf —— — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 125 g ai/haCompounds Preemergence 184 185 186 188 189 190 194 195 196 197 198 199200 201 Barnyardgrass 70  40  0 0 80  60  0 30  0 0 50  0 60  0 Corn — —— — 0 0 0 0 0 0 0 0 — — Crabgrass, Large — — — — 90  90  90  90  90  80 90  90  — — Foxtail, Giant 90  70  0 0 90  80  50  80  80  30  50  50 30  20  Kochia 0 0 0 0 — — — — — — — — 0 0 Morningglory — — — — 0 0 0 00 0 0 0 — — Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed 0 0 0 0 — — — —— — — — 0 0 Ryegrass, Italian 0 0 0 0 — — — — — — — — 0 0 Velvetleaf — —— — 0 0 0 0 0 0 0 0 — — Wheat — — — — 0 0 0 0 0 0 0 0 — — 125 g ai/haCompounds Preemergence 202 203 204 205 206 207 208 209 210 211 212 213214 215 Barnyardgrass 90 20  90  30  90 90 40  30  60  80 60  50  70 60  Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — —— — — — — Foxtail, Giant 90 30  90  60  90 90 80  50  80  80 70  80  80 80  Kochia 70 0 0 20  70 20 0 0 0 40 0 0 0 0 Morningglory — — — — — — —— — — — — — — Pigweed 60 0 0 0 30  0 0 0 0 20 0 0 0 0 Ragweed 50 0 0 060  0 0 0 0 30 0 0 0 0 Ryegrass, Italian 60 0 20  0 40 20 0 0 0  0 0 0 00 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — —— 125 g ai/ha Compounds Preemergence 216 217 218 219 220 221 222 223 224225 226 227 228 229 Barnyardgrass 20  70 80 30  30  0 70  90 90 20  50 20  50  70  Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — —— — — — — — — — — Foxtail, Giant 40  90 90 90  80  60  90  90 90 80  70 80  80  90  Kochia 0 30 30 10  0 0 0 30 80 0 0 20  0 0 Morningglory — —— — — — — — — — — — — — Pigweed 0 20 30 0 0 0 0 20 80 0 0 0 0 0 Ragweed0  0  0 0 0 0 0 30 90 0 0 0 0 0 Ryegrass, Italian 0 40 40 0 0 0 20  3060 0 0 0 30  10  Velvetleaf — — — — — — — — — — — — — — Wheat — — — — —— — — — — — — — — 125 g ai/ha Compounds Preemergence 230 231 232 233 234235 236 239 240 241 242 244 245 246 Barnyardgrass 30  90 90 80 60 0 050  20  80 60 40 20  80  Corn — — — — — — — — — 20 0 0 0 0 Crabgrass,Large — — — — — — — — — 90 90 90 60  90  Foxtail, Giant 90  90 90 90 7040  0 80  70  90 90 90 60  80  Kochia 0 70 70 50 20 0 0 0 0 — — — — —Morningglory — — — — — — — — —  0 0 0 0 0 Pigweed 0 70 50 30  0 0 0 0 0 0 0 30 0 0 Ragweed 0 70 30 40  0 0 0 0 0 — — — — — Ryegrass, Italian 040 40 30 30 0 0 0 0 — — — — — Velvetleaf — — — — — — — — —  0 0 0 0 0Wheat — — — — — — — — — 20 20 0 0 0 125 g ai/ha Compounds Preemergence247 248 249 250 251 256 257 258 259 260 261 262 263 264 Barnyardgrass90  30  50  20  20  0 40  20  10  70 0 80 80 50 Corn 0 0 0 0 0 0 0 0 0 0 0 0  0 0 Crabgrass, Large 90  90  80  80  80  80  90  90  — 90 80  9090 100 Foxtail, Giant 80  80  50  50  40  20  80  50  60  80 10  80 9080 Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 0 200 0  0 0 Pigweed 0 0 0 0 0 0 0 0 0 60 0 50 60 50 Ragweed — — — — — — — —— — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 00 0 0 0 0 0 0 — 0 0 50 0 Wheat 0 0 0 0 0 0 0 0 0  0 0 0  0 0 125 g ai/haCompounds Preemergence 267 268 269 270 271 272 273 275 276 277 278 279280 281 Barnyardgrass 70  70 70 60  90 70  50  90 0 90 80  80  80  50 Corn 0 0 0 — — — — — — — — — — — Crabgrass, Large 90  80 80 — — — — — —— — — — — Foxtail, Giant 80  70 80 80  90 90  90  90 0 90 90  90  90 10  Kochia — — — 0 50 0 0 60 0 30 0 40  0 0 Morningglory 0 0 0 — — — — —— — — — — — Pigweed 0 30 50 0 40 0 0 20 0 20 0 0 0 0 Ragweed — — — 0 200 0 20 0 20 0 0 0 0 Ryegrass, Italian — — — 0  0 0 0 30 0 30 0 0 0 0Velvetleaf 0 0 0 — — — — — — — — — — — Wheat 0 0 0 — — — — — — — — — — —125 g ai/ha Compounds Preemergence 282 283 284 285 286 287 288 289 290291 292 293 294 295 Barnyardgrass 60  0 0 0 60 50  30  50  60  20  70 20  70  0 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — —— — — — — — — — Foxtail, Giant 20  0 40  0 80 50  30  60  60  20  50 80  70  0 Kochia 0 0 0 0 30 0 30  0 0 20  30  0 40  0 Morningglory — — —— — — — — — — — — — — Pigweed 0 0 0 0 20 0 0 — 0 0 0 0 0 0 Ragweed 0 0 00  0 0 0 0 0 0 0 — 0 0 Ryegrass, Italian 0 0 0 0  0 0 0 0 0 0 0 0 0 0Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — —125 g ai/ha Compounds Preemergence 296 297 298 299 300 301 302 303 304305 306 307 308 309 Barnyardgrass 0 0 0 10  0 0 90 90 90 80 90 80  70 80  Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — —— — — — — Foxtail, Giant 0 30  0 50  0 0 90 90 90 90 90 80  80  90 Kochia 0 0 0 0 0 0 50 70 — 70 70 0 0 0 Morningglory — — — — — — — — — —— — — — Pigweed 0 0 0 0 0 0 10 20 70  0 80 0 0 0 Ragweed 0 0 0 0 0 0  0 0  0 30 — 0 0 0 Ryegrass, Italian 0 0 0 0 0 0  0 30  0 70 40 0 0 0Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — —125 g ai/ha Compounds Preemergence 310 311 312 313 314 315 316 317 318319 320 321 322 323 Barnyardgrass 90 70  80 50  20  90 80 90  90 90 20 0 0 90 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — —— — — — — — Foxtail, Giant 90 80  90 30  30  90 90 90  90 90 30  0 0 90Kochia 30 0 20 0 0 40  0 0 20 60 0 0 0 50 Morningglory — — — — — — — — —— — — — — Pigweed 40 0  0 0 0 30 20 0  0  0 0 0 0 20 Ragweed  0 0  0 0 020 20 0 20 30 0 0 0 20 Ryegrass, Italian 30 0 20 0 0 40 20 0 20 30 20  00 20 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — —— — — 125 g ai/ha Compounds Preemergence 324 325 326 327 328 329 330 331332 333 334 335 336 337 Barnyardgrass 90 90 0 70 40  0 60 20  70  50  00 50  0 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — —— — — — — — — Foxtail, Giant 90 90 50  80 80  0 50 50  80  80  0 70  80 0 Kochia 70 70 40  30 0 0 20 0 0 0 0 40  0 0 Morningglory — — — — — — —— — — — — — — Pigweed 30 30 0  0 0 0  0 0 0 0 0 0 0 0 Ragweed 30 30 0 200 0  0 0 0 0 0 0 0 0 Ryegrass, Italian 30 30 0 40 0 0 30 0 0 0 0 0 0 0Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — —125 g ai/ha Compounds Preemergence 338 339 340 341 342 343 344 345 346347 348 349 350 Barnyardgrass 0 60  60  50  50  20  50  80  80  50  3070  90 Corn — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — —— — — — Foxtail, Giant 30  70  80  80  70  60  80  90  90  20  90 80  90Kochia 0 0 0 0 0 0 0 10  0 0  0 50  80 Morningglory — — — — — — — — — —— — — Pigweed 0 0 0 0 0 0 0 0 20  0 20 0 50 Ragweed 0 0 0 0 0 0 0 0 0 0— 0 30 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0  0 0  0 Velvetleaf — — — —— — — — — — — — — Wheat — — — — — — — — — — — — —Test B

Plant species in the flooded paddy test selected from rice (Oryzasativa), sedge, umbrella (small-flower umbrella sedge, Cyperusdifformis), ducksalad (Heteranthera limosa), and barnyardgrass(Echinochloa crus-galli) were grown to the 2-leaf stage for testing. Attime of treatment, test pots were flooded to 3 cm above the soilsurface, treated by application of test compounds directly to the paddywater, and then maintained at that water depth for the duration of thetest. Treated plants and controls were maintained in a greenhouse for 13to 15 days, after which time all species were compared to controls andvisually evaluated. Plant response ratings, summarized in Table B, arebased on a scale of 0 to 100 where 0 is no effect and 100 is completecontrol. A dash (−) response means no test result.

TABLE B 1000 g ai/ha Compounds Flood 98 99 100 104 105 106 108 109 110115 116 117 193 194 Barnyardgrass 0 80 25 70 25 60 50 0 0 20 20 40 0 65Ducksalad 90 95 75 95 90 90 95 95 95 90 80 90 60 80 Rice 0 10 0 0 10 150 0 0 0 15 0 20 20 Sedge, Umbrella 0 0 0 0 0 0 0 80 50 0 0 0 20 0 1000 gai/ha Compounds Flood 195 196 197 198 199 200 201 209 213 214 215 234235 236 Barnyardgrass 70 20 30 65 20 85 20 45 60 75 60 75 45 40Ducksalad 100 90 75 95 80 95 70 95 85 90 80 85 50 70 Rice 15 0 10 15 015 0 0 0 20 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1000 gai/ha Compounds Flood 240 241 242 244 245 246 247 248 249 250 251 259260 261 Barnyardgrass 70 75 55 30 20 60 85 55 55 0 45 20 0 0 Ducksalad85 100 100 100 90 95 95 95 85 80 90 90 95 90 Rice 0 10 0 0 0 20 0 0 15 00 10 0 0 Sedge, Umbrella 0 20 0 0 0 20 0 0 40 0 0 10 0 0 1000 g ai/haCompounds Flood 262 263 264 267 268 269 344 345 346 Barnyardgrass 20 0 020 0 0 85 0 85 Ducksalad 100 90 100 100 100 100 90 30 100 Rice 0 0 0 1520 0 10 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 500 g ai/ha CompoundsFlood 103 118 119 120 121 122 123 124 125 126 127 128 129 130Barnyardgrass 85 20 80 80 70 65 60 40 30 60 40 60 60 40 Ducksalad 100100 100 100 100 100 100 100 85 80 40 95 100 40 Rice 0 0 10 20 35 15 0 00 0 20 20 15 20 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 30 0 0 0 500 g ai/haCompounds Flood 131 132 133 139 140 141 142 143 144 146 147 148 149 150Barnyardgrass 40 40 30 60 70 50 75 35 65 80 70 40 70 80 Ducksalad 70 8560 100 100 100 100 100 100 100 100 100 100 100 Rice 0 0 0 0 0 0 0 0 0 00 0 0 0 Sedge, Umbrella 30 0 0 0 0 0 0 0 0 0 0 0 0 0 500 g ai/haCompounds Flood 151 152 153 154 160 161 162 163 164 165 166 167 168 169Barnyardgrass 90 60 60 70 60 65 75 90 80 75 75 75 65 80 Ducksalad 100100 100 90 100 100 100 100 100 100 100 100 100 100 Rice 0 15 10 0 10 100 15 20 10 0 10 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 gai/ha Compounds Flood 170 171 175 181 182 202 216 217 218 219 220 221222 223 Barnyardgrass 85 70 0 0 0 65 0 40 70 40 0 0 60 75 Ducksalad 100100 30 0 30 100 0 100 100 100 100 0 100 100 Rice 15 0 0 0 0 15 0 0 0 0 00 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 g ai/ha CompoundsFlood 224 225 226 227 228 229 230 231 232 233 239 272 273 274Barnyardgrass 70 0 0 0 0 50 60 0 85 60 50 20 0 0 Ducksalad 100 90 100 9090 100 75 0 100 100 100 100 70 35 Rice 0 0 0 0 0 0 0 0 20 0 0 0 0 0Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 g ai/ha Compounds Flood275 276 277 278 279 280 281 282 283 284 285 286 287 288 Barnyardgrass 850 90 60 75 65 20 30 20 0 20 15 30 20 Ducksalad 100 30 100 100 100 100 7595 85 80 100 75 75 65 Rice 0 0 0 0 10 0 0 0 0 10 0 10 0 0 Sedge,Umbrella 30 0 0 0 0 0 0 30 0 0 0 0 0 0 500 g ai/ha Compounds Flood 289290 291 292 293 294 295 296 297 298 299 300 301 302 Barnyardgrass 30 400 50 35 20 30 30 0 0 30 0 0 80 Ducksalad 90 75 0 100 95 98 40 60 0 0 500 0 98 Rice 20 0 20 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 00 0 0 0 0 0 0 500 g ai/ha Compounds Flood 303 304 305 306 307 308 309310 311 312 313 314 315 316 Barnyardgrass 80 80 75 75 65 70 65 60 50 7560 25 70 60 Ducksalad 100 100 100 100 98 90 100 100 98 100 0 40 100 100Rice 30 35 15 50 0 0 0 0 0 20 0 15 15 0 Sedge, Umbrella 0 0 0 0 0 0 0 00 0 0 0 0 0 500 g ai/ha Compounds Flood 317 318 319 320 321 322 323 324325 326 327 328 329 330 Barnyardgrass 75 75 70 45 20 0 80 80 70 0 0 0 00 Ducksalad 80 100 100 100 40 100 100 100 100 0 60 35 0 100 Rice 0 15 00 15 0 20 30 20 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 40 0 0 0 0 0500 g ai/ha Compounds Flood 331 332 333 334 335 336 337 338 339 340 341342 343 348 Barnyardgrass 40 40 0 30 0 50 0 0 40 0 0 0 0 40 Ducksalad 6575 20 40 65 60 0 0 65 50 0 0 0 100 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Compounds 500 g ai/ha Flood349 350 Barnyardgrass 40 60 Ducksalad 90 100 Rice 0 0 Sedge, Umbrella 00 250 g ai/ha Compounds Flood 30 31 32 33 34 35 36 37 38 39 40 41 42 43Barnyardgrass 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ducksalad 0 0 50 100 95 80 600 0 0 0 70 60 0 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 00 0 40 20 0 0 0 20 0 0 250 g ai/ha Compounds Flood 45 46 47 48 49 50 5152 53 54 55 56 57 58 Barnyardgrass 0 0 0 40 0 0 20 55 0 0 50 0 0 0Ducksalad 80 0 0 100 70 90 80 90 100 70 75 0 0 0 Rice 20 0 0 20 0 0 1525 0 20 50 0 0 0 Sedge, Umbrella 40 0 0 60 40 55 45 85 20 0 70 0 0 0 250g ai/ha Compounds Flood 59 60 61 62 63 64 65 66 67 68 69 70 72 73Barnyardgrass 40 30 0 20 20 0 0 0 0 40 40 40 0 0 Ducksalad 75 90 0 75 6080 80 75 70 90 85 85 60 60 Rice 20 0 0 0 0 15 0 0 0 25 30 35 0 0 Sedge,Umbrella 60 60 30 80 0 40 40 50 50 70 65 70 0 0 250 g ai/ha CompoundsFlood 74 75 76 77 78 79 80 81 82 83 84 87 89 95 Barnyardgrass 0 0 0 20 00 30 20  0 30 0 60 60 0 Ducksalad 90 0 90 100 85 90 75 70 70 50 0 80 7090 Rice 0 0 0 10 0 0 0 — — 0 0 0 20 0 Sedge, Umbrella 0 0 0 0 0 0 0  080 0 0 0 0 0 250 g ai/ha Compounds Flood 97 194 195 196 197 198 199 235241 242 243 256 257 258 Barnyardgrass 50 0 30 0 0 0 20 0 55 40 0 0 0 0Ducksalad 70 45 35 0 0 70 90 0 100 90 0 60 70 60 Rice 50 0 0 0 0 0 0 0 020 0 0 15 0 Sedge, Umbrella 75 0 0 0 0 0 0 0 0 0 0 50 0 40Test C

Seeds of plant species selected from blackgrass (Alopecurusmyosuroides), ryegrass, Italian (Italian ryegrass, Lolium multiflorum),wheat (winter wheat, Triticum aestivum), galium (catchweed bedstraw,Galium aparine), corn (Zea mays), crabgrass, large (large crabgrass,Digitaria sanguinalis), foxtail, giant (giant foxtail, Setaria faberii),johnsongrass (Sorghum halepense), lambsquarters (Chenopodium album),morningglory (Ipomoea coccinea), nutsedge, yellow (yellow nutsedge,Cyperus esculentus), pigweed (Amaranthus retroflexus), ragweed (commonragweed, Ambrosia elation), soybean (Glycine max), barnyardgrass(Echinochloa crus-galli), oilseed rape (Brassica napus), waterhemp(common waterhemp, Amaranthus rudis), Kochia (Kochia scoparia), oat,wild (wild oat, Avena fatua), surinam grass (Brachiaria decumbens),foxtail, green (green foxtail, Setaria viridis), goosegrass (Eleusineindica), bromegrass, downy (downy bromegrass, Bromus tectorum),nightshade (eastern black nightshade, Solanum ptycanthum), cocklebur(common cocklebur, Xanthium strumarium), cupgrass, woolly (woollycupgrass, Eriochloa villosa), bermudagrass (Cynodon dactylon),sunflower, (common oilseed sunflower, Helianthus annuus), Russianthistle (Salsola kali) and velvetleaf (Abutilon theophrasti) wereplanted into a blend of loam soil and sand and treated preemergence withtest chemicals formulated in a non-phytotoxic solvent mixture whichincluded a surfactant.

At the same time, plants selected from these crop and weed species andalso barley (winter barley, Hordeum vulgare), windgrass (Aperaspica-venti), chickweed (common chickweed, Stellaria media), deadnettle(henbit deadnettle, Lamium amplexicaule), and canarygrass (littleseedcanarygrass, Phalaris minor) were planted in pots containing Redi-Earth®planting medium (Scotts Company, 14111 Scottslawn Road, Marysville, Ohio43041) comprising spaghnum peat moss, vermiculite, wetting agent andstarter nutrients and treated with postemergence applications of testchemicals formulated in the same manner. Plants ranged in height from 2to 18 cm (1- to 4-leaf stage) for postemergence treatments. Treatedplants and controls were maintained in a greenhouse for 13 to 15 days,after which time all species were compared to controls and visuallyevaluated. Plant response ratings, summarized in Table C, are based on ascale of 0 to 100 where 0 is no effect and 100 is complete control. Adash (−) response means no test result.

Plant species in the flooded paddy test consisted of rice (Oryzasativa), sedge, umbrella (small-flower umbrella sedge, Cyperusdifformis), ducksalad (Heteranthera limosa), and barnyardgrass(Echinochloa crus-galli) grown to the 2-leaf stage for testing. At timeof treatment, test pots were flooded to 3 cm above the soil surface,treated by application of test compounds directly to the paddy water,and then maintained at that water depth for the duration of the test.Treated plants and controls were maintained in a greenhouse for 13 to 15days, after which time all species were compared to controls andvisually evaluated. Plant response ratings, summarized in Table C, arebased on a scale of 0 to 100 where 0 is no effect and 100 is completecontrol. A dash (−) response means no test result.

TABLE C 250 g ai/ha Compounds Postemergence 17 34 50 52 76 79 80 81 101103 106 109 119 120 Barley 0 0 0 15 — — — 0 — — — — — — Barnyardgrass —— — — 90 60  70 — 90 65  30  45  80  65  Bermudagrass 0 0 0 10 — — — 0 —— — — — — Blackgrass 0 0 0  0 10 5  5 0  5 0 0 0 0 0 Bromegrass, Downy 00 0 10 — — — 7 — — — — — — Canarygrass 0 0 0  0 — — — 0 — — — — — —Chickweed 10  5 5 60 80 90  90 0 80 5 30  0 — — Cocklebur 0 25 5  5 — —— 0 — — — — — — Corn 0 0 5  5  0 0 10 0  0 0 0 5 5 0 Crabgrass, Large70  60 75 75 75 75  75 7 85 85  60  70  90  75  Cupgrass, Woolly 0 30 1010 — — — 0 — — — — — — Deadnettle 0 0 — — — — — — — — — — — — Foxtail,Giant 10  35 10 25 70 15  45 7 90 80  50  70  90  85  Foxtail, Green 060 30 80 — — — 48  — — — — — — Galium 0 10 — — 65 — 65 — 70 50  35  30 — — Goosegrass 0 25 25 20 — — — 0 — — — — — — Johnsongrass 0 0 10  0  05 10 0  0 0 0 0 5 0 Kochia 5 5 0 50 65 — 65 0 50 40  35  0 — —Lambsquarters 0 55 15 40 50 85  70 3 70 30  0 5 70  70  Morningglory 010 10 30 40 5  5 0 55 40  5 15  5 5 Nutsedge, Yellow 0 10 5 10  0 0  0 0 5 0 0 0 0 0 Oat, Wild 0 0 0  0  0 0  0 0  0 0 0 0 0 0 Oilseed Rape — —— — 10 0 60 — 35 5 0 5 5 0 Pigweed 0 10 20 60 30 35  75 0 45 10  30  10 25  60  Ragweed 0 5 10 55 55 45  30 0 45 10  5 5 25  45  Ryegrass,Italian 5 0 0  0  5 0  0 0  0 0 5 0 5 10  Soybean 0 10 20  5 10 10  25 8 5 0 5 5 5 0 Surinam Grass 60  60 15 30 — — — 0 — — — — — — Velvetleaf 05 45 35  0 0 25 0 30 0 5 5 20  25  Waterhemp — — — — 10 30  65 — 35 10 20  0 40  20  Wheat 0 0 0  0  5 0  0 0  0 0 0 0 0 0 Windgrass 0 5 0 20 —— — 20  — — — — — — 250 g ai/ha Compounds Postemergence 202 204 206 207223 224 232 244 275 278 279 302 303 305 Barley — — — — — — — — — — — — —— Barnyardgrass 85 90 80 65 60 75 75 5 85 75  85 90 70 80 Bermudagrass —— — — — — — — — — — — — — Blackgrass 10 50 60  0  0  0  0 0 40 0  0  5 0 10 Bromegrass, Downy — — — — — — — — — — — — — — Canarygrass — — — —— — — — — — — — — — Chickweed 85 65 85 90 80 85 85 65  85 0  5 70 — —Cocklebur — — — — — — — — — — — — — — Corn 35 40 50  5  5 10  0 0 55 0 0  0 15 45 Crabgrass, Large 75 80 80 65 80 75 75 40  85 75  80 85 90 80Cupgrass, Woolly — — — — — — — — — — — — — — Deadnettle — — — — — — — —— — — — — — Foxtail, Giant 85 90 85 75 35 35 70 5 90 75  90 80 90 90Foxtail, Green — — — — — — — — — — — — — — Galium 80 60 75 50 70 85 8065  80 20  30 45 — — Goosegrass — — — — — — — — — — — — — — Johnsongrass25  0 35  0  0 25 25 5 25 0  0 10  5 20 Kochia 80 40 70 30 60 70 75 50 85 5 35 60 — — Lambsquarters 85 30 20 15 60 60 85 35  75 20  45 70 80 65Morningglory 10 35 45 20 35 35 60 5 20 0 25 25  0 20 Nutsedge, Yellow  0 0  0  0  0  0  5 5 20 15   0 20  0  0 Oat, Wild 10  5 50  0  0 15 30 0 5 0  0  0  0 30 Oilseed Rape 50 45 55 30 10  5 40 10  45 0  0  0 30  0Pigweed 85 10 30 20 60 65 85 10  35 15  20 30 25 65 Ragweed 85  0  5 1535 80 75 0 70 0 35 55 55 45 Ryegrass, Italian 35 15 35  0  0  5 40 0 250  0  0  5 45 Soybean 10  5  5  5 30  5 20 5 10 15  10 65  0  0 SurinamGrass — — — — — — — — — — — — — — Velvetleaf 55 10 15  0 20 35 60 5 5020  10 20 35 65 Waterhemp 85  5 30 10 10 30 80 5 20 5 15 25 25 40 Wheat 5  0 45  0  0  5  5 0  0 0  0  0  0  5 Windgrass — — — — — — — — — — —— — — 250 g ai/ha Compounds Postemergence 306 309 310 312 315 316 317323 324 325 345 346 Barley — — — — — — — — — — — — Barnyardgrass 85 6075 75 85 70 70  70 65 80 — 60 Bermudagrass — — — — — — — — — — — —Blackgrass  5  5  5  0 25  0 0 15  0 35 —  5 Bromegrass, Downy — — — — —— — — — — — — Canarygrass — — — — — — — — — — — — Chickweed — 70 85 — —— — — — — 30 85 Cocklebur — — — — — — — — — — — — Corn 20 20 30 10 60  00 10  0 35 —  0 Crabgrass, Large 85 65 70 90 75 70 50  80 75 85 — 75Cupgrass, Woolly — — — — — — — — — — — — Deadnettle — — — — — — — — — —— — Foxtail, Giant 85 80 70 80 85 85 50  70 60 75 — 85 Foxtail, Green —— — — — — — — — — — — Galium — 60 65 — — — — — — — — 70 Goosegrass — — —— — — — — — — — — Johnsongrass  0 15  5  0 35  0 5 10 10  0 —  0 Kochia— 75 80 — — — — — — — — 40 Lambsquarters 75 70 70 55 80 65 25  65 65 65— 65 Morningglory  5 10 70 20 10 10 10  25 15 50 —  5 Nutsedge, Yellow 0  0 25  0  0  0 0  0  0  0 —  5 Oat, Wild  5  0  0  0  0 30 0  0  5 15—  0 Oilseed Rape 70  5 40  0 10  0 0  0  0 60 —  0 Pigweed 90 60 70 4580 75 5 25 55 65 — 40 Ragweed 85 40 60 55 70 65 40  20 40 35 — 20Ryegrass, Italian 20  5  5 10 45  5 0  5  0 30 —  0 Soybean  5  0  0  015  0 0  0  0  0 —  5 Surinam Grass — — — — — — — — — — — — Velvetleaf65 15 40 35 55 35 0  0 55 40 — 20 Waterhemp 80 10 10 20 65 55 0 20 40 35— 40 Wheat  0  0  0  0  5  0 0  0  0  5 —  0 Windgrass — — — — — — — — —— — — 125 g ai/ha Compounds Postemergence 17 34 48 50 52 60 76 79 80 81101 103 106 109 Barley 0 0 0 0 0 20 — — — 0 — — — — Barnyardgrass — — —— — — 85  35 35 — 65 35  0 0 Bermudagrass 0 0 10 0 0 0 — — — 0 — — — —Blackgrass 0 0 0 0 0 0 0  0  0 0 10 0 0 0 Bromegrass, Downy 0 0 0 0 0 5— — — 0 — — — — Canarygrass 0 0 0 0 0 0 — — — 0 — — — — Chickweed 0 5 300 45 30 65  90 90 0 70 5 5 0 Cocklebur 0 5 10 5 5 0 — — — 0 — — — — Corn0 0 5 5 5 0 0  0  5 0  0 0 0 0 Crabgrass, Large 45  40 75 40  55 75 70 65 65 3 80 75  25  40  Cupgrass, Woolly 0 0 5 0 5 5 — — — 0 — — — —Deadnettle 0 0 — — — — — — — — — — — — Foxtail, Giant 0 5 40 5 0 30 20 15 45 0 75 45  45  50  Foxtail, Green 0 60 65 0 30 45 — — — 20  — — — —Galium 0 0 — — — — 50  60 65 — 30 40  50  30  Goosegrass 0 15 10 25  200 — — — 0 — — — — Johnsongrass 0 0 0 0 0 5 0  0  5 0  0 0 0 0 Kochia 0 520 0 40 45 50  55 65 0 50 35  30  0 Lambsquarters 0 10 10 10  40 20 40 85 60 0 35 40  0 0 Morningglory 0 5 10 10  10 10 40   5  5 0 25 10  10 5 Nutsedge, Yellow 0 10 0 0 10 5 0  0  0 0  0 0 0 0 Oat, Wild 0 0 0 0 00 0  0  0 0  0 0 0 0 Oilseed Rape — — — — — — 0  0 20 — 50 0 0 5 Pigweed0 0 40 20  50 20 10  35 60 0 15 5 5 5 Ragweed 0 5 35 0 50 35 40  20 30 0 5 10  0 0 Ryegrass, Italian 0 0 0 0 0 0 0  0  0 0  0 0 0 0 Soybean 0 510 15  5 5 5 10  5 3  5 0 5 5 Surinam Grass 45  55 25 5 — 0 — — — 0 — —— — Velvetleaf 0 5 35 25  20 5 0  0 — 0 10 0 5 0 Waterhemp — — — — — — 510 45 — 20 5 10  0 Wheat 0 0 5 0 0 5 0  0  0 0  0 0 0 0 Windgrass 0 0 00 20 0 — — — 20  — — — — 125 g ai/ha Compounds Postemergence 119 120 202204 206 207 223 224 232 244 275 277 278 279 Barley — — — — — — — — — — —— — — Barnyardgrass 65  40  65 80  80 35  45  50 70 5 75 80 55  85Bermudagrass — — — — — — — — — — — — — — Blackgrass 0 0  5 0 40 0 0  0 0 0  5  0 0  0 Bromegrass, Downy — — — — — — — — — — — — — —Canarygrass — — — — — — — — — — — — — — Chickweed — — 85 55  85 60  50 70 85 20  85 40 0 30 Cocklebur — — — — — — — — — — — — — — Corn 0 0 10 030 0 0 10  0 0  0 10 0  0 Crabgrass, Large 80  70  60 70  70 40  55  5560 5 65 70 65  70 Cupgrass, Woolly — — — — — — — — — — — — — —Deadnettle — — — — — — — — — — — — — — Foxtail, Giant 85  75  70 90  5065  30  60 15 5 35 85 40  90 Foxtail, Green — — — — — — — — — — — — — —Galium — — 80 60  75 0 45  60 80 55  75 75 5 30 Goosegrass — — — — — — —— — — — — — — Johnsongrass 0 0 25 0  0 0 0 15 20 0  0 10 0  0 Kochia — —80 40  30 0 30  50 70 40  85 60 0 85 Lambsquarters 75  60  80 75  10 35 35  70 85 10  75 40 20  45 Morningglory 5 0 70 15  35 5 0 35 25 5 20 4045  30 Nutsedge, Yellow 0 0  0 0  0 0 0  0  5 5  0  0 0  0 Oat, Wild 0 030 0 45 0 0  5  0 0  0  5 0  0 Oilseed Rape 0 0 50 0 50 10  0 20 65 5 35 0 5  0 Pigweed 15  40  85 10  50 10  10  60 85 5 30 30 15  30 Ragweed45  40  80 0 25 0 35  45 85 0 70 40 10  35 Ryegrass, Italian 0 0  5 0 100 0  5  0 0  5 35 0  0 Soybean 0 0  5 0  5 5 0  5 10 5  0  0 40   0Surinam Grass — — — — — — — — — — — — — — Velvetleaf 15  5 30 0 15 0 025 30 5 10 15 10  10 Waterhemp 0 15  75 0 35 0 10  30 80 5  0  5 5 15Wheat 0 0  0 0 30 0 0  5  5 0  0  0 0  0 Windgrass — — — — — — — — — — —— — — 125 g ai/ha Compounds Postemergence 302 303 304 305 306 309 310312 315 316 317 323 324 325 Barley — — — — — — — — — — — — — —Barnyardgrass 40  70  40 70 85 55 50 70 70 60  25  35  55 70Bermudagrass — — — — — — — — — — — — — — Blackgrass 0 0  0 30  5  5  5 0 30 0 0 0  0  0 Bromegrass, Downy — — — — — — — — — — — — — —Canarygrass — — — — — — — — — — — — — — Chickweed 5 — — — — 65 90 — — —— — — — Cocklebur — — — — — — — — — — — — — — Corn 0 0  5 40  0  0 60 1010 0 0 5 55 10 Crabgrass, Large 70  65  80 75 75 60 70 80 70 60  45  70 70 65 Cupgrass, Woolly — — — — — — — — — — — — — — Deadnettle — — — — —— — — — — — — — — Foxtail, Giant 80  85  45 85 60 40 30 75 85 85  0 35 75 65 Foxtail, Green — — — — — — — — — — — — — — Galium 10  — — — — 5550 — — — — — — — Goosegrass — — — — — — — — — — — — — — Johnsongrass 0 0 0 20  0  0  0 25  0 0 0 0  0  0 Kochia 0 — — — — 75 90 — — — — — — —Lambsquarters 60  65  70 50 90 65 65 95 65 40  25  65  70 70Morningglory 50  0 45 75 65 25 10 10 35 10  0 5 10 35 Nutsedge, Yellow 00  0  0 — 30  0  0  0 0 0 0  0  0 Oat, Wild 0 0  0  0  0  0  0  0  0 5 00  0  5 Oilseed Rape 40  0  0  0 40 40  0  0  0 0 0 0  0 50 Pigweed 20 10  55 65 85 50 60 25 65 60  5 25  65 50 Ragweed 20  40  35 40 80 35 2045 65 35  25  15  25 25 Ryegrass, Italian 0 0  0  0  5  0  0 35 15 0 0 0 0  0 Soybean 0 0 10  0  5 15  0  0  0 0 0 0  0  0 Surinam Grass — — — —— — — — — — — — — — Velvetleaf 0 25  15 40 50  5  0  0 30 45  0 0 50 20Waterhemp 20  0 80 35 80 10 10 20 60 10  20  0 20 25 Wheat 0 0  0  0  0 0  0  0  0 0 0 0  0  0 Windgrass — — — — — — — — — — — — — — Compound125 g ai/ha Postemergence 346 Barley — Barnyardgrass 30  Bermudagras s —Blackgrass 0 Bromegrass, Downy — Canarygrass — Chickweed 40  Cocklebur —Corn 0 Crabgrass, Large 60  Cupgrass, Woolly — Deadnettle — Foxtail,Giant 40  Foxtail, Green — Galium 40  Goosegrass — Johnsongrass 0 Kochia45  Lambsquarters 5 Morningglory 15  Nutsedge, Yellow 0 Oat, Wild 0Oilseed Rape 0 Pigweed 20  Ragweed 0 Ryegrass, Italian 0 Soybean 0Surinam Grass — Velvetleaf 5 Waterhemp 15  Wheat 0 Windgrass — 62 gai/ha Compounds Postemergence 17 34 48 50 52 60 76 79 80 81 101 103 106109 Barley 0 0 0 0 0 0 — — — 0 — — — — Barnyardgrass — — — — — — 35  020  — 35  10  0 0 Bermudagrass 0 0 0 0 0 0 — — — 0 — — — — Blackgrass 00 0 0 0 0 0 0 0 0 0 0 0 0 Bromegrass, Downy 0 0 0 0 0 0 — — — 0 — — — —Canarygrass 0 0 0 0 0 0 — — — 0 — — — — Chickweed 0 0 30  0 25 10  40 80  85  0 60  5 0 0 Cocklebur 0 5 10  5 5 0 — — — 0 — — — — Corn 0 0 5 00 0 0 0 5 0 0 0 0 0 Crabgrass, Large 0 30  65  25  55 50  50  5 40  050  15  10  10  Cupgrass, Woolly 0 0 5 0 5 0 — — — 0 — — — — Deadnettle0 0 — — — — — — — — — — — — Foxtail, Giant 0 5 20  5 0 15  5 15  0 0 20 0 35  15  Foxtail, Green 0 60  0 0 10 35  — — — 5 — — — — Galium 0 0 — —— — 50  60  55  — 50  0 0 0 Goosegrass 0 15  10  25  0 0 — — — 0 — — — —Johnsongrass 0 0 0 0 0 5 0 0 5 0 0 0 0 0 Kochia 0 5 10  0 35 10  50  55 55  0 30  30  40  0 Lambsquarters 0 0 — 10  10 20  40  50  55  0 25  025  0 Morningglory 0 5 10  0 10 10  10  0 5 0 15  0 5 0 Nutsedge, Yellow0 5 0 0 10 0 0 0 0 0 0 0 0 0 Oat, Wild 0 0 0 0 0 0 0 0 0 0 0 0 0 0Oilseed Rape — — — — — — 0 0 0 — 10  0 0 0 Pigweed 0 0 30  10  40 20 10  35  40  0 10  0 0 5 Ragweed 0 5 5 0 10 25  40  20  30  0 0 0 0 0Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Soybean 0 0 10  15  0 0 00 5 3 0 0 0 0 Surinam Grass 0 0 25  5 5 0 — — — 0 — — — — Velvetleaf 0 515  15  20 0 0 0 15  0 0 0 0 0 Waterhemp — — — — — — 5 10  45  — 5 5 0 0Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Windgrass 0 0 0 0 0 0 — — — 0 — — — —62 g ai/ha Compounds Postemergence 119 120 202 204 206 207 223 224 232244 271 275 277 278 Barley — — — — — — — — — — — — — — Barnyardgrass 40 30  65 55  40 10  0 30 55 0 0 60  70  10  Bermudagrass — — — — — — — — —— — — — — Blackgrass 0 0  0 0  0 0 0  0  0 0 0 0 0 0 Bromegrass, Downy —— — — — — — — — — — — — — Canarygrass — — — — — — — — — — — — — —Chickweed — — 80 30  60 50  45  70 85 50  50  60  0 0 Cocklebur — — — —— — — — — — — — — — Corn 0 0  0 0  0 0 0  0  0 0 0 0 20  0 Crabgrass,Large 65  70  50 50  50 15  10  35 35 5 5 40  65  30  Cupgrass, Woolly —— — — — — — — — — — — — — Deadnettle — — — — — — — — — — — — — —Foxtail, Giant 25  65  25 10  50 0 35   0  5 0 0 75  85  10  Foxtail,Green — — — — — — — — — — — — — — Galium — — 80 45  75 0 5 45 80 30  30 55  60  0 Goosegrass — — — — — — — — — — — — — — Johnsongrass 0 0 20 0 0 0 0  0 20 0 10  0 0 0 Kochia — — 75 30  70 0 5 40 70 10  10  85  5 0Lambsquarters 50  55  80 65  75 10  5 50 85 20  55  60  40  0Morningglory 0 5 10 5 20 5 0  5  0 0 45  10  30  0 Nutsedge, Yellow 0 0 0 0 20 0 0  0  0 10  0 0 0 0 Oat, Wild 0 0  0 0  5 0 0  0  0 0 0 0 0 0Oilseed Rape 0 0  0 0 30 0 0 15 50 0 20  5 0 0 Pigweed 10  20  80 10  4010  10  55 85 5 30  5 10  5 Ragweed 0 45  75 0  0 0 0 65 80 0 40  65 35  0 Ryegrass, Italian 0 0  0 0  0 0 0  0  0 0 0 0 5 0 Soybean 5 0  0 0 5 5 0 10 10 5 60  0 0 55  Surinam Grass — — — — — — — — — — — — — —Velvetleaf 0 0 20 0  0 0 0  0 15 5 5 10  0 0 Waterhemp 0 0 65 0  0 0 035 75 5 5 0 5 0 Wheat 0 0  0 0  0 0 0  0  0 0 0 0 0 0 Windgrass — — — —— — — — — — — — — — 62 g ai/ha Compounds Postemergence 279 302 303 304305 306 309 310 312 315 316 317 323 324 Barley — — — — — — — — — — — — —— Barnyardgrass 55 20  60  0 55  45 15  25  70  65  35  0 10  35 Bermudagrass — — — — — — — — — — — — — — Blackgrass  0 0 0 0 0  0 0 0 00 0 0 0 0 Bromegrass, Downy — — — — — — — — — — — — — — Canarygrass — —— — — — — — — — — — — — Chickweed 75 0 — — — — 50  45  — — — — — —Cocklebur — — — — — — — — — — — — — — Corn  0 0 0 0 5  0 0 0 15  0 0 0 00 Crabgrass, Large 65 50  40  60  55  45 30  10  50  65  50  25  40  60 Cupgrass, Woolly — — — — — — — — — — — — — — Deadnettle — — — — — — — —— — — — — — Foxtail, Giant 30 45  80  10  65  75 0 5 75  40  5 0 0 10 Foxtail, Green — — — — — — — — — — — — — — Galium 15 15  — — — — 40  50 — — — — — — Goosegrass — — — — — — — — — — — — — — Johnsongrass  0 0 0 00  0 0 0 0 0 0 0 0 0 Kochia 30 0 — — — — 5 50  — — — — — — Lambsquarters 0 20  85  75  35  70 65  65  75  60  65  0 10  55  Morningglory 60 15 60  20  20  35 10  0 0 65  0 0 25  5 Nutsedge, Yellow  0 0 0 0 0  0 5 00 0 0 0 0 0 Oat, Wild  0 0 0 0 0  0 0 0 0 0 0 0 0 0 Oilseed Rape 30 0 00 0 50 30  0 0 0 0 0 0 0 Pigweed 10 20  0 55  60  85 50  40  20  65  50 5 5 35  Ragweed 20 20  0 0 0 55 0 10  35  20  0 0 0 20  Ryegrass,Italian  0 0 0 5 0  0 0 0 0 5 0 0 0 0 Soybean 10 0 0 5 0  5 0 10  0 0 00 0 5 Surinam Grass — — — — — — — — — — — — — — Velvetleaf 10 0 0 15 40  10 5 0 0 25  0 0 20  55  Waterhemp 20 20  35  65  10  65 5 10  45 60  10  0 0 10  Wheat  0 0 0 0 0  0 0 0 0 0 0 0 0 0 Windgrass — — — — —— — — — — — — — — Compounds 62 g ai/ha Postemergence 325 346 Barley — —Barnyardgrass 25  0 Bermudagrass — — Blackgrass 0 0 Bromegrass, Downy —— Canarygrass — — Chickweed — 65  Cocklebur — — Corn 0 0 Crabgrass,Large 65  25  Cupgrass, Woolly — — Deadnettle — — Foxtail, Giant 35  0Foxtail, Green — — Galium — 25  Goosegrass — — Johnsongrass 0 0 Kochia —50  Lambsquarters 45  5 Morningglory 5 5 Nutsedge, Yellow 0 0 Oat, Wild0 0 Oilseed Rape 0 0 Pigweed 55  5 Ragweed 10  0 Ryegrass, Italian 0 0Soybean 0 5 Surinam Grass — — Velvetleaf 15  0 Waterhemp 0 0 Wheat 0 0Windgrass — — 31 g ai/ha Compounds Postemergence 17 34 48 50 52 60 76 7980 81 101 103 106 109 Barley 0 0 0 0 0 0 — — — 0 — — — — Barnyardgrass —— — — — — 0 0 0 — 0 0 0 0 Bermudagrass 0 0 0 0 0 0 — — — 0 — — — —Blackgrass 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Bromegrass, Downy 0 0 0 0 0 0 — —— 0 — — — — Canarygrass 0 0 0 0 0 0 — — — 0 — — — — Chickweed 0 0 0 0 —0 40  60  70  0 35  0 0 0 Cocklebur 0 0 5 5 5 0 — — — 0 — — — — Corn 0 05 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 0 0 40  10  50  20  0 5 5 0 25 0 10  10  Cupgrass, Woolly 0 0 0 0 0 0 — — — 0 — — — — Deadnettle 0 0 —— — — — — — — — — — — Foxtail, Giant 0 0 5 0 0 0 0 15  0 0 0 0 50  60 Foxtail, Green 0 0 0 0 0 20  — — — 5 — — — — Galium 0 0 — — — — 30  30 5 — 50  0 0 0 Goosegrass 0 10  10  25  0 0 — — — 0 — — — — Johnsongrass0 0 0 0 0 5 0 0 5 0 0 0 0 0 Kochia 0 5 10  0 30  0 40  5 30  0 45  30  00 Lambsquarters 0 0 10  5 — 5 40  25  55  0 10  0 0 0 Morningglory 0 010  0 5 5 10  0 0 0 15  20  0 20  Nutsedge, Yellow 0 5 0 0 10  0 0 0 0 00 0 0 0 Oat, Wild 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Oilseed Rape — — — — — — 00 0 — 5 0 0 0 Pigweed 0 0 25  10  25  — 5 35  40  0 0 0 0 5 Ragweed 0 55 0 10  10  25  20  30  0 0 0 25  0 Ryegrass, Italian 0 0 0 0 0 0 0 0 00 0 0 0 0 Soybean 0 0 10  10  0 0 0 0 0 0 0 0 0 0 Surinam Grass 0 0 5 50 0 — — — 0 — — — — Velvetleaf 0 5 0 0 10  0 0 0 15  0 0 0 0 0 Waterhemp— — — — — — 0 10  30  — 0 0 0 0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0Windgrass 0 0 0 0 0 0 — — — 0 — — — — 31 g ai/ha Compounds Postemergence119 120 202 204 206 207 223 224 232 244 271 275 277 278 Barley — — — — —— — — — — — — — — Barnyardgrass 25  0 25  5 25  0 0 0 5 0 0 30  15  0Bermudagrass — — — — — — — — — — — — — — Blackgrass 0 0 0 0 0 0 0 0 0 00 0 0 0 Bromegrass, Downy — — — — — — — — — — — — — — Canarygrass — — —— — — — — — — — — — — Chickweed — — 80  0 85  30  40  70  70  45  5 50 40  0 Cocklebur — — — — — — — — — — — — — — Corn 0 0 0 0 0 0 0 0 0 0 0 00 0 Crabgrass, Large 55  55  30  0 45  10  0 0 25  5 5 15  15  0Cupgrass, Woolly — — — — — — — — — — — — — — Deadnettle — — — — — — — —— — — — — — Foxtail, Giant 10  25  5 0 0 20  0 0 0 0 0 10  10  10 Foxtail, Green — — — — — — — — — — — — — — Galium — — 80  10  60  0 5 575  30  30  50  45  0 Goosegrass — — — — — — — — — — — — — —Johnsongrass 0 0 0 0 0 0 0 0 0 0 10  0 0 0 Kochia — — 70  10  50  0 0 060  0 0 70  0 0 Lambsquarters 5 55  70  35  50  0 0 5 80  10  50  10 30  0 Morningglory 0 0 5 5 20  5 0 5 15  0 10  10  30  0 Nutsedge,Yellow 0 0 0 0 0 10  0 0 0 0 0 0 10  0 Oat, Wild 0 0 0 0 0 0 0 0 0 0 0 00 0 Oilseed Rape 0 0 0 0 0 0 0 0 0 0 0 5 0 0 Pigweed 10  5 80  20  30  05 40  80  5 10  5 10  0 Ragweed 20  20  70  0 5 0 0 20  75  0 25  20 40  0 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Soybean 5 0 0 0 5 010  0 0 5 15  0 0 50  Surinam Grass — — — — — — — — — — — — — —Velvetleaf 0 25  10  0 0 0 0 0 5 5 5 5 0 0 Waterhemp 0 0 60  0 0 0 0 25 75  5 0 0 5 0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Windgrass — — — — — — —— — — — — — — 31 g ai/ha Compounds Postemergence 279 302 303 304 305 306309 310 312 315 316 317 323 324 Barley — — — — — — — — — — —  — — —Barnyardgrass 15  0 10  0 20  0 0 5 40  25  10 0 0 0 Bermudagrass — — —— — — — — — — — — — — Blackgrass 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Bromegrass,Downy — — — — — — — — — — — — — — Canarygrass — — — — — — — — — — — — —— Chickweed 5 0 — — — — 30  20  — — — — — — Cocklebur — — — — — — — — —— — — — — Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 25  0 0 10 40  10  0 0 25  55  0 0 0 25  Cupgrass, Woolly — — — — — — — — — — — — —— Deadnettle — — — — — — — — — — — — — — Foxtail, Giant 0 0 — 0 0 5 10 0 55  0 5 0 0 0 Foxtail, Green — — — — — — — — — — — — — — Galium 0 10 — — — — 30  35  — — — — — — Gooesgrass — — — — — — — — — — — — — —Johnsongrass 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Kochia 0 0 — — — — 5 40  — — —— — — Lambsquarters 0 10  35  35  60  60  10  25  65  60  55  0 10  0Morningglory 5 10  10  50  25  0 60  10  0 25  55  0 0 10  Nutsedge,Yellow 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Oat, Wild 0 0 0 0 0 0 0 0 0 0 0 0 0 0Oilseed Rape 0 0 0 0 0 0 35  0 0 0 0 0 0 0 Pigweed 30  15  0 35  55  75 30  35  10  25  15  5 0 0 Ragweed 15  10  0 0 0 60  0 10  40  0 45  0 05 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Soybean 40  0 0 0 10  00 10  0 0 0 0 0 0 Surinam Grass — — — — — — — — — — — — — — Velvetleaf 00 35  5 10  0 5 35  30  10  0 0 0 0 Waterhemp 5 10  0 50  10  65  0 5 050  10  0 0 0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Windgrass — — — — — — —— — — — — — — Compounds 31 g ai/ha Postemergence 325 346 Barley — —Barnyardgrass 10  0 Bermudagrass — — Blackgrass 0 0 Bromegrass, Downy —— Canarygrass — — Chickweed — 40  Cocklebur — — Corn 0 0 Crabgrass,Large 55  0 Cupgrass, Woolly — — Deadnettle — — Foxtail, Giant 0 20 Foxtail, Green — — Galium — 30  Goosegrass — — Johnsongrass 0 100 Kochia — 45  Lambsquarters 20  45  Morningglory 5 0 Nutsedge, Yellow 0 0Oat, Wild 0 0 Oilseed Rape 0 0 Pigweed 40  5 Ragweed 10  0 Ryegrass,Italian 0 0 Soybean 0 0 Surinam Grass — — Velvetleaf 0 0 Waterhemp 0 0Wheat 0 0 Windgrass — — Compounds 16 g ai/ha Postemergence 48 271 277304 Barley 0 — — — Barnyardgrass — 0 5 0 Bermudagrass 0 — — — Blackgrass0 0 0 0 Bromegrass, Downy 0 — — — Canarygrass 0 — — — Chickweed 0 5 0 —Cocklebur 0 — — — Corn 0 0 0 0 Crabgrass, Large 20  0 5 10  Cupgrass,Woolly 0 — — — Foxtail, Giant 0 0 0 0 Foxtail, Green 0 — — — Galium — 540  — Goosegrass 10  — — — Johnsongrass 0 10  0 0 Kochia 0 0 0 —Lambsquarters — 45  25  65  Morningglory 10  0 15  20  Nutsedge, Yellow0 0 0 0 Oat, Wild 0 0 0 0 Oilseed Rape — 0 0 0 Pigweed 10  5 5 25 Ragweed 0 15  10  0 Ryegrass, Italian 0 0 0 0 Soybean 5 45  0 0 SurinamGrass 0 — — — Velvetleaf 0 0 0 0 Waterhemp — 0 5 40  Wheat 0 0 0 0Windgrass 0 — — — Compound 8 g ai/ha Postemergence 271 Barnyardgrass 0Blackgrass 0 Chickweed 0 Corn 0 Crabgrass, Large 0 Foxtail, Giant 0Galium 0 Johnsongrass 10 Kochia 0 Lambsquarters 10 Morningglory 0Nutsedge, Yellow 0 Oat, Wild 0 Oilseed Rape 0 Pigweed 5 Ragweed 0Ryegrass, Italian 0 Soybean 5 Velvetleaf 0 Waterhemp 0 Wheat 0 250 gai/ha Compounds Preemergence 5 14 16 17 33 34 35 52 53 59 62 64 66 68Barnyardgrass — — — — — — — — — — — — — — Bermudagrass 45 95 95 90 98 4575 65 50 50 60 55 0 85 Blackgrass 30 0 — 95  5 45 50  0 0 60 80 30 20 80Bromegrass, Downy 0 0 35 65 55 30 40  0 0 20  0 50 5  0 Cocklebur 0 0  05 10 0 0 — 5 —  5 — — — Corn 0 0 10 70 30 10 5 10 20 45 55 60 20 50Crabgrass, Large 100 100 100  100 100  100 100 95 90 100  98 95 98 95Cupgrass, Woolly 95 80 95 95 90 95 90 85 80 80 85 90 85 90 Foxtail,Giant 100 95 95 100 98 98 98 85 85 90 85 98 95 95 Foxtail, Green 95 9590 98 100  100 98 90 90 98 90 98 98 95 Galium 40 85 — 90 90 60 30 90 7085 90  0 0 90 Goosegrass 80 55 80 95 85 45 25 80 40 80 80 50 10 85Johnsongrass 0 40 25 75 15 20 45 15 10  5 40 75 40 75 Kochia 0 0  0 80 0 0 10 20 20 40 25 35 10 35 Lambsquarters 95 — — 100 25 80 20 75 65 3585 35 0 75 Morningglory 0 0  0 0  0 5 20  0 0 25 20 30 40 15 Nightshade98 0  0 40 15 0 0 40 70 30 70  5 0 55 Nutsedge, Yellow 0 0 45 0 40 0 025 20 35 20 40 10 10 Oat, Wild 20 0 15 80 90 85 75 10 0 80 50 70 5 30Oilseed Rape — — — — — — — — — — — — — — Pigweed 0 0  0 60 20 40 5 70 2555 95 30 0 85 Ragweed 0 0  0 50 20 15 0 10 15 35 45 30 25  0 RussianThistle — 0  0 — — 95 — — —  0 85  0 0 — Ryegrass, Italian 0 10 — 70 3045 30  5 0  0 50  0 0  5 Soybean 0 0  0 0  5 5 0 15 20 20 35 40 20 15Sunflower 0 0  0 50 10 0 10 20 20 40 60 25 5 15 Surinam Grass 95 95 100 95 95 100 100 80 75 80 85 80 75 85 Velvetleaf 0 0  0 10 10 0 20  5 10 2530 25 25 25 Waterhemp — — — — — — — — — — — — — — Wheat 60 10 45 85 4080 65 25 0  0 10 15 25 50 250 g ai/ha Compounds Preemergence 69 76 77 7879 80 81 101 103 109 119 120 202 204 Barnyardgrass — 98 95 95 98 95 — 9595  98 98 98 95 95 Bermudagrass 55 — — — — — 0 — — — — — — — Blackgrass35 80 95 85 85 90 0 90 0 95 85 70 90 90 Bromegrass, Downy 0 — — — — — 0— — — — — — — Cocklebur 0 — — — — — 0 — — — — — — — Corn 30 65 70 60 3065 0 65 10  75 45 65 85 75 Crabgrass, Large 95 100  98 98 100  100  95 100  100  100  100  100  98 95 Cupgrass, Woolly 90 — — — — — 82  — — — —— — — Foxtail, Giant 90 98 100  98 98 98 73  98 98  100  98 98 98 95Foxtail, Green 95 — — — — — 90  — — — — — — — Galium 75 85 90 85 90 90 085 80  100  90 90 90 90 Goosegrass 75 — — — — — 0 — — — — — — —Johnsongrass 0 80 90 60 10 55 0 75 40  70 70 65 85 85 Kochia 25 — — — —— — — — — — — — — Lambsquarters 85 35 98 85 90 90 27  90 65   0 85 90100  100  Morningglory 25 40  0  0  0 20 0 25 0 30 35 40 40 40Nightshade 0 — — — — — 0 — — — — — — — Nutsedge, Yellow 10 55  0  0  010 0  0 0  5  0  0  0  0 Oat, Wild 5 — — — — — 0 — — — — — — — OilseedRape — 75 85 75 80 90 — 80 5 40 80 90 90 60 Pigweed 25 40 85 40 65 90 085 5 20 85 80 100  75 Ragweed 20 — — — — — 0  5 0 10 80 80 100  65Russian Thistle — — — — — — 0 — — — — — — — Ryegrass, Italian 10 40 4545 30 45 0 50 0 70 40 30  5 30 Soybean 0  0  0  0  0  0 0 10 0  0  0  010 10 Sunflower 15 — — — — — 0 — — — — — — — Surinam Grass 85 — — — — —90  — — — — — — — Velvetleaf 30 35 40 20 35 50 0 70 0 10 50 40 65 30Waterhemp — 60 85 85 85 90 — 85 40  20 80 85 100  90 Wheat 5 80 90 90 7580 0 55 10  85 90 85 60 90 250 g ai/ha Compounds Preemergence 206 207211 218 223 224 231 232 233 241 246 247 262 263 Barnyardgrass 95 95 9095 95 95 95 95 90 95 90 90 95  98 Bermudagrass — — — — — — — — — — — — —— Blackgrass 90 90 90 80 85 85 90 85 90 85 70 70 0 70 Bromegrass, Downy— — — — — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn60 30 80  0 45 85 85 75 35 90  0 60 10  10 Crabgrass, Large 95 95 95100  100  100  100  90 90 100  98 100  100  100  Cupgrass, Woolly — — —— — — — — — — — — — — Foxtail, Giant 95 98 95 95 98 98 95 95 95 95 95100  95  98 Foxtail, Green — — — — — — — — — — — — — — Galium 85 90 100 90 90 85 90 90 90 85 90 90 85  90 Goosegrass — — — — — — — — — — — — — —Johnsongrass 85 60 65 40 55 85 60 70 45 90  5  5 0  0 Kochia — — — — — —— — — — — — — — Lambsquarters 100  70 100  85 90 95 100  90 90 100  9080 100  80 Morningglory 10  0  0 20 20 30 20 20 20 30  5 20 10  10Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow  0  0 10  0  0 0  0 100   0  0  0  0 0  0 Oat, Wild — — — — — — — — — — — — — —Oilseed Rape 90 80 90 70  5 85 90 85 85 85 30 80 70  90 Pigweed 85  0 7085 30 85 90 95 70 70 100  90 5 95 Ragweed 98  5 100  85 25 100  85 90 8570 40 98 75  100  Russian Thistle — — — — — — — — — — — — — — Ryegrass,Italian 20  0 50 50 15 15 15 40 40 55 10 50 0 35 Soybean  0  0  0 20 15 5  5  5  0  0 10  0 0  0 Sunflower — — — — — — — — — — — — — — SurinamGrass — — — — — — — — — — — — — — Velvetleaf 60  0 35 40 35 40 60 75 4540  0 25 0  5 Waterhemp 100  75 90 90 25 80 95 95 95 60 90 85 50  100 Wheat 70 45 45 10 35 45 80  5  0 80 30  0 0 50 250 g ai/ha CompoundsPreemergence 274 275 278 279 280 302 303 305 306 307 309 310 312 315Barnyardgrass 90 98 100  98 95 100  98 98 95 95 95 95 95 95 Bermudagrass— — — — — — — — — — — — — — Blackgrass 90 80 0 85  0 85 90 90 90  5 4545 75 85 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — —— — — — — — — — — — Corn 45 75 5 65  5 50 45 80 75 40 70 55 70 85Crabgrass, Large 100  100  100  100  100  100  100  95 98 100  98 95 9598 Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 95 100 100  98 95 100  100  95 100  95 95 90 95 98 Foxtail, Green — — — — — — —— — — — — — — Galium — 85 5 85 85 85 85 90 90 85 85 70 80 90 Goosegrass— — — — — — — — — — — — — — Johnsongrass 30 85 0 80 10 65 80 90 85 45 8075 85 90 Kochia — — — — — — — — — — — — — — Lambsquarters  0 98 0 90 1065 80 75 80 85 50 80 60 80 Morningglory  0 50 0 10 30  0 45 65 35  0 10 5 55 45 Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow  0 100 5 55 100  10 25 100  10  0  0  0  0 20 Oat, Wild — — — — — — — — — — — —— — Oilseed Rape 30 90 5 60  0 10 85 90 75  5 70 85 30 80 Pigweed  0 400 75 20  0 80 85 90 35 40 20 55 85 Ragweed  0 85 0 65 60 10 80 75 80 3565 35 10 80 Russian Thistle — — — — — — — — — — — — — — Ryegrass,Italian 30 60 0 60  5 40 75 80 70 10 10 25 30 50 Soybean  0 15 10  10  0 0 20  0  0  0  0  0  0  0 Sunflower — — — — — — — — — — — — — — SurinamGrass — — — — — — — — — — — — — — Velvetleaf 20 30 0 30 10  0 55 55 65 0 15 35 40 50 Waterhemp  0 60 0 80 35 55 75 80 90  0 40 25 80 85 Wheat40 90 0 30  0 30 90 90 85 15  0 10 65 90 250 g ai/ha CompoundsPreemergence 316 317 318 319 323 324 325 345 346 350 Barnyardgrass 90 9595 98 98 98 95 95 98 90 Bermudagrass — — — — — — — — — — Blackgrass 6050 45 80 85 95 85 90 85 55 Bromegrass, Downy — — — — — — — — — —Cocklebur — — — — — — — — — — Corn 75 30 60 65 75 85 85 85  5 40Crabgrass, Large 98 98 100  98 100  98 100  98 100  90 Cupgrass, Woolly— — — — — — — — — — Foxtail, Giant 95 95 90 95 98 95 95 98 98 90Foxtail, Green — — — — — — — — — — Galium 90  0 100  85 85 85 80 85 9090 Goosegrass — — — — — — — — — — Johnsongrass 85 30 60 75 60 85 75 9060 30 Kochia — — — — — — — — — — Lambsquarters 65 10 60 75 95 85 80 85100  90 Morningglory 35  0 40 40 30 55 40 35  0 100  Nightshade — — — —— — — — — — Nutsedge, Yellow 70 70  0 30 75 35  0  0  0  0 Oat, Wild — —— — — — — — — — Oilseed Rape 60  0  5 65 85 90 90 85 60 85 Pigweed 65  050 40 65 85 85 60 70 90 Ragweed 35  0 20 85 80 85 85 70 70 80 RussianThistle — — — — — — — — — — Ryegrass, Italian  0 10 50 50 70 60 50 55 7035 Soybean  0 10  0  0  0  0  0  0 10  0 Sunflower — — — — — — — — — —Surinam Grass — — — — — — — — — — Velvetleaf 30  5 35 65 45 50 65 40 25 5 Waterhemp 45 30 70 40 75 90 85 45 40 90 Wheat 45 35  5 35 80 85 70 8040 15 125 g ai/ha Compounds Preemergence 5 14 16 17 33 34 35 48 52 53 5960 62 64 Barnyardgrass — — — — — — — — — — — — — — Bermudagrass 20  95 90  85 70 0 0 0 40 50 40 0 50 25 Blackgrass 0 0 10  80 0 10 5 50 0 0 3040 80 5 Bromegrass, Downy 0 0 30  45 0 10 5 0 0 0 0 0  0 0 Cocklebur 0 —0  5 10 0 0 5 0 5 — 0  0 — Corn 0 0 5 30 20 0 5 20 10 20 10 20 30 55Crabgrass, Large 100  98  100  100  100 100 100 95 90 90 90 95 95 95Cupgrass, Woolly 90  0 95  90 90 95 85 85 75 80 80 75 80 85 Foxtail,Giant 100  90  90  100  98 98 98 95 80 65 85 90 85 90 Foxtail, Green 90 90  80  98 100 98 98 90 90 90 90 90 90 90 Galium — 70  — 70 60 5 5 60 900 30 5 85 0 Goosegrass 0 0 0 85 40 10 5 15 60 30 35 0 70 25 Johnsongrass0 0 0 65 0 10 0 20 10 0 0 20 30 75 Kochia 0 0 0 60 0 0 5 10 15 0 10 0 1520 Lambsquarters 95  — — 60 25 80 0 65 70 40 0 10 70 30 Morningglory 0 00 — 0 5 10 15 0 0 15 10 15 20 Nightshade 45  — 0 40 0 0 0 0 0 40 25 0 —0 Nutsedge, Yellow 0 0 0  0 — 0 0 20 25 — 0 15 20 20 Oat, Wild 0 0 15  0 20 60 0 10 0 0 0 5 50 10 Oilseed Rape — — — — — — — — — — — — — —Pigweed 0 0 0 50 0 0 0 0 55 25 — 20 70 30 Ragweed 0 0 0 30 0 0 0 10 0 100 25 45 30 Russian Thistle — 0 0 — — 0 — — — — 0 60 85 0 Ryegrass,Italian 0 0 — 35 0 20 5 0 0 0 0 0 30 0 Soybean 0 0 0  0 0 5 0 15 15 1520 25 35 40 Sunflower 0 0 0 20 — 0 10 0 0 20 15 0 25 0 Surinam Grass 95 95  98  90 95 100 100 85 45 75 60 70 80 65 Velvetleaf 0 0 0  0 10 0 20 05 0 0 0 25 10 Waterhemp — — — — — — — — — — — — — — Wheat 5 10  0  0 3535 10 45 10 0 0 0  0 15 125 g ai/ha Compounds Preemergence 66 68 69 7677 78 79 80 81 101 103 109 119 120 Barnyardgrass — — — 95 95 85 95 95 —95 95 95 95 95 Bermudagrass 0 85 50 — — — — — 0 — — — — — Blackgrass 060 30 80 85 75 85 85 0 70 30 90 80 50 Bromegrass, Downy 0  0 0 — — — — —0 — — — — — Cocklebur — — — — — — — — 0 — — — — — Corn 10 25 25 40 55 4010  0 0  5  0 60 15 20 Crabgrass, Large 98 95 95 100  98 98 100  98 90 98 100  100  100  100  Cupgrass, Woolly 80 85 85 — — — — — 67  — — — — —Foxtail, Giant 85 90 85 95 95 95 95 98 37  98 95 98 98 98 Foxtail, Green90 95 95 — — — — — 80  — — — — — Galium 0 90 5 — 80 60 85 90 0 90 40 5085 50 Goosegrass 10 80 40 — — — — — 0 — — — — — Johnsongrass — 40 0 4575 15 10 30 0 55 15 40 30 25 Kochia 10  0 0 — — — — — — — — — — —Lambsquarters 0 65 65  0 85 85 90 90 0 90 55  5 85 85 Morningglory 35 1525 40  0  0  0 20 0 30  0  5 35 35 Nightshade 0 55 0 — — — — — 0 — — — —— Nutsedge, Yellow 0 10 0 20  0  0  0  0 0  0  0  0  0  0 Oat, Wild 0  05 — — — — — 0 — — — — — Oilseed Rape — — — 30 60 10 70 90 — 80  0  5 8070 Pigweed 0 85 25  0 60 40 50 90 0 55  0  0 75 65 Ragweed 25  0 0 — — —— — 0  5 40  0 75 55 Russian Thistle 0 — — — — — — — 0 — — — — —Ryegrass, Italian 0  0 0 40 40 40 30 40 0 30  0 20 30 10 Soybean 20 10 0 0  0  0  0  0 0  0  0 55  0  0 Sunflower 0 10 10 — — — — — 0 — — — — —Surinam Grass 75 75 85 — — — — — 77  — — — — — Velvetleaf 25 10 30 25 3020 20 35 0  5  0  0 40 35 Waterhemp — — — 50 70 85 80 90 — 50 65  0 7075 Wheat 5 30 5 70 80 60 60 80 0 50  0 50 60 30 125 g ai/ha CompoundsPreemergence 189 202 204 206 207 211 218 223 224 231 232 233 241 246Barnyardgrass 90  95 95 95 85 85 95 90 90 95 95 85 95 75 Bermudagrass —— — — — — — — — — — — — — Blackgrass 55  90 90 90 85 85 50 85 70 85 7060 80  5 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — —— — — — — — — — — — Corn 40  75 55 65 55  0  0  0 85 70 70 10 80  5Crabgrass, Large 98  98 100  95 95 95 100  95 90 100  90 90 98 95Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 95  95 95 9590 90 90 90 95 98 90 90 95 95 Foxtail, Green — — — — — — — — — — — — — —Galium 80  90 90 70 85 85 85 90 85 90 90 90 85 90 Goosegrass — — — — — —— — — — — — — — Johnsongrass 15  70 75 85 30 30 15 35 75 45 60 20 85  0Kochia — — — — — — — — — — — — — — Lambsquarters 5 90 75 100  60 100  7585 95 85 90 95 10 80 Morningglory 0 25 20  0  0  0 25 10  5  0 15 20 1010 Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow 0  0  0  0 0 0  0  0  0  0  0  0  0 100  Oat, Wild — — — — — — — — — — — — — —Oilseed Rape 20  85  0 75  0 90 20  0 70 85 50 80 70  0 Pigweed 0 90  0100   0  0 75 20 60 85 85 60 25 75 Ragweed 0 85 100  70  0 85 50 10 100 80 85 40 30  0 Russian Thistle — — — — — — — — — — — — — — Ryegrass,Italian 45 30 50 45  0 40  0 10  0 15 20 30 30 10 Soybean 0  0  5  0  0 5 40  5  0  0  0  5  0  0 Sunflower — — — — — — — — — — — — — — SurinamGrass — — — — — — — — — — — — — — Velvetleaf 0 50  0 40  0 30 15 25 4535 65 45  5  0 Waterhemp 0 100  80 100  85 100  90  0 70 100  90 85 4590 Wheat 0 55 80 70  5 30  0 10  0 20  0  0 90 10 125 g ai/ha CompoundsPreemergence 247 262 263 274 275 277 278 279 280 302 303 304 305 306Barnyardgrass 90 90 95 85  95 98 95  95 85  100  95 95 95 90Bermudagrass — — — — — — — — — — — — — — Blackgrass 60  0 40 75  70 90 030 0 60  80 70 70 60 Bromegrass, Downy — — — — — — — — — — — — — —Cocklebur — — — — — — — — — — — — — — Corn 60 10  0 10  75 90 0  5 0 035 65 75 80 Crabgrass, Large 98 100  100  98  100  100  98  98 95  100 98 98 90 95 Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant98 95 98 90  98 98 95  98 90  100  98 95 95 95 Foxtail, Green — — — — —— — — — — — — — — Galium 90 60 85 80  30 100  0 85 0 85  85 85 90 90Goosegrass — — — — — — — — — — — — — — Johnsongrass 10  0  0 0 75 85 070 10  45  65 35 90 80 Kochia — — — — — — — — — — — — — — Lambsquarters70 80 70 — 85 80 0 65 10  60  65 80 70 75 Morningglory  5 10 20 0  0 450 10 0 0 15 40 40 35 Nightshade — — — — — — — — — — — — — — Nutsedge,Yellow 20  0 100  0 35 20 5  0 0 0  0  0  0  0 Oat, Wild — — — — — — — —— — — — — — Oilseed Rape 30 35 60 5 90 80 0 30 0 0 80 55 80 75 Pigweed85  0 98 0 10 40 0  0 20  25  65 85 80 85 Ragweed 70 10 80 0 60 40 0 100 5 75 80 35 75 Russian Thistle — — — — — — — — — — — — — — Ryegrass,Italian 40  0  0 5 50 40 0 30 0 5 70 40 50 55 Soybean  0  0 100  5  0  510   0 0 0  0  0  0  0 Sunflower — — — — — — — — — — — — — — SurinamGrass — — — — — — — — — — — — — — Velvetleaf 30  0 20 20  25 35 0  0 0 050 50 55 60 Waterhemp 100  60 90 — 15 55 0 55 75  65  65 85 80 85 Wheat 5  0 15 0 50 80 0 30 0 15  80 85 90 90 125 g ai/ha CompoundsPreemergence 307 309 310 312 315 316 317 318 319 323 324 325 345 346Barnyardgrass 85  90 90 90 90 90 95  95 95 98 95 95 95 95 Bermudagrass —— — — — — — — — — — — — — Blackgrass 10  50 50 70 65 30 50  30 30 45 7070 90 75 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — —— — — — — — — — — — Corn 40  65 55 55 80 65 25  10 60 10 75 70 65  0Crabgrass, Large 95  95 95 95 95 95 95  98 95 98 98 95 95 98 Cupgrass,Woolly — — — — — — — — — — — — — — Foxtail, Giant 85  90 90 90 95 90 90 75 95 95 95 98 95 98 Foxtail, Green — — — — — — — — — — — — — — Galium100  75  0  5 80  0 0 40 80 85 85 50 90 90 Goosegrass — — — — — — — — —— — — — — Johnsongrass 0 60 45 80 85 75 0 45 65 45 80 75 85 20 Kochia —— — — — — — — — — — — — — Lambsquarters 10  30 55 50 70 65 0 50 65 75 8080 85 100  Morningglory 0 10  5 40 35 25 0 30 45  0 35 30  0 30Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow 0  0  0  0 20  020   0  0 25  0  0  0  0 Oat, Wild — — — — — — — — — — — — — — OilseedRape 0 50 40 15 85 20 0  5 60 70 85 85 85 50 Pigweed 40   0 20 45 75 450 20 40 55 80 75 65 60 Ragweed 0 25  5 50 50 10 0  0 40 40 75 80 15 35Russian Thistle — — — — — — — — — — — — — — Ryegrass, Italian 5  0 20 3550 10 0  0 20  0 35 50 10  5 Soybean 0  0  0  0  0  0 0  0  0  0  0  0 5  0 Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — —— — — — — — — Velvetleaf 0  0  5 20 40 10 0 25 45 40 40 55 25 10Waterhemp 0 30 25 65 85 35 10  10 35 60 80 80 40 10 Wheat 5  0  0 60 9040 0  5 10 40 65 65 70  0 Compound 125 g ai/ha Preemergence 350Barnyardgrass 90 Bermudagrass — Blackgrass 50 Bromegrass, Downy —Cocklebur — Corn  5 Crabgrass, Large 90 Cupgrass, Woolly — Foxtail,Giant 90 Foxtail, Green — Galium 90 Goosegrass — Johnsongrass  0 Kochia— Lambsquarters 90 Morningglory 100  Nightshade — Nutsedge, Yellow  0Oat, Wild — Oilseed Rape 80 Pigweed 80 Ragweed  5 Russian Thistle —Ryegrass, Italian  5 Soybean  0 Sunflower — Surinam Grass — Velvetleaf 0 Waterhemp 90 Wheat  0 62 g ai/ha Compounds Preemergence 5 14 16 17 3334 35 48 52 53 59 60 62 64 Barnyardgrass — — — — — — — — — — — — — —Bermudagrass 0 90  0 45 0 0 0 0 40 40 20 0 30 0 Blackgrass 0 0 5 50 0 00 20 0 0 0 10 45 5 Bromegrass, Downy 0 0 5 30 0 0 0 0 0 0 0 0  0 0Cocklebur 0 0 0 5 — 0 0 0 0 — 0 0 — 0 Corn 0 0 0 0 10  0 0 20 10 20 1010 20 0 Crabgrass, Large 100 98  95  98 98  98 98 90 90 85 85 95 90 90Cupgrass, Woolly 85 0 95  85 85  85 80 70 70 65 70 75 75 70 Foxtail,Giant 100 85  70  95 95  95 90 85 80 65 85 85 80 80 Foxtail, Green 9090  35  95 98  98 98 90 90 90 90 90 90 85 Galium 5 0 0 70 0 0 0 30 0 0 50  0 0 Goosegrass 0 0 0 50 5 5 0 10 20 10 25 0 25 20 Johnsongrass 0 0 05 0 10 0 10 0 0 0 20 10 40 Kochia 0 0 0 50 0 0 0 10 10 0 0 0  0 0Lambsquarters 95 — — 60 0 40 0 65 40 0 0 — 65 10 Morningglory 0 0 0 0 00 10 0 0 0 0 10 10 20 Nightshade 45 0 0 20 0 0 0 0 0 0 — 0 15 0Nutsedge, Yellow 0 0 0 0 10  0 0 0 25 20 0 0 10 20 Oat, Wild 0 0 5 0 0 00 0 0 0 0 0 40 10 Oilseed Rape — — — — — — — — — — — — — — Pigweed 0 0 00 0 0 0 0 20 25 35 10 40 0 Ragweed 0 0 0 0 0 0 0 10 0 10 0 10 15 0Russian Thistle 0 0 0 — — 0 0 — — — 0 50 30 0 Ryegrass, Italian 0 0 0 50 0 5 0 0 0 0 0  0 0 Soybean 0 0 0 0 — 0 0 10 10 15 15 25 30 35Sunflower 0 0 0 10 10  0 0 0 0 15 5 0 20 0 Surinam Grass 85 80  95  9080  95 90 75 35 25 35 70 60 50 Velvetleaf 0 0 0 0 10  0 20 0 5 0 0 0 2010 Waterhemp — — — — — — — — — — — — — — Wheat 0 10  0 0 0 0 0 20 0 0 00  0 5 62 g ai/ha Compounds Preemergence 66 68 69 76 77 78 79 80 81 101103 109 119 120 Barnyardgrass — — — 85 95 75 95  95 — 95 90  85  90 90Bermudagrass 0 50 35 — — — — — 0 — — — — — Blackgrass 0 60  5 50 85 7565  80 0 50 0 60  70 50 Bromegrass, Downy 0 0  0 — — — — — 0 — — — — —Cocklebur — — — — — — — — 0 — — — — — Corn 0 25 15 10 20  0 0  0 0  0 05  0  0 Crabgrass, Large 95  90 90 98 95 98 98  98 75  98 98  100  98100  Cupgrass, Woolly 75  75 85 — — — — — 32  — — — — — Foxtail, Giant75  90 85 95 90 95 90  95 17  95 95  95  90 95 Foxtail, Green 80  90 90— — — — — 67  — — — — — Galium 0 5  0 —  5 50 5 90 0 40 80  100  80 95Goosegrass 5 75 40 — — — — — 0 — — — — — Johnsongrass — 35  0 45 55  0 0 0 0 15 10  10   0  0 Kochia 0 0  0 — — — — — — — — — — — Lambsquarters0 55 35  0 85 40 90  85 0 85 0 0 60 70 Morningglory 25  0 —  0  0  0 0 0 0  0 0 0  0  0 Nightshade 0 50  0 — — — — — 0 — — — — — Nutsedge,Yellow 0 10 —  0  0  0 0  0 0  0 0 5  0  0 Oat, Wild 0 —  0 — — — — — 0— — — — — Oilseed Rape — — —  0 30 10 5 85 — 35 0 0  5  0 Pigweed 0 7525  0 60 40 40  90 0  0 0 0 60 45 Ragweed 20  0  0 — — — — — 0  0 0 0 3520 Russian Thistle 0 — — — — — — — 0 — — — — — Ryegrass, Italian 0 0  025 40 40 5 40 0 15 0 40  15  5 Soybean 20  0  0  0  0  0 0  0 0  0 10  020  0 Sunflower 0 0 10 — — — — — 0 — — — — — Surinam Grass 0 75 75 — — —— — 53  — — — — — Velvetleaf 20  10 30  0 25 15 0 30 0  0 0 0 15 20Waterhemp — — — 50 40 75 40  80 — 70 0 50  65 60 Wheat 0 5  0 45 55 3040   5 0 20 0 10   5 35 62 g ai/ha Compounds Preemergence 189 202 204206 207 211 218 223 224 231 232 233 241 246 Barnyardgrass 90  90 90 9085  65 90 85  85 90 85 75 95 75 Bermudagrass — — — — — — — — — — — — — —Blackgrass 50  80 90 90 80  20 10 35  65 85 70 45 70  0 Bromegrass,Downy — — — — — — — — — — — — — — Cocklebur — — — — — — — — — — — — — —Corn 0 85 25 60 0 25  0 0  0  5 35  0 65  0 Crabgrass, Large 95  95 9090 90  95 90 90  90 95 90 90 95 95 Cupgrass, Woolly — — — — — — — — — —— — — — Foxtail, Giant 90  90 90 90 90  70 90 85  90 90 90 90 95 90Foxtail, Green — — — — — — — — — — — — — — Galium 0 90 90 70 0  5  0 040 85 85 80 80 90 Goosegrass — — — — — — — — — — — — — — Johnsongrass 060 40 65 0  0 10 0 35 10 20  0 80 20 Kochia — — — — — — — — — — — — — —Lambsquarters 0 90 100  100  0 85 40 70  65 85 85 85  0 65 Morningglory0 25  0  0 0  0  0 0 25  0 15  0  0  5 Nightshade — — — — — — — — — — —— — — Nutsedge, Yellow 0  0  0  0 0  0  0 0 10  0  0  0  0 100  Oat,Wild — — — — — — — — — — — — — — Oilseed Rape 0 80  0 70 0 35 60 0  5 5530 40  0 30 Pigweed 0 85  0 100  0  0 50 5 25 70 85 50  0 75 Ragweed 085 30 10 0 10 35 0 40 100  85 40 25  0 Russian Thistle — — — — — — — — —— — — — — Ryegrass, Italian 30  30  0 40 0 35  0 0  0 10  0  0 20  0Soybean 10  25 —  0 0  0  5 5 100   0  0  0  0  0 Sunflower — — — — — —— — — — — — — — Surinam Grass — — — — — — — — — — — — — — Velvetleaf 030  0 50 0 10  0 0  5 25 40 25  0  0 Waterhemp 5 95 75 100  0 75 75 0  585 90 80 40 98 Wheat 0 30 70 40 0  0  0 5  0 15  0  0 45  0 62 g ai/haCompounds Preemergence 247 262 263 271 274 275 277 278 279 280 302 303304 305 Barnyardgrass 85 70  90  95 65  95 98 90  95  65  85  95 90 95Bermudagrass — — — — — — — — — — — — — — Blackgrass 50 0 0 50 70  60 700 0 0 30  40 60 75 Bromegrass, Downy — — — — — — — — — — — — — —Cocklebur — — — — — — — — — — — — — — Corn 15 0 0  0 5 10 85 0 0 0 0 2040 75 Crabgrass, Large 95 98  100  100  90  95 100  95  95  90  98  9895 95 Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 95 70 95  98 85  95 98 90  95  80  95  95 95 95 Foxtail, Green — — — — — — — —— — — — — — Galium 90 40  85  — 0 90 90 0 0 0 5  0 95 80 Goosegrass — —— — — — — — — — — — — — Johnsongrass  0 0 0 10 0 50 65 0 25  0 15  55 3585 Kochia — — — — — — — — — — — — — — Lambsquarters 90 70  100  20 0 7575 0 0 0 0 60 70 70 Morningglory  0 0 0 10 0  0  0 0 0 25  0  0 50 30Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow 20 0 0  0 0 2520 0 0 0 0  0 25  0 Oat, Wild — — — — — — — — — — — — — — Oilseed Rape30 35  60  20 0 50  0 0 0 30  0 35 55 60 Pigweed 55 0 70  25 0  0 35 0 50 20  55 75 70 Ragweed 85 20  90  10 0  5  0 0 0 0 5 70 60 15 RussianThistle — — — — — — — — — — — — — — Ryegrass, Italian 35 0 0 10 0 40 350 10  0 0 35 75 50 Soybean  0 0 0  0 0  0  0 0 0 5 30   0  0  0Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — — — — —— — — — Velvetleaf 20 0 5 10 20   0  0 0 0 0 0 25 35 30 Waterhemp 100 50  80  35 0  0 50 0 15  65  35  65 80 65 Wheat  0 0 10   0 0 45 70 015  0 5 75 50 90 62 g ai/ha Compounds Preemergence 306 307 309 310 312315 316 317 318 319 323 324 325 345 Barnyardgrass 90 70  90  90  90 9085  90  95  95 85 95 90 95 Bermudagrass — — — — — — — — — — — — — —Blackgrass 30 0 0 5 45 60 0 40  0  0  0 30 50 50 Bromegrass, Downy — — —— — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 60 0 00 60 80 75  0 0 30  0 70 60 35 Crabgrass, Large 95 95  90  90  95 95 95 95  98  98 98 95 95 98 Cupgrass, Woolly — — — — — — — — — — — — — —Foxtail, Giant 95 85  90  85  90 90 90  90  70  85 95 90 95 90 Foxtail,Green — — — — — — — — — — — — — — Galium 60 0 0 0  0 80 0 0 0 70  0 6020 90 Goosegrass — — — — — — — — — — — — — — Johnsongrass 55 0 10  0 5085 75  0 0 55  0 65 35 75 Kochia — — — — — — — — — — — — — —Lambsquarters 65 0 0 5  0 40 20  0 55  65 50 70 70 75 Morningglory 35 00 0 35 25 0 0 40  40  0  0 30  0 Nightshade — — — — — — — — — — — — — —Nutsedge, Yellow  0 0 0 0 35  0 0 0 0  0 25  0  0  0 Oat, Wild — — — — —— — — — — — — — — Oilseed Rape 70 0 0 5  0 30 0 0 0  5 10 70 65 55Pigweed 85 0 0 5 40 60 25  0 20  25 35 75 65 30 Ragweed 75 0 10  0  0 200 0 0 15 10 60 60 40 Russian Thistle — — — — — — — — — — — — — —Ryegrass, Italian 40 0 0 0 30 50 0 0 0 10 10 10 40 45 Soybean  0 0 0 0 0  0 0 0 0  0  0  0  0  0 Sunflower — — — — — — — — — — — — — — SurinamGrass — — — — — — — — — — — — — — Velvetleaf 60 0 0 0 15 30 10  0 10  2015 35 35  0 Waterhemp 85 0 0 0 45 75 35  0 30  35 50 70 75  5 Wheat 50 00 0 30 50 5 0 0  0 30 25 40 10 Compounds 62 g ai/ha Preemergence 346 350Barnyardgrass 70 90  Bermudagrass — — Blackgrass 60 0 Bromegrass, Downy— — Cocklebur — — Corn  0 0 Crabgrass, Large 95 90  Cupgrass, Woolly — —Foxtail, Giant 90 90  Foxtail, Green — — Galium 20 85  Goosegrass — —Johnsongrass  0 0 Kochia — — Lambsquarters 35 90  Morningglory  0 100 Nightshade — — Nutsedge, Yellow  0 0 Oat, Wild — — Oilseed Rape  0 70 Pigweed 55 10  Ragweed 35 0 Russian Thistle — — Ryegrass, Italian 10 0Soybean  0 0 Sunflower — — Surinam Grass — — Velvetleaf  0 0 Waterhemp25 50  Wheat  0 0 31 g ai/ha Compounds Preemergence 5 14 16 17 33 34 3548 52 53 59 60 62 64 Barnyardgrass — — — — — — — — — — — — — —Bermudagrass 0 75  0 0 0 0 0 0 0 40 20  0 0 0 Blackgrass 0 0 0 5 0 0 0 00 0 0 0 0 0 Bromegrass, Downy 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Cocklebur 0 00 0 0 0 0 0 0 — — — 0 — Corn 0 0 0 0 0 0 0 0 10 10 0 0 20 0 Crabgrass,Large 100  90  95  95 95  95 95 85  80 80 85  85 85 85 Cupgrass, Woolly80  0 55  80 60  50 55 70  40 35 40  55 65 30 Foxtail, Giant 95  85  090 75  90 80 80  55 40 50  70 65 50 Foxtail, Green 85  25  5 95 95  9890 80  80 30 85  90 75 70 Galium 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Goosegrass0 0 0 0 5 0 0 0 10 0 15  0 10 20 Johnsongrass 0 0 0 0 0 10 0 0 0 0 0 0 0— Kochia 0 0 0 0 0 0 0 0 10 0 0 0 0 0 Lambsquarters 95  — 0 60 0 0 0 0 00 — 0 40 0 Morningglory 0 0 0 0 0 0 5 0 0 0 0 0 0 15 Nightshade 0 0 0 200 0 0 0 0 0 0 0 — 0 Nutsedge, Yellow 0 0 0 0 0 0 0 0 25 15 0 0 10 0 Oat,Wild 0 0 0 0 0 0 0 0 0 0 0 0 20 0 Oilseed Rape — — — — — — — — — — — — —— Pigweed 0 0 0 0 0 0 0 0 20 25 35  0 40 0 Ragweed 0 0 0 0 0 0 0 0 0 0 010 15 0 Russian Thistle — 0 0 — — 0 0 — — — 0 0 0 0 Ryegrass, Italian 00 0 0 0 0 0 0 0 0 0 0 0 0 Soybean 0 0 0 0 0 0 0 10  — 15 15  10 20 35Sunflower 0 0 0 0 0 0 0 0 0 0 5 0 10 0 Surinam Grass 65  55  80  85 80 95 85 75  10 20 0 10 0 20 Velvetleaf 0 0 0 0 0 0 0 0 5 0 0 0 10 10Waterhemp — — — — — — — — — — — — — — Wheat 0 5 0 0 0 0 0 0 0 0 0 0 0 031 g ai/ha Compounds Preemergence 66 68 69 76 77 78 79 80 81 101 103 109119 120 Barnyardgrass — — — 80  90  60  40  85  — 90  50  70  80  85 Bermudagrass 0 30 35 — — — — — 0 — — — — — Blackgrass 0 0 0 50  85  30 0 30  0 0 0 0 0 35  Bromegrass, Downy 0 0 0 — — — — — 0 — — — — —Cocklebur 0 15 0 — — — — — 0 — — — — — Corn 0 15 15 0 0 0 0 0 0 0 0 0 00 Crabgrass, Large 90 90 90 98  95  95  95  95  50  95  95  98  98  98 Cupgrass, Woolly 10 75 75 — — — — — 0 — — — — — Foxtail, Giant 20 85 7590  90  85  80  90  0 95  85  90  90  90  Foxtail, Green 50 90 90 — — —— — 20  — — — — — Galium 0 0 0 5 — 50  0 5 0 0 0 60  80  5 Goosegrass 555 20 — — — — — 0 — — — — — Johnsongrass 30 0 0 20  20  0 0 0 0 0 0 0 00 Kochia 0 0 0 — — — — — — — — — — — Lambsquarters 0 55 35 — 75  — 90 40  0 30  0 0 25  35  Morningglory 15 0 20 0 0 0 0 0 0 0 0 0 0 0Nightshade 0 10 0 — — — — — 0 — — — — — Nutsedge, Yellow 0 10 0 0 0 0 00 0 0 0 0 0 0 Oat, Wild 0 — — — — — — — 0 — — — — — Oilseed Rape — — — 00 0 0 5 — 0 0 0 0 0 Pigweed 0 45 15 — 0 0 10  75  0 0 0 30  30  50 Ragweed 10 0 0 — — — — — 0 15  40  0 60  0 Russian Thistle 0 — — — — — —— 0 — — — — — Ryegrass, Italian 0 0 0 0 40  0 0 0 0 30  0 0 0 10 Soybean 15 0 0 0 0 0 0 0 0 0 10  100  0 0 Sunflower 0 0 10 — — — — — 0 —— — — — Surinam Grass 0 40 60 — — — — — 0 — — — — — Velvetleaf 10 10 300 0 15  0 0 0 15  0 0 0 0 Waterhemp — — — 50  40  50  25  15  — 50  0 020  0 Wheat 0 0 0 35  0 10  10  0 0 0 0 0 5 10  31 g ai/ha CompoundsPreemergence 189 202 204 206 207 211 218 223 224 231 232 233 241 246Barnyardgrass 85  90 80  90 75  30  80  65  75  85  85 80  90  20 Bermudagrass — — — — — — — — — — — — — — Blackgrass 10  70 90  85 0 0 035  0 50  60 30  50  0 Bromegrass, Downy — — — — — — — — — — — — — —Cocklebur — — — — — — — — — — — — — — Corn 0 20 45  30 0 0 0 0 10  0  00 85  0 Crabgrass, Large 95  90 90  90 90  100  90  85  90  90  85 90 95  95  Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 80 90 90  90 85  0 85  70  80  90  85 85  90  85  Foxtail, Green — — — — —— — — — — — — — — Galium 0 85 — 20 0 — 0 0 0 0 85 0 20  10  Goosegrass —— — — — — — — — — — — — — Johnsongrass 0 10 10  25 0 0 0 0 0 0  0 0 85 0 Kochia — — — — — — — — — — — — — — Lambsquarters 0 80 100  75 0 100 10  70  55  40  75 85  0 65  Morningglory 0 15 0  0 0 0 0 0 5 0  0 0 0 5Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow 0  0 0  0 0 0 0100  0 0  0 0 0 85  Oat, Wild — — — — — — — — — — — — — — Oilseed Rape 025 0  5 0 0 0 0 0 0 30 0 0 0 Pigweed 0 85 0 70 0 — 5 20  0 35  85 50  030  Ragweed 0 65 30  80 0 0 40  0 10  80  65 10  0 0 Russian Thistle — —— — — — — — — — — — — — Ryegrass, Italian 0  0 0 30 0 0 0 0 0 0  0 0 20 0 Soybean 5  0 5  0 0 0 0 0 0 0  0 0 0 0 Sunflower — — — — — — — — — — —— — — Surinam Grass — — — — — — — — — — — — — — Velvetleaf 0 10 0  0 0 00 0 0 10  25 15  0 0 Waterhemp 0 85 100  70 0 85  30  90  75  75  85 95 25  100  Wheat 0  0 0 35 0 0 0 0 0 0  0 0 0 0 31 g ai/ha CompoundsPreemergence 247 262 263 271 274 275 277 278 279 280 302 303 304 305Barnyardgrass 15  45  75  90 55  80  95 65  80  55  90  90 85 90Bermudagrass — — — — — — — — — — — — — — Blackgrass 0 0 0 0 0 45  70 0 00 0  0 35 60 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — —— — — — — — — — — — — — Corn 5 0 0 0 0 0 25 0 0 0 0 10  0 65 Crabgrass,Large 95  95  100  95 85  90  98 90  95  85  95  95 95 95 Cupgrass,Woolly — — — — — — — — — — — — — — Foxtail, Giant 95  20  65  90 80  90 98 80  90  70  90  90 90 95 Foxtail, Green — — — — — — — — — — — — — —Galium 90  0 70  — 0 0 100  0 0 0 0 90 85 80 Goosegrass — — — — — — — —— — — — — — Johnsongrass 0 0 5 0 0 10  40 0 0 0 0  0  0 80 Kochia — — —— — — — — — — — — — — Lambsquarters 0 100  50  0 — 70  20 0 0 0 0 55 6560 Morningglory 0 0 0 0 0 0  0 0 0 10  0  0  5  0 Nightshade — — — — — —— — — — — — — — Nutsedge, Yellow 0 75  0 0 0 45   0 0 0 0 0  0  0  0Oat, Wild — — — — — — — — — — — — — — Oilseed Rape 5 0 40  0 0 0  0 0 00 0  0 50 20 Pigweed 0 0 70  0 0 0 10 5 0 10  0 35 55 10 Ragweed 100  00 0 — 5  0 0 0 0 35   5 60  0 Russian Thistle — — — — — — — — — — — — —— Ryegrass, Italian 0 0 0 0 0 15  40 0 0 0 0 30 30 15 Soybean 0 0 0 0 00  0 0 0 0 0  0  0  0 Sunflower — — — — — — — — — — — — — — SurinamGrass — — — — — — — — — — — — — — Velvetleaf 0 0 5 0 0 0  0 0 0 0 0 1020 25 Waterhemp 70  0 75  0 0 0 35 0 0 0 30  40 75 40 Wheat 0 0 0 0 0 560 0 0 0 0  0 40 45 31 g ai/ha Compounds Preemergence 306 307 309 310312 315 316 317 318 319 323 324 325 345 Barnyardgrass 90 40  60  50  8590 85  90  80  90 80  90 85 80 Bermudagrass — — — — — — — — — — — — — —Blackgrass  0 0 0 0 40 60 0 0 0 40 0 100   5 50 Bromegrass, Downy — — —— — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 40 0 00 10 50 15  0 0  0 0 25 10 40 Crabgrass, Large 90 90  90  90  90 90 90 95  95  95 95  95 95 95 Cupgrass, Woolly — — — — — — — — — — — — — —Foxtail, Giant 90 65  90  80  90 90 85  80  10  70 90  90 90 85 Foxtail,Green — — — — — — — — — — — — — — Galium 90 0 0 0 90 90 0 0 0 95 0  0  020 Goosegrass — — — — — — — — — — — — — — Johnsongrass 35 0 10  0 30 7550  0 0 40 0 40 20 35 Kochia — — — — — — — — — — — — — — Lambsquarters55 0 0 0  0 40 0 0 10  60 40  50 45 100  Morningglory  0 0 0 0  0 20 025  30  55 0  0  0 25 Nightshade — — — — — — — — — — — — — — Nutsedge,Yellow  0 0 0 0  0  0 0 0 0  0 20   0  0  0 Oat, Wild — — — — — — — — —— — — — — Oilseed Rape 50 0 0 0  0  5 0 0 0  0 0  0  0 50 Pigweed 80 0 00 25 45 25  0 0 30 35  55 65 30 Ragweed 50 50  10  0  0  0 0 0 0  0 0 60 5 10 Russian Thistle — — — — — — — — — — — — — — Ryegrass, Italian 15 00 0 10 40 0 0 10   0 0  0 10  0 Soybean  0 0 0 0  0  0 0 0 0  0 0  0  0 0 Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — — — —— — — — — Velvetleaf 25 0 0 5 10 30 0 0 0 30 15   0  0  0 Waterhemp 85 00 0 10 65 0 0 0 35 50  55 70  0 Wheat  5 0 0 0 30 50 0 0 0  0 5  0 10  0Compounds 31 g ai/ha Preemergence 346 350 Barnyardgrass 50 75 Bermudagrass — — Blackgrass 20  0 Bromegrass, Downy — — Cocklebur — —Corn 0 0 Crabgrass, Large 95  90  Cupgrass, Woolly — — Foxtail, Giant90  85  Foxtail, Green — — Galium 10  30  Goosegrass — — Johnsongrass 00 Kochia — — Lambsquarters 35  — Morningglory 0 100  Nightshade — —Nutsedge, Yellow 0 0 Oat, Wild — — Oilseed Rape 0 5 Pigweed 40  0Ragweed 50  0 Russian Thistle — — Ryegrass, Italian 0 0 Soybean 0 0Sunflower — — Surinam Grass — — Velvetleaf 0 0 Waterhemp 75  0 Wheat 0 016 g ai/ha Compounds Preemergence 48 189 271 277 304 Barnyardgrass — 45 75  95  85 Bermudagrass 0 — — — — Blackgrass 0 0 — 40  30 Bromegrass,Downy 0 — — — — Cocklebur 0 — — — — Corn 0 0 0 0  0 Crabgrass, Large 7590  90  95  90 Cupgrass, Woolly 25 — — — — Foxtail, Giant 40 85  75  95 90 Foxtail, Green 70 — — — — Galium 0 0 — 0 100  Goosegrass 0 — — — —Johnsongrass 0 0 0 0  0 Kochia 0 — — — — Lambsquarters 0 0 0 0 30Morningglory 0 0 0 0  0 Nightshade 0 — — — — Nutsedge, Yellow 0 0 0 0  0Oat, Wild 0 — — — — Oilseed Rape — 0 0 0 30 Pigweed 0 0 0 0 40 Ragweed 00 0 0 25 Ryegrass, Italian 0 0 0 30  10 Soybean 10 0 0 0  0 Sunflower 0— — — — Surinam Grass 10 — — — — Velvetleaf 0 0 0 0  0 Waterhemp — 0 0 070 Wheat 0 0 0 40   5 Compound 8 g ai/ha Preemergence 271 Barnyardgrass0 Blackgrass 0 Corn 0 Crabgrass, Large 50 Foxtail, Giant 55 Johnsongrass0 Lambsquarters 0 Morningglory 0 Nutsedge, Yellow 0 Oilseed Rape 0Ragweed 0 Ryegrass, Italian 0 Soybean 0 Velvetleaf 0 Waterhemp 0 Wheat 0Compounds 2000 g ai/ha Flood 77 247 Barnyardgrass 70 80 Ducksalad 100100 Rice 60 15 Sedge, Umbrella 40 0 1000 g ai/ha Compounds Flood 77 8789 101 102 103 107 111 112 113 114 189 190 200 Barnyardgrass 40 40 75 750 85 20 0 0 0 0 75 65 55 Ducksalad 100 100 100 100 0 100 70 40 0 70 80100 100 100 Rice 20 30 0 10 0 10 0 0 0 0 0 0 15 0 Sedge, Umbrella 20 0 00 0 0 0 0 0 0 0 0 0 0 1000 g ai/ha Compounds Flood 203 204 205 206 207208 210 211 212 247 270 271 344 346 Barnyardgrass 40 80 45 85 75 65 7580 65 70 80 80 55 70 Ducksalad 50 100 65 100 80 100 100 100 100 100 100100 85 100 Rice 0 10 0 15 15 15 0 15 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 00 0 0 30 0 0 0 0 0 0 500 g ai/ha Compounds Flood 77 87 89 101 102 103107 111 112 113 114 120 189 190 Barnyardgrass 30 25 40 60 0 60 0 0 0 0 075 50 50 Ducksalad 100 100 100 100 0 95 60 30 0 50 70 100 95 85 Rice 0 00 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500g ai/ha Compounds Flood 200 203 204 205 206 207 208 210 211 212 247 270271 275 Barnyardgrass 40 0 75 30 75 70 45 70 55 40 35 60 75 70 Ducksalad100 20 100 50 100 100 45 100 75 75 85 100 100 100 Rice 0 0 0 0 15 15 0 015 0 0 0 0 10 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Compounds 500g ai/ha Flood 277 344 346 Barnyardgrass 70 40 65 Ducksalad 95 65 100Rice 0 0 0 Sedge, Umbrella 0 0 0 250 g ai/ha Compounds Flood 1 2 3 4 5 78 10 11 12 14 15 16 17 Barnyardgrass 0 0 55 40 55 0 0 0 0 65 0 0 15 25Ducksalad 0 0 90 85 80 0 0 0 0 0 85 0 100 100 Rice 0 0 0 0 0 0 0 0 0 0 00 0 0 Sedge, Umbrella 0 0 50 0 0 0 0 0 0 0 20 0 0 40 250 g ai/haCompounds Flood 18 19 20 21 23 25 26 27 28 29 52 77 80 87 Barnyardgrass0 0 0 0 0 0 0 0 0 0 0 20 20 0 Ducksalad 0 0 0 85 100 60 80 30 85 40 9595 100 95 Rice 0 0 0 0 0 0 0 0 0 0 15 0 0 0 Sedge, Umbrella 0 0 0 0 30 00 0 0 0 75 0 65 0 250 g ai/ha Compounds Flood 89 92 93 101 102 103 107111 112 113 114 119 120 189 Barnyardgrass 20 10 40 55 0 40 0 0 0 0 0 7560 30 Ducksalad 85 70 85 95 0 90 30 0 0 30 30 100 100 80 Rice 0 20 30 00 0 0 0 0 0 0 20 0 0 Sedge, Umbrella 0 0 100 0 0 0 0 0 0 0 0 0 0 0 250 gai/ha Compounds Flood 190 200 203 204 205 206 207 208 210 211 212 223224 232 Barnyardgrass 25 25 0 70 20 60 60 20 45 50 15 0 60 60 Ducksalad75 70 0 95 0 100 75 45 80 100 70 95 100 95 Rice 0 0 0 0 0 0 15 0 0 0 0 020 15 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 250 g ai/ha CompoundsFlood 247 263 270 271 275 277 303 312 317 318 323 324 344 346Barnyardgrass 25 80 30 45 60 70 70 60 30 70 65 70 35 45 Ducksalad 75 10085 100 100 85 100 95 0 100 100 100 60 100 Rice 0 15 0 0 10 0 0 0 0 15 300 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha CompoundsFlood 1 2 3 4 5 7 8 10 11 12 16 17 18 19 Barnyardgrass 0 0 40 30 20 0 00 0 0 0 20 0 0 Ducksalad 0 0 85 80 70 0 0 0 0 0 85 100 0 0 Rice 0 0 0 00 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 gai/ha Compounds Flood 20 21 28 29 52 80 87 89 92 93 101 102 103 107Barnyardgrass 0 0 0 0 0 0 0 20 10 0 20 0 10 0 Ducksalad 0 50 40 0 75 10075 70 20 0 90 0 85 0 Rice 0 0 0 0 10 0 0 0 20 20 0 0 0 0 Sedge, Umbrella0 0 0 0 50 55 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Flood 111 112 113114 119 120 189 190 200 203 204 205 206 207 Barnyardgrass 0 0 0 0 60 5010 10 15 0 50 0 35 40 Ducksalad 0 0 20 20 100 100 75 50 70 0 50 0 90 60Rice 0 0 0 0 10 0 0 0 0 0 0 0 0 15 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 00 0 0 125 g ai/ha Compounds Flood 208 210 211 212 223 224 232 263 270271 275 277 303 312 Barnyardgrass 0 0 0 0 0 40 40 45 10 40 45 65 60 30Ducksalad 0 0 60 0 65 80 75 100 75 70 100 80 70 65 Rice 0 0 0 0 0 0 0 00 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 g ai/haCompounds Flood 317 318 323 324 344 346 Barnyardgrass 30 60 50 60 0 30Ducksalad 0 100 90 95 50 95 Rice 0 10 0 0 0 0 Sedge, Umbrella 0 0 0 0 00 62 g ai/ha Compounds Flood 1 2 3 4 5 7 8 10 11 12 14 15 16 17Barnyardgrass 0 0 20 0 0 0 0 0 0 0 0 0 0 0 Ducksalad 0 0 60 30 30 0 0 00 0 40 0 40 80 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 00 0 0 0 0 0 0 0 0 0 62 g ai/ha Compounds Flood 18 19 20 21 23 25 26 2728 29 52 80 92 93 Barnyardgrass 0 0 0 0 0 0 0 0 0 0 0 0 10 0 Ducksalad 00 0 0 30 0 0 0 30 0 40 70 20 0 Rice 0 0 0 0 0 0 0 0 0 0 10 0 10 20Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 40 35 0 0 62 g ai/ha Compounds Flood119 120 223 224 232 263 275 277 303 312 317 318 323 324 Barnyardgrass 5040 0 20 30 35 35 50 20 0 0 30 45 0 Ducksalad 100 100 50 40 75 90 85 6560 60 0 60 75 70 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 00 0 0 0 0 0 0 0 0 0 0 31 g ai/ha Compounds Flood 1 2 3 4 7 8 10 11 12 1617 18 19 20 Barnyardgrass 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ducksalad 0 0 4020 0 0 0 0 0 0 40 0 0 0 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella0 0 0 0 0 0 0 0 0 0 0 0 0 0 31 g ai/ha Compounds Flood 21 28 29 52 80 9293 119 223 224 232 263 303 312 Barnyardgrass 0 0 0 0 0 10 0 30 0 0 0 200 0 Ducksalad 0 20 0 40 70 0 0 100 30 0 50 70 50 50 Rice 0 0 0 10 0 1010 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 35 0 0 0 0 0 0 0 0 0 Compounds31 g ai/ha Flood 317 318 323 324 Barnyardgrass 0 20 25 0 Ducksalad 0 5050 40 Rice 0 0 0 0 Sedge, Umbrella 0 0 0 0Test D

Seeds of plant species selected from bluegrass (annual bluegrass, Poaannua), blackgrass (Alopecurus myosuroides), canarygrass (littleseedcanarygrass, Phalaris minor), chickweed (common chickweed, Stellariamedia), galium (catchweed bedstraw, Galium aparine), bromegrass, downy(downy bromegrass, Bromus tectorum), field poppy (Papaver rhoeas), fieldviolet (Viola arvensis), foxtail, green (green foxtail, Setariaviridis), deadnettle (henbit deadnettle, Lamium amplexicaule), ryegrass,Italian (Italian ryegrass, Lolium multiflorum), Kochia (Kochiascoparia), lambsquarters (Chenopodium album), oilseed rape (Brassicanapus), pigweed (Amaranthus retroflexus), chamomile (scentlesschamomile, Matricaria inodora), Russian thistle (Salsola kali),speedwell (bird's-eye speedwell, Veronica persica), barley, spring(spring barley, Hordeum vulgare), wheat, spring (spring wheat, Triticumaestivum), buckwheat, wild (wild buckwheat, Polygonum convolvulus),mustard, wild (wild mustard, Sinapis arvensis), oat, wild (wild oat,Avena fatua), radish, wild (wild radish, Raphanus raphanistrum),windgrass (Apera spica-venti), barley, winter (winter barley, Hordeumvulgare), and wheat, winter (winter wheat, Triticum aestivum) wereplanted into a silt loam soil and treated preemergence with testchemicals formulated in a non-phytotoxic solvent mixture which includeda surfactant.

At the same time, these species were planted in pots containingRedi-Earth® planting medium (Scotts Company, 14111 Scottslawn Road,Marysville, Ohio 43041) comprising spaghnum peat moss, vermiculite,wetting agent and starter nutrients and treated with postemergenceapplications of the test chemicals formulated in the same manner. Plantsranged in height from 2 to 18 cm (1- to 4-leaf stage). Treated plantsand controls were maintained in a controlled growth environment for 7 to21 days after which time all species were compared to controls andvisually evaluated. Plant response ratings, summarized in Table D, arebased on a scale of 0 to 100 where 0 is no effect and 100 is completecontrol. A dash (−) response means no test result.

TABLE D 250 g ai/ha Compounds Postemergence 6 12 17 33 34 52 80 202 231Barley, Spring 0 5 0 0 0 0 0 5 0 Barley, Winter 0 0 0 0 0 0 0 0 0Blackgrass 10 20 0 0 0 0 5 40 20 Bluegrass 0 10 0 0 0 0 10 15 10Bromegrass, Downy 0 5 0 0 0 0 20 15 25 Buckwheat, Wild 10 10 20 10 0 0 010 0 Canarygrass 0 30 0 0 0 0 0 0 0 Chamomile 0 0 0 0 0 20 50 60 50Chickweed 30 30 30 10 20 25 85 80 80 Deadnettle 10 20 10 10 0 25 40 7070 Field Poppy 30 80 0 0 20 0 50 100 50 Field Violet 25 40 10 0 20 0 2530 25 Foxtail, Green 20 25 0 0 0 0 65 70 70 Galium 0 25 30 0 0 35 60 7055 Kochia 10 35 40 10 25 35 75 75 65 Lambsquarters 30 25 40 20 20 30 3575 75 Mustard, Wild 0 — 30 0 20 25 85 85 75 Oat, Wild 5 20 0 0 0 0 10 1510 Oilseed Rape 20 25 40 30 20 25 60 55 40 Pigweed 20 50 50 10 10 40 7580 45 Radish, Wild 10 25 15 0 0 — 60 70 70 Russian Thistle 100 80 40 0 00 35 35 35 Ryegrass, Italian 0 15 0 0 0 0 0 15 0 Speedwell 15 25 0 10 3070 65 90 75 Wheat, Spring 5 0 0 0 0 0 0 5 0 Wheat, Winter 0 0 0 0 0 0 50 0 Windgrass 0 5 0 0 0 0 25 45 15 Compounds Postemergence 6 12 17 33 3450 52 80 202 231 125 g ai/ha Barley, Spring 0 5 0 0 0 0 0 0 0 0 Barley,Winter 0 0 0 0 0 0 0 0 0 0 Blackgrass 5 15 0 0 0 0 0 5 10 10 Bluegrass 010 0 0 0 0 0 15 10 10 Bromegrass, Downy 0 0 0 0 0 0 0 20 5 25 Buckwheat,Wild 0 10 10 0 0 10 0 0 0 0 Canarygrass 0 15 0 0 0 0 0 0 0 0 Chamomile 00 0 0 0 0 20 35 65 50 Chickweed 10 20 25 10 10 15 15 85 80 80 Deadnettle10 15 10 0 0 0 20 70 60 35 Field Poppy 20 60 0 0 0 0 0 20 100 0 FieldViolet 20 35 0 0 0 0 0 15 30 10 Foxtail, Green 0 20 0 0 0 0 0 65 70 70Galium 0 20 10 0 0 0 25 55 70 55 Kochia 5 20 20 0 10 0 25 70 75 60Lambsquarters 20 10 20 0 0 20 30 40 70 70 Mustard, Wild 0 100 30 0 10 4020 85 80 65 Oat, Wild 0 15 0 0 0 0 0 5 10 10 Oilseed Rape 15 20 20 20 05 10 45 60 20 Pigweed 20 30 50 10 0 10 30 70 75 35 Radish, Wild 0 25 150 0 0 — 35 75 75 Russian Thistle 0 30 20 0 0 5 0 25 30 35 Ryegrass,Italian 0 10 0 0 0 0 0 0 10 0 Speedwell 0 10 0 0 0 — 40 70 85 75 Wheat,Spring 5 0 0 0 0 0 0 0 0 0 Wheat, Winter 0 0 0 0 0 0 0 10 0 0 Windgrass0 0 0 0 0 0 0 10 35 0 62 g ai/ha Barley, Spring 0 5 0 0 0 0 0 0 0 0Barley, Winter 0 0 0 0 0 0 0 0 0 0 Blackgrass 5 10 0 0 0 0 0 5 5 10Bluegrass 0 0 0 0 0 0 0 10 10 10 Bromegrass, Downy 0 0 0 0 0 0 0 15 0 20Buckwheat, Wild 0 10 0 0 0 10 0 10 0 0 Canarygrass 0 15 0 0 0 0 0 0 0 0Chamomile 0 0 0 0 0 0 0 30 60 25 Chickweed 0 0 0 0 0 20 10 45 75 80Deadnettle 0 10 0 0 0 0 0 60 35 70 Field Poppy 20 50 0 0 0 0 0 55 75 20Field Violet 20 30 0 0 0 0 0 20 30 20 Foxtail, Green 0 10 0 0 0 0 0 4565 65 Galium 0 15 0 0 0 0 0 45 70 45 Kochia 5 20 20 0 0 15 20 75 70 60Lambsquarters 20 10 0 0 0 5 0 45 60 50 Mustard, Wild — 40 10 0 0 — 20 8080 65 Oat, Wild 0 10 0 0 0 0 0 10 10 10 Oilseed Rape 10 10 10 10 0 5 050 70 10 Pigweed 10 25 40 0 0 0 0 70 75 35 Radish, Wild 0 20 0 0 0 0 —70 70 70 Russian Thistle 0 20 0 0 0 10 0 30 30 35 Ryegrass, Italian 0 00 0 0 0 0 0 0 0 Speedwell 0 10 0 0 0 — 25 70 75 70 Wheat, Spring 5 0 0 00 0 0 0 0 0 Wheat, Winter 0 0 0 0 0 0 0 0 0 0 Windgrass 0 0 0 0 0 0 0 1010 5 31 g ai/ha Barley, Spring 0 0 0 0 0 0 0 0 0 0 Barley, Winter 0 0 00 0 0 0 0 0 0 Blackgrass 0 10 0 0 0 0 0 5 0 0 Bluegrass 0 0 0 0 0 0 0 50 5 Bromegrass, Downy 0 0 0 0 0 0 0 15 0 15 Buckwheat, Wild 0 0 0 0 0 100 0 0 0 Canarygrass 0 0 0 0 0 0 0 0 0 0 Chamomile 0 0 0 0 0 0 0 20 5 20Chickweed 0 0 0 0 0 15 0 35 75 25 Deadnettle 0 0 0 0 0 0 0 70 5 35 FieldPoppy 0 0 0 0 0 0 0 25 0 0 Field Violet 0 0 0 0 0 0 0 15 40 20 Foxtail,Green 0 0 0 0 0 0 0 45 60 10 Galium 0 0 0 0 0 0 0 20 60 40 Kochia 5 5 00 — 15 0 65 70 55 Lambsquarters 10 0 0 0 0 5 0 45 65 55 Mustard, Wild 010 0 0 0 60 10 70 85 35 Oat, Wild 0 0 0 0 0 0 0 10 5 5 Oilseed Rape 1010 0 0 0 5 0 30 60 15 Pigweed 10 10 0 0 0 0 0 40 75 20 Radish, Wild 0 00 0 0 0 — 50 50 30 Russian Thistle 0 0 0 0 0 0 0 20 30 20 Ryegrass,Italian 0 0 0 0 0 0 0 0 0 0 Speedwell 0 0 0 0 0 — 20 60 60 60 Wheat,Spring 0 0 0 0 0 0 0 0 0 0 Wheat, Winter 0 0 0 0 0 0 0 0 0 0 Windgrass 00 0 0 0 0 0 0 0 0 16 g ai/ha Compounds Postemergence 6 12 17 33 34 50 52Barley, Spring 0 0 0 0 0 0 0 Barley, Winter 0 0 0 0 0 0 0 Blackgrass 0 50 0 0 0 0 Bluegrass 0 0 0 0 0 0 0 Bromegrass, Downy 0 0 0 0 0 0 0Buckwheat, Wild 0 0 0 0 0 10 0 Canarygrass 0 0 0 0 0 0 0 Chamomile 0 0 00 0 0 0 Chickweed 0 0 0 0 0 10 0 Deadnettle 0 0 0 0 0 0 0 Field Poppy 00 0 0 0 0 0 Field Violet 0 0 0 0 0 0 0 Foxtail, Green 0 0 0 0 0 0 0Galium 0 0 0 0 0 0 0 Kochia 0 5 0 0 0 10 0 Lambsquarters 0 0 0 0 0 5 0Mustard, Wild 0 0 0 0 0 40 0 Oat, Wild 0 0 0 0 0 0 0 Oilseed Rape 10 100 0 0 5 0 Pigweed 0 0 0 0 0 5 0 Radish, Wild 0 0 0 0 0 0 — RussianThistle 0 0 0 0 0 5 0 Ryegrass, Italian 0 0 0 0 0 0 0 Speedwell 0 0 0 00 0 20 Wheat, Spring 0 0 0 0 0 0 0 Wheat, Winter 0 0 0 0 0 0 0 Windgrass0 0 0 0 0 0 0 250 g ai/ha Compounds Preemergence 6 12 52 77 80 202 204206 207 231 241 Barley, Spring 10 0 5 25 30 30 45 55 25 35 35 Barley,Winter 20 0 25 55 25 25 35 65 45 20 65 Blackgrass 0 0 0 65 25 75 65 9075 55 75 Bluegrass 0 40 20 55 45 70 35 70 30 25 70 Bromegrass, Downy 1010 0 25 10 20 45 70 15 15 60 Buckwheat, Wild 0 100 10 55 15 15 25 55 3510 80 Canarygrass 20 40 0 85 20 75 75 85 75 35 75 Chamomile 90 20 80 —85 100 — — 85 100 — Chickweed — 0 — 100 100 95 100 95 100 90 100Deadnettle 40 50 30 75 70 85 35 75 20 85 45 Field Poppy 100 0 80 100 100100 95 95 100 95 100 Field Violet 0 0 — 55 25 15 25 25 35 0 30 Foxtail,Green 10 0 60 85 80 95 100 98 90 98 90 Galium 100 10 20 85 75 85 25 8020 40 80 Kochia 50 0 40 85 75 85 70 80 60 85 70 Lambsquarters 0 30 20 9090 85 90 90 90 90 90 Mustard, Wild 20 70 10 45 70 75 20 75 30 15 25 Oat,Wild 0 0 0 45 20 40 40 55 20 30 55 Oilseed Rape 20 20 10 5 30 75 0 5 055 10 Pigweed 0 0 15 80 45 90 35 50 5 80 80 Radish, Wild — — — 30 70 800 30 15 0 0 Russian Thistle 30 0 30 — — 40 — — — 30 — Ryegrass, Italian0 0 0 35 15 10 60 75 15 0 50 Speedwell 50 100 100 100 100 100 70 90 30100 85 Wheat, Spring 0 0 0 25 20 35 30 65 10 20 40 Wheat, Winter 0 0 1055 10 25 20 30 20 25 25 Windgrass 100 0 60 95 90 90 95 90 65 85 98Compounds Preemergence 6 12 50 52 77 80 202 204 206 207 231 241 125 gai/ha Barley, Spring 0 0 0 0 25 15 25 20 40 20 5 20 Barley, Winter 0 0 00 45 15 20 25 40 25 0 30 Blackgrass 0 0 0 0 40 20 65 40 85 20 15 50Bluegrass 0 20 0 0 45 20 65 15 35 15 15 45 Bromegrass, Downy 0 0 0 0 105 0 35 55 15 0 15 Buckwheat, Wild 0 0 — 10 55 5 10 25 50 25 0 20Canarygrass 20 20 0 0 65 10 60 10 85 0 20 65 Chamomile 70 0 5 75 — 80 75— — 85 80 — Chickweed — 0 0 — 100 100 90 100 70 70 95 95 Deadnettle 40 0100 0 60 65 80 25 40 20 60 35 Field Poppy 0 0 65 — 95 100 90 80 90 80100 95 Field Violet 0 0 0 — 20 20 10 25 35 35 10 20 Foxtail, Green 0 040 0 70 75 98 98 98 75 95 90 Galium 100 0 0 0 85 65 80 10 50 45 35 35Kochia 40 0 0 20 80 70 85 15 70 10 80 80 Lambsquarters 0 30 0 20 90 9085 65 85 65 90 90 Mustard, Wild 10 20 80 0 25 65 20 20 0 25 0 15 Oat,Wild 0 0 0 0 20 10 35 60 40 5 25 20 Oilseed Rape 10 10 0 10 5 10 45 0 00 45 5 Pigweed 0 0 5 10 80 20 90 35 40 0 60 85 Radish, Wild — — — — 2530 0 0 30 15 0 0 Russian Thistle 10 0 0 20 — — 35 — — — 15 — Ryegrass,Italian 0 0 0 0 25 5 5 45 55 5 0 20 Speedwell 30 0 0 100 35 85 90 10 6525 100 70 Wheat, Spring 0 0 0 0 20 10 25 25 45 10 0 25 Wheat, Winter 0 00 0 25 10 25 15 25 10 15 10 Windgrass 100 0 0 40 90 75 90 85 90 20 75 9562 g ai/ha Barley, Spring 0 0 0 0 5 10 25 15 35 5 5 10 Barley, Winter 00 0 0 0 5 20 20 30 10 0 10 Blackgrass 0 0 0 0 25 10 35 10 70 5 0 55Bluegrass 0 0 0 0 5 10 25 0 30 15 0 15 Bromegrass, Downy 0 0 0 0 0 5 020 25 15 0 15 Buckwheat, Wild 0 0 0 0 75 0 10 25 65 15 0 15 Canarygrass10 0 0 0 45 0 10 10 75 5 15 45 Chamomile 30 0 0 75 — 80 65 — — 80 75 —Chickweed — 0 0 — 90 100 80 100 100 60 85 80 Deadnettle 0 0 100 0 65 065 25 35 0 75 30 Field Poppy 0 0 0 50 90 100 85 85 90 75 80 95 FieldViolet 0 0 0 — 20 20 0 15 35 15 0 15 Foxtail, Green 0 0 50 0 80 65 90 9895 60 80 90 Galium 50 0 0 0 55 45 70 10 40 60 40 25 Kochia 30 0 10 20 7535 85 45 60 10 20 30 Lambsquarters 0 0 0 0 85 80 85 30 80 30 80 90Mustard, Wild 0 0 0 0 20 25 0 20 0 25 10 15 Oat, Wild 0 0 0 0 15 5 20 2535 0 20 15 Oilseed Rape 0 10 0 0 5 10 35 0 0 0 0 0 Pigweed 0 0 25 10 7010 80 5 20 0 50 15 Radish, Wild — — 0 — 10 30 0 0 25 10 0 0 RussianThistle 0 0 0 0 — — 20 — — — 5 — Ryegrass, Italian 0 0 0 0 15 5 5 15 305 0 20 Speedwell 10 0 0 90 25 85 90 10 25 20 80 35 Wheat, Spring 0 0 0 010 10 5 0 25 10 5 0 Wheat, Winter 0 0 0 0 0 5 10 15 0 15 10 5 Windgrass0 0 5 0 85 20 85 65 75 20 70 90 31 g ai/ha Barley, Spring 0 0 0 0 5 0 00 5 0 0 0 Barley, Winter 0 0 0 0 0 0 20 0 15 5 0 10 Blackgrass 0 0 0 010 5 30 5 30 0 0 20 Bluegrass 0 0 0 0 0 0 10 0 0 0 5 15 Bromegrass,Downy 0 0 0 0 0 0 0 0 10 0 0 0 Buckwheat, Wild 0 0 0 0 0 0 0 20 45 0 015 Canarygrass 0 0 0 0 25 0 5 0 55 0 0 20 Chamomile 0 0 0 20 — 80 60 — —75 75 — Chickweed — — 0 — 75 85 45 100 30 60 75 90 Deadnettle 0 0 50 015 0 40 25 20 0 35 35 Field Poppy 0 0 50 50 75 90 85 75 80 55 80 90Field Violet 0 0 0 — 15 0 0 10 15 10 0 15 Foxtail, Green 0 0 0 0 15 2090 90 85 15 45 35 Galium 0 0 0 0 35 0 75 0 10 55 20 20 Kochia 0 0 10 2035 15 85 20 45 10 0 20 Lambsquarters 0 0 0 0 85 85 80 35 50 0 45 85Mustard, Wild 0 0 — 0 0 0 0 0 0 10 0 10 Oat, Wild 0 0 0 0 10 0 5 0 25 020 15 Oilseed Rape 0 0 0 0 5 0 0 0 0 0 0 0 Pigweed 0 0 10 10 25 5 75 0 50 50 15 Radish, Wild — — — — 0 15 0 0 25 15 0 0 Russian Thistle 0 0 0 0— — 15 — — — 0 — Ryegrass, Italian 0 0 0 0 15 0 0 5 35 0 0 15 Speedwell10 0 0 90 20 10 90 0 0 20 75 10 Wheat, Spring 0 0 0 0 10 0 0 0 10 5 0 0Wheat, Winter 0 0 0 0 0 5 5 5 0 0 5 0 Windgrass 0 0 0 0 45 5 65 50 75 555 65 16 g ai/ha Compounds Preemergence 6 12 50 52 Barley, Spring 0 0 00 Barley, Winter 0 0 0 0 Blackgrass 0 0 0 0 Bluegrass 0 0 0 0Bromegrass, Downy 0 0 0 0 Buckwheat, Wild 0 0 0 0 Canarygrass 0 0 0 0Chamomile 0 0 0 20 Chickweed — — 0 — Deadnettle 0 0 50 0 Field Poppy — 00 30 Field Violet 0 0 0 — Foxtail, Green 0 0 0 0 Galium 0 0 0 0 Kochia 00 5 0 Lambsquarters 0 0 0 0 Mustard, Wild 0 0 50 0 Oat, Wild 0 0 0 0Oilseed Rape 0 0 0 0 Pigweed 0 0 10 0 Russian Thistle 0 0 0 0 Ryegrass,Italian 0 0 0 0 Speedwell 0 0 0 40 Wheat, Spring 0 0 0 0 Wheat, Winter 00 0 0 Windgrass 0 0 0 0Test E

Seeds of plant species selected from corn (Zea mays), soybean (Glycinemax), velvetleaf (Abutilon theophrasti), lambsquarters (Chenopodiumalbum), wild poinsettia (Euphorbia heterophylla), pigweed, palmer(palmer pigweed, Amaranthus palmeri), waterhemp (common waterhemp,Amaranthus rudis), surinam grass (Brachiaria decumbens), crabgrass,large (large crabgrass, Digitaria sanguinalis), crabgrass, Brazil(Brazilian crabgrass, Digitaria horizontalis), Panicum, fall (fallPanicum, Panicum dichotomiflorum), foxtail, giant (giant foxtail,Setaria faberii), foxtail, green (green foxtail, Setaria viridis),goosegrass (Eleusine indica), johnsongrass (Sorghum halepense), ragweed(common ragweed, Ambrosia elation), barnyardgrass (Echinochloacrus-galli), sandbur (southern sandbur, Cenchrus echinatus), arrowleafsida (Sida rhombifolia), ryegrass, Italian (Italian ryegrass, Loliummultiflorum), dayflower, VA (Virginia dayflower, Commelina virginica),field bindweed (Convolvulus arvensis), morningglory (Ipomoea coccinea),nightshade (eastern black nightshade, Solanum ptycanthum), Kochia(Kochia scoparia), nutsedge, yellow (yellow nutsedge, Cyperusesculentus), cocklebur (common cocklebur, Xanthium strumarium),smartweed (ladysthumb smartweed, Polygonum persicaria) and beggarticks(hairy beggarticks, Bidens pilosa), were planted into a silt loam soiland treated preemergence with test chemicals formulated in anon-phytotoxic solvent mixture which included a surfactant. Treatedplants and controls were maintained in a greenhouse for 21 days, afterwhich time all species were compared to controls and visually evaluated.Plant response ratings, summarized in Table E, are based on a scale of 0to 100 where 0 is no effect and 100 is complete control. A dash (−)response means no test result.

TABLE E Compounds Preemergence 14 16 17 66 80 103 202 204 206 232 350250 g ai/ha Arrowleaf Sida 0 0 0 0 10 65 80 0 50 90 50 Barnyardgrass 7570 98 50 80 90 98 98 98 95 98 Beggarticks 0 0 — 0 60 15 80 0 0 60 20Cocklebur 0 0 — — 0 — — — 0 — — Corn 0 0 0 0 30 0 60 40 70 0 0Crabgrass, Brazil 95 98 98 98 95 98 98 98 98 98 98 Crabgrass, Large 9098 95 98 95 98 98 98 100 98 98 Dayflower, VA 0 — 0 0 0 0 40 30 20 10 40Field Bindweed 0 0 0 0 0 35 70 30 50 40 60 Foxtail, Giant 90 95 98 — 9098 98 98 98 98 80 Foxtail, Green 70 95 95 60 90 98 98 98 98 98 85Goosegrass 0 0 35 0 80 0 98 0 90 95 25 Johnsongrass 0 0 0 0 30 20 25 4090 25 0 Kochia 0 0 50 0 90 0 98 40 80 98 90 Lambsquarters 70 0 0 0 90 9898 65 98 98 95 Morningglory 0 0 — 0 40 10 30 30 0 35 0 Nightshade 70 0 00 70 0 80 100 10 — 80 Nutsedge, Yellow 0 0 15 0 0 15 0 0 75 0 15Panicum, Fall 40 — 0 0 0 0 85 75 98 60 0 Pigweed, Palmer 0 0 0 — 90 2580 0 0 65 35 Poinsettia, Wild 25 0 20 20 0 0 65 20 25 40 30 Ragweed 0 00 20 20 0 90 0 75 95 65 Ryegrass, Italian 0 30 0 0 60 0 50 30 65 40 35Sandbur 30 95 95 35 70 95 80 80 98 90 85 Smartweed — — — — 40 — — — — —— Soybean 0 0 0 0 40 0 0 — 0 0 0 Surinam Grass 60 60 75 35 70 95 95 9598 98 65 Velvetleaf 0 0 0 0 0 0 40 0 50 80 0 Waterhemp 0 0 0 0 60 0 95 050 95 35 125 g ai/ha Arrowleaf Sida 0 0 0 0 0 0 70 0 10 65 20Barnyardgrass 40 10 95 50 75 50 85 98 95 98 60 Beggarticks 0 0 — 0 20 035 0 0 20 20 Cocklebur 0 0 0 — 0 — — — 0 — — Corn 0 0 0 0 0 0 40 0 40 00 Crabgrass, Brazil 95 80 95 98 70 95 98 98 98 98 95 Crabgrass, Large 9075 75 90 95 98 98 98 98 98 98 Dayflower, VA 0 0 0 0 0 0 0 20 0 0 0 FieldBindweed 0 0 0 0 0 40 50 0 30 40 65 Foxtail, Giant 10 25 95 98 80 95 9595 98 95 50 Foxtail, Green 10 25 70 35 80 95 98 95 98 98 80 Goosegrass 00 0 0 70 0 90 0 70 85 0 Johnsongrass 0 0 0 0 10 0 20 35 75 0 0 Kochia 00 25 0 80 0 95 0 50 98 75 Lambsquarters 50 — 0 0 90 65 98 90 95 100 98Morningglory 0 0 — 0 20 0 0 20 0 0 0 Nightshade 50 0 0 — 70 0 90 100 598 50 Nutsedge, Yellow 0 0 0 0 0 0 0 0 20 0 0 Panicum, Fall — 0 0 0 0 050 75 98 50 0 Pigweed, Palmer 0 0 0 — 65 0 85 0 0 80 35 Poinsettia, Wild20 0 0 0 0 0 25 20 0 35 0 Ragweed 0 0 0 0 0 0 85 0 0 95 60 Ryegrass,Italian 0 0 0 0 45 0 25 25 80 20 20 Sandbur 0 70 65 0 65 75 85 75 95 9065 Smartweed 0 Soybean 0 0 0 0 0 0 0 0 0 0 0 Surinam Grass 20 35 70 0 6065 65 98 85 70 50 Velvetleaf 0 0 0 0 0 0 0 0 30 20 0 Waterhemp 0 0 0 050 0 95 0 50 85 0 62 g ai/ha Arrowleaf Sida 0 0 0 0 0 0 30 0 0 20 0Barnyardgrass 0 0 80 20 50 30 80 75 75 70 40 Beggarticks 0 — — 0 0 0 0 00 0 0 Cocklebur 0 0 0 0 0 — — — 0 — — Corn 0 0 0 0 0 0 0 0 50 0 0Crabgrass, Brazil 80 65 95 95 — 95 98 95 98 98 75 Crabgrass, Large 25 3070 75 95 98 98 98 98 98 70 Dayflower, VA 0 0 0 0 0 0 0 0 0 0 0 FieldBindweed 0 0 0 0 0 0 40 0 20 0 60 Foxtail, Giant 0 15 35 0 75 90 50 9598 90 20 Foxtail, Green 0 10 40 0 70 60 75 98 98 95 35 Goosegrass 0 0 00 60 0 70 0 0 80 0 Johnsongrass 0 0 0 0 0 0 0 0 50 0 0 Kochia 0 — 0 0 600 95 0 0 95 40 Lambsquarters 0 0 0 0 85 0 98 98 65 98 60 Morningglory —0 — 0 0 0 0 0 0 0 0 Nightshade 30 0 0 0 60 0 50 20 0 75 0 Nutsedge,Yellow 0 0 0 0 0 0 0 0 15 0 0 Panicum, Fall 0 0 0 0 0 0 0 0 98 50 0Pigweed, Palmer 0 0 0 — — 0 70 0 0 0 0 Poinsettia, Wild 15 0 0 0 0 0 0 010 0 0 Ragweed 0 0 0 0 0 0 80 0 0 75 0 Ryegrass, Italian 0 0 0 0 0 0 0 035 10 25 Sandbur 0 35 50 0 50 35 70 50 80 65 35 Smartweed — — — — 20 — —— — — — Soybean 0 0 0 0 0 0 0 0 0 0 0 Surinam Grass 0 20 50 0 50 50 — 6095 50 0 Velvetleaf 0 0 0 0 0 0 0 0 35 0 0 Waterhemp 0 0 0 0 30 0 60 0 —80 0 31 g ai/ha Arrowleaf Sida 0 0 0 0 0 0 0 0 0 0 0 Barnyardgrass 0 0 00 20 0 40 20 70 60 15 Beggarticks 0 — — 0 0 0 0 0 0 0 0 Cocklebur — 0 00 — — — — 0 — — Corn 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Brazil 65 25 65 85— 70 80 95 80 95 0 Crabgrass, Large — 20 20 10 90 65 98 95 98 95 50Dayflower, VA 0 — 0 0 0 0 0 0 0 0 0 Field Bindweed 0 0 0 0 0 0 60 0 20 040 Foxtail, Giant 0 0 35 0 65 60 35 50 90 35 0 Foxtail, Green 0 0 25 060 20 10 40 80 80 20 Goosegrass 0 0 0 0 30 0 35 0 0 35 0 Johnsongrass 00 0 0 0 0 0 0 30 0 0 Kochia 0 0 0 0 60 0 95 0 0 90 0 Lambsquarters 0 0 00 80 0 0 98 35 95 80 Morningglory 0 0 — 0 0 0 0 0 0 0 0 Nightshade 0 0 —0 — 0 0 0 0 25 0 Nutsedge, Yellow 0 0 0 0 0 0 0 0 15 0 0 Panicum, Fall 00 0 0 0 0 0 0 75 35 0 Pigweed, Palmer 0 0 0 — 0 0 0 0 0 0 0 Poinsettia,Wild 0 0 0 0 0 0 0 0 0 0 0 Ragweed 0 — 0 0 0 0 20 0 0 35 0 Ryegrass,Italian 0 0 0 0 0 0 0 0 0 0 0 Sandbur 0 0 0 0 30 10 35 20 65 35 15Smartweed — — — — 0 — — — — — — Soybean 0 0 0 0 0 0 0 0 0 0 0 SurinamGrass 0 0 0 0 40 20 20 35 50 40 0 Velvetleaf 0 0 0 0 0 0 0 0 0 0 0Waterhemp 0 0 0 0 20 0 50 0 50 35 0 16 g ai/ha Compounds Preemergence 1416 17 66 80 Arrowleaf Sida 0 0 0 0 0 Barnyardgrass 0 0 0 0 0 Beggarticks0 0 — 0 0 Cocklebur — 0 0 0 0 Corn 0 0 0 0 0 Crabgrass, Brazil 0 25 4085 — Crabgrass, Large 0 10 15 0 50 Dayflower, VA 0 0 0 0 0 FieldBindweed 0 0 0 0 0 Foxtail, Giant 0 0 0 0 0 Foxtail, Green 0 0 0 0 50Goosegrass 0 0 0 0 10 Johnsongrass 0 0 0 0 0 Kochia 0 — 0 0 —Lambsquarters 0 0 0 0 50 Morningglory 0 0 — 0 0 Nightshade 0 0 0 0 50Nutsedge, Yellow 0 0 0 0 0 Panicum, Fall 0 0 0 0 0 Pigweed, Palmer 0 0 0— 0 Poinsettia, Wild 0 0 0 0 0 Ragweed 0 — 0 0 0 Ryegrass, Italian 0 0 00 0 Sandbur 0 0 0 0 20 Smartweed — — — — 0 Soybean 0 0 0 0 0 SurinamGrass 0 0 0 0 30 Velvetleaf 0 0 0 0 0 Waterhemp 0 0 0 0 0Test F

Three plastic pots (ca. 16-cm diameter) per rate were partially filledwith sterilized Tama silt loam soil comprising a 35:50:15 ratio of sand,silt and clay and 2.6% organic matter. Separate plantings for each ofthe three pots were as follows. Seeds from the U.S. of Monochoria(Monochoria vaginalis), sedge, umbrella (small-flower umbrella sedge,Cyperus difformis), bulrush, hardstem (hardstem bulrush, Scirpusjuncoides), and redstem (purple redstem, Ammannia coccinea), wereplanted into one 16-cm pot for each rate. Seeds from the U.S. offlatsedge, rice (rice flatsedge, Cyperus iria), sprangletop, Brdd.(bearded sprangletop, Leptochloa fascicularis), one stand of 9 or 10water seeded rice seedlings (Rice, W. S. Jap, Oryza sativa cv.‘Japonica—M202’ or Rice, W. S. Ind, ‘Indica’), and two stands of 3 or 4seedlings of rice, transplanted (transplanted rice, Oryza sativa cv.‘Japonica—M202’) were planted into one 16-cm pot for each rate. Seedsfrom the U.S. of barnyardgrass (Echinochloa crus-galli), waterplantain(common waterplantain, Alisma plantago-aquatica), and watergrass, late(late watergrass, Echinochloa oryzicola) were planted into one 16-cm potfor each rate. Plantings were sequential so that crop and weed specieswere at the 2.0 to 2.5-leaf stage at time of treatment.

Potted plants were grown in a greenhouse with day/night temperaturesettings of 30/27° C., and supplemental balanced lighting was providedto maintain a 16-h photoperiod. Test pots were maintained in thegreenhouse until test completion.

At time of treatment, test pots were flooded to 3 cm above the soilsurface, treated by application of test compounds directly to the paddywater, and then maintained at that water depth for the duration of thetest. Effects of treatments on rice and weeds were visually evaluated bycomparison to untreated controls after 21 d. Plant response ratings,summarized in Table F, are based on a scale of 0 to 100 where 0 is noeffect and 100 is complete control. A dash (−) response means no testresult.

TABLE F 2000 g ai/ha Compounds Flood 5 17 247 Barnyardgrass 90 100 75Bulrush, Hardstem — 40 — Flatsedge, Rice 0 40 35 Monochoria 75 95 75Recistem 45 40 55 Rice, Transplanted 0 10 15 Rice, W.S. Jap — 85 —Sedge, Umbrella 0 20 0 Sprangletop, Brdd. 90 100 98 Watergrass, Late 10095 90 Waterplantain 90 — 90 1000 g ai/ha Compounds Flood 5 17 103 247Barnyardgrass 90 95 100 70 Bulrush, Hardstem — 0 — — Flatsedge, Rice 035 — 0 Monochoria 75 95 100 75 Redstern 45 35 — 50 Rice, Transplanted 010 0 10 Rice, W.S. Ind — — 15 — Rice, W.S. Jap — 60 — — Sedge, Umbrella0 0 — 0 Sprangletop, Brdd. 85 85 100 98 Watergrass, Late 100 90 100 85Waterplantain 85 — — 90 Compounds Flood 3 5 17 99 101 103 204 206 207210 247 271 303 500 g ai/ha Barnyardgrass 90 75 90 80 90 100 100 100 100100 70 100 100 Bulrush, Hardstem 30 — 0 — — — — — — — — — 80 Flatsedge,Rice 20 0 20 — — — — — — — 0 — 0 Monochoria 100 75 95 95 100 100 100 100100 100 75 100 100 Redstem 20 40 0 — — — — — — — 0 — 30 Rice,Transplanted 0 0 10 0 0 0 0 40 0 0 0 15 30 Rice, W.S. Ind — — — 0 60 020 65 10 0 — 60 70 Rice, W.S. Jap 10 — 15 — — — — — — — — — — Sedge,Umbrella 0 0 0 — — — — — — — 0 — 0 Sprangletop, Brdd. 85 85 85 85 95 100100 100 100 100 98 95 90 Watergrass, Late 85 75 90 50 85 98 98 100 90 9070 100 100 Waterplantain — 80 — — — — — — — — 90 — — 250 g ai/haBarnyardgrass 90 65 90 50 85 100 100 100 100 100 65 100 100 Bulrush,Hardstem 0 — 0 — — — — — — — — — 70 Flatsedge, Rice 0 0 20 — — — — — — —0 — 0 Monochoria 90 75 90 85 100 100 100 100 100 85 70 100 100 Redstem 00 0 — — — — — — — 0 — 0 Rice, Transplanted 0 0 10 0 0 0 0 10 0 0 0 0 15Rice, W.S. Ind — — — 0 35 0 10 45 0 0 — 30 40 Rice, W.S. Jap 0 — 15 — —— — — — — — — — Sedge, Umbrella 0 0 0 — — — — — — — 0 — 0 Sprangletop,Brdd. 80 85 85 75 95 100 100 100 100 100 95 80 85 Watergrass, Late 80 7085 40 85 98 98 100 85 75 65 100 100 Waterplantain — 70 — — — — — — — —85 — — 125 g ai/ha Barnyardgrass 55 90 25 85 60 100 100 60 75 60 75 100— Bulrush, Hardstem — 0 — — — — — — — — — 0 — Flatsedge, Rice 0 20 — — —— — — — 0 — 0 — Monochoria 75 90 50 100 100 95 90 65 65 70 100 100 —Redstem 0 0 — — — — — — — 0 — 0 — Rice, Transplanted 0 10 0 0 0 0 0 0 00 0 0 — Rice, W.S. Ind — — 0 20 0 0 25 0 0 — 15 25 — Rice, W.S. Jap — 0— — — — — — — — — — — Sedge, Umbrella 0 0 — — — — — — — 0 — 0 —Sprangletop, Brdd. 85 85 0 85 80 98 95 100 100 90 30 80 — Watergrass,Late 55 80 30 75 60 70 100 65 55 65 75 95 — Waterplantain 55 — — — — — —— — 80 — — — 64 g ai/ha Compounds Flood 101 103 206 271 Barnyardgrass 6060 90 55 Monochoria 75 85 80 85 Rice, Transplanted 0 0 0 0 Rice, W.S.Ind 0 0 15 0 Sprangletop, Brdd. 75 80 90 20 Watergrass, Late 65 40 90 4562 g ai/ha Compound Flood 303 Barnyardgrass 100 Bulrush, Hardstem 0Flatsedge, Rice 0 Monochoria 100 Redstem 0 Rice, Transplanted 0 Rice,Water Seeded 0 Sedge, Umbrella 0 Sprangletop, Brdd. 70 Watergrass, Late95Test G

Seeds of small-flower umbrella sedge (CYPDI, Cyperus difformis) andducksalad (HETLI, Heteranthera limosa) were sown on the soil surface intwo separate quadrants of 11-cm (4-inch) tubs filled with steampasteurized Tama soil. Simultaneously, plantings of barnyardgrass(ECHCG, Echinochloa crus-galli) and transplanted Japonica rice (ORYSA,Oryza sativa) were established in separate “plug” flats. Plants weregrown in a greenhouse using supplemental lighting to maintain aphotoperiod of approximately 16 h; daytime and nighttime temperatureswere approximately 27-30° C. and 24-27° C., respectively. After 8 d,barnyardgrass plants were transplanted to one of the remaining quadrantsof the tub, and the water level was adjusted to a final depth of 3-cm.Herbicide application timing was targeted at the 2.0 to 2.5 leaf stageand the plants were treated with test chemicals formulated in anon-phytotoxic solvent. Treated plants and controls were maintained in agreenhouse for 14 d, after which time all species were compared tocontrols and visually evaluated. Plant response ratings are summarizedin Tables G1 through G12, and are based on a scale of 0 to 100 where 0is no effect and 100 is complete control. A dash (−) response means notest result.

Colby's Equation was used to determine the herbicidal effects expectedfrom the mixtures. Colby's Equation (Colby, S. R. “CalculatingSynergistic and Antagonistic Responses of Herbicide Combinations,”Weeds, 15(1), pp 20-22 (1967)) calculates the expected additive effectof herbicidal mixtures and for two active ingredients is of the form:

P_(a + b) = P_(a) + P_(b) − (P_(a)P_(b)/100)

where

-   -   P_(a+b) is the percentage effect of the mixture expected from        additive contribution of the individual components:    -   P_(a) is the observed percentage effect of the first active        ingredient at the same use rate as in the mixture, and    -   P_(b) is the observed percentage effect of the second active        ingredient at the same use rate as in the mixture.        In the following Tables, rates are shown in grams of active        ingredient per hectare (g a.i./ha); “Obsd.” is the observed        effect. “Exp.” is the expected effect calculated from Colby's        Equation.

TABLE G1 Observed and Expected Results from Compound 204 Alone and inCombination with Fentrazamide Application Rate (g a.i./ha) CYPDI HETLIECHCG ORYSA Cmpd. 204 Fentrazamide Obsd. Exp. Obsd. Exp. Obsd. Exp.Obsd. Exp. 125 — 0 — 100 — 65 — 0 — 500 — 0 — 100 — 90 — 0 — — 100 90 —85 — 50 — 0 — — 200 100 — 100 — 95 — 15 — 125 100 95 90 100 100 80 83 00 125 200 95 90 100 100 95 95 0 0 500 100 100 100 100 100 95 98 0 15 500200 100 100 100 100 95 100 0 15

TABLE G2 Observed and Expected Results from Compound 103 Alone and inCombination with Fentrazamide Application Rate (g a.i./ha) CYPDI HETLIECHCG ORYSA Cmpd. 103 Fentrazamide Obsd. Exp. Obsd. Exp. Obsd. Exp.Obsd. Exp. 125 — 0 — 100 — 60 — 0 — 500 — 0 — 100 — 80 — 15 — — 100 100— 100 — 85 — 0 — — 200 100 — 100 — 85 — 0 — 125 100 70 100 100 100 50 940 0 125 200 100 100 100 100 75 97 0 15 500 100 100 100 100 100 80 94 100 500 200 100 100 100 100 80 97 10 15

TABLE G3 Observed and Expected Results from Compound 204 Alone and inCombination with Tefuryltrione Application Rate (g a.i./ha) CYPDI HETLIECHCG ORYSA Cmpd. 204 Tefuryltrione Obsd. Exp. Obsd. Exp. Obsd. Exp.Obsd. Exp. 125 — 0 — 100 — 65 — 0 — 500 — 0 — 100 — 90 — 0 — — 100 100 —100 — 40 — 0 — 125 100 100 100 100 100 95 79 0 0 500 100 100 100 100 10095 94 0 0

TABLE G4 Observed and Expected Results from Compound 103 Alone and inCombination with Tefuryltrione Application Rate (g a.i./ha) CYPDI HETLIECHCG ORYSA Cmpd. 103 Tefuryltrione Obsd. Exp. Obsd. Exp. Obsd. Exp.Obsd. Exp. 125 — 0 — 100 — 60 — 0 — 500 — 0 — 100 — 80 — 15 — — 100 90 —90 — 0 — 0 — 125 100 98 90 100 100 55 60 0 0 500 100 98 90 100 100 90 800 15

TABLE G5 Observed and Expected Results from Compound 204 Alone and inCombination with Triafamone Application Rate (g a.i./ha) CYPDI HETLIECHCG ORYSA Cmpd. 204 Triafamone Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd.Exp. 125 — 0 — 100 — 65 — 0 — 500 — 0 — 100 — 90 — 0 — — 20 0 — 0 — 90 —0 — 125 20 0 0 98 100 85 97 0 0 500 20 45 0 100 100 90 99 0 0

TABLE G6 Observed and Expected Results from Compound 103 Alone and inCombination with Triafamone Application Rate (g a.i./ha) CYPDI HETLIECHCG ORYSA Cmpd. 103 Triafamone Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd.Exp. 125 — 0 — 100 — 60 — 0 — 500 — 0 — 100 — 80 — 15 — — 20 0 — 0 — 85— 0 — 125 20 0 0 100 100 85 94 0 0 500 20 0 0 100 100 90 97 0 15

TABLE G7 Observed and Expected Results from Compound 204 Alone and inCombination with Pyrimisulfan Application Rate (g a.i./ha) CYPDI HETLIECHCG ORYSA Cmpd. 204 Pyrimisulfan Obsd. Exp. Obsd. Exp. Obsd. Exp.Obsd. Exp. 125 — 0 — 100 — 65 — 0 — 500 — 0 — 100 — 90 — 0 — — 20 98 —100 — 75 — 25 — 125 20 100 98 100 100 85 91 25 25 500 20 100 98 100 10095 98 25 25

TABLE G8 Observed and Expected Results from Compound 103 Alone and inCombination with Pyrimisulfan Application Rate (g a.i./ha) CYPDI HETLIECHCG ORYSA Cmpd. 103 Pyrimisulfan Obsd. Exp. Obsd. Exp. Obsd. Exp.Obsd. Exp. 125 — 0 — 100 — 60 — 0 — 500 — 0 — 100 — 80 — 15 — — 20 100 —100 — 80 — 20 — 125 20 100 100 100 100 85 92 20 20 500 20 100 100 100100 85 96 0 32

TABLE G9 Observed and Expected Results from Compound 204 Alone and inCombination with Mefenecet Application Rate (g a.i./ha) CYPDI HETLIECHCG ORYSA Cmpd. 204 Mefenecet Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd.Exp. 125 — 0 — 100 — 65 — 0 — 500 — 0 — 100 — 90 — 0 — — 300 100 — 100 —30 — 0 — 125 300 100 98 100 100 60 76 0 0 500 300 100 98 100 100 90 93 00

TABLE G10 Observed and Expected Results from Compound 103 Alone and inCombination with Mefenecet Application Rate (g a.i./ha) CYPDI HETLIECHCG ORYSA Cmpd. 103 Mefenecet Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd.Exp. 125 — 0 — 100 — 60 — 0 — 500 — 0 — 100 — 80 — 15 — — 300 100 — 100— 65 — 10 — 125 300 100 98 100 100 70 86 10 10 500 300 100 98 100 100 8093 20 24

TABLE G11 Observed and Expected Results from Compound 204 Alone and inCombination with Bensulfuron-methyl Application Rate (g a.i./ha) CYPDIHETLI ECHCG ORYSA Cmpd. 204 Bensulfuron-methyl Obsd. Exp. Obsd. Exp.Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 65 — 0 — 500 — 0 — 100 — 90 — 0 —— 20 100 — 100 — 65 — 10 — 125 20 100 100 100 100 70 88 0 10 500 20 100100 100 100 90 97 0 10

TABLE G12 Observed and Expected Results from Compound 103 Alone and inCombination with Bensulfuron-methyl Application Rate (g a.i./ha) CYPDIHETLI ECHCG ORYSA Cmpd. 103 Bensulfuron-methyl Obsd. Exp. Obsd. Exp.Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 60 — 0 — 500 — 0 — 100 — 80 — 15 —— 20 98 — 100 — 65 — 0 — 125 20 98 98 100 100 65 86 0 0 500 20 100 98100 100 85 93 10 15Test H

This test evaluated the effect of mixtures of compound 80 with severalcommercial herbicides on four plant species. Seeds of plant speciesselected from corn (ZEAMD, Zea mays), soybean (GLXMA, Glycine max),waterhemp (common waterhemp, AMATA, Amaranthus rudis), and giant foxtail(SETFA, Setaria faberii) were planted into a silt loam soil and treatedpreemergence with test chemicals formulated in a non-phytotoxic solventmixture which included a surfactant and applied using a volume of 281L/ha. Each treatment was replicated three times. Treated plants andcontrols were maintained in a greenhouse using supplemental lighting tomaintain a photoperiod of about 16 h; daytime and nighttime temperatureswere about 24-30° C. and 19-21° C., respectively. Nutrients were appliedusing a balanced fertilizer applied through the watering system. At 21 dafter treatment, all species were compared to controls and visuallyevaluated. Plant response ratings were calculated as the means of thethree replicates, are summarized in Tables H1 through H5, and are basedon a scale of 0 to 100 where 0 is no effect and 100 is complete control.A dash (−) response means no test result. The Expected (Exp.) resultswere calculated using Colby's Equation as described for Test G above.

TABLE H1 Observed and Expected Results from Compound 80 Alone and inCombination with Chlorimuron-ethyl Application Rate (g a.i./ha) ZEAMDGLXMA AMATA SETFA Cmpd 80 Chlorimuron-ethyl Obsd. Exp. Obsd. Exp. Obsd.Exp. Obsd. Exp. 62 — 17 — 12 — 0 — 52 — 125 — 13 — 0 — 33 — 78 — — 1 22— 0 — 47 — 0 — — 31 73 — 22 — 89 — 47 — 62 1 22 35 18 12 73 47 25 52 1251 15 32 5 0 73 64 67 78 62 31 96 78 35 31 69 89 58 75 125 31 75 77 0 2294 93 78 88

TABLE H2 Observed and Expected Results from Compound 80 Alone and inCombination with S-metolachlor Application Rate (g a.i./ha) ZEAMD GLXMAAMATA SETFA Cmpd 80 S-metolachlor Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd.Exp. 62 — 17 — 12 — 0 — 52 — 125 — 13 — 0 — 33 — 78 — — 31 13 — 18 — 0 —73 — — 125 20 — 15 — 85 — 99 — 62 31 10 28 8 28 33 0 93 87 125 31 30 2425 18 75 33 96 94 62 125 25 34 28 25 85 85 98 100 125 125 37 30 12 15 9890 93 100

TABLE H3 Observed and Expected Results from Compound 80 Alone and inCombination with Saflufenacil Application Rate (g a.i./ha) ZEAMD GLXMAAMATA SETFA Cmpd 80 Saflufenacil Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd.Exp. 62 — 17 — 12 — 0 — 52 — 125 — 13 — 0 — 33 — 78 — — 1 20 — 0 — 0 — 0— — 31 0 — 13 — 83 — 23 — 62 1 22 34 40 12 38 0 57 52 125 1 15 30 15 033 33 80 78 62 31 30 17 25 23 73 83 40 63 125 31 25 13 0 13 97 89 80 83

TABLE H4 Observed and Expected Results from Compound 80 Alone and inCombination with Atrazine Application Rate (g a.i./ha) ZEAMD GLXMA AMATASETFA Cmpd 80 Atrazine Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 62 —17 — 12 — 0 — 52 — 125 — 13 — 0 — 33 — 78 — — 62 0 — 13 — 33 — 0 — — 1250 — 48 — 90 — 8 — 62 62 18 17 20 23 83 33 63 52 125 62 10 13 0 13 87 5578 78 62 125 20 17 5 54 100 90 58 56 125 125 23 13 30 48 98 93 70 80

TABLE H5 Observed and Expected Results from Compound 80 Alone and inCombination with Mesotrione Application Rate (g a.i./ha) ZEAMD GLXMAAMATA SETFA Cmpd 80 Mesotrione Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd.Exp. 62 — 17 — 12 — 0 — 52 — 125 — 13 — 0 — 33 — 78 — — 16 12 — 25 — 96— 0 — 62 16 20 27 28 34 93 96 25 52 125 16 32 23 83 25 93 97 48 78

What is claimed is:
 1. A compound of Formula 1:

or a salt thereof, wherein Q¹ is a 5- to 6-membered fully unsaturatedheterocyclic ring, each ring containing ring members selected fromcarbon atoms and 1 to 4 heteroatoms independently selected from up to 2O, up to 2 S and up to 4 N atoms, each ring optionally substituted withup to 5 substituents independently selected from R⁷ on carbon atom ringmembers and selected from R⁹ on nitrogen atom ring members; Q² is aphenyl ring substituted with 1 to 2 substituents independently selectedfrom R¹⁰; Y¹ is O; Y² is O; R¹ is H or CH₃; R² is H; R³ is H; R⁴ is H;R⁵ is H; R⁶ is H; each R⁷ is independently halogen or C₁-C₂ haloalkyl;each R⁹ is CH₃; each R¹⁰ is independently halogen or C₁ haloalkyl;provided that when Q¹ comprises a 3-furanyl or 3-pyridinyl ring directlybonded to the remainder of Formula 1, then said ring is substituted withat least one substituent selected from R⁷.
 2. A herbicidal compositioncomprising a compound of claim 1 and at least one component selectedfrom the group consisting of surfactants, solid diluents, and liquiddiluents.
 3. The herbicidal composition of claim 2 further comprising atleast one additional active ingredient selected from the groupconsisting of other herbicides and herbicide safeners.
 4. A herbicidalmixture comprising (a) the compound of claim 1 and (b) at least oneadditional active ingredient selected from photosystem II inhibitors,acetohydroxy acid synthase (AHAS) inhibitors, acetyl-CoA carboxylase(ACCase) inhibitors, auxin mimics, 5-enol-pyruvylshikimate-3-phosphate(EPSP) synthase inhibitors, photosystem I electron diverters,protoporphyrinogen oxidase (PPO) inhibitors, glutamine synthetase (GS)inhibitors, very long chain fatty acid (VLCFA) elongase inhibitors,auxin transport inhibitors, phytoene desaturase (PDS) inhibitors,4-hydroxyphenyl-pyruvate dioxyenase (HPPD) inhibitors, homogentisatesolanesyltransferase (HST) inhibitors, cellulose biosynthesisinhibitors, other herbicides selected from mitotic disruptors, organicarsenicals, asulam, bromobutide, cinmethylin, cumyluron, dazomet,difenzoquat, dymron, etobenzanid, flurenol, fosamine, foamine-ammonium,metam, methyldymron, oleic acid, oxaziclomefone, pelargonic acid andpyributicarb, and herbicide safeners; and salts thereof.
 5. A herbicidalmixture comprising (a) a compound of claim 1 and (b) at least oneadditional active ingredient selected from acetohydroxy acid synthase(AHAS) inhibitors, very long chain fatty acid (VLCFA) elongaseinhibitors, and 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) inhibitors;and salts thereof.
 6. A method for controlling the growth of weedscomprising contacting the weeds or their environment with a herbicidallyeffective amount of a compound of claim
 1. 7. A mixture comprising acompound of claim 1 and a compound selected from benzobicyclon,bromobutide, fenquinotrione, metazosulturon, pethoxamid, pretilachlor,pyrazolynate, pyrazolsulfuron-ethyl, pyrimisulfan, and triafamone.
 8. Acompound of Formula 1:

or a salt thereof, wherein

R^(v) is R⁷ or R⁹; wherein substituent R⁷ is on the carbon atom ringmembers and substituent R⁹ is on the nitrogen atom ring members; r is 1or 2; Q² is Ph(2,3-di-F) or Ph(2-F); Y¹ is O; Y² is O; R¹ is H or CH₃;R² is H; R³ is H; R⁴ is H; R⁵ is H; R⁶ is H; each R⁷ is independentlyhalogen or C₁-C₂ haloalkyl; and each R⁹ is CH₃, provided when Q¹comprises a 3-pyridinyl ring directly bonded to the remainder of Formula1, then said ring is substituted with at least one substituent selectedfrom R′.
 9. The compound of claim 8, or a salt thereof, wherein Q¹ is


10. The compound of claim 8, or a salt thereof, wherein Q¹ is


11. The compound of claim 8, or a salt thereof, wherein Q¹ is


12. The compound of claim 8, or a salt thereof, wherein Q² isPh(2,3-di-F).
 13. The compound of claim 8, or a salt thereof, wherein Q²is Ph(2-F).
 14. The compound of claim 8, or a salt thereof, wherein R¹is H.
 15. The compound of claim 8, or a salt thereof, wherein R¹ is CH₃.16. The compound of claim 8, or a salt thereof, wherein each R⁷ isindependently halogen or C haloalkyl.
 17. The compound of claim 8, or asalt thereof, wherein each R⁷ is independently halogen or C₁fluoroalkyl.
 18. The compound of claim 8, or a salt thereof, whereineach R⁷ is independently halogen or CF₃.
 19. The compound of claim 8, ora salt thereof, wherein each R⁷ is independently F, Cl, Br or CF₃. 20.The compound of claim 8, or a salt thereof, wherein each R⁷ isindependently F or CF₃.
 21. The compound of claim 8, or a salt thereof,wherein Q¹ is

Q² is Ph(2,3-di-F), and R¹ is CH₃.
 22. A herbicidal compositioncomprising a compound of claim 8 and at least one component selectedfrom the group consisting of surfactants, solid diluents, and liquiddiluents.
 23. The herbicidal composition of claim 22 further comprisingat least one additional active ingredient selected from the groupconsisting of other herbicides and herbicide safeners.
 24. A herbicidalmixture comprising (a) the compound of claim 8 and (b) at least oneadditional active ingredient selected from photosystem II inhibitors,acetohydroxy acid synthase (AHAS) inhibitors, acetyl-CoA carboxylase(ACCase) inhibitors, auxin mimics, 5-enol-pyruvylshikimate-3-phosphate(EPSP) synthase inhibitors, photosystem I electron diverters,protoporphyrinogen oxidase (PPO) inhibitors, glutamine synthetase (GS)inhibitors, very long chain fatty acid (VLCFA) elongase inhibitors,auxin transport inhibitors, phytoene desaturase (PDS) inhibitors,4-hydroxyphenyl-pyruvate dioxyenase (HPPD) inhibitors, homogentisatesolanesyltransferase (HST) inhibitors, cellulose biosynthesisinhibitors, other herbicides selected from mitotic disruptors, organicarsenicals, asulam, bromobutide, cinmethylin, cumyluron, dazomet,difenzoquat, dymron, etobenzanid, flurenol, fosamine, foamine-ammonium,metam, methyldymron, oleic acid, oxaziclomefone, pelargonic acid andpyributicarb, and herbicide safeners; and salts thereof.
 25. Aherbicidal mixture comprising (a) a compound of claim 8 and (b) at leastone additional active ingredient selected from acetohydroxy acidsynthase (AHAS) inhibitors, very long chain fatty acid (VLCFA) elongaseinhibitors, and 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) inhibitors;and salts thereof.
 26. A method for controlling the growth of weedscomprising contacting the weeds or their environment with a herbicidallyeffective amount of a compound of claim
 8. 27. A mixture comprising acompound of claim 8 and a compound selected from benzobicyclon,bromobutide, fenquinotrione, metazosulfuron, pethoxamid, pretilachlor,pyrazolynate, pyrazolsulfuron-ethyl, pyrimisulfan, and triafamone.